CTP:phosphocholine cytidylyltransferase, a new sterol-and SREBP-responsive gene

Journal of Lipid Research

Volumn 42, Issue 8, 2001, Pages 1266-1272

  Kast, Heidi Rachelle ^a   Nguyen, Catherine M ^a   Anisfeld, Andrew M ^a   Ericsson, Johan ^b   Edwards, Peter A ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

CT gene; Phosphatidylcholine; Sterol response element

Indexed keywords

CHOLINE PHOSPHATE CYTIDYLYLTRANSFERASE; COMPLEMENTARY DNA; MESSENGER RNA; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; STEROL REGULATORY ELEMENT BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CULTURE MEDIUM; GENE EXPRESSION REGULATION; HEPATOMA CELL; HUMAN; HUMAN CELL; NONHUMAN; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADIPOCYTES; ANIMALS; CARCINOMA, HEPATOCELLULAR; CCAAT-ENHANCER-BINDING PROTEINS; CELL DIFFERENTIATION; CHO CELLS; CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE; CRICETINAE; DNA-BINDING PROTEINS; GENE EXPRESSION; GENES, REPORTER; HUMANS; LIVER NEOPLASMS; LUCIFERASES; PROMOTER REGIONS (GENETICS); RESPONSE ELEMENTS; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROLS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0034879757     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. CTP:phosphocholine cytidylyltransferase
2. Distribution of CTP:phosphocholine cytidylyltranferase (CCT) isoforms. Identification of a new CCTbeta splice variant
3. Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase
4. Regulation of mammalian cell membrane biosynthesis
5. Eukaryotic phospholipid biosynthesis
6. Integration of phospholipid and sterol metabolism in mammalian cells
7. Induction of hepatocyte proliferation after partial hepatectomy is accompanied by a markedly reduced expression of phosphatidylethanolamine N-methyltranferase-2
8. Colony-stimulating factor 1 regulates CTP:phosphocholine cytidylyltransferase mRNA levels
9. Lipoprotein deprivation stimulates transcription of the CTP:phosphocholine cytidylyltransferase gene
10. Macrophages deficient in CTP:phosphocholine cytidylyltransferase-alpha are viable under normal culture conditions but are highly susceptible to free cholesterol-induced death. Molecular genetic evidence that the induction of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response
11. Transcriptional enhancer factor-4 as a transcriptional modulator of CTP:phosphocholine cytidylyltransferase
12. Transcriptional activation of the murine CTP:phosphocholine cytidylyltransferase gene (Ctpct): Combined action of upstream stimulatory and inhibitory cis-acting elements
13. Functional significance of Sp1, Sp2, and Sp3 transcription factors in regulation of the murine CTP:phosphocholine cytidylyltransferase alpha promoter
14. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
15. A proteolytic pathway that controls the cholesterol content of membranes, cell, and blood
16. Sterols and isoprenoids: Signaling molecules derived from the cholesterol biosynthetic pathway
17. Regulation of gene expression by SREBP and SCAP
18. Transport-dependent proteolysis of SREBP: Relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to the Golgi
19. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXR alpha and LXR beta
20. Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA is rat hepatoma cells requires endogenous LXR ligands
21. Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1-and sterol regulatory element-binding protein-responsive gene
22. Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1
23. Expression of wild-type and mutant rat liver CTP:phosphocholine cytidylyltransferase in an cytidylyltransferase-deficient Chinese hamster ovary cell line
24. Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene
25. Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor
26. Interleukin 8 is induced by cholesterol loading of macrophages and expressed by macrophage foam cells in human atheroma
27. Role for sterol regulatory element binding protein in the regulation of farnesyl diphosphate synthase and in the control of cellular levels of cholesterol and triglyceride; evidence from sterol regulation defective cells
28. Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene
29. The structure of the gene for murine CTP:phosphocholine cytidylyltransferase, Ctpct. Relationship of exon structure to functional domains and identification of transcriptional start sites and potential upstream regulatory elements
30. Identification of conserved cis-elements and transcriptional factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2
31. ADD1: A novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation
32. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism
33. Free cholesterol loading of macrophages stimulates phosphatidylcholine biosynthesis and up-regulation of CTP:phosphocholine cytidylyltransferase
34. Regulation of phosphatidylcholine metabolism in Chinese hamster ovary cells by the sterol regulatory element-binding protein (SREBP)/SREBP cleavage-activating protein pathway
35. Decreased phosphatidylcholine biosynthesis and abnormal distribution of CTP:phosphocholine cytidylyltransferase in cholesterol auxotrophic Chinese hamster ovary cells
36. Synergistic activation of transcription by nuclear factor Y and sterol regulatory element binding protein
37. Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene
38. NF-Y has a novel role in sterol-dependent transcription of two cholesterogenic genes