Functional and molecular defects of pancreatic islets in human type 2 diabetes

Diabetes

Volumn 54, Issue 3, 2005, Pages 727-735

  Del Guerra, Silvia ^a   Lupi, Roberto ^a   Marselli, Lorella ^a   Masini, Matilde ^a   Bugliani, Marco ^a   Sbrana, Simone ^a   Torri, Scilla ^a   Pollera, Maria ^a   Boggi, Ugo ^a   Mosca, Franco ^a   Del Prato, Stefano ^a   Marchetti, Piero ^a  

^a CISANELLO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; 8 HYDROXYDEOXYGUANOSINE; ARGININE; GLIBENCLAMIDE; GLUCOKINASE; GLUCOSE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 2; GLUTATHIONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; MESSENGER RNA; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR PDX 1;

ADULT; AGED; ARTICLE; CADAVER; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EXPOSURE; ELECTRON MICROSCOPY; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; GLUCOSE OXIDATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RELEASE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; ORGAN DONOR; OXIDATIVE STRESS; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ADULT; AGED; DEOXYGUANOSINE; DIABETES MELLITUS, TYPE 2; FEMALE; GENE EXPRESSION; GLUCOSE; GLUTATHIONE; HUMANS; INSULIN; ISLETS OF LANGERHANS; MALE; MIDDLE AGED; MULTIENZYME COMPLEXES; OXIDATIVE STRESS; PROTEIN-SERINE-THREONINE KINASES; TIME FACTORS; TYROSINE;

EID: 20044390365     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.54.3.727     Document Type: Article

References (44)

