Sending the right signal: Notch and stem cells

Biochimica et Biophysica Acta - General Subjects

Volumn 1830, Issue 2, 2013, Pages 2307-2322

  Perdigoto, Carolina N ^b,c   Bardin, Allison J ^a  

^a INSTITUT CURIE   (France)

^b INSTITUT CURIE   (France)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Differentiation; Notch signaling; Proliferation; Self renewal; Stem cell

Indexed keywords

LIGAND; NOTCH LIGAND; NOTCH RECEPTOR; NOTCH1 RECEPTOR; UNCLASSIFIED DRUG;

ADULT STEM CELL; CELL DIFFERENTIATION; CELL FATE; CELL LINEAGE; CELL PROLIFERATION; DROSOPHILA MELANOGASTER; ENDOCYTOSIS; GENETIC TRANSCRIPTION; HEMATOPOIETIC STEM CELL; HUMAN; INDUCTIVE SIGNALING; INTESTINAL STEM CELL; INTRACELLULAR SIGNALING; LUNG STEM CELL; MOLECULAR DYNAMICS; NONHUMAN; NOTCH EXTRACELLULAR DOMAIN; NOTCH INTRACELLULAR DOMAIN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; RESPIRATORY SYSTEM; REVIEW; SKELETAL MUSCLE SATELLITE CELL; SKIN STEM CELL; STEM CELL; TISSUE SPECIFICITY; TRANSMEMBRANE DOMAIN; TURNOVER TIME;

ANIMALS; HUMANS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; STEM CELLS; TRANSCRIPTION, GENETIC;

MAMMALIA;

EID: 84872502135     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2012.08.009     Document Type: Review

References (270)

1. O.L. Mohr Character changes caused by mutation of an entire region of a chromosome in Drosophila Genetics 4 1919 275 282
2. D.F. Poulson Chromosomal control of embryogenesis in Drosophila Am. Nat. 79 1945 340 363
3. R. Lehmann, F. Jiménez, U. Dietrich, and J. Campos-Ortega On the phenotype and development of mutants of early neurogenesis in Drosophila melanogaster Roux's Arch. Dev. Biol. 192 1983 62 74
4. S. Artavanis-Tsakonas, M.A. Muskavitch, and B. Yedvobnick Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster Proc. Natl. Acad. Sci. U. S. A. 80 1983 1977 1981
5. K.A. Wharton, K.M. Johansen, T. Xu, and S. Artavanis-Tsakonas Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats Cell 43 1985 567 581
6. S. Kidd, M.R. Kelley, and M.W. Young Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors Mol. Cell. Biol. 6 1986 3094 3108
7. C.C. Kopczynski, A.K. Alton, K. Fechtel, P.J. Kooh, and M.A. Muskavitch Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates Genes Dev. 2 1988 1723 1735
8. H. Vassin, K.A. Bremer, E. Knust, and J.A. Campos-Ortega The neurogenic gene Delta of Drosophila melanogaster is expressed in neurogenic territories and encodes a putative transmembrane protein with EGF-like repeats EMBO J. 6 1987 3431 3440
9. R.J. Fleming, T.N. Scottgale, R.J. Diederich, and S. Artavanis-Tsakonas The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster Genes Dev. 4 1990 2188 2201
10. P. Heitzler, and P. Simpson The choice of cell fate in the epidermis of Drosophila Cell 64 1991 1083 1092
11. S. Artavanis-Tsakonas, M.D. Rand, and R.J. Lake Notch signaling: cell fate control and signal integration in development Science 284 1999 770 776
12. F. Schweisguth Regulation of notch signaling activity Curr. Biol. 14 2004 R129 R138
13. S.J. Bray Notch signalling: a simple pathway becomes complex Nat. Rev. Mol. Cell Biol. 7 2006 678 689
14. R. Kopan, and M.X. Ilagan The canonical Notch signaling pathway: unfolding the activation mechanism Cell 137 2009 216 233
15. C.M. Blaumueller, H. Qi, P. Zagouras, and S. Artavanis-Tsakonas Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane Cell 90 1997 281 291
16. F. Logeat, C. Bessia, C. Brou, O. LeBail, S. Jarriault, N.G. Seidah, and A. Israel The Notch1 receptor is cleaved constitutively by a furin-like convertase Proc. Natl. Acad. Sci. U. S. A. 95 1998 8108 8112
17. B. D'Souza, A. Miyamoto, and G. Weinmaster The many facets of Notch ligands Oncogene 27 2008 5148 5167
18. W.R. Gordon, D. Vardar-Ulu, G. Histen, C. Sanchez-Irizarry, J.C. Aster, and S.C. Blacklow Structural basis for autoinhibition of Notch Nat. Struct. Mol. Biol. 14 2007 295 300
19. A.C. Tien, A. Rajan, and H.J. Bellen A Notch updated J. Cell Biol. 184 2009 621 629
20. C. Brou, F. Logeat, N. Gupta, C. Bessia, O. LeBail, J.R. Doedens, A. Cumano, P. Roux, R.A. Black, and A. Israel A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE Mol. Cell 5 2000 207 216
21. J. Rooke, D. Pan, T. Xu, and G.M. Rubin KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis Science 273 1996 1227 1231
22. B. De Strooper, W. Annaert, P. Cupers, P. Saftig, K. Craessaerts, J.S. Mumm, E.H. Schroeter, V. Schrijvers, M.S. Wolfe, W.J. Ray, A. Goate, and R. Kopan A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain Nature 398 1999 518 522
23. G. Struhl, and I. Greenwald Presenilin is required for activity and nuclear access of Notch in Drosophila Nature 398 1999 522 525
24. G. Struhl, and A. Adachi Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins Mol. Cell 6 2000 625 636
25. W. Song, P. Nadeau, M. Yuan, X. Yang, J. Shen, and B.A. Yankner Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations Proc. Natl. Acad. Sci. U. S. A. 96 1999 6959 6963
26. Y. Ye, N. Lukinova, and M.E. Fortini Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants Nature 398 1999 525 529
27. S. Kidd, T. Lieber, and M.W. Young Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos Genes Dev. 12 1998 3728 3740
28. G. Struhl, and A. Adachi Nuclear access and action of notch in vivo Cell 93 1998 649 660
29. M. Lecourtois, and F. Schweisguth Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos Curr. Biol. 8 1998 771 774
30. V. Morel, M. Lecourtois, O. Massiani, D. Maier, A. Preiss, and F. Schweisguth Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila Curr. Biol. 11 2001 789 792
31. S. Barolo, T. Stone, A.G. Bang, and J.W. Posakony Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to Suppressor of Hairless Genes Dev. 16 2002 1964 1976
32. F. Oswald, M. Winkler, Y. Cao, K. Astrahantseff, S. Bourteele, W. Knöchel, and T. Borggrefe RBP-JŒ ∫/SHARP recruits CtIP/CtBP corepressors to silence notch target genes Mol. Cell. Biol. 25 2005 10379 10390
33. M. Furriols, and S. Bray Dissecting the mechanisms of suppressor of hairless function Dev. Biol. 227 2000 520 532
34. M. Furriols, and S. Bray A model Notch response element detects Suppressor of Hairless-dependent molecular switch Curr. Biol. 11 2001 60 64
