The role of phosphatidylcholine and choline metabolites to cell proliferation and survival

Critical Reviews in Biochemistry and Molecular Biology

Volumn 48, Issue 1, 2013, Pages 20-38

  Ridgway, Neale D ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Cancer; Choline; Choline kinase; CTP:phosphocholine cytidylyltransferase; Phosphatidylcholine

Indexed keywords

CALCIUM INDEPENDENT PHOSPHOLIPASE A2; CHOLINE; CHOLINE KINASE; CHOLINE PHOSPHATE CYTIDYLYLTRANSFERASE; ETHANOLAMINE PHOSPHOTRANSFERASE; GLYCEROPHOSPHORYLCHOLINE; PHOSPHATIDYLCHOLINE;

APOPTOSIS; CANCER CELL; CANCER GROWTH; CELL CYCLE REGULATION; CELL FATE; CELL PROLIFERATION; CELL SURVIVAL; ENZYME ACTIVITY; FATTY ACID SYNTHESIS; GENE EXPRESSION; LIPID DEGRADATION; LIPID METABOLISM; LIPID TRANSPORT; LIPOGENESIS; LIVER CELL CARCINOMA; METABOLITE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVIEW; TRANSCRIPTION REGULATION;

ANIMALS; CELL PROLIFERATION; CELL SURVIVAL; CHOLINE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; PHOSPHATIDYLCHOLINES;

EID: 84872931107     PISSN: 10409238     EISSN: 15497798     Source Type: Journal    
DOI: 10.3109/10409238.2012.735643     Document Type: Review

References (258)

1. Agarwal AK, Garg A. 2010. Enzymatic activity of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 11: upregulated in breast and cervical cancers. J Lipid Res 51:2143-2152.
2. Agassandian M, Chen BB, Pulijala R, Kaercher L, Glasser JR, Mallampalli RK. 2012. Calcium-calmodulin kinase I cooperatively regulates nucleocytoplasmic shuttling of CCTa by accessing a nuclear export signal. Mol Biol Cell 23:2755-2769.
3. Agassandian M, Chen BB, Schuster CC, Houtman JC, Mallampalli RK. 2010. 14-3-3zeta escorts CCTalpha for calcium-activated nuclear import in lung epithelia. FASEB J 24:1271-1283.
4. Akech J, Sinha Roy S, Das SK. 2005. Modulation of cholinephosphotransferase activity in breast cancer cell lines by Ro5-4864, a peripheral benzodiazepine receptor agonist. Biochem Biophys Res Commun 333:35-41.
5. Altomare DA, Testa JR. 2005. Perturbations of the AKT signaling pathway in human cancer. Oncogene 24:7455-7464.
6. Anthony ML, Zhao M, Brindle KM. 1999. Inhibition of phosphatidylcholine biosynthesis following induction of apoptosis in HL-60 cells. J Biol Chem 274:19686-19692.
7. Aoyama C, Ishidate K, Sugimoto H, Vance DE. 2007. Induction of choline kinase alpha by carbon tetrachloride (CCl4) occurs via increased binding of c-jun to an AP-1 element. Biochim Biophys Acta 1771:1148-1155.
8. Aoyama C, Liao H, Ishidate K. 2004. Structure and function of choline kinase isoforms in mammalian cells. Prog Lipid Res 43:266-281.
9. Aoyama C, Ohtani A, Ishidate K. 2002. Expression and characterization of the active molecular forms of choline/ethanolamine kinasealpha and-beta in mouse tissues, including carbon tetrachlorideinduced liver. Biochem J 363:777-784.
10. Araki W, Wurtman RJ. 1997. Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth. Proc Natl Acad Sci USA 94:11946-11950.
11. Atsumi G, Murakami M, Kojima K, Hadano A, Tajima M, Kudo I. 2000. Distinct roles of two intracellular phospholipase A2s in fatty acid release in the cell death pathway. Proteolytic fragment of type IVA cytosolic phospholipase A2alpha inhibits stimulus-induced arachidonate release, whereas that of type VI Ca2+independent phospholipase A2 augments spontaneous fatty acid release. J Biol Chem 275:18248-18258.
12. Atsumi G, Tajima M, Hadano A, Nakatani Y, Murakami M, Kudo I. 1998. Fas-induced arachidonic acid release is mediated by Ca2+independent phospholipase A2 but not cytosolic phospholipase A2, which undergoes proteolytic inactivation. J Biol Chem 273:13870-13877.
13. Attard GS, Templer RH, Smith WS, Hunt AN, Jackowski S. 2000. Modulation of CTP:phosphocholine cytidylyltransferase by membrane curvature elastic stress. Proc Natl Acad Sci USA 97:9032-9036.
14. Baburina I, Jackowski S. 1998. Apoptosis triggered by 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine is prevented by increased expression of CTP:phosphocholine cytidylyltransferase. J Biol Chem 273:2169-2173.
15. Baburina I, Jackowski S. 1999. Cellular responses to excess phospholipid. J Biol Chem 274:9400-9408.
16. Bakovic M, Waite K, Vance DE. 2003. Oncogenic Ha-Ras transformation modulates the transcription of the CTP:phosphocholine cytidylyltransferase alpha gene via p42/44MAPK and transcription factor Sp3. J Biol Chem 278:14753-14761.
17. Bakovic M, Waite KA, Vance DE. 2000. Functional significance of Sp1, Sp2, and Sp3 transcription factors in regulation of the murine CTP:phosphocholine cytidylyltransferase alpha promoter. J Lipid Res 41:583-594.
18. Banchio C, Lingrell S, Vance DE. 2007. Sp-1 binds promoter elements that are regulated by retinoblastoma and regulate CTP:phosphocholine cytidylyltransferase-alpha transcription. J Biol Chem 282:14827-14835.
19. Banchio C, Schang LM, Vance DE. 2004. Phosphorylation of Sp1 by cyclin-dependent kinase 2 modulates the role of Sp1 in CTP:phosphocholine cytidylyltransferase alpha regulation during the S phase of the cell cycle. J Biol Chem 279:40220-40226.
20. Barbour SE, Kapur A, Deal CL. 1999. Regulation of phosphatidylcholine homeostasis by calcium-independent phospholipase A2. Biochim Biophys Acta 1439:77-88.
21. Bauer DE, Hatzivassiliou G, Zhao F, Andreadis C, Thompson CB. 2005. ATP citrate lyase is an important component of cell growth and transformation. Oncogene 24:6314-6322.
22. Berwick DC, Hers I, Heesom KJ, Moule SK, Tavare JM. 2002. The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes. J Biol Chem 277:33895-33900.
23. Bjeka G, Overvatn A, Diaz-Meco MT, Moscat J, Johansen T. 1995. Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C. J Biol Chem 270:21299-21306.
24. BrockMüler SF, Bucher E, Müler BM, Budczies J, Hilvo M, Griffin JL, Orešic M, Kallioniemi O, Iljin K, Loibl S, Darb-Esfahani S, Sinn BV, Klauschen F, Prinzler J, Bangemann N, Ismaeel F, Fiehn O, Dietel M, Denkert C. 2012. Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancerlink to patient survival, hormone receptor status, and metabolic profiling. J Proteome Res 11:850-860.
25. Brusselmans K, De Schrijver E, Verhoeven G, Swinnen JV. 2005. RNA interference-mediated silencing of the acetyl-CoA-carboxylasealpha gene induces growth inhibition and apoptosis of prostate cancer cells. Cancer Res 65:6719-6725.
