Modulation of cholinephosphotransferase activity in breast cancer cell lines by Ro5-4864, a peripheral benzodiazepine receptor agonist

Biochemical and Biophysical Research Communications

Volumn 333, Issue 1, 2005, Pages 35-41

  Akech, Jacqueline ^a   Roy, Somdutta Sinha ^a   Das, Salil K ^a  

^a MEHARRY MEDICAL COLLEGE   (United States)

Author keywords

Breast cancer; C fos; Cholinephosphotransferase; Gene expression; Peripheral benzodiazepine receptor; Phosphatidylcholine

Indexed keywords

4' CHLORODIAZEPAM; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; CHOLINEPHOSPHOTRANSFERASE; PHOSPHATIDYLCHOLINE; PROTEIN C FOS;

ARTICLE; BIOSYNTHESIS; BREAST CANCER; CANCER CELL CULTURE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

BENZODIAZEPINONES; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DIACYLGLYCEROL CHOLINEPHOSPHOTRANSFERASE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; PHOSPHATIDYLCHOLINES; RECEPTORS, GABA; TUMOR MARKERS, BIOLOGICAL;

MINK CELL FOCUS-FORMING VIRUS;

EID: 20444480933     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.05.071     Document Type: Article

References (39)

1. Z. Cui, M. Houweling, M.H. Chen, M. Record, H. Chap, D.E. Vance, and F. Tercé A genetic defect in phosphatidylcholine biosynthesis triggers apoptosis in chinese hamster ovary cells J. Biol. Chem. 271 1996 14668 14671
2. R. Dahiya, T.A. Dudeja, and T.A. Brasitus Premalignant alterations in the glycosphingolipid composition of colonic epithelial cells of treated 1,2 dimethylhydrazine Cancer Res. 47 1987 1031 1035
3. D.S. Roos, and P.W. Choppin Biochemical studies on cell fusion. II. Control of fusion response by lipid alteration J. Cell Biol. 101 1985 1591 1598
4. R. Dahiya, B. Boyle, B.B. Goldberg, W.H. Yoon, K. Konely, T.B. Chen, W. Blumenfeld, and P. Narayan Metastasis associated alterations in phospholipids and fatty acids of human prostatic adenocarcinoma cell lines Biochem. Cell Biol. 70 1992 548 554
5. Beinlich, R. Strohmeier, M. Kaufman, and H. Kuhl Specific binding of benzodiazepines to human breast cancer cell lines Life Sci. 65 1999 2099 2108
6. E.O. Aboagye, and Z. Bhujwalla Malignant transformation alters membrane choline phospholipid metabolism of human mammary epithelial cells Cancer Res. 59 1999 80 84
7. R. Katz-Brull, D. Seger, D. Rivenson-Sega, and H. Degani Metabolic markers of breast cancer: enhanced choline metabolism and reduced choline-ether-phospholipid synthesis Cancer Res. 62 2002 1966 1970
8. I.S. Gribbestad, B. Sitter, S. Lundgren, J. Krane, and D. Axelson Metabolite composition in breast tumors examined by proton nuclear magnetic resonance spectroscopy Anticancer Res. 19 1999 1737 1746
9. E. Ackerstaff, B.R. Pflug, J.B. Nelson, and Z.M. Bhujwalla Detection of increased choline compounds with proton nuclear magnetic resonance spectroscopy subsequent to malignant transformation of human prostatic epithelial cells Cancer Res. 61 2002 3599 3603
10. M. Preul, Z. Caramanos, D.L. Collins, J.G. Villemure, R. Leblanc, A. Olivier, R. Pokrupa, and D.L. Arnold Accurate, noninvasive diagnosis of human brain tumors by using proton magnetic resonance spectroscopy Nat. Med. 2 1996 323 325
11. X.L. Li, A. Pirzkall, T. McKnight, and S.J. Nelson Analysis of the spatial characteristics of metabolic abnormalities in newly diagnosed glioma patients J. Magn. Res. Imaging 16 2002 229 237
12. Y-L.T. Ting, D. Sherr, and H. Degani Variations in energy and phospholipids metabolism in normal and cancer human mammary epithelial cells Anticancer Res. 16 1996 1381 1388
13. R. Sleight, and C. Kent Regulation of phosphatidylcholine biosynthesis in mammalian cell. Effects of phospholipase C treatment on phosphatidyl choline metabolism in Chinese hamster ovary cells and L.M. mouse fibroblasts J. Biol. Chem. 258 1983 824 830
14. A. Ghosh, J. Akech, S. Mukherjee, and S.K. Das Differential expression of cholinephosphotransferase in normal and cancerous human mammary epithelial cells Biochem. Biophys. Res. Commun. 297 2002 1043 1048
15. J-X. Lu, M.A. Caporini, and G.A. Lorigan The effects of cholesterol on magnetically aligned phospholipid bilayers: a solid-state NMR and EPR spectroscopy study J. Magn. Res. 168 2004 18 30