35. A.G. Bang, V. Hartenstein, and J.W. Posakony Hairless is required for the development of adult sensory organ precursor cells in Drosophila Development 111 1991 89 104
36. A.G. Bang, and J.W. Posakony The Drosophila gene Hairless encodes a novel basic protein that controls alternative cell fates in adult sensory organ development Genes Dev. 6 1992 1752 1769
37. H. Goodfellow, A. Krejci, Y. Moshkin, C.P. Verrijzer, F. Karch, and S.J. Bray Gene-specific targeting of the histone chaperone asf1 to mediate silencing Dev. Cell 13 2007 593 600
38. C. Brou, F. Logeat, M. Lecourtois, J. Vandekerckhove, P. Kourilsky, F. Schweisguth, and A. Israel Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless Genes Dev. 8 1994 2491 2503
39. S. Bray, and F. Bernard Notch targets and their regulation Curr. Top. Dev. Biol. 92 2010 253 275
40. S.H. Choi, T.E. Wales, Y. Nam, D.J. O'Donovan, P. Sliz, J.R. Engen, and S.C. Blacklow Conformational locking upon cooperative assembly of Notch transcription complexes Structure 20 2012 340 349
41. C.J. Fryer, J.B. White, and K.A. Jones Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover Mol. Cell 16 2004 509 520
42. R. Fior, and D. Henrique "Notch-Off": a perspective on the termination of Notch signalling Int. J. Dev. Biol. 53 2009 1379 1384
43. T. Borggrefe, and R. Liefke Fine-tuning of the intracellular canonical Notch signaling pathway Cell Cycle 11 2012 264 276
44. M.Y. Chiang, M.L. Xu, G. Histen, O. Shestova, M. Roy, Y. Nam, S.C. Blacklow, D.B. Sacks, W.S. Pear, and J.C. Aster Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1 Mol. Cell. Biol. 26 2006 6261 6271
45. A.P. Weng, A.A. Ferrando, W. Lee, J.P. Morris Iv, L.B. Silverman, C. Sanchez-Irizarry, S.C. Blacklow, A.T. Look, and J.C. Aster Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia Science 306 2004 269 271
46. R. Kageyama, T. Ohtsuka, and T. Kobayashi The Hes gene family: repressors and oscillators that orchestrate embryogenesis Development 134 2007 1243 1251
47. A.L. Fisher, S. Ohsako, and M. Caudy The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain Mol. Cell. Biol. 16 1996 2670 2677
48. Z. Paroush, R.L. Finley Jr., T. Kidd, S.M. Wainwright, P.W. Ingham, R. Brent, and D. Ish-Horowicz Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins Cell 79 1994 805 815
49. A. Krejci, and S. Bray Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers Genes Dev. 21 2007 1322 1327
50. R. Fior, and D. Henrique A novel hes5/hes6 circuitry of negative regulation controls Notch activity during neurogenesis Dev. Biol. 281 2005 318 333
51. M.T.D. Cooper, D.M. Tyler, M. Furriols, A. Chalkiadaki, C. Delidakis, and S. Bray Spatially restricted factors cooperate with Notch in the regulation of Enhancer of split genes Dev. Biol. 221 2000 390 403
52. S. Pascoal, C.R. Carvalho, J. Rodriguez-León, M.C. Delfini, D. Duprez, S. Thorsteinsdóttir, and I. Palmeirim A molecular clock operates during chick autopod proximal-distal outgrowth J. Mol. Biol. 368 2007 303 309
53. H. Shimojo, T. Ohtsuka, and R. Kageyama Oscillations in notch signaling regulate maintenance of neural progenitors Neuron 58 2008 52 64
54. A.J. Bardin, C.N. Perdigoto, T.D. Southall, A.H. Brand, and F. Schweisguth Transcriptional control of stem cell maintenance in the Drosophila intestine Development 137 2010 705 714
55. V. Morel, and F. Schweisguth Repression by suppressor of hairless and activation by Notch are required to define a single row of single-minded expressing cells in the Drosophila embryo Genes Dev. 14 2000 377 388
56. J. Kim, A. Sebring, J.J. Esch, M.E. Kraus, K. Vorwerk, J. Magee, and S.B. Carroll Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene Nature 382 1996 133 138
57. D. Amsen, A. Antov, D. Jankovic, A. Sher, F. Radtke, A. Souabni, M. Busslinger, B. McCright, T. Gridley, and R.A. Flavell Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch Immunity 27 2007 89 99
58. T.C. Fang, Y. Yashiro-Ohtani, C. Del Bianco, D.M. Knoblock, S.C. Blacklow, and W.S. Pear Notch directly regulates Gata3 expression during T helper 2 cell differentiation Immunity 27 2007 100 110
59. A. Krejci, F. Bernard, B.E. Housden, S. Collins, and S.J. Bray Direct response to Notch activation: signaling crosstalk and incoherent logic Sci. Signal. 2 2009 (ra1)
60. T. Palomero, K.L. Wei, D.T. Odom, M.L. Sulis, P.J. Real, A. Margolin, K.C. Barnes, J. O'Neil, D. Neuberg, A.P. Weng, J.C. Aster, F. Sigaux, J. Soulier, A.T. Look, R.A. Young, A. Califano, and A.A. Ferrando NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth Proc. Natl. Acad. Sci. U. S. A. 103 2006 18261 18266
61. S. Jeffries, D.J. Robbins, and A.J. Capobianco Characterization of a high-molecular-weight Notch complex in the nucleus of Notchic-transformed RKE cells and in a human T-cell leukemia cell line Mol. Cell. Biol. 22 2002 3927 3941
62. C. Ronchini, and A.J. Capobianco Induction of cyclin D1 transcription and CDK2 activity by Notchic: implication for cell cycle disruption in transformation by Notchic Mol. Cell. Biol. 21 2001 5925 5934
63. A. Rangarajan, C. Talora, R. Okuyama, M. Nicolas, C. Mammucari, H. Oh, J.C. Aster, S. Krishna, D. Metzger, P. Chambon, L. Miele, M. Aguet, F. Radtke, and G.P. Dotto Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation EMBO J. 20 2001 3427 3436
64. J. Rusch, and M. Levine Threshold responses to the dorsal regulatory gradient and the subdivision of primary tissue territories in the Drosophila embryo Curr. Opin. Genet. Dev. 6 1996 416 423
65. F. Bernard, A. Krejci, B. Housden, B. Adryan, and S.J. Bray Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors Development 137 2010 2633 2642
66. S.T. Moran, A. Cariappa, H. Liu, B. Muir, D. Sgroi, C. Boboila, and S. Pillai Synergism between NF-κB1/p50 and Notch2 during the development of marginal zone B lymphocytes J. Immunol. 179 2007 195 200
67. I. Joshi, L.M. Minter, J. Telfer, R.M. Demarest, A.J. Capobianco, J.C. Aster, P. Sicinski, A. Fauq, T.E. Golde, and B.A. Osborne Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases Blood 113 2009 1689 1698
68. E.C. Lai, G.A. Deblandre, C. Kintner, and G.M. Rubin Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta Dev. Cell 1 2001 783 794
69. E. Pavlopoulos, C. Pitsouli, K.M. Klueg, M.A.T. Muskavitch, N.K. Moschonas, and C. Delidakis Neuralized encodes a peripheral membrane protein involved in delta signaling and endocytosis Dev. Cell 1 2001 807 816