26. Burg MB. 1995. Molecular basis of osmotic regulation. Am J Physiol 268:F983-F996.
27. Buzzai M, Bauer DE, Jones RG, Deberardinis RJ, Hatzivassiliou G, Elstrom RL, Thompson CB. 2005. The glucose dependence of Akttransformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation. Oncogene 24:4165-4173.
28. Cai J, Abramovici H, Gee SH, Topham MK. 2009. Diacylglycerol kinases as sources of phosphatidic acid. Biochim Biophys Acta 1791:942-948.
29. Cao MD, Dkens M, Krishnamachary B, Vesuna F, Gadiya MM, Lning PE, Bhujwalla ZM, Gribbestad IS, Glunde K. 2012. Glycerophosphodiester phosphodiesterase domain containing 5 (GDPD5) expression correlates with malignant choline phospholipid metabolite profiles in human breast cancer. NMR Biomed 25:1033-1042.
30. Chen M, O'Connor KL. 2005. Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells. Oncogene 24:5125-5130.
31. Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC. 2008a. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 452:230-233.
32. Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. 2008b. Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature 452:181-186.
33. Chua BT, Gallego-Ortega D, Ramirez de Molina A, Ullrich A, Lacal JC, Downward J. 2009. Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells. Mol Cancer 8:131.
34. Coon M, Ball A, Pound J, Ap S, Hollenback D, White T, Tulinsky J, Bonham L, Morrison DK, Finney R, Singer JW. 2003. Inhibition of lysophosphatidic acid acyltransferase beta disrupts proliferative and survival signals in normal cells and induces apoptosis of tumor cells. Mol Cancer Ther 2:1067-1078.
35. Cornell R, Vance DE. 1987. Translocation of CTP: phosphocholine cytidylyltransferase from cytosol to membranes in HeLa cells: stimulation by fatty acid, fatty alcohol, mono-and diacylglycerol. Biochim Biophys Acta 919:26-36.
36. Cornell RB, Northwood IC. 2000. Regulation of CTP:phosphocholine cytidylyltransferase by amphitropism and relocalization. Trends Biochem Sci 25:441-447.
37. Cui Z, Houweling M. 2002. Phosphatidylcholine and cell death. Biochim Biophys Acta 1585:87-96.
38. Cui Z, Houweling M, Chen MH, Record M, Chap H, Vance DE, Tercé F. 1996. A genetic defect in phosphatidylcholine biosynthesis triggers apoptosis in Chinese hamster ovary cells. J Biol Chem 271:14668-14671.
39. Cui Z, Houweling M, Vance DE. 1994. Suppression of rat hepatoma cell growth by expression of phosphatidylethanolamine N-methyltransferase-2. J Biol Chem 269:24531-24533.
40. Cui Z, Shen YJ, Vance DE. 1997. Inverse correlation between expression of phosphatidylethanolamine N-methyltransferase-2 and growth rate of perinatal rat livers. Biochim Biophys Acta 1346:10-16.
41. Cui Z, Vance JE, Chen MH, Voelker DR, Vance DE. 1993. Cloning and expression of a novel phosphatidylethanolamine N-methyltransferase. A specific biochemical and cytological marker for a unique membrane fraction in rat liver. J Biol Chem 268:16655-16663.
42. Daly PF, Lyon RC, Faustino PJ, Cohen JS. 1987. Phospholipid metabolism in cancer cells monitored by 31P NMR spectroscopy. J Biol Chem 262:14875-14878.
43. Davies SM, Epand RM, Kraayenhof R, Cornell RB. 2001. Regulation of CTP: phosphocholine cytidylyltransferase activity by the physical properties of lipid membranes: an important role for stored curvature strain energy. Biochemistry 40:10522-10531.
44. De Schrijver E, Brusselmans K, Heyns W, Verhoeven G, Swinnen JV. 2003. RNA interference-mediated silencing of the fatty acid synthase gene attenuates growth and induces morphological changes and apoptosis of LNCaP prostate cancer cells. Cancer Res 63:3799-3804.
45. DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. 2008. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7:11-20.
46. DeLong CJ, Hicks AM, Cui Z. 2002. Disruption of choline methyl group donation for phosphatidylethanolamine methylation in hepatocarcinoma cells. J Biol Chem 277:17217-17225.
47. DeLong CJ, Shen YJ, Thomas MJ, Cui Z. 1999. Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway. J Biol Chem 274:29683-29688.
48. Dennis MK, Taneva SG, Cornell RB. 2011. The intrinsically disordered nuclear localization signal and phosphorylation segments distinguish the membrane affinity of two cytidylyltransferase isoforms. J Biol Chem 286:12349-12360.
49. Dong Z, Liu Y, Scott KF, Levin L, Gaitonde K, Bracken RB, Burke B, Zhai QJ, Wang J, Oleksowicz L, Lu S. 2010. Secretory phospholipase A2-IIa is involved in prostate cancer progression and may potentially serve as a biomarker for prostate cancer. Carcinogenesis 31:1948-1955.
50. Dueck DA, Chan M, Tran K, Wong JT, Jay FT, Littman C, Stimpson R, Choy PC. 1996. The modulation of choline phosphoglyceride metabolism in human colon cancer. Mol Cell Biochem 162:97-103.
51. Dunne SJ, Cornell RB, Johnson JE, Glover NR, Tracey AS. 1996. Structure of the membrane binding domain of CTP:phosphocholine cytidylyltransferase. Biochemistry 35:11975-11984.
52. Eliyahu G, Kreizman T, Degani H. 2007. Phosphocholine as a biomarker of breast cancer: molecular and biochemical studies. Int J Cancer 120:1721-1730.
53. Elstrom RL, Bauer DE, Buzzai M, Karnauskas R, Harris MH, Plas DR, Zhuang H, Cinalli RM, Alavi A, Rudin CM, Thompson CB. 2004. Akt stimulates aerobic glycolysis in cancer cells. Cancer Res 64:3892-3899.
54. Ericsson J, Jackson SM, Kim JB, Spiegelman BM, Edwards PA. 1997. Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1-and sterol regulatory element-binding protein-responsive gene. J Biol Chem 272:7298-7305.
55. Euer N, Schwirzke M, Evtimova V, Burtscher H, Jarsch M, Tarin D, Weidle UH. 2002. Identification of genes associated with metastasis of mammary carcinoma in metastatic versus non-metastatic cell lines. Anticancer Res 22:733-740.
56. Fagone P, Sriburi R, Ward-Chapman C, Frank M, Wang J, Gunter C, Brewer JW, Jackowski S. 2007. Phospholipid biosynthesis program underlying membrane expansion during B-lymphocyte differentiation. J Biol Chem 282:7591-7605.
57. Falvella FS, Pascale RM, Gariboldi M, Manenti G, De Miglio MR, Simile MM, Dragani TA, Feo F. 2002. Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats. Carcinogenesis 23:1933-1936.
58. Fricker M, Hollinshead M, White N, Vaux D. 1997. Interphase nuclei of many mammalian cell types contain deep, dynamic, tubular membrane-bound invaginations of the nuclear envelope. J Cell Biol 136:531-544.
59. Gajate C, Gonzalez-Camacho F, Mollinedo F. 2009. Involvement of raft aggregates enriched in Fas/CD95 death-inducing signaling complex in the antileukemic action of edelfosine in Jurkat cells. PLoS ONE 4:e5044.
