Pharmacological inhibitors of fatty acid synthase (FASN)-catalyzed endogenous fatty acid biogenesis: A new family of anti-cancer agents?

Current Pharmaceutical Biotechnology

Volumn 7, Issue 6, 2006, Pages 483-494

  Lupu, Ruth ^a,b   Menendez, Javier A ^c,d,e  

^a EVANSTON NORTHWESTERN HEALTHCARE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c GIRONA BIOMEDICAL RESEARCH INSTITUTE IDIBGI   (Spain)

^d CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^e HOSPITAL JOSEP TRUETA   (Spain)

Author keywords

C75; Cancer; Cerulenin; Fatty acid synthase; Green tea; Orlistat; Triclosan

Indexed keywords

4 CARBOXY 5 OCTYL 3 METHYLENEBUTYROLACTONE; ACETYL COENZYME A; ANTINEOPLASTIC AGENT; APIGENIN; C 75; CERULENIN; CM 55; EBELACTONE A; EBELACTONE B; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIGALLOCATECHIN GALLATE; FATTY ACID; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; KAEMPFEROL; LONG CHAIN FATTY ACID; LUTEOLIN; MALONYL COENZYME A; OLEIC ACID; OLIVE OIL; PACLITAXEL; PROTEIN KINASE B; PROTEIN P53; QUERCETIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TAXIFOLIN; TETRAHYDROLIPSTATIN; TRICLOSAN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BREAST CANCER; CANCER; CANCER CELL; CANCER INHIBITION; CANCER RISK; CELL DEATH; CYTOSTASIS; CYTOTOXICITY; DIET THERAPY; DIETARY INTAKE; DOWN REGULATION; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG POTENTIATION; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME STRUCTURE; FATTY ACID SYNTHESIS; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; MAMMAL; MEDITERRANEAN DIET; NONHUMAN; PROSTATE CANCER; PROTEIN EXPRESSION; REVIEW; RNA INTERFERENCE; STRUCTURE ACTIVITY RELATION; UPREGULATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CATALYSIS; DRUG DESIGN; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS, ESSENTIAL; HUMANS; LIPOGENESIS; NEOPLASM PROTEINS; NEOPLASMS; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 33845909566     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920106779116928     Document Type: Review

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