70. M. Itoh, C.H. Kim, G. Palardy, T. Oda, Y.J. Jiang, D. Maust, S.Y. Yeo, K. Lorick, G.J. Wright, L. Ariza-McNaughton, A.M. Weissman, J. Lewis, S.C. Chandrasekharappa, and A.B. Chitnis Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta Dev. Cell 4 2003 67 82
71. E.C. Lai, F. Roegiers, X. Qin, Y.N. Jan, and G.M. Rubin The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta Development 132 2005 2319 2332
72. R. Le Borgne, S. Remaud, S. Hamel, and F. Schweisguth Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila PLoS Biol. 3 2005 e96
73. C. Pitsouli, and C. Delidakis The interplay between DSL proteins and ubiquitin ligases in Notch signaling Development 132 2005 4041 4050
74. W. Wang, and G. Struhl Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila Development 132 2005 2883 2894
75. E.M. Hansson, F. Lanner, D. Das, A. Mutvei, U. Marklund, J. Ericson, F. Farnebo, G. Stumm, H. Stenmark, E.R. Andersson, and U. Lendahl Control of Notch-ligand endocytosis by ligand-receptor interaction J. Cell Sci. 123 2010 2931 2942
76. M. Yamamoto, R. Morita, T. Mizoguchi, H. Matsuo, M. Isoda, T. Ishitani, A.B. Chitnis, K. Matsumoto, J.G. Crump, K. Hozumi, S. Yonemura, K. Kawakami, and M. Itoh Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions Development 137 2010 2527 2537
77. T. Takeuchi, Y. Adachi, and Y. Ohtsuki Skeletrophin, a novel ubiquitin ligase to the intracellular region of Jagged-2, is aberrantly expressed in multiple myeloma Am. J. Pathol. 166 2005 1817 1826
78. A.L. Parks, K.M. Klueg, J.R. Stout, and M.A. Muskavitch Ligand endocytosis drives receptor dissociation and activation in the Notch pathway Development 127 2000 1373 1385
79. R. Le Borgne, and F. Schweisguth Unequal segregation of Neuralized biases Notch activation during asymmetric cell division Dev. Cell 5 2003 139 148
80. W. Wang, and G. Struhl Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch Development 131 2004 5367 5380
81. R. Le Borgne, A. Bardin, and F. Schweisguth The roles of receptor and ligand endocytosis in regulating Notch signaling Development 132 2005 1751 1762
82. G. Weinmaster, and J.A. Fischer Notch ligand ubiquitylation: what is it good for? Dev. Cell 21 2011 134 144
83. N. Benhra, F. Vignaux, A. Dussert, F. Schweisguth, and R. Le Borgne Neuralized promotes basal to apical transcytosis of Delta in epithelial cells Mol. Biol. Cell 21 2010 2078 2086
84. G. Emery, A. Hutterer, D. Berdnik, B. Mayer, F. Wirtz-Peitz, M.G. Gaitan, and J.A. Knoblich Asymmetric Rab11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system Cell 122 2005 763 773
85. H. Jafar-Nejad, H.K. Andrews, M. Acar, V. Bayat, F. Wirtz-Peitz, S.Q. Mehta, J.A. Knoblich, and H.J. Bellen Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors Dev. Cell 9 2005 351 363
86. A. Rajan, A.C. Tien, C.M. Haueter, K.L. Schulze, and H.J. Bellen The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors Nat. Cell Biol. 11 2009 815 824
87. S.F. Heuss, D. Ndiaye-Lobry, E.M. Six, A. Israël, and F. Logeat The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity Proc. Natl. Acad. Sci. U. S. A. 105 2008 11212 11217
88. B. Shergill, L. Meloty-Kapella, A.A. Musse, G. Weinmaster, and E. Botvinick Optical tweezers studies on notch: single-molecule interaction strength is independent of ligand endocytosis Dev. Cell 22 2012 1313 1320
89. L. Meloty-Kapella, B. Shergill, J. Kuon, E. Botvinick, and G. Weinmaster Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin Dev. Cell 22 2012 1299 1312
90. L. Seugnet, P. Simpson, and M. Haenlin Requirement for dynamin during Notch signaling in Drosophila neurogenesis Dev. Biol. 192 1997 585 598
91. J.T. Nichols, A. Miyamoto, S.L. Olsen, B. D'Souza, C. Yao, and G. Weinmaster DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur J. Cell Biol. 176 2007 445 458
92. C. Brou Intracellular trafficking of Notch receptors and ligands Exp. Cell Res. 315 2009 1549 1555
93. P. Chastagner, A. Israel, and C. Brou AIP4/Itch regulates Notch receptor degradation in the absence of ligand PLoS One 3 2008 e2735
94. T. Sakata, H. Sakaguchi, L. Tsuda, A. Higashitani, T. Aigaki, K. Matsuno, and S. Hayashi Drosophila Nedd4 regulates endocytosis of Notch and suppresses its ligand-independent activation Curr. Biol. 14 2004 2228 2236
95. M.B. Wilkin, A.-M. Carbery, M. Fostier, H. Aslam, S.L. Mazaleyrat, J. Higgs, A. Myat, D.A.P. Evans, M. Cornell, and M. Baron Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins Curr. Biol. 14 2004 2237 2244
96. B.M. Jehn, I. Dittert, S. Beyer, K. von der Mark, and W. Bielke c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1 J. Biol. Chem. 277 2002 8033 8040
97. L. Qiu, C. Joazeiro, N. Fang, H.Y. Wang, C. Elly, Y. Altman, D. Fang, T. Hunter, and Y.C. Liu Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase J. Biol. Chem. 275 2000 35734 35737
98. M. Fostier, D.A.P. Evans, S. Artavanis-Tsakonas, and M. Baron Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: a regulator of notch signaling Genetics 150 1998 1477 1485
99. M. Cornell, D.A.P. Evans, R. Mann, M. Fostier, M. Flasza, M. Monthatong, S. Artavanis-Tsakonas, and M. Baron The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase Genetics 152 1999 567 576
100. D. Berdnik, and J.A. Knoblich Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis Curr. Biol. 12 2002 640 647
101. M. Guo, L.Y. Jan, and Y.N. Jan Control of daughter cell fates during asymmetric division: interaction of Numb and Notch Neuron 17 1996 27 41
102. E. Santolini, C. Puri, A.E. Salcini, M.C. Gagliani, P.G. Pelicci, C. Tacchetti, and P.P. Di Fiore Numb is an endocytic protein J. Cell Biol. 151 2000 1345 1352
103. D. Berdnik, T. Torok, M. Gonzalez-Gaitan, and J.A. Knoblich The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila Dev. Cell 3 2002 221 231
104. K.M. O'Connor-Giles, and J.B. Skeath Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila Dev. Cell 5 2003 231 243
105. C.A. Dye, J.K. Lee, R.C. Atkinson, R. Brewster, P.L. Han, and H.J. Bellen The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein Development 125 1998 1845 1856
106. J.B. Skeath, and C.Q. Doe Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS Development 125 1998 1857 1865
107. L. Couturier, N. Vodovar, and F. Schweisguth Endocytosis by Numb breaks Notch symmetry at cytokinesis Nat. Cell Biol. 14 2012 131 139