60. Gallazzini M, Ferraris JD, Burg MB. 2008. GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC. Proc Natl Acad Sci USA 105:11026-11031.
61. Gallego-Ortega D, Ramirez de Molina A, Ramos MA, Valdes-Mora F, Barderas MG, Sarmentero-Estrada J, Lacal JC. 2009. Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment. PLoS ONE 4:e7819.
62. Gehrig K, Cornell RB, Ridgway ND. 2008. Expansion of the nucleoplasmic reticulum requires the coordinated activity of lamins and CTP:phosphocholine cytidylyltransferase alpha. Mol Biol Cell 19:237-247.
63. Gehrig K, Lagace TA, Ridgway ND. 2009a. Oxysterol activation of phosphatidylcholine synthesis involves CTP:phosphocholine cytidylyltransferase alpha translocation to the nuclear envelope. Biochem J 418:209-217.
64. Gehrig K, Morton CC, Ridgway ND. 2009b. Nuclear export of the ratelimiting enzyme in phosphatidylcholine synthesis is mediated by its membrane binding domain. J Lipid Res 50:966-976.
65. Geilen CC, Wieder T, Boremski S, Wieprecht M, Orfanos CE. 1996. c-Ha-ras oncogene expression increases choline uptake, CTP: phosphocholine cytidylyltransferase activity and phosphatidylcholine biosynthesis in the immortalized human keratinocyte cell line HaCaT. Biochim Biophys Acta 1299:299-305.
66. George TP, Morash SC, Cook HW, Byers DM, Palmer FB, Spence MW. 1989. Phosphatidylcholine biosynthesis in cultured glioma cells: evidence for channeling of intermediates. Biochim Biophys Acta 1004:283-291.
67. Ghosh A, Akech J, Mukherjee S, Das SK. 2002. Differential expression of cholinephosphotransferase in normal and cancerous human mammary epithelial cells. Biochem Biophys Res Commun 297:1043-1048.
68. Glunde K, Ackerstaff E, Mori N, Jacobs MA, Bhujwalla ZM. 2006. Choline phospholipid metabolism in cancer: consequences for molecular pharmaceutical interventions. Mol Pharm 3:496-506.
69. Glunde K, Bhujwalla ZM, Ronen SM. 2011. Choline metabolism in malignant transformation. Nat Rev Cancer 11:835-848.
70. Glunde K, Jie C, Bhujwalla ZM. 2004. Molecular causes of the aberrant choline phospholipid metabolism in breast cancer. Cancer Res 64:4270-4276.
71. Glunde K, Shah T, Winnard PT, Raman V, Takagi T, Vesuna F, Artemov D, Bhujwalla ZM. 2008. Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model. Cancer Res 68:172-180.
72. Golfman LS, Bakovic M, Vance DE. 2001. Transcription of the CTP:phosphocholine cytidylyltransferase alpha gene is enhanced during the S phase of the cell cycle. J Biol Chem 276:43688-43692.
73. Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB, Hay N. 2001. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev 15:1406-1418.
74. Gruber J, See Too WC, Wong MT, Lavie A, McSorley T, Konrad M. 2012. Balance of human choline kinase isoforms is critical for cell cycle regulation: implications for the development of choline kinasetargeted cancer therapy. FEBS J 279:1915-1928.
75. Gustin SE, Western PS, McClive PJ, Harley VR, Koopman PA, Sinclair AH. 2008. Testis development, fertility, and survival in Ethanolamine kinase 2-deficient mice. Endocrinology 149:6176-6186.
76. Hatzivassiliou G, Zhao F, Bauer DE, Andreadis C, Shaw AN, Dhanak D, Hingorani SR, Tuveson DA, Thompson CB. 2005. ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell 8:311-321.
77. Henderson FC, Miakotina OL, Mallampalli RK. 2006. Proapoptotic effects of P. aeruginosa involve inhibition of surfactant phosphatidylcholine synthesis. J Lipid Res 47:2314-2324.
78. Henneberry AL, McMaster CR. 1999. Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine. Biochem J 339 (Pt 2):291-298.
79. Henneberry AL, Wistow G, McMaster CR. 2000. Cloning, genomic organization, and characterization of a human cholinephosphotransferase. J Biol Chem 275:29808-29815.
80. Henneberry AL, Wright MM, McMaster CR. 2002. The major sites of cellular phospholipid synthesis and molecular determinants of Fatty Acid and lipid head group specificity. Mol Biol Cell 13:3148-3161.
81. Hess D, Chisholm JW, Igal RA. 2010. Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS ONE 5:e11394.
82. Hitosugi T, Fan J, Chung TW, Lythgoe K, Wang X, Xie J, Ge Q, Gu TL, Polakiewicz RD, Roesel JL, Chen GZ, Boggon TJ, Lonial S, Fu H, Khuri FR, Kang S, Chen J. 2011. Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. Mol Cell 44:864-877.
83. Hoffman RD, Kligerman M, Sundt TM, Anderson ND, Shin HS. 1982. Stereospecific chemoattraction of lymphoblastic cells by gradients of lysophosphatidylcholine. Proc Natl Acad Sci USA 79:3285-3289.
84. Hal G, Wagner A, Cole LK, Malli R, Reicher H, Kotzbeck P, Kaeler H, Haler G, Frank S, Bogner-Strauss JG, Sattler W, Vance DE, Steyrer E. 2011. Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo. J Biol Chem 286:17338-17350.
85. Horton JD, Shah NA, Warrington JA, Anderson NN, Park SW, Brown MS, Goldstein JL. 2003. Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. Proc Natl Acad Sci USA 100:12027-12032.
86. Houweling M, Cui Z, Tessitore L, Vance DE. 1997. Induction of hepatocyte proliferation after partial hepatectomy is accompanied by a markedly reduced expression of phosphatidylethanolamine N-methyltransferase-2. Biochim Biophys Acta 1346:1-9.
87. Houweling M, Cui Z, Vance DE. 1995. Expression of phosphatidylethanolamine N-methyltransferase-2 cannot compensate for an impaired CDP-choline pathway in mutant Chinese hamster ovary cells. J Biol Chem 270:16277-16282.
88. Houweling M, Jamil H, Hatch GM, Vance DE. 1994. Dephosphorylation of CTP-phosphocholine cytidylyltransferase is not required for binding to membranes. J Biol Chem 269:7544-7551.
89. Hsu PP, Sabatini DM. 2008. Cancer cell metabolism: Warburg and beyond. Cell 134:703-707.
90. Igal RA. 2010. Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer. Carcinogenesis 31:1509-1515.
91. Iorio E, Mezzanzanica D, Alberti P, Spadaro F, Ramoni C, D'Ascenzo S, Millimaggi D, Pavan A, Dolo V, Canevari S, Podo F. 2005. Alterations of choline phospholipid metabolism in ovarian tumor progression. Cancer Res 65:9369-9376.
92. Ishimoto K, Nakamura H, Tachibana K, Yamasaki D, Ota A, Hirano K, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T. 2009. Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells. J Biol Chem 284:22195-22205.
93. Jackowski S. 1994. Coordination of membrane phospholipid synthesis with the cell cycle. J Biol Chem 269:3858-3867.
94. Jackowski S. 1996. Cell cycle regulation of membrane phospholipid metabolism. J Biol Chem 271:20219-20222.
95. Jackowski S, Rehg JE, Zhang YM, Wang J, Miller K, Jackson P, Karim MA. 2004. Disruption of CCTbeta2 expression leads to gonadal dysfunction. Mol Cell Biol 24:4720-4733.