16. A. Cuadrado, A. Carnero, F. Dolfi, B. Jimenez, and J.C. Lacal Phosphocholine: a novel second messenger essential for mitogenic activity of growth factors Oncogene 8 1993 2959 2968
17. J.H. Exton Phosphatidylcholine breakdown and signal transduction Biochim. Biophys. Acta 1212 1994 26 42
18. S.L. Pelech, and D.E. Vance Signal transduction via phosphatidylcholine cycles Trends Biochem. Sci. 14 1989 28 30
19. H. Cai, P. Erhardt, J. Troppmair, M.T. Diaz-Meco, G. Sithanandam, U.R. Rapp, J. Moscat, and G.M. Cooper Hydrolysis of phosphatidylcholine couples Ras to activation of Raf protein kinase during mitogenic signal transduction Mol. Cell. Biol. 13 1993 7645 7651
20. D. Teegarden, E.J. Tarparowsky, and C. Kent Altered phosphophatidylcholine metabolism in C3H10T1/2 cells transfected with Harvey-ras oncogene J. Biol. Chem. 265 1990 6042 6047
21. M. Gavish, I. Bachman, R. Shoukrun, Y. Katz, L. Veenman, G. Weisinger, and A. Weizman Enigma of the peripheral benzodiazepine receptor Pharmacol. Rev. 51 1999 629 650
22. J. Kunert-Radek, H. Stepien, and M. Pawlikowski Inhibition of rat pituitary tumor cell proliferation by benzodiazepines in vitro Neuroendocrinology 59 1994 92 96
23. A. Camins, C. Diez-Fernandez, E. Pujada, J. Camarasa, and E. Escubedo A new aspect of the antiproliferative action of peripheral-type benzodiazepine receptor ligands Eur. J. Pharmacol. 272 1995 289 292
24. M. Hardwick, D. Fertikh, M. Culty, H. Li, B. Vidic, and V. Papadopoulos Peripheral-type benzodiazepine receptor in human breast cancer: correlation of breast cancer cell aggressive phenotype with PBR expression, nuclear localization, and PBR-mediated cell proliferation and nuclear transport of cholesterol Cancer Res. 59 1999 831 842
25. I. Carmel, F.A. Fares, S. Leshiner, H. Scherubl, G. Weisinger, and M. Gavish Peripheral-type benzodiazepine receptors in the regulation of proliferation of MCF-7 human breast carcinoma cell line Biochem. Pharmacol. 58 1999 273 278
26. Y. Katz, G. Ben-Baruch, Y. Kloog, J. Menczer, and M. Gavish Increased density of peripheral benzodiazepine receptor sites in ovarian carcinomas as compared with benign ovarian tumors and normal ovaries Clin. Sci. 78 1990 155 158
27. K.L. Black, K. Ikezaki, E. Santori, D.P. Becker, and H.V. Vinters Specific high binding affinity binding of peripheral benzodiazepine receptor ligands to brain tumors in rat and man Cancer 65 1990 93 97
28. M. Pawlikowski, K. Lyson, J. Kunert-Radek, and H. Stepien Effects of benzodiazepine on the proliferation of mouse spleen lymphocytes in vitro J. Neural. Transm. 73 1988 161 166
29. K.L. Black, T. Shiraishi, K. Ikezaki, K. Tabuchi, and D.P. Becker Peripheral benzodiazepine stimulates secretion of growth hormone and mitochondrial proliferation in pituitary tumor GH3 cells Neurol. Res. 16 1994 74 80
30. E. Matthew, J.D. Laskin, E.A. Zimmerman, I.B. Weinstein, K.C. Hsu, and D.L. Engelhardt Benzodiazepines have high affinity binding sites and induce melanogenesis in B16/C3 melanoma cells Proc. Natl. Acad. Sci. USA 78 1981 3935 3939
31. Y. Katz, A. Eitan, and M. Gavish Increase in peripheral benzodiazepine binding sites in colonic adenocarcinoma Oncology 47 1990 139 142
32. P. Cornu, J. Benavides, B. Scatton, J.J. Hauw, and J. Phillipon Increase in peripheral type benzodiazepine binding densities in different types of human brain tumors: a quantitative autoradiography study Acta Neurochir. 119 1992 146 152
33. T. Curran, and J.I. Morgan Superinduction of c-fos by nerve growth factor in the presence of peripherally active benzodiazepines Science 229 1985 1265 1268
34. D.F. Bussolino, M.E. Guido, G.A. Gil, A. Borioli, M.L. Renner, V.R. Grabois, C.B. Conde, and B.L. Caputto C-fos associates with the endoplasmic reticulum and activates phospholipid metabolism FASEB J. 15 2001 556 558
35. O.H. Lowry, N.J. Rosenbrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin Phenol reagent J. Biol. Chem. 193 1951 265 275
36. K. Polyak On the birth of breast cancer Biochim. Biophy. Acta/Rev. Cancer 1152 2001 1 13
37. J.I. Morgan, and T. Curran Immediate early genes: ten years on Trends Neurosci. 18 1995 66 67
38. T.T.J. Martin Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking Annu. Rev. Dev. Biol. 14 1998 231 264
39. K. Tamiya-Koizumi Nuclear lipid metabolism and signaling J. Biochem. 132 2002 13 22