108. M.A. McGill, and C.J. McGlade Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain J. Biol. Chem. 278 2003 23196 23203
109. Y. Wakamatsu, T.M. Maynard, S.U. Jones, and J.A. Weston NUMB localizes in the basal cortex of mitotic avian neuroepithelial cells and modulates neuronal differentiation by binding to NOTCH-1 Neuron 23 1999 71 81
110. A. Jory, I. Le Roux, B. Gayraud-Morel, P. Rocheteau, M. Cohen-Tannoudji, A. Cumano, and S. Tajbakhsh Numb promotes an increase in skeletal muscle progenitor cells in the embryonic somite Stem Cells 27 2009 2769 2780
111. J.T. Chang, V.R. Palanivel, I. Kinjyo, F. Schambach, A.M. Intlekofer, A. Banerjee, S.A. Longworth, K.E. Vinup, P. Mrass, J. Oliaro, N. Killeen, J.S. Orange, S.M. Russell, W. Weninger, and S.L. Reiner Asymmetric T lymphocyte division in the initiation of adaptive immune responses Science 315 2007 1687 1691
112. Q. Shen, W. Zhong, Y.N. Jan, and S. Temple Asymmetric Numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts Development 129 2002 4843 4853
113. J.A. Knoblich Mechanisms of asymmetric stem cell division Cell 132 2008 583 597
114. K. Sato, T. Watanabe, S. Wang, M. Kakeno, K. Matsuzawa, T. Matsui, K. Yokoi, K. Murase, I. Sugiyama, M. Ozawa, and K. Kaibuchi Numb controls E-cadherin endocytosis through p120 catenin with aPKC Mol. Biol. Cell 22 2011 3103 3119
115. A. Klinakis, C. Lobry, O. Abdel-Wahab, P. Oh, H. Haeno, S. Buonamici, I. van De Walle, S. Cathelin, T. Trimarchi, E. Araldi, C. Liu, S. Ibrahim, M. Beran, J. Zavadil, A. Efstratiadis, T. Taghon, F. Michor, R.L. Levine, and I. Aifantis A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia Nature 473 2011 230 233
116. M.-R. Rasin, V.-R. Gazula, J.J. Breunig, K.Y. Kwan, M.B. Johnson, S. Liu-Chen, H.-S. Li, L.Y. Jan, Y.-N. Jan, P. Rakic, and N. Sestan Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors Nat. Neurosci. 10 2007 819 827
117. D.J. Moloney, L.H. Shair, F.M. Lu, J. Xia, R. Locke, K.L. Matta, and R.S. Haltiwanger Mammalian Notch1 is modified with two unusual forms of O-linked glycosylation found on epidermal growth factor-like modules J. Biol. Chem. 275 2000 9604 9611
118. L. Shao, Y. Luo, D.J. Moloney, and R. Haltiwanger O-glycosylation of EGF repeats: identification and initial characterization of a UDP-glucose: protein O-glucosyltransferase Glycobiology 12 2002 763 770
119. A. Matsuura, M. Ito, Y. Sakaidani, T. Kondo, K. Murakami, K. Furukawa, D. Nadano, T. Matsuda, and T. Okajima O-linked N-acetylglucosamine is present on the extracellular domain of notch receptors J. Biol. Chem. 283 2008 35486 35495
120. M. Acar, H. Jafar-Nejad, H. Takeuchi, A. Rajan, D. Ibrani, N.A. Rana, H. Pan, R.S. Haltiwanger, and H.J. Bellen Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling Cell 132 2008 247 258
121. T. Sasamura, H.O. Ishikawa, N. Sasaki, S. Higashi, M. Kanai, S. Nakao, T. Ayukawa, T. Aigaki, K. Noda, E. Miyoshi, N. Taniguchi, and K. Matsuno The O-fucosyltransferase O-fut1 is an extracellular component that is essential for the constitutive endocytic trafficking of Notch in Drosophila Development 134 2007 1347 1356
122. T. Sasamura, N. Sasaki, F. Miyashita, S. Nakao, H.O. Ishikawa, M. Ito, M. Kitagawa, K. Harigaya, E. Spana, D. Bilder, N. Perrimon, and K. Matsuno neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions Development 130 2003 4785 4795
123. T. Okajima, and K.D. Irvine Regulation of notch signaling by o-linked fucose Cell 111 2002 893 904
124. T. Okajima, A. Xu, L. Lei, and K.D. Irvine Chaperone activity of protein O-fucosyltransferase 1 promotes notch receptor folding Science 307 2005 1599 1603
125. Y. Wang, L. Shao, S. Shi, R.J. Harris, M.W. Spellman, P. Stanley, and R.S. Haltiwanger Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase J. Biol. Chem. 276 2001 40338 40345
126. M. Stahl, K. Uemura, C. Ge, S. Shi, Y. Tashima, and P. Stanley Roles of Pofut1 and O-fucose in mammalian Notch signaling J. Biol. Chem. 283 2008 13638 13651
127. K. Bruckner, L. Perez, H. Clausen, and S. Cohen Glycosyltransferase activity of Fringe modulates Notch-Delta interactions Nature 406 2000 411 415
128. D.J. Moloney, V.M. Panin, S.H. Johnston, J. Chen, L. Shao, R. Wilson, Y. Wang, P. Stanley, K.D. Irvine, R.S. Haltiwanger, and T.F. Vogt Fringe is a glycosyltransferase that modifies Notch Nature 406 2000 369 375
129. H. Takeuchi, and R.S. Haltiwanger Role of glycosylation of Notch in development Semin. Cell Dev. Biol. 21 2010 638 645
130. R. Fernandez-Valdivia, H. Takeuchi, A. Samarghandi, M. Lopez, J. Leonardi, R.S. Haltiwanger, and H. Jafar-Nejad Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi Development 138 2011 1925 1934
131. H. Jafar-Nejad, J. Leonardi, and R. Fernandez-Valdivia Role of glycans and glycosyltransferases in the regulation of Notch signaling Glycobiology 20 2010 931 949
132. C.N. Perdigoto, F. Schweisguth, and A.J. Bardin Distinct levels of Notch activity for commitment and terminal differentiation of stem cells in the adult fly intestine Development 138 2011 4585 4595
133. I. Greenwald, and G. Seydoux Analysis of gain-of-function mutations of the lin-12 gene of Caenorhabditis elegans Nature 346 1990 197 199
134. D. Sprinzak, A. Lakhanpal, L. Lebon, L.A. Santat, M.E. Fontes, G.A. Anderson, J. Garcia-Ojalvo, and M.B. Elowitz Cis-interactions between Notch and Delta generate mutually exclusive signalling states Nature 465 2010 86 90
135. D. Del Alamo, H. Rouault, and F. Schweisguth Ligand-receptor inhibitory interactions in Notch signaling 2010
136. I. Greenwald LIN-12/Notch signaling in C. elegans WormBook 2005 1 16
137. P.W. Sternberg Vulval development WormBook 2005 1 28
138. J.A. Knoblich, L.Y. Jan, and Y.N. Jan Asymmetric segregation of Numb and Prospero during cell division Nature 377 1995 624 627
139. M. Ruiz Gomez, and M. Bate Segregation of myogenic lineages in Drosophila requires numb Development 124 1997 4857 4866
140. P.H. Petersen, K. Zou, J.K. Hwang, Y.N. Jan, and W. Zhong Progenitor cell maintenance requires numb and numblike during mouse neurogenesis Nature 419 2002 929 934
141. H.S. Li, D. Wang, Q. Shen, M.D. Schonemann, J.A. Gorski, K.R. Jones, S. Temple, L.Y. Jan, and Y.N. Jan Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis Neuron 40 2003 1105 1118
