Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 29, 2004, Pages 10715-10720

  Menendez, Javier A ^a,b   Vellon, Luciano ^a,b   Mehmi, Inderjit ^a   Oza, Bharvi P ^a   Ropero, Santiago ^c   Colomer, Ramon ^d   Lupu, Ruth ^a,b  

^a Evanston Northwestern Healthcare ^*  (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c Centro Nacional de Investigaciones Oncológicas   (Spain)

^d HOSPITAL JOSEP TRUETA   (Spain)

Author keywords

Chemotherapy; Lipogenesis Herceptin; Small interfereing RNA; Trastuzumab

Indexed keywords

C 75; CERULETIDE; ENZYME INHIBITOR; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; MESSENGER RNA; ONCOPROTEIN; PROTEIN P185; PROTEIN TYROSINE KINASE; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR PEA3; TRASTUZUMAB; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BIOSENSOR; BREAST CANCER; CANCER; CANCER CELL; CANCER CHEMOTHERAPY; CARCINOGENESIS; CELL NUCLEUS; CELL STRUCTURE; CELLULAR DISTRIBUTION; CYTOTOXICITY; ENERGY BALANCE; ENZYME ACTIVITY; ENZYME INHIBITION; FAS GENE; GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; OBESITY; ONCOGENE NEU; OVARY CANCER; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA INTERFERENCE;

4-BUTYROLACTONE; ANTIBIOTICS, ANTIFUNGAL; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE; CELL SIZE; CELL SURVIVAL; CERULENIN; FATTY ACID SYNTHETASE COMPLEX; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, ERBB-2; HUMANS; OVARIAN NEOPLASMS; RECEPTOR, ERBB-2; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL;

EID: 3242685815     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0403390101     Document Type: Article

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