Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains

Biochemical and Biophysical Research Communications

Volumn 302, Issue 4, 2003, Pages 898-903

  Swinnen, Johannes V ^a   Van Veldhoven, Paul P ^a   Timmermans, Leen ^a   De Schrijver, Ellen ^a   Brusselmans, Koen ^a   Vanderhoydonc, Frank ^a   Van De Sande, Tine ^a   Heemers, Hannelore ^a   Heyns, Walter ^a   Verhoeven, Guido ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Cancer; DRM; Fatty acid synthase; Lipogenesis; LNCaP; Microdomain; Raft

Indexed keywords

DETERGENT; FATTY ACID SYNTHASE; PHOSPHOLIPID; RNA;

ARTICLE; CANCER CELL; CELL FUNCTION; CELL MIGRATION; CELL POLARITY; HUMAN; HUMAN CELL; MALE; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

EID: 0344838439     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)00265-1     Document Type: Article

References (25)

1. Wakil S.J. Fatty acid synthase, a proficient multifunctional enzyme. Biochemistry. 28:1989;4523-4530.
2. Weiss L., Hoffmann G.E., Schreiber R., Andres H., Fuchs E., Korber E., Kolb H.J. Fatty acid biosynthesis in man, a pathway of minor importance: purification, optimal assay conditions, and organ distribution of fatty acid synthase. Biol. Chem. Hoppes-Seyer. 367:1986;905-912.
3. Kuhajda F.P. Fatty acid synthesis: a potential selective target for antineoplastic therapy. Nutrition. 16:2000;202-208.
4. Swinnen J.V., Roskams T., Joniau S., Van Poppel H., Oyen R., Baert L., Heyns W., Verhoeven G. Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer. Int. J. Cancer. 98:2002;19-22.
5. Kuhajda F.P., Jenner K., Wood F.D., Hennigar R.A., Jacobs L.B., Dick J.D., Pasternack G.R. Fatty acid synthase: a potential selective target for antineoplastic therapy. Proc. Natl. Acad. Sci. USA. 91:1994;6379-6383.
6. Rashid A., Pizer E.S., Moga M., Milgraum L.Z., Zahurak M., Pasternack G.R., Kuhajda F.P., Hamilton S.R. Elevated expression of fatty acid synthase and fatty acid synthetic activity in colorectal neoplasia. Am. J. Pathol. 150:1997;201-208.
7. Swinnen J.V., Ulrix W., Heyns W., Verhoeven G. Coordinate regulation of lipogenic gene expression by androgens: evidence for a cascade mechanism involving sterol regulatory element binding proteins. Proc. Natl. Acad. Sci. USA. 94:1997;12975-12980.
8. Swinnen J.V., Heemers H., Deboel L., Foufelle F., Heyns W., Verhoeven G. Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway. Oncogene. 19:2000;5173-5181.
9. Heemers H., Maes B., Foufelle F., Heyns W., Verhoeven G., Swinnen J.V. Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the SCAP/SREBP pathway. Mol. Endocrinol. 15:2001;1817-1828.
10. ′ -kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCAP prostate cancer cells Cancer Res. 62:2002;642-646.
11. Yang Y.A., Han W.F., Morin P.J., Chrest F.J., Pizer E.S. Activation of fatty acids synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Exp. Cell Res. 279:2002;80-90.
12. Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschi T. Duplex of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 411:2001;494-498.
13. Swinnen J.V., Van Veldhoven P.P., Esquenet M., Heyns W., Verhoeven G. Androgens stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP. Endocrinology. 137:1996;4468-4474.
14. Swinnen J.V., Esquenet M., Goossens K., Heyns W., Verhoeven G. Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP. Cancer Res. 57:1997;1086-1090.
15. Van Veldhoven P., Bell R.M. Effect of harvesting methods, growth conditions and growth phase on diacylglycerol levels in cultures human adherent cells. Biochim. Biophys. Acta. 959:1988;185-196.
16. Van Veldhoven P.P. Activity measurements of acyl-CoA oxidases in human liver. J. Inherited Metab. Dis. 18(Suppl. 1):1995;125-134.
17. Simons K., Toomre D. Lipid rafts and signal transduction. Nat. Rev. Mol. Cell. Biol. 1:2000;31-39.
18. 3 -mediated lipid efflux from compositionally distinct cholesterol-based microdomains Traffic. 3:2002;268-278.
19. Rouquette-Jazdanian A.K., Pelassy C., Breittmayer J.-P., Cousin J.-L., Aussel C. Metabolic labeling of membrane microdomains/rafts in Jurkat cells indicates the presence of glycerophospholipids implicated in signal transduction by the CD3 T-cell receptor. Biochem. J. 363:2002;645-655.
20. Stevens V.L., Tang J. Fumonisisn B1-induced shingolipid depletion inhibits vitamin optake via the glycosylphosphatidylinositol-anchored folate receptor. J. Biol. Chem. 272:1997;18020-18025.
21. Bagnat M., Simons K. Cell surface polarization during yeast mating. Proc. Natl. Acad. Sci. USA. 99:2002;1483-1488.
22. Ikonen E., Simons K. Protein and lipid sorting from trans-Golgi network to the plasma membrane in polarized cells. Semin. Cell Dev. Biol. 9:1998;503-509.
23. Manes S., Mira E., Gomez-Mouton C., Lacalle R.A., Keller P., Labrador J.P., Martinez A.C. Membrane raft microdomains mediate front-rear polarity in migrating cells. EMBO J. 18:1999;6211-6220.
24. Röper K., Corbeil D., Huttner W.B. Retention of prominin in microvilli reveals distinct cholesterol-based lipid micro-domains in the apical plasma membrane. Nat. Cell Biol. 2:2000;582-592.
25. Mayor S., Maxfield F.R. Insolubility and redistribution of GPI-anchored proteins at the cell surface after detergent treatment. Mol. Biol. Cell. 6:1995;929-944.