142. M. Cayouette, A.V. Whitmore, G. Jeffery, and M. Raff Asymmetric segregation of Numb in retinal development and the influence of the pigmented epithelium J. Neurosci. 21 2001 5643 5651
143. V. Shinin, B. Gayraud-Morel, D. Gomes, and S. Tajbakhsh Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells Nat. Cell Biol. 8 2006 677 687
144. Z. Dong, N. Yang, S.Y. Yeo, A. Chitnis, and S. Guo Intralineage directional notch signaling regulates self-renewal and differentiation of asymmetrically dividing radial glia Neuron 74 2012 65 78
145. S. Bray Notch signalling in Drosophila: three ways to use a pathway Semin. Cell Dev. Biol. 9 1998 591 597
146. N. Haines, and K.D. Irvine Glycosylation regulates Notch signalling Nat. Rev. Mol. Cell Biol. 4 2003 786 797
147. Y.J. Jiang, B.L. Aerne, L. Smithers, C. Haddon, D. Ish-Horowicz, and J. Lewis Notch signalling and the synchronization of the somite segmentation clock Nature 408 2000 475 479
148. E.M. Özbudak, and O. Pourquié The vertebrate segmentation clock: the tip of the iceberg Curr. Opin. Genet. Dev. 18 2008 317 323
149. C. Jouve, I. Palmeirim, D. Henrique, J. Beckers, A. Gossler, D. Ish-Horowicz, and O. Pourquie Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm Development 127 2000 1421 1429
150. D.L. Jones, and T.A. Rando Emerging models and paradigms for stem cell ageing Nat. Cell Biol. 13 2011 506 512
151. H. Clevers The cancer stem cell: premises, promises and challenges Nat. Med. 2011 313 319
152. D. Hanahan, and R.A. Weinberg Hallmarks of cancer: the next generation Cell 144 2011 646 674
153. C.A. Micchelli, and N. Perrimon Evidence that stem cells reside in the adult Drosophila midgut epithelium Nature 439 2006 475 479
154. B. Ohlstein, and A. Spradling The adult Drosophila posterior midgut is maintained by pluripotent stem cells Nature 439 2006 470 474
155. B. Ohlstein, and A. Spradling Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling Science 315 2007 988 992
156. M. Buszczak, S. Paterno, and A.C. Spradling Drosophila stem cells share a common requirement for the histone H2B ubiquitin protease scrawny Science 323 2009 248 251
157. H. Cheng, and C.P. Leblond Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian theory of the origin of the four epithelial cell types Am. J. Anat. 141 1974 537
158. H. Cheng, and C.P. Leblond Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. I. Columnar cell Am. J. Anat. 141 1974 461
159. N. Barker, J.H. van Es, J. Kuipers, P. Kujala, and M. Van Den Born Identification of stem cells in small intestine and colon by marker gene Lgr5 Nature 449 2007 1003
160. L.G. van der Flier, and H. Clevers Stem cells, self-renewal, and differentiation in the intestinal epithelium Annu. Rev. Physiol. 71 2009 241 260
161. E. Sangiorgi, and M.R. Capecchi Bmi1 is expressed in vivo in intestinal stem cells Nat. Genet. 40 2008 915 920
162. J. Milano, J. McKay, C. Dagenais, L. Foster-Brown, and F. Pognan Modulation of Notch processing by γ-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation Toxicol. Sci. 82 2004 341
163. O. Riccio, M.E. van Gijn, A.C. Bezdek, L. Pellegrinet, and J.H. van Es Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2 EMBO Rep. 9 2008 377
164. J.H. van Es, M.E. van Gijn, O. Riccio, M. Van Den Born, and M. Vooijs Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells Nature 435 2005 959
165. G.T. Wong, D. Manfra, F.M. Poulet, Q. Zhang, and H. Josien Chronic treatment with the γ-secretase inhibitor LY-411,575 inhibits β-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation J. Biol. Chem. 279 2004 12876
166. S. Fre, M. Huyghe, P. Mourikis, S. Robine, D. Louvard, and S. Artavanis-Tsakonas Notch signals control the fate of immature progenitor cells in the intestine Nature 435 2005 964 968
167. B.Z. Stanger, R. Datar, L.C. Murtaugh, and D.A. Melton Direct regulation of intestinal fate by Notch Proc. Natl. Acad. Sci. U. S. A. 102 2005 12443
168. S. Fre, S.K. Pallavi, M. Huyghe, M. Lae, K.P. Janssen, S. Robine, S. Artavanis-Tsakonas, and D. Louvard Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine Proc. Natl. Acad. Sci. U. S. A. 106 2009 6309 6314
169. L. Pellegrinet, V. Rodilla, Z. Liu, S. Chen, U. Koch, L. Espinosa, K.H. Kaestner, R. Kopan, J. Lewis, and F. Radtke Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells Gastroenterology 140 2011 1230 1240 (e1231-1237)
170. M. Vooijs, C.T. Ong, B. Hadland, S. Huppert, Z. Liu, J. Korving, M. van den Born, T. Stappenbeck, Y. Wu, H. Clevers, and R. Kopan Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE Development 134 2007 535 544
171. S. Fre, E. Hannezo, S. Sale, M. Huyghe, D. Lafkas, H. Kissel, A. Louvi, J. Greve, D. Louvard, and S. Artavanis-Tsakonas Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice PLoS One 6 2011 e25785
172. T. Sato, J.H. van Es, H.J. Snippert, D.E. Stange, R.G. Vries, M. van den Born, N. Barker, N.F. Shroyer, M. van de Wetering, and H. Clevers Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts Nature 469 2011 415 418
173. D. Stamataki, M. Holder, C. Hodgetts, R. Jeffery, E. Nye, B. Spencer-Dene, D.J. Winton, and J. Lewis Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system PLoS One 6 2011 e24484
174. M. Bjerknes, and H. Cheng Neurogenin 3 and the enteroendocrine cell lineage in the adult mouse small intestinal epithelium Dev. Biol. 300 2006 722 735
175. M. Bjerknes, C. Khandanpour, T. Möröy, T. Fujiyama, M. Hoshino, T.J. Klisch, Q. Ding, L. Gan, J. Wang, M.n.G. Martín, and H. Cheng Origin of the brush cell lineage in the mouse intestinal epithelium Dev. Biol. 362 2012 194 218
176. J. Jensen, E.E. Pedersen, P. Galante, J. Hald, and R.S. Heller Control of endodermal endocrine development by Hes-1 Nat. Genet. 24 2000 36
177. Y. Wu, C. Cain-Hom, L. Choy, T.J. Hagenbeek, G.P. de Leon, Y. Chen, D. Finkle, R. Venook, X. Wu, J. Ridgway, D. Schahin-Reed, G.J. Dow, A. Shelton, S. Stawicki, R.J. Watts, J. Zhang, R. Choy, P. Howard, L. Kadyk, M. Yan, J. Zha, C.A. Callahan, S.G. Hymowitz, and C.W. Siebel Therapeutic antibody targeting of individual Notch receptors Nature 464 2010 1052 1057
178. V.n. Rodilla, A. Villanueva, A. Obrador-Hevia, Ä. Robert-Moreno, V. Fern√ ndez-Majada, A. Grilli, N. L√≥pez-Bigas, N.s. Bellora, M.M. Alb√†, F. Torres, M. Du√±ach, X. Sanjuan, S. Gonzalez, T. Gridley, G. Capella, A. Bigas, and L.s. Espinosa Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer Proc. Natl. Acad. Sci. 106 2009 6315 6320
