Insights into mechanism of glucokinase activation: Observation of multiple distinct protein conformations

Journal of Biological Chemistry

Volumn 287, Issue 17, 2012, Pages 13598-13610

  Liu, Shenping ^a   Ammirati, Mark J ^a   Song, Xi ^a   Knafels, John D ^a   Zhang, Jeff ^a   Greasley, Samantha E ^a   Pfefferkorn, Jeffrey A ^a   Qiu, Xiayang ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC COMPLEXES; CLINICAL TRIAL; COOPERATIVITY; GLUCOKINASE; GLUCOSE-STIMULATED INSULIN SECRETIONS; KINETIC PROPERTIES; OPEN CONFORMATION; PLASMA GLUCOSE; PLASMA GLUCOSE LEVEL; PROTEIN CONFORMATION; SMALL ANGLE X-RAY SCATTERING; SMALL MOLECULES; THEORETICAL MODELS; WILD TYPES;

CHEMICAL ACTIVATION; GLUCOSE; INSULIN; PLASMAS;

CONFORMATIONS;

GLUCOKINASE; GLUCOSE;

ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME MODIFICATION; MOLECULAR MODEL; MOLECULAR SIZE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; WILD TYPE; X RAY;

ALLOSTERIC SITE; CATALYSIS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GLUCOKINASE; GLUCOSE; HOMEOSTASIS; HUMANS; HYPOGLYCEMIA; KINETICS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; SCATTERING, RADIATION; X-RAYS;

EID: 84859991127     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.274126     Document Type: Article

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