Induction of apoptosis by lipophilic activators of CTP:phosphocholine cytidylyltransferase α (CCTα)

Biochemical Journal

Volumn 392, Issue 3, 2005, Pages 449-456

  Lagace, Thomas A ^a,b   Ridgway, Neale D ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Apoptosis; CTP:phosphocholine cytidylyltransferase (CCT); Diacylglycerol; Farnesol (FOH); Lipophilic activator; Phosphatidylcholine

Indexed keywords

BIOCHEMISTRY; ENZYME INHIBITION; ENZYMES; SYNTHESIS (CHEMICAL);

APOPTOSIS; CTP:PHOSPHOCHOLINE CYTIDYLYLTRANSFERASE (CCT); DIACYLGLYCEROL; FARNESOL (FOH); LIPOPHILIC ACTIVATOR; PHOSPHATIDYLCHOLINE;

ALCOHOLS;

CASPASE; CITICOLINE; DIACYLGLYCEROL; DIOCTANOIN; FARNESOL; OLEIC ACID; OLEYL ALCOHOL; TRANSFERASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; NONHUMAN; NUCLEAR EXPORT SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNTHESIS;

ANIMALS; APOPTOSIS; CHO CELLS; CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE; CRICETINAE; DIGLYCERIDES; ENZYME ACTIVATORS; FARNESOL; FATTY ALCOHOLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; PHOSPHATIDYLCHOLINES; PROTEIN TRANSPORT;

ANIMALIA;

EID: 29644442769     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051021     Document Type: Article

References (45)