96. Jacobs MA, Barker PB, Bottomley PA, Bhujwalla Z, Bluemke DA. 2004a. Proton magnetic resonance spectroscopic imaging of human breast cancer: a preliminary study. J Magn Reson Imaging 19:68-75.
97. Jacobs RL, Devlin C, Tabas I, Vance DE. 2004b. Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins. J Biol Chem 279:47402-47410.
98. Jacobs RL, Lingrell S, Zhao Y, Francis GA, Vance DE. 2008. Hepatic CTP:phosphocholine cytidylyltransferase-alpha is a critical predictor of plasma high density lipoprotein and very low density lipoprotein. J Biol Chem 283:2147-2155.
99. Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK. 2012. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science 336:1040-1044.
100. Jimez B, del Peso L, Montaner S, Esteve P, Lacal JC. 1995. Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-kinases in growth factors-induced mitogenic stimulation. J Cell Biochem 57:141-149.
101. Johnson JE, Rao NM, Hui SW, Cornell RB. 1998. Conformation and lipid binding properties of four peptides derived from the membranebinding domain of CTP:phosphocholine cytidylyltransferase. Biochemistry 37:9509-9519.
102. Joo JH, Jetten AM. 2010. Molecular mechanisms involved in farnesolinduced apoptosis. Cancer Lett 287:123-135.
103. Karim M, Jackson P, Jackowski S. 2003. Gene structure, expression and identification of a new CTP:phosphocholine cytidylyltransferase beta isoform. Biochim Biophys Acta 1633:1-12.
104. Kast HR, Nguyen CM, Anisfeld AM, Ericsson J, Edwards PA. 2001. CTP:phosphocholine cytidylyltransferase, a new sterol-and SREBP-responsive gene. J Lipid Res 42:1266-1272.
105. Katz-Brull R, Degani H. 1996. Kinetics of choline transport and phosphorylation in human breast cancer cells; NMR application of the zero trans method. Anticancer Res 16:1375-1380.
106. Katz-Brull R, Lavin PT, Lenkinski RE. 2002a. Clinical utility of proton magnetic resonance spectroscopy in characterizing breast lesions. J Natl Cancer Inst 94:1197-1203.
107. Katz-Brull R, Seger D, Rivenson-Segal D, Rushkin E, Degani H. 2002b. Metabolic markers of breast cancer: enhanced choline metabolism and reduced choline-ether-phospholipid synthesis. Cancer Res 62:1966-1970.
108. Kent C. 1997. CTP:phosphocholine cytidylyltransferase. Biochim Biophys Acta 1348:79-90.
109. Kim SJ, Gershov D, Ma X, Brot N, Elkon KB. 2002. I-PLA(2) activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation. J Exp Med 196:655-665.
110. Kimura T, Itoh T, Fusazaki T, Matsui H, Sugawara S, Ogino Y, Endo H, Kobayashi K, Nakamura M. 2010. Low-density lipoproteincholesterol/high-density lipoprotein-cholesterol ratio predicts lipid-rich coronary plaque in patients with coronary artery disease-integrated-backscatter intravascular ultrasound study. Circ J 74:1392-1398.
111. Kohn AD, Summers SA, Birnbaum MJ, Roth RA. 1996. Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271:31372-31378.
112. Kopp F, Komatsu T, Nomura DK, Trauger SA, Thomas JR, Siuzdak G, Simon GM, Cravatt BF. 2010. The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice. Chem Biol 17:831-840.
113. Kouji H, Inazu M, Yamada T, Tajima H, Aoki T, Matsumiya T. 2009. Molecular and functional characterization of choline transporter in human colon carcinoma HT-29 cells. Arch Biochem Biophys 483:90-98.
114. Krycer JR, Sharpe LJ, Luu W, Brown AJ. 2010. The Akt-SREBP nexus: cell signaling meets lipid metabolism. Trends Endocrinol Metab 21:268-276.
115. Kuhajda FP, Jenner K, Wood FD, Hennigar RA, Jacobs LB, Dick JD, Pasternack GR. 1994. Fatty acid synthesis: a potential selective target for antineoplastic therapy. Proc Natl Acad Sci USA 91: 6379-6383.
116. Lagace TA, Miller JR, Ridgway ND. 2002. Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis. Mol Cell Biol 22:4851-4862.
117. Lagace TA, Ridgway ND. 2005a. Induction of apoptosis by lipophilic activators of CTP:phosphocholine cytidylyltransferase alpha (CCTalpha). Biochem J 392:449-456.
118. Lagace TA, Ridgway ND. 2005b. The rate-limiting enzyme in phosphatidylcholine synthesis regulates proliferation of the nucleoplasmic reticulum. Mol Biol Cell 16:1120-1130.
119. Lagace TA, Storey MK, Ridgway ND. 2000. Regulation of phosphatidylcholine metabolism in Chinese hamster ovary cells by the sterol regulatory element-binding protein (SREBP)/SREBP cleavage-activating protein pathway. J Biol Chem 275:14367-14374.
120. Larrodera P, Cornet ME, Diaz-Meco MT, Lopez-Barahona M, Diaz-Laviada I, Guddal PH, Johansen T, Moscat J. 1990. Phospholipase C-mediated hydrolysis of phosphatidylcholine is an important step in PDGF-stimulated DNA synthesis. Cell 61:1113-1120.
121. Lauber K, Bohn E, Krder SM, Xiao YJ, Blumenthal SG, Lindemann RK, Marini P, Wiedig C, Zobywalski A, Baksh S, Xu Y, Autenrieth IB, Schulze-Osthoff K, Belka C, Stuhler G, Wesselborg S. 2003. Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell 113:717-730.
122. Lei X, Barbour SE, Ramanadham S. 2010. Group VIA Ca2+independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death. Biochimie 92:627-637.
123. Li J, Ding SF, Habib NA, Fermor BF, Wood CB, Gilmour RS. 1994. Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues. Int J Cancer 57:348-352.
124. Li JN, Gorospe M, Chrest FJ, Kumaravel TS, Evans MK, Han WF, Pizer ES. 2001. Pharmacological inhibition of fatty acid synthase activity produces both cytostatic and cytotoxic effects modulated by p53. Cancer Res 61:1493-1499.
125. Li Z, Vance DE. 2008. Phosphatidylcholine and choline homeostasis. J Lipid Res 49:1187-1194.
126. Liang G, Yang J, Horton JD, Hammer RE, Goldstein JL, Brown MS. 2002. Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J Biol Chem 277:9520-9528.
127. Lim P, Cornell R, Vance DE. 1986. The supply of both CDP-choline and diacylglycerol can regulate the rate of phosphatidylcholine synthesis in HeLa cells. Biochem Cell Biol 64:692-698.
128. Lu S, Archer MC. 2005. Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer. Carcinogenesis 26:153-157.
129. Lupu R, Menendez JA. 2006. Pharmacological inhibitors of Fatty Acid Synthase (FASN)-catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? Curr Pharm Biotechnol 7:483-493.
130. Lykidis A, Baburina I, Jackowski S. 1999. Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant. J Biol Chem 274:26992-27001.
131. Lykidis A, Murti KG, Jackowski S. 1998. Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase. J Biol Chem 273:14022-14029.
132. Lykidis A, Wang J, Karim MA, Jackowski S. 2001. Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDPethanolamine pathway. J Biol Chem 276:2174-2179.
