I-PLA2 activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation

Journal of Experimental Medicine

Volumn 196, Issue 5, 2002, Pages 655-665

  Kim, Sun Jun ^a   Gershov, Debra ^a   Ma, Xiaojing ^a   Brot, Nathan ^a   Elkon, Keith B ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Autoimmunity; Complement; IgM; Macrophages

Indexed keywords

CALCIUM; EPITOPE; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN M ANTIBODY; LYSOPHOSPHATIDYLCHOLINE; PHOSPHOLIPASE A2; PHOSPHOLIPID; PHOSPHORYLCHOLINE;

ANIMAL CELL; ANTIGEN BINDING; APOPTOSIS; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CELL MEMBRANE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROLYSIS; MACROPHAGE; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; T LYMPHOCYTE;

ANIMALS; ANNEXIN A5; ANTIBODY SPECIFICITY; APOPTOSIS; COMPLEMENT ACTIVATION; COMPLEMENT C1Q; COMPLEMENT C3; ENZYME ACTIVATION; HUMANS; IMMUNOGLOBULIN M; JURKAT CELLS; KINETICS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYSOPHOSPHATIDYLCHOLINES; MEMBRANE LIPIDS; MICE; MODELS, BIOLOGICAL; PHOSPHOLIPASES A;

EID: 0036719167     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20020542     Document Type: Article

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