Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers

Biochemical and Biophysical Research Communications

Volumn 296, Issue 3, 2002, Pages 580-583

  Ramírez de Molina, Ana ^a   Rodríguez González, Agustín ^a   Gutiérrez, Ruth ^a   Martínez Pieiro, Luis ^b   Sánchez, José J ^c   Bonilla, Félix ^d   Rosell, Rafael ^e   Lacal, Juan Carlos ^a  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^d HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^e HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

Choline kinase; Colorectal tumors; Lung cancer; Prostate tumors; Tumor markers

Indexed keywords

CHOLINE KINASE;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; COLORECTAL CARCINOMA; CONTROLLED STUDY; DISEASE MARKER; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG CARCINOMA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN EXPRESSION;

ADULT; AGED; CARCINOMA; CELLS, CULTURED; CHOLINE KINASE; COLON; COLORECTAL NEOPLASMS; HUMANS; LUNG; LUNG NEOPLASMS; MALE; MIDDLE AGED; PROSTATE; PROSTATIC NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 0036385709     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00920-8     Document Type: Article

References (17)

1. A. Cuadrado, A. Carnero, F. Dolfi, B. Jiménez, J.C. Lacal, Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors, Oncogene 8 (1993) 2959-2968.
2. B. Jiménez, L. del Peso, S. Montaner, P. Esteve, J.C. Lacal, Generation of phosphorylcholine as an essential event in the activation of Raf-1 and MAP-Kinases in growth factors/induced mitogenic stimulation, J. Cell. Biochem. 57 (1995) 141-149.
3. L.E. Rameh, L.C. Cantley, The role of phosphoinositide 3-kinase lipid products in cell function, J. Biol. Chem. 274 (13) (1999) 8347-8350.
4. Z. Kiss, T. Chung, Choline phosphate and phosbol esters potentiate the mitogenic effect of insulin by competitive mechanism in NIH3T3 cells, Biochem. Biophys. Res. Commun. 218 (1996) 505-509.
5. T. Chung, K.S. Crilly, W.H. Anderson, J.J. Murherjee, Z. Kiss, ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of pp70 S6 kinase and phosphatydilinositol 3′-kinase through an extracellular site, J. Biol. Chem. 272 (1997) 3064-3072.
6. D. Teegarden, E.J. Taparowsky, C. Kent, Altered phosphatidylcholine metabolism in C3H10T1/2 cells transfected with the Harveyras oncogene, J. Biol. Chem. 265 (1990) 6042-6047.
7. S. Ratnam, C. Kent, Early increase in choline kinase activity upon induction of the H-ras oncogene in mouse fibroblast cell lines, Arch. Biochem. Biophys. 323 (1995) 313-322.
8. A. Ramirez de Molina, A. Rodriguez-Gonzalez, V. Penalva, L. Lucas, J.C. Lacal, Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells, Biochem. Biophys. Res. Commun. 285 (4) (2001) 873-879.
9. A. Ramírez de Molina, V. Penalva, L. Lucas, J.C. Lacal, Regulation of choline kinase activity by ras proteins involves Ral-GDS and PI3K, Oncogene 21 (6) (2002) 937-946.
10. A. Ramírez de Molina, R. Gutiérrez, M.A. Ramos, J.M. Silva, J. Silva, J.J. Sánchez, F. Bonilla, J.C. Lacal, Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy, Oncogene 21 (2002) 4317-4322.
11. J. Ruiz-Cabello, J.S. Cohen, Phospholipid metabolites as indicators of cancer cell function, NMR Biomed. 5 (1992) 226-233.
12. 31P MRS of experimental tumours, NMR Biomed. 6 (1993) 345-365.
13. T.A.D. Smith, C. Bush, C. Jameson, J.C. Titley, M.O. Leach, D.E.V. Wilman, V.R. McCready, Phospholipid metabolites, prognosis and proliferation in human breast carcinoma, NMR Biomed. 6 (1993) 318-323.
14. R. Hernandez-Alcoceba, L. Saniger, J. Campos, M.C. Nuñez, F. Khaless, M.A. Gallo, A. Espinosa, J.C. Lacal, Choline kinase inhibitors as a novel approach for antiproliferative drug design, Oncogene 15 (1997) 2289-2301.
15. R. Hernández-Alcoceba, F. Fernández, J.C. Lacal, A novel mechanism for anitcancer drug discovery: in vivo antitumor activity by inhibition of phosphorylcholine production, Cancer Res. 59 (1999) 3112-3118.
16. J.C. Lacal, Choline kinase inhibitors: a novel target to search for antitumor drugs, Idrugs 4 (2001) 419-426.
17. A. Ramírez de Molina, A. Rodríguez-Gonzalez, J.C. Lacal, Targeting new anticancer drugs within signalling pathways regulated by the Ras GTPases superfamily, Int. J. Oncol. 19 (1) (2001) 5-17.