133. Macara IG. 1989. Elevated phosphocholine concentration in rastransformed NIH 3T3 cells arises from increased choline kinase activity, not from phosphatidylcholine breakdown. Mol Cell Biol 9:325-328.
134. MacDonald JI, Kent C. 1994. Identification of phosphorylation sites in rat liver CTP: phosphocholine cytidylyltransferase. J Biol Chem 269:10529-10537.
135. Maddocks OD, Vousden KH. 2011. Metabolic regulation by p53. J Mol Med 89:237-245.
136. Malhas A, Goulbourne C, Vaux DJ. 2011. The nucleoplasmic reticulum: form and function. Trends Cell Biol 21:362-373.
137. Manguikian AD, Barbour SE. 2004. Cell cycle dependence of group VIA calcium-independent phospholipase A2 activity. J Biol Chem 279:52881-52892.
138. Mansilla F, da Costa KA, Wang S, Kruhfer M, Lewin TM, Orntoft TF, Coleman RA, Birkenkamp-Demtrer K. 2009. Lysophosphatidylcholine acyltransferase 1 (LPCAT1) overexpression in human colorectal cancer. J Mol Med 87:85-97.
139. Martin A, Duffy PA, Liossis C, Gomez-Muz A, O'Brien L, Stone JC, Brindley DN. 1997. Increased concentrations of phosphatidate, diacylglycerol and ceramide in ras-and tyrosine kinase (fps)-transformed fibroblasts. Oncogene 14:1571-1580.
140. Medes G, Thomas A, Weinhouse S. 1953. Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res 13:27-29.
141. Menendez JA, Lupu R. 2007. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 7:763-777.
142. Menendez JA, Vellon L, Mehmi I, Oza BP, Ropero S, Colomer R, Lupu R. 2004. Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc Natl Acad Sci USA 101:10715-10720.
143. Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G. 2012. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 481:380-384.
144. Michel V, Yuan Z, Ramsubir S, Bakovic M. 2006. Choline transport for phospholipid synthesis. Exp Biol Med (Maywood) 231:490-504.
145. Mills GB, Moolenaar WH. 2003. The emerging role of lysophosphatidic acid in cancer. Nat Rev Cancer 3:582-591.
146. Minville-Walz M, Pierre AS, Pichon L, Bellenger S, Fare C, Bellenger J, Tessier C, Narce M, Rialland M. 2010. Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells. PLoS ONE 5:e14363.
147. Miquel K, Pradines A, TercíF, Selmi S, Favre G. 1998. Competitive inhibition of choline phosphotransferase by geranylgeraniol and farnesol inhibits phosphatidylcholine synthesis and induces apoptosis in human lung adenocarcinoma A549 cells. J Biol Chem 273:26179-26186.
148. Mitsuhashi S, Ohkuma A, Talim B, Karahashi M, Koumura T, Aoyama C, Kurihara M, Quinlivan R, Sewry C, Mitsuhashi H, Goto K, Koksal B, Kale G, Ikeda K, Taguchi R, Noguchi S, Hayashi YK, Nonaka I, Sher RB, Sugimoto H, Nakagawa Y, Cox GA, Topaloglu H, Nishino I. 2011. A congenital muscular dystrophy with mitochondrial structural abnormalities caused by defective de novo phosphatidylcholine biosynthesis. Am J Hum Genet 88:845-851.
149. Miyake T, Parsons SJ. 2012. Functional interactions between Choline kinase a, epidermal growth factor receptor and c-Src in breast cancer cell proliferation. Oncogene 31:1431-1441.
150. Mollinedo F, Gajate C, Mart-Santamar S, Gago F. 2004. ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor. Curr Med Chem 11:3163-3184.
151. Momchilova A, Markovska T, Pankov R. 1999. Ha-ras-transformation alters the metabolism of phosphatidylethanolamine and phosphatidylcholine in NIH 3T3 fibroblasts. Cell Biol Int 23:603-610.
152. Morrish F, Isern N, Sadilek M, Jeffrey M, Hockenbery DM. 2009. c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry. Oncogene 28:2485-2491.
153. Mueller RB, Sheriff A, Gaipl US, Wesselborg S, Lauber K. 2007. Attraction of phagocytes by apoptotic cells is mediated by lysophosphatidylcholine. Autoimmunity 40:342-344.
154. Nakagawa H, Ikeda H, Nakamura K, Ohkawa R, Masuzaki R, Tateishi R, Yoshida H, Watanabe N, Tejima K, Kume Y, Iwai T, Suzuki A, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Omata M, Igarashi K, Aoki J, Koike K, Yatomi Y. 2011. Autotaxin as a novel serum marker of liver fibrosis. Clin Chim Acta 412:1201-1206.
155. Nakamura K, Igarashi K, Ohkawa R, Yokota H, Masuda A, Nakagawa S, Yano T, Ikeda H, Aoki J, Yatomi Y. 2012. Serum Autotaxin is not a Useful Biomarker for Ovarian Cancer. Lipids 47:927-930.
156. Nam SW, Clair T, Campo CK, Lee HY, Liotta LA, Stracke ML. 2000. Autotaxin (ATX), a potent tumor motogen, augments invasive and metastatic potential of ras-transformed cells. Oncogene 19:241-247.
157. Ng MN, Kitos TE, Cornell RB. 2004. Contribution of lipid second messengers to the regulation of phosphatidylcholine synthesis during cell cycle re-entry. Biochim Biophys Acta 1686:85-99.
158. Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW, Cravatt BF. 2010. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell 140:49-61.
159. Northwood IC, Tong AH, Crawford B, Drobnies AE, Cornell RB. 1999. Shuttling of CTP:Phosphocholine cytidylyltransferase between the nucleus and endoplasmic reticulum accompanies the wave of phosphatidylcholine synthesis during the G(0)-G(1) transition. J Biol Chem 274:26240-26248.
160. Okazaki Y, Ohshima N, Yoshizawa I, Kamei Y, MariggiS, Okamoto K, Maeda M, Nogusa Y, Fujioka Y, Izumi T, Ogawa Y, Shiro Y, Wada M, Kato N, Corda D, Yanaka N. 2010. A novel glycerophosphodiester phosphodiesterase, GDE5, controls skeletal muscle development via a non-enzymatic mechanism. J Biol Chem 285:27652-27663.
161. Okuda T, Okamura M, Kaitsuka C, Haga T, Gurwitz D. 2002. Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate. J Biol Chem 277:45315-45322.
162. Pagel JM, Laugen C, Bonham L, Hackman RC, Hockenbery DM, Bhatt R, Hollenback D, Carew H, Singer JW, Press OW. 2005. Induction of apoptosis using inhibitors of lysophosphatidic acid acyltransferase-beta and anti-CD20 monoclonal antibodies for treatment of human non-Hodgkin's lymphomas. Clin Cancer Res 11:4857-4866.
163. Pelech SL, Pritchard PH, Brindley DN, Vance DE. 1983. Fatty acids promote translocation of CTP:phosphocholine cytidylyltransferase to the endoplasmic reticulum and stimulate rat hepatic phosphatidylcholine synthesis. J Biol Chem 258:6782-6788.
164. Peter C, Waibel M, Radu CG, Yang LV, Witte ON, Schulze-Osthoff K, Wesselborg S, Lauber K. 2008. Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A. J Biol Chem 283:5296-5305.
165. Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM. 2011. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 146:408-420.
