Fatty acid synthase expression in endometrial carcinoma: Correlation with cell proliferation and hormone receptors

Cancer

Volumn 83, Issue 3, 1998, Pages 528-537

  Pizer, Ellen S ^a,b   Lax, Sigurd F ^a   Kuhajda, Francis P ^a   Pasternack, Gary R ^a   Kurman, Robert J ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b JOHNS HOPKINS BAYVIEW MEDICAL CENTER   (United States)

Author keywords

Endometrium carcinoma; Estrogen receptor; Fatty acid synthase; Proliferation

Indexed keywords

ESTROGEN RECEPTOR; FATTY ACID SYNTHASE; KI 67 ANTIGEN; PROGESTERONE RECEPTOR;

ARTICLE; CANCER GRADING; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOMETRIUM CARCINOMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR DIFFERENTIATION;

CELL DIVISION; ENDOMETRIAL NEOPLASMS; FATTY ACID SYNTHETASE COMPLEX; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE;

EID: 0032147199     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0142(19980801)83:3<528::AID-CNCR22>3.0.CO;2-X     Document Type: Article

References (29)

1. Wakil S. Fatty acid synthase, a proficient multifunctional enzyme. Biochem 1989;28:4523-30.
2. Roncari DAK. Mammalian fatty acid synthase. I. Purification and properties of human liver complex. Can J Biochem 1974;52:221-30.
3. Witkowski A, Rangan VS, Randhawa ZI, Amy CM, Smith S. Structural organization of the multifunctional animal fattyacid synthase. Int J Biochem 1991;198:571-9.
4. Thompson BJ, Smith S. Biosynthesis of fatty acids by lactating human breast epithelial cells: an evaluation of the contribution to the overall composition of human milk fat. Pediatr Res 1985;19:139-43.
5. Xu Z-X, Stenzel W, Sasic SM, Smart DA, Rooney SA. Glucocorticoid regulation of fatty acid synthase gene expression in fetal rat lung. Am J Physiol 1993;265:L140-7.
6. Weiss L, Hoffmann GE, Schreiber R, Andres H, Fuchs E, Korber E, et al. Fatty-acid biosynthesis in man: a pathway of minor importance. Biol Chem Hoppe Seyler 1986;367:905-12.
7. Pizer ES, Kurman RJ, Pasternack GR, Kuhajda FP. Expression of fatty acid synthase is closely linked to proliferation and decidualization in cycling endometrium. Int J Gynecol Pathol 1997;16:45-51.
8. Press MF, Nousek-Goebl NA, Bur M, Greene GL. Estrogen receptor localization in the female genital tract. Am J Pathol 1986;123:280-92.
9. Press MF, Udove JA, Greene GL. Progesterone receptor distribution in the human endometrium: analysis using monoclonal antibodies to the human progesterone receptor. Am J Pathol 1988;131:112-24.
10. Snijders MPML, de Goeij AFMP, Debets-Te Baerts MCJ, Rousch MJM, Koudstaal J, Bosman FT. Immunocytochemical analysis of estrogen receptors and progesterone receptors in the human uterus throughout the menstrual cycle and after the menopause. J Reprod Fert 1992;94:363-71.
11. Gerdes J, Lemke H, Baisch H, Wacker H-H, Schwab U, Stein H. Cell cycle analysis of a cell proliferation-associated human nuclear antigen denned by the monoclonal antibody Ki-67. J Immunol 1984;133:1710-5.
12. Ferenczy A, Bertrand G, Gelfand MM. Proliferation kinetics of human endometrium during the normal menstrual cycle. Am J Obstet Gynecol 1979; 133:859-67.
13. Jensen V, Ladekari M, Holm-Nielsen P, Flemming BS, Flemming M. The prognostic value of oncogenic antigen 519 (OA519) expression and proliferative activity detected by antibody MIB-1 in node negative breast cancer. J Pathol 1995;176:343-52.
14. Hardman W, Gansler T, Schaffei S, Hennigar R. OA-519 immunostaining portends poor prognosis in ovarian cancer [abstract]. Mod Pathol 1995;8:90A.
15. Epstein JI, Carmichael M, Partin AW. OA-519 (fatty acid synthase) as an independent predictor of pathologic stage in adenocarcinoma of the prostate. Urology 1995;45:81-6.
16. Kuhajda FP, Jenner K, Wood FD, Hennigar RA, Jacobs LB, Dick JD, et al. Fatty acid synthase: a potential selective target for antineoplastic therapy. Proc Natl Acad Sci USA 1994; 91:6379-83.
17. Pizer ES, Wood FD, Heine HS, Romantsev F, Pasternack GR, Kuhajda FP. Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer. Cancer Res 1996;56:1189-93.
18. Rashid A, Pizer ES, Moga M, Milgraum LZ, Zahurak M, Pasternack, et al. Elevation of fatty acid synthase expression and fatty acid synthetic activity in colorectal neoplasia. Am J Pathol 1997;150:201-8.
19. Scully RE, Poulson H, Sobin LH. International histological classification and histologic typing of female genital tract tumors. Berlin:Springer-Verlag, 1994.
20. Remmele W, Schicketanz KH. Immunohistochemical determination of estrogen and progesterone receptor content in human breast cancer: computer assisted image analysis (QIC Score) vs. subjective grading (IRS). Pathol Res Pract 1993;189:862-6.
21. Pizer ES, Jackisch CJ, Wood FD, Pasternack GR, Davidson NE, Kuhajda FP. Inhibition of fatty acid synthase induces programmed cell death in human breast cancer cells. Cancer Res 1996;56:2745-7.
22. Kurman RJ, Zaino RJ, Norris HJ. Endometrial carcinoma. In: Kurman RJ, editor. Blaustein's pathology of the female genital tract. 4th edition. New York: Springer-Verlag, 1994:327-66.
23. Persson I, Adami H.-O, Bergkvist L, Lindgren A, Pettersson B, Hoover R, et al. Risk of endometrial cancer after treatment with oestrogens alone or in conjunction with progestogens: results of a prospective study. Br Med J 1989;298: 147-51.
24. Hoskins WJ, Perez CA, Young RC. Gynecologic tumors. In: De Vita VT Jr., Hellman S, Rosenberg SA, editors. Cancer: principles and practice of oncology. Philadelphia: J. B. Lippincott, 1993:1153-1225.
25. Hendrickson MR, Kempson RL. Endometrial epithelial metaplasias: proliferations frequently misdiagnosed as adenocarcinoma. Report of 89 cases and proposed classification. Am J Surg Pathol 1980;4:525-42.
26. Andersen WA, Taylor PT, Fechner RE, Pinkerton JAV. Endometrial metaplasia associated with endometrial carcinoma. Am J Obster Gynecol 1987;157:597-604.
27. Creasman WT. Announcement, FIGO stages: 1988 revisions. Gynecol Oncol 1989;35:125-7.
28. Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol Oncol 1983;15:10-17.
29. Sherman ME, Bitterman P, Rosenshein NB, Delgado G, Kurman RJ. Uterine serous carcinoma: a morphologically diverse neoplasm with unifying clinicopathologic features. Am J Surg Pathol 1992;16:600-10.