1. Jackowski, S. (1994) Coordination of membrane phospholipid synthesis with the cell cycle. J. Biol. Chem. 269, 3858-3867
2. Jackowski, S. (1996) Cell cycle regulation of membrane phospholipid metabolism J. Biol. Chem. 271, 20219-20222
3. Cui, Z., Houweling, M., Chen, M. H., Record, M., Chap, H., Vance, D. E. and Terce, F. (1996) A genetic defect in phosphatidylcholine biosynthesis triggers apoptosis in Chinese hamster ovary cells. J. Biol. Chem. 271, 14668-14671
4. Wang, L., Magdaleno, S., Tabas, I. and Jackowski, S. (2005) Early embryonic lethality in mice with targeted deletion of the CTP:phosphocholine cytidylyltranslerase alpha gene (Pcyt1a). Mol. Cell. Biol. 25, 3357-3363
5. Rodriguez-Gonzalez, A., de Molina, A. R., Fernandez, F., Ramos, M. A., Nunez Mdel, C., Campos, J. and Lacal, J. C. (2003) Inhibition of choline kinase as a specific cytotoxic strategy in oncogene-transformed cells. Oncogene 22, 8803-8812
6. Yen, C. L., Mar, M. H. and Zeisel, S. H. (1999) Choline deficiency-induced apoptosis in PC12 cells is associated with diminished membrane phosphatidylcholine and sphingomyelin, accumulation of ceramide and diacylglycerol, and activation of a caspase. FASEB J. 13, 135-142
7. Cornell, R. B. and Northwood, I. C. (2000) Regulation of CTP:phosphocholine cytidylyltransferase by amphitropism and relocalization. Trends Biochem Sci. 25, 441-447
8. Lykidis, A., Murti, K. G. and Jackowski, S. (1998) Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase. J. Biol. Chem. 273, 14022-14029
9. Lykidis, A., Baburina, I. and Jackowski, S. (1999) Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant. J. Biol. Chem. 274, 26992-27001
10. Wang, Y., MacDonald, J. I. and Kent, C. (1993) Regulation of CTP:phosphocholine cytidylyltransferase in HeLa cells. Effect of oleate on phosphorylation and intracellular localization. J. Biol. Chem. 268, 5512-5518
11. Wang, Y., MacDonald, J. I. and Kent, C. (1995) Identification of the nuclear localization signal of rat liver CTP:phosphocholine cytidylyltransferase. J. Biol. Chem. 270, 354-360
12. DeLong, C. J., Qin, L. and Cui, Z. (2000) Nuclear localization of enzymatically active green fluorescent protein- CTP:phosphocholine cytidylyltransferase alpha fusion protein is independent of cell cycle conditions and cell types. J. Biol. Chem. 275, 32325-32330
13. Ridsdale, R., Tseu, I., Wang, J. and Post, M. (2001) CTP:phosphocholine cytidylyltransferase alpha is a cytosolic protein in pulmonary epithelial cells and tissues. J. Biol. Chem. 276, 49148-49155
14. Lagace, T. A. and Ridgway, N. D. (2005) The rate-limiting enzyme in phosphatidylcholine synthesis regulates proliferation of the nucleoplasmic reticulum. Mol. Biol. Cell 16, 1120-1130
15. Echevarria, W., Leite, M. F., Guerra, M. T., Zipfel, W. R. and Nathanson, M. H. (2003) Regulation of calcium signals in the nucleus by a nucleoplasmic reticulum. Nat. Cell Biol. 5, 440-446
16. Fricker, M., Hollinshead, M., White, N. and Vaux, D. (1997) Interphase nuclei of many mammalian cell types contain deep, dynamic, tubular membrane-bound invaginations of the nuclear envelope. J. Cell Biol. 136, 531-544
17. Golfman, L. S., Bakovic, M. and Vance, D. E. (2001) Transcription of the CTP:phosphocholine cytidylyltransferase alpha gene is enhanced during the S phase of the cell cycle. J. Biol. Chem. 276, 43688-43692
18. Northwood, I. C., Tong, A. H., Crawford, B., Drobnies, A. E. and Cornell, R. B. (1999) Shuttling of CTP:phosphocholine cytidylyltransferase between the nucleus and endoplasmic reticulum accompanies the wave of phosphatidylcholine synthesis during the G(0) → G(1) transition. J. Biol. Chem. 274, 26240-26248
19. Anthony, M. L., Zhao, M. and Brindle, K. M. (1999) Inhibition of phosphatidylcholine biosynthesis following induction of apoptosis in HL-60 cells. J. Biol. Chem. 274, 19686-19692
20. Boggs, K., Rock, C. O. and Jackowski, S. (1998) The antiproliferative effect of hexadecylphosphocholine toward HL60 cells is prevented by exogenous lysophosphatidylcholine. Biochim. Biophys. Acta 1389, 1-12
21. Boggs, K. P., Rock, C. O. and Jackowski, S. (1995) Lysophosphatidylcholine and 1-0-octadecyl-2-0-methyl-rac-glycero-3- phosphocholine inhibit the CDP-choline pathway of phosphatidylcholine synthesis at the CTP:phosphocholine cytidylyltransferase step. J. Biol. Chem. 270, 7757-7764
22. Baburina, I. and Jackowski, S. (1998) Apoptosis triggered by 1-0-octadecyl-2-0-methyl-rac-glycero-3-phosphocholine is prevented by increased expression of CTP:phosphocholine cytidylyltransferase. J. Biol. Chem. 273, 2169-2173
23. Miquel, K., Pradines, A., Terce, F., Selmi, S. and Ravre, G. (1998) Competitive inhibition of choline phosphotransferase by geranylgeraniol and farnesol inhibits phosphatidylcholine synthesis and induces apoptosis in human lung adenocarcinoma A549 cells. J. Biol. Chem. 273, 26179-26186