166. Pizer ES, Lax SF, Kuhajda FP, Pasternack GR, Kurman RJ. 1998. Fatty acid synthase expression in endometrial carcinoma: correlation with cell proliferation and hormone receptors. Cancer 83:528-537.
167. Pizer ES, Pflug BR, Bova GS, Han WF, Udan MS, Nelson JB. 2001. Increased fatty acid synthase as a therapeutic target in androgenindependent prostate cancer progression. Prostate 47:102-110.
168. Porstmann T, Griffiths B, Chung YL, Delpuech O, Griffiths JR, Downward J, Schulze A. 2005. PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 24:6465-6481.
169. Porstmann T, Santos CR, Griffiths B, Cully M, Wu M, Leevers S, Griffiths JR, Chung YL, Schulze A. 2008. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab 8:224-236.
170. Prentki M, Madiraju SR. 2008. Glycerolipid metabolism and signaling in health and disease. Endocr Rev 29:647-676.
171. Ramanadham S, Hsu FF, Zhang S, Jin C, Bohrer A, Song H, Bao S, Ma Z, Turk J. 2004. Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta. Biochemistry 43:918-930.
172. Ramirez De Molina A, Banez-Coronel M, Gutierrez R, Rodriguez-Gonzalez A, Olmeda D, Megias D, Lacal JC. 2004. Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression. Cancer Res 64, 6732-6739.
173. Ramirez De Molina A, Penalva V, Lucas L, Lacal JC. 2002a. Regulation of choline kinase activity by Ras proteins involves Ral-GDS and PI3K. Oncogene 21, 937-946.
174. Ramirez De Molina A, Rodriguez-Gonzalez A, Gutierrez R, Martinez-Pineiro L, Sanchez J, Bonilla F, Rosell R, Lacal J. 2002b. Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers. Biochem Biophys Res Commun 296:580-583.
175. Rao M, Sockanathan S. 2005. Transmembrane protein GDE2 induces motor neuron differentiation in vivo. Science 309:2212-2215.
176. Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, Thompson CB. 2003. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol 23:7315-7328.
177. Ratnam S, Kent C. 1995. Early increase in choline kinase activity upon induction of the H-ras oncogene in mouse fibroblast cell lines. Arch Biochem Biophys 323:313-322.
178. Ridgway ND, Lagace TA. 2003. Regulation of the CDP-choline pathway by sterol regulatory element binding proteins involves transcriptional and post-transcriptional mechanisms. Biochem J 372:811-819.
179. Ridgway ND, Vance DE. 1988. Specificity of rat hepatic phosphatidylethanolamine N-methyltransferase for molecular species of diacyl phosphatidylethanolamine. J Biol Chem 263:16856-16863.
180. Ridsdale R, Tseu I, Wang J, Post M. 2001. CTP:phosphocholine cytidylyltransferase alpha is a cytosolic protein in pulmonary epithelial cells and tissues. J Biol Chem 276:49148-49155.
181. Righi V, Roda JM, Paz J, Mucci A, Tugnoli V, Rodriguez-Tarduchy G, Barrios L, Schenetti L, Cerd S, Garcí-Mart ML. 2009. 1H HR-MAS and genomic analysis of human tumor biopsies discriminate between high and low grade astrocytomas. NMR Biomed 22:629-637.
182. Rioja A, Pizzey AR, Marson CM, Thomas NS. 2000. Preferential induction of apoptosis of leukaemic cells by farnesol. FEBS Lett 467:291-295.
183. Rocha CM, Barros AS, Gil AM, Goodfellow BJ, Humpfer E, Spraul M, Carreira IM, Melo JB, Bernardo J, Gomes A, Sousa V, Carvalho L, Duarte IF. 2010. Metabolic profiling of human lung cancer tissue by 1H high resolution magic angle spinning (HRMAS) NMR spectroscopy. J Proteome Res 9:319-332.
184. Ros S, Santos CR, Moco S, Baenke F, Kelly G, Howell M, Zamboni N, Schulze A. 2012. Functional metabolic screen identifies 6-phosphofructo-2-kinase/ fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival. Cancer Discov 2:328-343.
185. Ryan AJ, Andrews M, Zhou J, Mallampalli RK. 2006. c-Jun N-terminal kinase regulates CTP:phosphocholine cytidylyltransferase. Arch Biochem Biophys 447:23-33.
186. Samborski RW, Ridgway ND, Vance DE. 1990. Evidence that only newly made phosphatidylethanolamine is methylated to phosphatidylcholine and that phosphatidylethanolamine is not significantly deacylated-reacylated in rat hepatocytes. J Biol Chem 265:18322-18329.
187. Scaglia N, Caviglia JM, Igal RA. 2005. High stearoyl-CoA desaturase protein and activity levels in simian virus 40 transformed-human lung fibroblasts. Biochim Biophys Acta 1687:141-151.
188. Scaglia N, Igal RA. 2008. Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis. Int J Oncol 33:839-850.
189. Scott KF, Sajinovic M, Hein J, Nixdorf S, Galettis P, Liauw W, de Souza P, Dong Q, Graham GG, Russell PJ. 2010. Emerging roles for phospholipase A2 enzymes in cancer. Biochimie 92:601-610.
190. Sher RB, Aoyama C, Huebsch KA, Ji S, Kerner J, Yang Y, Frankel WN, Hoppel CL, Wood PA, Vance DE, Cox GA. 2006. A rostrocaudal muscular dystrophy caused by a defect in choline kinase beta, the first enzyme in phosphatidylcholine biosynthesis. J Biol Chem 281:4938-4948.
191. Shindou H, Hishikawa D, Harayama T, Yuki K, Shimizu T. 2009. Recent progress on acyl CoA: lysophospholipid acyltransferase research. J Lipid Res 50 Suppl:S46-S51.
192. Shinzawa K, Tsujimoto Y. 2003. PLA2 activity is required for nuclear shrinkage in caspase-independent cell death. J Cell Biol 163:1219-1230.
193. Song J, Clair T, Noh JH, Eun JW, Ryu SY, Lee SN, Ahn YM, Kim SY, Lee SH, Park WS, Yoo NJ, Lee JY, Nam SW. 2005. Autotaxin (lysoPLD/NPP2) protects fibroblasts from apoptosis through its enzymatic product, lysophosphatidic acid, utilizing albumin-bound substrate. Biochem Biophys Res Commun 337:967-975.
194. Song Y, Wilkins P, Hu W, Murthy KS, Chen J, Lee Z, Oyesanya R, Wu J, Barbour SE, Fang X. 2007. Inhibition of calcium-independent phospholipase A2 suppresses proliferation and tumorigenicity of ovarian carcinoma cells. Biochem J 406:427-436.
195. Springett GM, Bonham L, Hummer A, Linkov I, Misra D, Ma C, Pezzoni G, Di Giovine S, Singer J, Kawasaki H, Spriggs D, Soslow R, Dupont J. 2005. Lysophosphatidic acid acyltransferase-beta is a prognostic marker and therapeutic target in gynecologic malignancies. Cancer Res 65:9415-9425.
196. Stadlbauer A, Ganslandt O, Buslei R, Hammen T, Gruber S, Moser E, Buchfelder M, Salomonowitz E, Nimsky C. 2006. Gliomas: histopathologic evaluation of changes in directionality and magnitude of water diffusion at diffusion-tensor MR imaging. Radiology 240:803-810.