179. C. Blanpain, and E. Fuchs Epidermal homeostasis: a balancing act of stem cells in the skin Nat. Rev. Mol. Cell Biol. 10 2009 207 217
180. B.C. Powell, E.A. Passmore, A. Nesci, and S.M. Dunn The Notch signalling pathway in hair growth Mech. Dev. 78 1998 189 192
181. S.E. Williams, S. Beronja, H.A. Pasolli, and E. Fuchs Asymmetric cell divisions promote Notch-dependent epidermal differentiation Nature 470 2011 353 358
182. C. Blanpain, W.E. Lowry, H.A. Pasolli, and E. Fuchs Canonical notch signaling functions as a commitment switch in the epidermal lineage Genes Dev. 20 2006 3022 3035
183. S. Demehri, M. Morimoto, M.J. Holtzman, and R. Kopan Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma PLoS Biol. 7 2009 e1000067
184. S. Demehri, Z. Liu, J. Lee, M.H. Lin, S.D. Crosby, C.J. Roberts, P.W. Grigsby, J.H. Miner, A.G. Farr, and R. Kopan Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity PLoS Biol. 6 2008 e123
185. A. Dumortier, A.D. Durham, M. Di Piazza, S. Vauclair, U. Koch, G. Ferrand, I. Ferrero, S. Demehri, L.L. Song, A.G. Farr, W.J. Leonard, R. Kopan, L. Miele, D. Hohl, D. Finke, and F. Radtke Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin PLoS One 5 2010 e9258
186. K. Lefort, A. Mandinova, P. Ostano, V. Kolev, V. Calpini, I. Kolfschoten, V. Devgan, J. Lieb, W. Raffoul, D. Hohl, V. Neel, J. Garlick, G. Chiorino, and G.P. Dotto Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases Genes Dev. 21 2007 562 577
187. N.J. Wang, Z. Sanborn, K.L. Arnett, L.J. Bayston, W. Liao, C.M. Proby, I.M. Leigh, E.A. Collisson, P.B. Gordon, L. Jakkula, S. Pennypacker, Y. Zou, M. Sharma, J.P. North, S.S. Vemula, T.M. Mauro, I.M. Neuhaus, P.E. Leboit, J.S. Hur, K. Park, N. Huh, P.Y. Kwok, S.T. Arron, P.P. Massion, A.E. Bale, D. Haussler, J.E. Cleaver, J.W. Gray, P.T. Spellman, A.P. South, J.C. Aster, S.C. Blacklow, and R.J. Cho Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma Proc. Natl. Acad. Sci. U. S. A. 108 2011 17761 17766
188. I. Rebay, R.J. Fleming, R.G. Fehon, L. Cherbas, P. Cherbas, and S. Artavanis-Tsakonas Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor Cell 67 1991 687 699
189. J. Cordle, C. Redfield, M. Stacey, P.A. Van Der Merwe, A.C. Willis, B.R. Champion, S. Hambleton, and P.A. Handford Localization of the delta-like-1-binding site in human Notch-1 and its modulation by calcium affinity J. Biol. Chem. 283 2008 11785 11793
190. S. Hambleton, N.V. Valeyev, A. Muranyi, V. Knott, J.M. Werner, A.J. McMichael, P.A. Handford, and A.K. Downing Structural and functional properties of the human notch-1 ligand binding region Structure 12 2004 2173 2183
191. P.A. Handford, M. Mayhew, M. Baron, P.R. Winship, I.D. Campbell, and G.G. Brownlee Key residues involved in calcium-binding motifs in EGF-like domains Nature 351 1991 164 167
192. E.E. Morrisey, and B.L. Hogan Preparing for the first breath: genetic and cellular mechanisms in lung development Dev. Cell 18 2010 8 23
193. E.L. Rawlins, T. Okubo, Y. Xue, D.M. Brass, R.L. Auten, H. Hasegawa, F. Wang, and B.L.M. Hogan The role of Scgb1a1 + Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium Cell Stem Cell 4 2009 525 534
194. T.-L. Hackett, F. Shaheen, A. Johnson, S. Wadsworth, D.V. Pechkovsky, D.B. Jacoby, A. Kicic, S.M. Stick, and D.A. Knight Characterization of side population cells from human airway epithelium Stem Cells 26 2008 2576 2585
195. K.U. Hong, S.D. Reynolds, S. Watkins, E. Fuchs, and B.R. Stripp In vivo differentiation potential of tracheal basal cells: evidence for multipotent and unipotent subpopulations Am. J. Physiol. Lung Cell. Mol. Physiol. 286 2004 L643 L649
196. J.R. Rock, M.W. Onaitis, E.L. Rawlins, Y. Lu, C.P. Clark, Y. Xue, S.H. Randell, and B.L.M. Hogan Basal cells as stem cells of the mouse trachea and human airway epithelium Proc. Natl. Acad. Sci. 106 2009 12771 12775
197. J.R. Rock, X. Gao, Y. Xue, S.H. Randell, Y.-Y. Kong, and B.L.M. Hogan Notch-dependent differentiation of adult airway basal stem cells Cell Stem Cell 8 2011 639 648
198. J.E. Boers, A.W. Ambergen, and F.B.J.M. Thunnissen Number and proliferation of basal and parabasal cells in normal human airway epithelium Am. J. Respir. Crit. Care Med. 157 1998 2000 2006
199. M. Nakajima, O. Kawanami, E. Jin, M. Ghazizadeh, M. Honda, G. Asano, K. Horiba, and V.J. Ferrans Immunohistochemical and ultrastructural studies of basal cells, Clara cells and bronchiolar cuboidal cells in normal human airways Pathol. Int. 48 1998 944 953
200. S.H. Randell Airway epithelial stem cells and the pathophysiology of chronic obstructive pulmonary disease Proc. Am. Thorac. Soc. 3 2006 718 725
201. J.R. Rock, S.H. Randell, and B.L.M. Hogan Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling DMM Dis. Models Mech. 3 2010 545 556
202. J.A. Voynow, B.M. Fischer, B.C. Roberts, and A.D. Proia Basal-like cells constitute the proliferating cell population in cystic fibrosis airways Am. J. Respir. Crit. Care Med. 172 2005 1013 1018
203. A.E. Tilley, B.-G. Harvey, A. Heguy, N.R. Hackett, R. Wang, T.P. O'Connor, and R.G. Crystal Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease Am. J. Respir. Crit. Care Med. 179 2009 457 466
204. A.R. Sandy, and I. Maillard Notch signaling in the hematopoietic system Expert Opin. Biol. Ther. 9 2009 1383 1398
205. F. Radtke, N. Fasnacht, and H.R. Macdonald Notch signaling in the immune system Immunity 32 2010 14 27
206. I. Godin, and A. Cumano The hare and the tortoise: an embryonic haematopoietic race Nat. Rev. Immunol. 2 2002 593 604
207. A.R. Sandy, M. Jones, and I. Maillard Notch signaling and development of the hematopoietic system Adv. Exp. Med. Biol. 727 2012 71 88
208. M.J. Yoon, B.K. Koo, R. Song, H.W. Jeong, J. Shin, Y.W. Kim, Y.Y. Kong, and P.G. Suh Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches Mol. Cell. Biol. 28 2008 4794 4804
209. K. Kumano Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells Immunity 18 2003 699 711
210. Ä. Robert-Moreno, J. Guiu, C. Ruiz-Herguido, M.E. López, J. Inglés-Esteve, L. Riera, A. Tipping, T. Enver, E. Dzierzak, T. Gridley, L. Espinosa, and A. Bigas Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1 EMBO J. 27 2008 1886 1895