24. Voziyan, P. A., Haug, J. S. and Melnykovych, G. (1995) Mechanism of farnesol cytotoxicity: further evidence for the role of PKC-dependent signal transduction in farnesol-induced apoptotic cell death. Biochem. Biophys. Res. Commun. 212, 479-486
25. Voziyan, P. A., Goldner, C. M. and Melnykovych, G. (1993) Farnesol inhibits phosphatidylcholine biosynthesis in cultured cells by decreasing cholinephosphotransferase activity. Biochem. J. 295, 757-762
26. Wright, M. M., Henneberry, A. L., Lagace, T. A., Ridgway, N. D. and McMaster, C. R. (2001) Uncoupling farnesol-induced apoptosis from its inhibition of phosphatidylcholine synthesis. J. Biol. Chem. 276, 25254-25261
27. Araki, W. and Wurtman, R. J. (1997) Control of membrane phosphatidylcholine biosynthesis bydiacylglycerol levels in neuronal cells undergoing neurite outgrowth. Proc. Natl. Acad. Sci. U.S.A. 94, 11946-11950
28. Lagace, T. A., Miller, J. R. and Ridgway, N. D. (2002) Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during larnesol-induced apoptosis. Mol. Cell. Biol. 22, 4851-4862
29. Houweling, M., Cui, Z. and Vance, D. E. (1995) Expression of phosphatidylethanolamine N-methyltransferase-2 cannot compensate for an impaired CDP-choline pathway in mutant Chinese hamster ovary cells. J. Biol. Chem. 270, 16277-16282
30. Storey, M. K., Byers, D. M., Cook, H. W. and Ridgway, N. D. (1997) Decreased phosphatidylcholine biosynthesis and abnormal distribution of CTP:phosphocholine cytidylyltransferase in cholesterol auxotrophic Chinese hamster ovary cells. J. Lipid Res. 38, 711-722
31. Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275
32. Preiss, J., Loomis, C. R., Bishop, W. R., Stein, R., Niedel, J. E. and Bell, R. M. (1986) Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells. J. Biol. Chem. 261, 8597-8600
33. Yang, J., Wang, J., Tseu, I., Kuliszewski, M., Lee, W. and Post, M. (1997) Identification of an 11-residue portion of CTP-phosphocholine cytidylyltransferase that is required for enzyme-membrane interactions. Biochem. J. 325, 29-38
34. Cornell, R. and Vance, D. E. (1987) Translocation of CTP:phosphocholine cytidylyltransferase from cytosol to membranes in HeLa cells: stimulation by fatty acid, fatty alcohol, mono- and diacylglycerol. Biochim. Biophys. Acta 919, 26-36
35. Igal, R. A., Wang, P. and Coleman, R. A. (1997) Triacsin C blocks de novo synthesis of glycerolipids and cholesterol esters but not recycling of fatty acid into phospholipid: evidence for functionally separate pools of acyl-CoA. Biochem. J. 324, 529-534
36. Lewin, T. M., Kim, J. H., Granger, D. A., Vance, J. E. and Coleman, R. A. (2001) Acyl-CoA synthetase isoforms 1,4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently. J. Biol. Chem. 276, 24674-24679
37. Jamil, H., Utal, A. K. and Vance, D. E. (1992) Evidence that cyclic AMP-induced inhibition of phosphatidylcholine biosynthesis is caused by a decrease in cellular diacylglycerol levels in cultured rat hepatocytes. J. Biol. Chem. 267, 1752-1760
38. Jackowski, S., Wang, J. and Baburina, I. (2000) Activity of the phosphatidylcholine biosynthetic pathway modulates the distribution of fatty acids into gtycerolipids in proliferating cells. Biochim. Biophys. Acta 1483, 301-315
39. Machida, K., Tanaka, T., Yano, Y., Otani, S. and Taniguchi, M. (1999) Farnesol-induced growth inhibition in Saccharomyces cerevisiae by a cell cycle mechanism. Microbiology 145, 293-299
40. George, T. P., Morash, S. C., Cook, H. W., Byers, D. M., Palmer, F. B. and Spence, M. W. (1989) Phosphatidylcholine biosynthesis in cultured glioma cells: evidence for channeling of intermediates. Biochim. Biophys. Acta 1004, 283-291
41. Henneberry, A. L., Wright, M. M. and McMaster, C. R. (2002) The major sites of cellular phospholipid synthesis and molecular determinants of fatty acid and lipid head group specificity. Mol. Biol. Cell 13, 3148-3161
42. Houweling, M., Cui, Z., Anfuso, C. D., Bussiere, M., Chen, M. H. and Vance, D. E. (1996) CTP:phosphocholine cytidylyltransferase is both a nuclear and cytoplasmic protein in primary hepatocytes. Eur. J. Cell Biol. 69, 55-63
43. Utal, A. K., Jamil, H. and Vance, D. E. (1991) Diacylglycerol signals the translocation of CTP:choline-phosphate cytidylyltransferase in HeLa cells treated with 12-0-tetradecanoylphorbol-13-acetate. J. Biol. Chem. 266, 24084-24091
44. Ridgway, N. D. and Lagace, T. A. (2003) Regulation of the CDP-choline pathway by sterol regulatory element binding proteins involves transcriptional and post-transcriptional mechanisms. Biochem. J. 372, 811-819
45. Melnykovych, G., Haug, J. S. and Goldner, C. M. (1992) Growth inhibition of leukemia cell line CEM-C1 by farnesol: effects of phosphatidylcholine and diacylglycerol. Biochem. Biophys. Res. Commun. 186, 543-548