197. Stewart JD, Marchan R, Lesjak MS, Lambert J, Hergenroeder R, Ellis JK, Lau CH, Keun HC, Schmitz G, Schiller J, Eibisch M, Hedberg C, Waldmann H, Lausch E, Tanner B, Sehouli J, Sagemueller J, Staude H, Steiner E, Hengstler JG. 2012. Choline-releasing glycerophosphodiesterase EDI3 drives tumor cell migration and metastasis. Proc Natl Acad Sci USA 109:8155-8160.
198. Sugimoto H, Bakovic M, Yamashita S, Vance DE. 2001. Identification of transcriptional enhancer factor-4 as a transcriptional modulator of CTP:phosphocholine cytidylyltransferase alpha. J Biol Chem 276:12338-12344.
199. Sugimoto H, Okamura K, Sugimoto S, Satou M, Hattori T, Vance DE, Izumi T. 2005. Sp1 is a co-activator with Ets-1, and Net is an important repressor of the transcription of CTP:phosphocholine cytidylyltransferase alpha. J Biol Chem 280:40857-40866.
200. Sun B, Zhang X, Talathi S, Cummings BS. 2008. Inhibition of Ca2+independent phospholipase A2 decreases prostate cancer cell growth by p53-dependent and independent mechanisms. J Pharmacol Exp Ther 326:59-68.
201. Swanson MG, Keshari KR, Tabatabai ZL, Simko JP, Shinohara K, Carroll PR, Zektzer AS, Kurhanewicz J. 2008. Quantification of cholineand ethanolamine-containing metabolites in human prostate tissues using 1H HR-MAS total correlation spectroscopy. Magn Reson Med 60:33-40.
202. Swinnen JV, Brusselmans K, Verhoeven G. 2006. Increased lipogenesis in cancer cells: new players, novel targets. Curr Opin Clin Nutr Metab Care 9:358-365.
203. Swinnen JV, Van Veldhoven PP, Timmermans L, De Schrijver E, Brusselmans K, Vanderhoydonc F, Van de Sande T, Heemers H, Heyns W, Verhoeven G. 2003. Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains. Biochem Biophys Res Commun 302:898-903.
204. Taneva S, Dennis MK, Ding Z, Smith JL, Cornell RB. 2008. Contribution of each membrane binding domain of the CTP:phosphocholine cytidylyltransferase- alpha dimer to its activation, membrane binding, and membrane cross-bridging. J Biol Chem 283:28137-28148.
205. Taneva S, Johnson JE, Cornell RB. 2003. Lipid-induced conformational switch in the membrane binding domain of CTP:phosphocholine cytidylyltransferase: a circular dichroism study. Biochemistry 42:11768-11776.
206. Taneva SG, Lee JM, Cornell RB. 2012. The amphipathic helix of an enzyme that regulates phosphatidylcholine synthesis remodels membranes into highly curved nanotubules. Biochim Biophys Acta 1818:1173-1186.
207. Tania M, Khan MA, Zhang H, Li J, Song Y. 2010. Autotaxin: a protein with two faces. Biochem Biophys Res Commun 401:493-497.
208. Teegarden D, Taparowsky EJ, Kent C. 1990. Altered phosphatidylcholine metabolism in C3H10T1/2 cells transfected with the Harvey-ras oncogene. J Biol Chem 265:6042-6047.
209. Tessitore L, Dianzani I, Cui Z, Vance DE. 1999. Diminished expression of phosphatidylethanolamine N-methyltransferase 2 during hepatocarcinogenesis. Biochem J 337 (Pt 1):23-27.
210. Tessitore L, Marengo B, Vance DE, Papotti M, Mussa A, Daidone MG, Costa A. 2003. Expression of phosphatidylethanolamine N-methyltransferase in human hepatocellular carcinomas. Oncology 65:152-158.
211. Tessner TG, Rock CO, Kalmar GB, Cornell RB, Jackowski S. 1991. Colony-stimulating factor 1 regulates CTP: phosphocholine cytidylyltransferase mRNA levels. J Biol Chem 266:16261-16264.
212. Tian Y, Pate C, Andreolotti A, Wang L, Tuomanen E, Boyd K, Claro E, Jackowski S. 2008. Cytokine secretion requires phosphatidylcholine synthesis. J Cell Biol 181:945-957.
213. Tokumura A, Majima E, Kariya Y, Tominaga K, Kogure K, Yasuda K, Fukuzawa K. 2002. Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J Biol Chem 277:39436-39442.
214. Topham MK, Epand RM. 2009. Mammalian diacylglycerol kinases: molecular interactions and biological functions of selected isoforms. Biochim Biophys Acta 1790:416-424.
215. Tsuda S, Okudaira S, Moriya-Ito K, Shimamoto C, Tanaka M, Aoki J, Arai H, Murakami-Murofushi K, Kobayashi T. 2006. Cyclic phosphatidic acid is produced by autotaxin in blood. J Biol Chem 281:26081-26088.
216. Umezu-Goto M, Kishi Y, Taira A, Hama K, Dohmae N, Takio K, Yamori T, Mills GB, Inoue K, Aoki J, Arai H. 2002. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J Cell Biol 158:227-233.
217. van der Luit AH, Budde M, Ruurs P, Verheij M, van Blitterswijk WJ. 2002. Alkyl-lysophospholipid accumulates in lipid rafts and induces apoptosis via raft-dependent endocytosis and inhibition of phosphatidylcholine synthesis. J Biol Chem 277:39541-39547.
218. van der Sanden MH, Houweling M, Duijsings D, Vaandrager AB, van Golde LM. 2004a. Inhibition of phosphatidylcholine synthesis is not the primary pathway in hexadecylphosphocholine-induced apoptosis. Biochim Biophys Acta 1636:99-107.
219. van der Sanden MH, Meems H, Houweling M, Helms JB, Vaandrager AB. 2004b. Induction of CCAAT/enhancer-binding protein (C/EBP)-homologous protein/growth arrest and DNA damage-inducible protein 153 expression during inhibition of phosphatidylcholine synthesis is mediated via activation of a C/EBP-activating transcription factor-responsive element. J Biol Chem 279:52007-52015.
220. van Meeteren LA, Moolenaar WH. 2007. Regulation and biological activities of the autotaxin-LPA axis. Prog Lipid Res 46:145-160.
221. Vance DE, Li Z, Jacobs RL. 2007. Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology. J Biol Chem 282:33237-33241.
222. Vance DE, Ridgway ND. 1988. The methylation of phosphatidylethanolamine. Prog Lipid Res 27:61-79.
223. Vance DE, Walkey CJ, Agellon LB. 1998. Why has phosphatidylethanolamine N-methyltransferase survived in evolution? Biochem Soc Trans 26:337-340.
224. Vousden KH, Prives C. 2009. Blinded by the Light: The Growing Complexity of p53. Cell 137:413-431.
225. Voziyan PA, Goldner CM, Melnykovych G. 1993. Farnesol inhibits phosphatidylcholine biosynthesis in cultured cells by decreasing cholinephosphotransferase activity. Biochem J 295 (Pt 3):757-762.
226. Voziyan PA, Haug JS, Melnykovych G. 1995. Mechanism of farnesol cytotoxicity: further evidence for the role of PKC-dependent signal transduction in farnesol-induced apoptotic cell death. Biochem Biophys Res Commun 212:479-486.
227. Waite KA, Vance DE. 2000. Why expression of phosphatidylethanolamine N-methyltransferase does not rescue Chinese hamster ovary cells that have an impaired CDP-choline pathway. J Biol Chem 275:21197-21202.
