Designing glucokinase activators with reduced hypoglycemia risk: Discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4- yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

MedChemComm

Volumn 2, Issue 9, 2011, Pages 828-839

  Pfefferkorn, Jeffrey A ^a   Guzman Perez, Angel ^a   Oates, Peter J ^a   Litchfield, John ^a   Aspnes, Gary ^a   Basak, Arindrajit ^a   Benbow, John ^a   Berliner, Martin A ^a   Bian, Jianwei ^a   Choi, Chulho ^a   Freeman Cook, Kevin ^a   Corbett, Jeffrey W ^a   Didiuk, Mary ^a   Dunetz, Joshua R ^a   Filipski, Kevin J ^a   Hungerford, William M ^a   Jones, Christopher S ^a   Karki, Kapil ^a   Ling, Anthony ^a   Li, Jian Cheng ^a   Patel, Leena ^a   Perreault, Christian ^a   Risley, Hud ^a   Saenz, James ^a   Song, Wei ^a   Tu, Meihua ^a   Aiello, Robert ^a   Atkinson, Karen ^a   Barucci, Nicole ^a   Beebe, David ^a   Bourassa, Patricia ^a   Bourbounais, Francis ^a   Brodeur, Anne M ^a   Burbey, Rena ^a   Chen, Jing ^a   D'Aquila, Theresa ^a   Derksen, David R ^a   Haddish Berhane, Nahor ^a   Huang, Cong ^a   Landro, James ^a   Lee Lapworth, Amanda ^a   MacDougall, Margit ^a   Perregaux, David ^a   Pettersen, John ^a   Robertson, Alan ^a   Tan, Beijing ^a   Treadway, Judith L ^a   Liu, Shenping ^a   Qiu, Xiayang ^a   Knafels, John ^a   Ammirati, Mark ^a   Song, Xi ^a   Dasilva Jardine, Paul ^a   Liras, Spiros ^a   Sweet, Laurel ^a   Rolph, Timothy P ^a   more..

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ACTIVATOR; GLUCOKINASE; GLUCOKINASE ACTIVATOR; N,N DIMETHYL 5 [2 METHYL 6 [(5 METHYLPYRAZIN 2 YL)CARBAMOYL]BENZOFURAN 4 YLOXY]PYRIMIDINE 2 CARBOXAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BILE FLOW; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG SCREENING; FEMALE; HAPLORHINI; HUMAN; HYPOGLYCEMIA; IN VITRO STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; URINARY EXCRETION;

EID: 80052381675     PISSN: 20402503     EISSN: 20402511     Source Type: Journal    
DOI: 10.1039/c1md00116g     Document Type: Article

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