211. B.K. Hadland A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development Blood 104 2004 3097 3105
212. C.E. Burns, D. Traver, E. Mayhall, J.L. Shepard, and L.I. Zon Hematopoietic stem cell fate is established by the Notch-Runx pathway Genes Dev. 19 2005 2331 2342
213. M. Nakagawa AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis Blood 108 2006 3329 3334
214. A. Robert-Moreno, L. Espinosa, J.L. de la Pompa, and A. Bigas RBPj[kappa]-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells Development 132 2005 1117 1126
215. M.H. Dallas, B. Varnum-Finney, C. Delaney, K. Kato, and I.D. Bernstein Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells J. Exp. Med. 201 2005 1361 1366
216. B. Varnum-Finney, C. Brashem-Stein, and I.D. Bernstein Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability Blood 101 2003 1784 1789
217. E. Lauret, C. Catelain, M. Titeux, S. Poirault, J.S. Dando, M. Dorsch, J.L. Villeval, A. Groseil, W. Vainchenker, F. Sainteny, and A. Bennaceur-Griscelli Membrane-bound Delta-4 Notch ligand reduces the proliferative activity of primitive human hematopoietic CD34+CD38low cells while maintaining their LTC-IC potential Leukemia 18 2004 788 797
218. B. Varnum-Finney, L.E. Purton, M. Yu, C. Brashem-Stein, D. Flowers, S. Staats, K.A. Moore, I. Le Roux, R. Mann, G. Gray, S. Artavanis-Tsakonas, and I.D. Bernstein The notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells Blood 91 1998 4084 4091
219. F.N. Karanu, B. Murdoch, L. Gallacher, D.M. Wu, M. Koremoto, S. Sakano, and M. Bhatia The Notch ligand Jagged-1 represents a novel growth factor of human hematopoietic stem cells J. Exp. Med. 192 2000 1365 1372
220. F.N. Karanu, L. Yuefei, L. Gallacher, S. Sakano, and M. Bhatia Differential response of primitive human CD34 - and CD34 + hematopoietic cells to the Notch ligand Jagged-1 Leukemia 17 2003 1366 1374
221. F.N. Karanu, B. Murdoch, T. Miyabayashi, M. Ohno, M. Koremoto, L. Gallacher, D. Wu, A. Itoh, S. Sakano, and M. Bhatia Human homologues of Delta-1 and Delta-4 function as mitogenic regulators of primitive human hematopoietic cells Blood 97 2001 1960 1967
222. W. Han, Q. Ye, and M.A.S. Moore A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells Blood 95 2000 1616 1625
223. V. Vas, L. Szilágyi, K. Pálóczi, and F. Uher Soluble Jagged-1 is able to inhibit the function of its multivalent form to induce hematopoietic stem cell self-renewal in a surrogate in vitro assay J. Leukoc. Biol. 75 2004 714 720
224. C. Delaney, B. Varnum-Finney, K. Aoyama, C. Brashem-Stein, and I.D. Bernstein Dose-dependent effects of the Notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells Blood 106 2005 2693 2699
225. C. Delaney, C. Brashem-Stein, and H. Voorhies Notch-mediated expansion of human cord blood progenitor cells results in rapid myeloid reconstitution in vivo following myeloablative cord blood transplantation Blood 112 2008 85 86
226. M.H. Dallas, B. Varnum-Finney, P.J. Martin, and I.D. Bernstein Enhanced T-cell reconstitution by hematopoietic progenitors expanded ex vivo using the Notch ligand Delta Blood 109 2007 3579 3587
227. K. Ohishi, B. Varnum-Finney, and I.D. Bernstein Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38 - cord blood cells J. Clin. Invest. 110 2002 1165 1174
228. L.A. Milner, A. Bigas, R. Kopan, C. Brashem-Stein, I.D. Bernstein, and D.I. Martin Inhibition of granulocytic differentiation by mNotch1 Proc. Natl. Acad. Sci. U. S. A. 93 1996 13014 13019
229. S. Tsai, J. Fero, and S. Bartelmez Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact Blood 96 2000 950 957
230. L.M. Calvi Osteoblastic cells regulate the haematopoietic stem cell niche Nature 425 2003 841 846
231. B. Varnum-Finney, L. Xu, C. Brashem-Stein, C. Nourigat, D. Flowers, S. Bakkour, W.S. Pear, and I.D. Bernstein Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling Nat. Med. 6 2000 1278 1281
232. A. Kunisato, S. Chiba, E. Nakagami-Yamaguchi, K. Kumano, T. Saito, S. Masuda, T. Yamaguchi, M. Osawa, R. Kageyama, H. Nakauchi, M. Nishikawa, and H. Hirai HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo Blood 101 2003 1777 1783
233. L. Walker, M. Lynch, S. Silverman, J. Fraser, J. Boulter, G. Weinmaster, and J.C. Gasson The notch/jagged pathway inhibits proliferation of human hematopoietic progenitors in vitro Stem Cells 17 1999 162 171
234. J.S. Dando, M. Tavian, C. Catelain, S. Poirault, A. Bennaceur-Griscelli, F. Sainteny, W. Vainchenker, B. Péault, and E. Lauret Notch/Delta4 interaction in human embryonic liver CD34+CD38 - cells: positive influence on BFU-E production and LTC-IC potential maintenance Stem Cells 23 2005 550 560
235. N. Carlesso, J.C. Aster, J. Sklar, and D.T. Scadden Notch1-induced delay of human hematopoietic progenitor cell differentiation is associated with altered cell cycle kinetics Blood 93 1999 838 848
236. I.D. Bernstein, R.L. Boyd, and M.R.M. van den Brink Clinical strategies to enhance posttransplant immune reconstitution Biol. Blood Marrow Transplant. 14 2008 94 99
237. I. Maillard, U. Koch, A. Dumortier, O. Shestova, L. Xu, H. Sai, S.E. Pross, J.C. Aster, A. Bhandoola, F. Radtke, and W.S. Pear Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells Cell Stem Cell 2 2008 356 366
238. H. Han, K. Tanigaki, N. Yamamoto, K. Kuroda, M. Yoshimoto, T. Nakahata, K. Ikuta, and T. Honjo Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision Int. Immunol. 14 2002 637 645
239. K. Tanigaki, H. Han, N. Yamamoto, K. Tashiro, M. Ikegawa, K. Kuroda, A. Suzuki, T. Nakano, and T. Honjo Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells Nat. Immunol. 3 2002 443 450
240. F. Radtke Deficient T cell fate specification in mice with an induced inactivation of Notch1 Immunity 10 1999 547 558
241. S.J.C. Mancini, N. Mantei, A. Dumortier, U. Suter, H.R. MacDonald, and F. Radtke Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation Blood 105 2005 2340 2342
242. B. Varnum-Finney, L.M. Halasz, M. Sun, T. Gridley, F. Radtke, and I.D. Bernstein Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells J. Clin. Invest. 121 2011 1207 1216
243. I. Maillard, T. Fang, and W.S. Pear Regulation of lymphoid development, differentiation, and function by the Notch pathway Annu. Rev. Immunol. 23 2005 945 974
244. F. Radtke, A. Wilson, S.J.C. Mancini, and H.R. MacDonald Notch regulation of lymphocyte development and function Nat. Immunol. 5 2004 247 253