228. Walkey CJ, Donohue LR, Bronson R, Agellon LB, Vance DE. 1997. Disruption of the murine gene encoding phosphatidylethanolamine N-methyltransferase. Proc Natl Acad Sci USA 94:12880-12885.
229. Walkey CJ, Kalmar GB, Cornell RB. 1994. Overexpression of rat liver CTP:phosphocholine cytidylyltransferase accelerates phosphatidylcholine synthesis and degradation. J Biol Chem 269:5742-5749.
230. Walkey CJ, Yu L, Agellon LB, Vance DE. 1998. Biochemical and evolutionary significance of phospholipid methylation. J Biol Chem 273:27043-27046.
231. Wang L, Magdaleno S, Tabas I, Jackowski S. 2005. Early embryonic lethality in mice with targeted deletion of the CTP:phosphocholine cytidylyltransferase alpha gene (Pcyt1a). Mol Cell Biol 25:3357-3363.
232. Wang Y, MacDonald JI, Kent C. 1993. Regulation of CTP:phosphocholine cytidylyltransferase in HeLa cells. Effect of oleate on phosphorylation and intracellular localization. J Biol Chem 268:5512-5518.
233. Wang Y, MacDonald JI, Kent C. 1995. Identification of the nuclear localization signal of rat liver CTP:phosphocholine cytidylyltransferase. J Biol Chem 270:354-360.
234. Watanabe N, Ikeda H, Nakamura K, Ohkawa R, Kume Y, Aoki J, Hama K, Okudaira S, Tanaka M, Tomiya T, Yanase M, Tejima K, Nishikawa T, Arai M, Arai H, Omata M, Fujiwara K, Yatomi Y. 2007a. Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C. J Clin Gastroenterol 41:616-623.
235. Watanabe N, Ikeda H, Nakamura K, Ohkawa R, Kume Y, Tomiya T, Tejima K, Nishikawa T, Arai M, Yanase M, Aoki J, Arai H, Omata M, Fujiwara K, Yatomi Y. 2007b. Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity. Life Sci 81:1009-1015.
236. Weidemann A, Johnson RS. 2008. Biology of HIF-1alpha. Cell Death Differ 15:621-627.
237. Wendel AA, Lewin TM, Coleman RA. 2009. Glycerol-3-phosphate acyltransferases: rate limiting enzymes of triacylglycerol biosynthesis. Biochim Biophys Acta 1791:501-506.
238. Wieprecht M, Wieder T, Paul C, Geilen CC, Orfanos CE. 1996. Evidence for phosphorylation of CTP:phosphocholine cytidylyltransferase by multiple proline-directed protein kinases. J Biol Chem 271:9955-9961.
239. Wise DR, Ward PS, Shay JE, Cross JR, Gruber JJ, Sachdeva UM, Platt JM, DeMatteo RG, Simon MC, Thompson CB. 2011. Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of a-ketoglutarate to citrate to support cell growth and viability. Proc Natl Acad Sci USA 108:19611-19616.
240. Worman HJ, Bonne G. 2007. "Laminopathies": a wide spectrum of human diseases. Exp Cell Res 313:2121-2133.
241. Wu G, Aoyama C, Young SG, Vance DE. 2008. Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis. J Biol Chem 283:1456-1462.
242. Wu G, Sher RB, Cox GA, Vance DE. 2010. Differential expression of choline kinase isoforms in skeletal muscle explains the phenotypic variability in the rostrocaudal muscular dystrophy mouse. Biochim Biophys Acta 1801:446-454.
243. Yamashita S, Ogawa M, Sakamoto K, Abe T, Arakawa H, Yamashita J. 1994a. Elevation of serum group II phospholipase A2 levels in patients with advanced cancer. Clin Chim Acta 228:91-99.
244. Yamashita S, Yamashita J, Ogawa M. 1994b. Overexpression of group II phospholipase A2 in human breast cancer tissues is closely associated with their malignant potency. Br J Cancer 69:1166-1170.
245. Yanaka N. 2007. Mammalian glycerophosphodiester phosphodiesterases. Biosci Biotechnol Biochem 71:1811-1818.
246. Yang W, Boggs KP, Jackowski S. 1995a. The association of lipid activators with the amphipathic helical domain of CTP:phosphocholine cytidylyltransferase accelerates catalysis by increasing the affinity of the enzyme for CTP. J Biol Chem 270:23951-23957.
247. Yang W, Jackowski S. 1995b. Lipid activation of CTP:phosphocholine cytidylyltransferase is regulated by the phosphorylated carboxylterminal domain. J Biol Chem 270:16503-16506.
248. Yuan Z, Tie A, Tarnopolsky M, Bakovic M. 2006. Genomic organization, promoter activity, and expression of the human choline transporter-like protein 1. Physiol Genomics 26:76-90.
249. Zakian KL, Sircar K, Hricak H, Chen HN, Shukla-Dave A, Eberhardt S, Muruganandham M, Ebora L, Kattan MW, Reuter VE, Scardino PT, Koutcher JA. 2005. Correlation of proton MR spectroscopic imaging with gleason score based on step-section pathologic analysis after radical prostatectomy. Radiology 234:804-814.
250. Zeisel SH. 2011. Nutritional genomics: defining the dietary requirement and effects of choline. J Nutr 141:531-534.
251. Zeisel SH, Mar MH, Zhou Z, da Costa KA. 1995. Pregnancy and lactation are associated with diminished concentrations of choline and its metabolites in rat liver. J Nutr 125:3049-3054.
252. Zhang XH, Zhao C, Ma ZA. 2007. The increase of cell-membranous phosphatidylcholines containing polyunsaturated fatty acid residues induces phosphorylation of p53 through activation of ATR. J Cell Sci 120:4134-4143.
253. Zhang XH, Zhao C, Seleznev K, Song K, Manfredi JJ, Ma ZA. 2006. Disruption of G1-phase phospholipid turnover by inhibition of Ca2+independent phospholipase A2 induces a p53-dependent cell-cycle arrest in G1 phase. J Cell Sci 119:1005-1015.
254. Zhao X, Wang D, Zhao Z, Xiao Y, Sengupta S, Xiao Y, Zhang R, Lauber K, Wesselborg S, Feng L, Rose TM, Shen Y, Zhang J, Prestwich G, Xu Y. 2006. Caspase-3-dependent activation of calcium-independent phospholipase A2 enhances cell migration in non-apoptotic ovarian cancer cells. J Biol Chem 281:29357-29368.
255. Zheng B, Berrie CP, Corda D, Farquhar MG. 2003. GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors. Proc Natl Acad Sci USA 100:1745-1750.
256. Zhou W, Simpson PJ, McFadden JM, Townsend CA, Medghalchi SM, Vadlamudi A, Pinn ML, Ronnett GV, Kuhajda FP. 2003. Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res 63:7330-7337.
257. Zhou X, Lawrence TJ, He Z, Pound CR, Mao J, Bigler SA. 2012. The expression level of lysophosphatidylcholine acyltransferase 1 (LPCAT1) correlates to the progression of prostate cancer. Exp Mol Pathol 92:105-110.
258. Zou W, Li ZY, Li YL, Ma KL, Tsui ZC. 2002. Overexpression of PEMT2 downregulates the PI3K/Akt signaling pathway in rat hepatoma cells. Biochim Biophys Acta 1581:49-56.