1. Zimmet P, Alberti KGMM, Shaw J: Global and societal implications of the diabetes epidemic. Nature 414:782-787, 2001
2. Amos AF, McCarthy D, Zimmet P: The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabet Med 14:S1-S85, 1997
3. American Diabetes Association: Economic consequences of diabetes mellitus in the U.S. in 1997. Diabetes Care 21:296-309, 1998
4. Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1. Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15:539-553, 1998
5. McCarthy MI, Froguel P: Genetic approaches to the molecular understanding of type 2 diabetes. Am J Physiol Endocrinol Metab 283:E217-E225, 2002
6. Atkinson MA, Maclaren NK: The pathogenesis of insulin-dependent diabetes mellitus. N Engl J Med U S A 331:1428-1436, 1994
7. Polonsky KS, Sturis J, Bell JI: Non-insulin dependent diabetes mellitus: a genetically programmed failure of the beta cell to compensate for insulin resistance. N Engl J Med 334:777-783, 1996
8. Kahn S: The importance of beta-cell failure in the development and progression of type 2 diabetes mellitus. J Clin Endocrinol Metab 86:4047-4058, 2001
9. Polonsky KS, Given BD, Hirsch LJ, Tillil H, Shapiro ET, Beebe C, Frank BH, Galloway JA, Van Cauter E: Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus. N Engl J Med 318:1231-1239, 1998
10. Schmitz O, Brock B, Hollingdal M, Juhl CB, Porksen N: High-frequency insulin pulsatility and type 2 diabetes: from physiology and pathophysiology to clinical pharmacology. Diabetes Metab 28:4814-4820, 2002
11. Weyer C, Bogardus C, Mott D, Prateley R: The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest 104:787-794, 1999
12. Fernandez-Alvarez J, Conget I, Rasschaert J, Sener A, Gomis R, Malaisse WJ: Enzymatic, metabolic and secretory patterns in human islets of type 2 (non-insulin-dependent) diabetic patients. Diabetologia 37:177-181, 1994
13. Lin JM, Fabregat ME, Gomis R, Bergsten P: Pulsatile insulin release from islets isolated from three subjects with type 2 diabetes. Diabetes 51:988-993, 2002
14. Deng S, Vatamaniuk M, Huang X, Doliba N, Lian MM, Frank A, Velidedeoglu E, Desai NM, Koeberlein B, Wolf B, Barker CF, Naji A, Matschinsky FM, Markmann JF: Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects. Diabetes 53:624-632, 2004
15. Marchetti P, Dotta F, Ling Z, Lupi R, Del Guerra S, Santangelo C, Realacci M, Marselli L, Di Mario U, Navalesi R: Function of pancreatic islets isolated from a type 1 diabetic patient. Diabetes Care 23:701-703, 2000
16. Marselli L, Dotta F, Piro S, Santangelo C, Masini M, Lupi R, Realacci M, del Guerra S, Mosca F, Boggi U, Purrello F, Navalesi R, Marchetti P: Th2 cytokines have a partial, direct protective effect on the function and survival of isolated human islets exposed to combined proinflammatory and Th1 cytokines. J Clin Endocrinol Metab 86:4974-4978, 2001
17. Lupi R, Del Guerra S, Fierabracci V, Marselli L, Novelli M, Patane G, Boggi U, Mosca F, Piro S, Del Prato S, Marchetti P: Lipotoxicity in human pancreatic islets and the protective effect of metformin. Diabetes 51:8134-S137, 2002
18. Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patane G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P: Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51:1437-1442, 2002
19. Marchetti P, Lupi R, Federici M, Marselli L, Masini M, Boggi U, Del Guerra S, Patane G, Piro S, Anello M, Bergamini E, Purrello F, Lauro R, Mosca F, Sesti G, Del Prato S: Insulin secretory function is impaired in isolated human islets carrying the Gly(972)→Arg IRS-1 polymorphism. Diabetes 51:1419-1424, 2002
20. Patanè G, Anello M, Piro S, Vigneri R, Purrello F, Rabuazzo AM: Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-γ inhibition. Diabetes 51:2749-2756, 2002
21. Lupi R, Del Guerra S, Marselli L, Bugliani M, Boggi U, Mosca F, Marchetti P, Del Prato S: Rosiglitazone prevents the impairment of human islet function induced by fatty acids: evidence for a role of PPARgamma2 in the modulation of insulin secretion. Am J Physiol Endocrinol Metab 286:E560-E567, 2004
22. da Silva XG, Leclerc I, Varadi A, Tsuboi T, Moule SK, Rutter GA: Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J 371:761-774, 2003
23. Kelly M, Keller C, Avilucea PR, Keller P, Luo Z, Xiang X, Giralt M, Hidalgo J, Saha AK, Pedersen BK, Ruderman NB: AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. Biochem Biophys Res Commun 320:449-454, 2004
24. Kuroki T, Isshiki K, King GL: Oxidative stress: the lead or supporting actor in the pathogenesis of diabetic complications. J Am Soc Nephrol 14:8216-S220, 2003
25. Quagliaro L, Piconi L, Assaloni R, Martinelli L, Motz E, Ceriello A: Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells: the role of protein kinase C and NAD(P)H-oxidase activation. Diabetes 52:2795-2804, 2003
26. Shibata MA, Shirai T, Ogawa K, Takahashi S, Wild CP, Montesano R, Tsuda H, Ito N: DNA methylation adduct formation and H-ras gene mutations in progression of N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder tumors caused by a single exposure to N-methyl-N-nitrosourea. Carcinogenesis 15:2965-2968, 1994
27. Del Prato S, Tiengo A: The importance of first-phase insulin secretion: implications for the therapy of type 2 diabetes mellitus. Diabetes Metab Res Rev 17:164-174, 2001
28. Carling D: The AMP-activated protein kinase cascade - a unifying system for energy control Trends Biochem Sci 29:18-24, 2004
29. Servitja JM, Ferrer J: Transcriptional networks controlling pancreatic development and beta cell function. Diabetologia 47:597-613, 2004
30. Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH 3rd, Wright CV, White MF, Arden KC, Accili D: The forkhead transcription factor Foxol links insulin signaling to Pdx1 regulation of pancreatic beta cell growth. J Clin Invest 110:1839-1847, 2002
31. Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H: Glucose toxicity in β-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 52:581-587, 2003
32. Brownlee M: A radical explanation for glucose-induced beta cell dysfunction. J Clin Invest 112:1788-1790, 2003
33. Steiner DF, James DE: Cellular and molecular biology of the beta cell. Diabetologia 35 (Suppl. 2):S41-S48, 1992
34. Lenzen S, Tiedge M: Regulation of pancreatic B-cell glucokinase and GLUT2 glucose transporter gene. Biochem Soc Trans 22:1-6, 1994
35. Matschinsky FM: Regulation of pancreatic beta-cell glucokinase: from basics to therapeutics. Diabetes 51 (Suppl. 3):S394-S404, 2002
36. Bouchè C, Serdy S, Kahn CR, Goldfine AB: The cellular fate of glucose and its relevance in type 2 diabetes. Endocr Rev 25:807-830, 2004
37. Henquin JC, Ravier MA, Nenquin M, Jonas JC, Gilon P: Hierarchy of the beta-cell signals controlling insulin secretion. Eur J Clin Invest 33:742-750, 2003
38. Maechler P, Wollheim C: Mitochondrial function in normal and diabetic beta-cells. Nature 414:807-812, 2001
39. Akkan AG, Malaisse WJ: Insulinotropic action of AICA riboside. I. Insulin release by isolated islets and the perfused pancreas. Diabetes Res 25:13-23, 1994
40. Melloul D: Transcription factors in islet development and physiology: Role of PDX-1 in beta-cell function. Ann N Y Acad Sci 1014:28-37, 2004
41. Robertson RP: Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. J Biol Chem 279:42351-42354, 2004
42. Lortz S, Tiedge M, Nachtwey T, Karlsen AE, Nerup J, Lenzen S: Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes. Diabetes 49:1123-1230
43. Paolisso G, Giugliano D, Pizza G, Gambardella A, Tesauro P, Varricchio M, D'Onofrio F: Glutathione infusion potentiates glucose-induced insulin secretion in aged patients with impaired glucose tolerance. Diabetes Care 15:1-7, 1992
44. Lupi R, Marselli L, Dionisi S, Del Guerra S, Boggi U, Del Chiaro M, Lencioni C, Bugliani M, Mosca F, Di Mario U, Del Prato S, Dotta F, Marchetti P: Improved insulin secretory function and reduced chemotactic properties after tissue culture of islets from type 1 diabetic patients. Diabetes Metab Res Rev 20:246-521, 2004