245. I. Visan, J.S. Yuan, J.B. Tan, K. Cretegny, and C.J. Guidos Regulation of intrathymic T-cell development by Lunatic Fringe-Notch1 interactions Immunol. Rev. 209 2006 76 94
246. J.C. Pui, D. Allman, L. Xu, S. DeRocco, F.G. Karnell, S. Bakkour, J.Y. Lee, T. Kadesch, R.R. Hardy, J.C. Aster, and W.S. Pear Notch1 expression in early lymphopoiesis influences B versus T lineage determination Immunity 11 1999 299 308
247. J.J. Bell, and A. Bhandoola The earliest thymic progenitors for T cells possess myeloid lineage potential Nature 452 2008 764 767
248. T.B. Feyerabend, G. Terszowski, A. Tietz, C. Blum, H. Luche, A. Gossler, N.W. Gale, F. Radtke, H.J. Fehling, and H.R. Rodewald Deletion of Notch1 converts Pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms Immunity 30 2009 67 79
249. H. Wada, K. Masuda, R. Satoh, K. Kakugawa, T. Ikawa, Y. Katsura, and H. Kawamoto Adult T-cell progenitors retain myeloid potential Nature 452 2008 768 772
250. M. De Smedt, I. Hoebeke, K. Reynvoet, G. Leclercq, and J. Plum Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment Blood 106 2005 3498 3506
251. U. Koch, E. Fiorini, R. Benedito, V. Besseyrias, K. Schuster-Gossler, M. Pierres, N.R. Manley, A. Duarte, H.R. MacDonald, and F. Radtke Delta-like 4 is the essential, nonredundant ligand for Notchl during thymic T cell lineage commitment J. Exp. Med. 205 2008 2515 2523
252. T. Maeda, T. Merghoyb, R.M. Hobbs, L. Dong, M. Maeda, J. Zakrzewski, M.R.M. Van Den Brink, A. Zelent, H. Shigematsu, K. Akashi, J. Teruya-Feldstein, G. Cattoretti, and P.P. Pandolfi Immunology: regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF Science 316 2007 860 866
253. T. Mercher, M.G. Cornejo, C. Sears, T. Kindler, S.A. Moore, I. Maillard, W.S. Pear, J.C. Aster, and D.G. Gilliland Notch signaling specifies megakaryocyte development from hematopoietic stem cells Cell Stem Cell 3 2008 314 326
254. S. Bai, R. Kopan, W. Zou, M.J. Hilton, C.T. Ong, F. Long, F. Patrick Ross, and S.L. Teitelbaum NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells J. Biol. Chem. 283 2008 6509 6518
255. M.J. Hilton, X. Tu, X. Wu, S. Bai, H. Zhao, T. Kobayashi, H.M. Kronenberg, S.L. Teitelbaum, F.P. Ross, R. Kopan, and F. Long Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation Nat. Med. 14 2008 306 314
256. L.W. Ellisen, J. Bird, D.C. West, A.L. Soreng, T.C. Reynolds, S.D. Smith, and J. Sklar TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms Cell 66 1991 649 661
257. W.R. Gordon, K.L. Arnett, and S.C. Blacklow The molecular logic of Notch signaling - a structural and biochemical perspective J. Cell Sci. 121 2008 3109 3119
258. W.R. Gordon, M. Roy, D. Vardar-Ulu, M. Garfinkel, M.R. Mansour, J.C. Aster, and S.C. Blacklow Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL Blood 113 2009 4381 4390
259. N. Gupta-Rossi, O. Le Bail, H. Gonen, C. Brou, F. Logeat, E. Six, A. Ciechanover, and A. Israël Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor J. Biol. Chem. 276 2001 34371 34378
260. X.S. Puente, M. Pinyol, V. Quesada, L. Conde, G.R. Ordóñez, N. Villamor, G. Escaramis, P. Jares, S. Beà, M. González- Díaz, L. Bassaganyas, T. Baumann, M. Juan, M. López-Guerra, D. Colomer, J.M.C. Tubío, C. López, A. Navarro, C. Tornador, M. Aymerich, M. Rozman, J.M. Hernández, D.A. Puente, J.M.P. Freije, G. Velasco, A. Gutiérrez-Fernández, D. Costa, A. Carrio, S. Guijarro, A. Enjuanes, L. Hernndez, J. Yage, P. Nicols, C.M. Romeo-Casabona, H. Himmelbauer, E. Castillo, J.C. Dohm, S. De Sanjos, M.A. Piris, E. De Alava, J.S. Miguel, R. Royo, J.L. Gelpi, D. Torrents, M. Orozco, D.G. Pisano, A. Valencia, R. Guigi, M. Bayes, S. Heath, M. Gut, P. Klatt, J. Marshall, K. Raine, L.A. Stebbings, P.A. Futreal, M.R. Stratton, P.J. Campbell, I. Gut, A. Lopez-Guillermo, X. Estivill, E. Montserrat, C. López-Otín, and E. Campo Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia Nature 475 2011 101 105
261. G. Fabbri, S. Rasi, D. Rossi, V. Trifonov, H. Khiabanian, J. Ma, A. Grunn, M. Fangazio, D. Capello, S. Monti, S. Cresta, E. Gargiulo, F. Forconi, A. Guarini, L. Arcaini, M. Paulli, L. Laurenti, L.M. Larocca, R. Marasca, V. Gattei, D. Oscier, F. Bertoni, C.G. Mullighan, R. Foá, L. Pasqualucci, R. Rabadan, R. Dalla-Favera, and G. Gaidano Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation J. Exp. Med. 208 2011 1389 1401
262. R. Kridel, B. Meissner, S. Rogic, M. Boyle, A. Telenius, B. Woolcock, J. Gunawardana, C. Jenkins, C. Cochrane, S. Ben-Neriah, K. Tan, R.D. Morin, S. Opat, L.H. Sehn, J.M. Connors, M.A. Marra, A.P. Weng, C. Steidl, and R.D. Gascoyne Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma Blood 119 2012 1963 1971
263. T. Mercher, G.D. Raffel, S.A. Moore, M.G. Cornejo, D. Baudry-Bluteau, N. Cagnard, J.L. Jesneck, Y. Pikman, D. Cullen, I.R. Williams, K. Akashi, H. Shigematsu, J.P. Bourquin, M. Giovannini, W. Vainchenker, R.L. Levine, B.H. Lee, O.A. Bernard, and D.G. Gilliland The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model J. Clin. Invest. 119 2009 852 864
264. S. Kuang, K. Kuroda, F. Le Grand, and M.A. Rudnicki Asymmetric self-renewal and commitment of satellite stem cells in muscle Cell 129 2007 999 1010
265. P.S. Zammit, F. Relaix, Y. Nagata, A.P. Ruiz, C.A. Collins, T.A. Partridge, and J.R. Beauchamp Pax7 and myogenic progression in skeletal muscle satellite cells J. Cell Sci. 119 2006 1824 1832
266. S. Tajbakhsh Skeletal muscle stem cells in developmental versus regenerative myogenesis J. Intern. Med. 266 2009 372 389
267. P. Mourikis, R. Sambasivan, D. Castel, P. Rocheteau, V. Bizzarro, and S. Tajbakhsh A critical requirement for notch signaling in maintenance of the quiescent skeletal muscle stem cell state Stem Cells 30 2012 243 252
268. C.R. Bjornson, T.H. Cheung, L. Liu, P.V. Tripathi, K.M. Steeper, and T.A. Rando Notch signaling is necessary to maintain quiescence in adult muscle stem cells Stem Cells 30 2012 232 242
269. I.M. Conboy, and T.A. Rando The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis Dev. Cell 3 2002 397 409
270. S. Fukada, A. Uezumi, M. Ikemoto, S. Masuda, M. Segawa, N. Tanimura, H. Yamamoto, Y. Miyagoe-Suzuki, and S. Takeda Molecular signature of quiescent satellite cells in adult skeletal muscle Stem Cells 25 2007 2448 2459