Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila

Development

Volumn 132, Issue 12, 2005, Pages 2883-2894

  Wang, Weidong ^a   Struhl, Gary ^a  

^a Columbia University College of Physicians and Surgeons ^*  (United States)

Author keywords

Delta; Drosophila; DSL Notch signaling; Endocytosis; Epsin liquid facets; Mindbomb; Neuralized; Serrate; Ubiquitination

Indexed keywords

EPSIN; JAGGED1; LIGAND; MEMBRANE PROTEIN; MIND BOMB PROTEIN; NEURALIZED PROTEIN; NOTCH RECEPTOR; PROTEIN LAG2; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DROSOPHILA; ENDOCYTOSIS; GENE MUTATION; GENOTYPE; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; UBIQUITINATION;

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; CALCIUM-BINDING PROTEINS; CELL COMMUNICATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENDOCYTOSIS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MEMBRANE PROTEINS; MUTATION; RECEPTORS, NOTCH; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; VESICULAR TRANSPORT PROTEINS; WING;

ANIMALIA; DANIO RERIO;

EID: 21644462494     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.01860     Document Type: Article

References (49)

1. Artavanis-Tsakonas, S., Rand, M. D. and Lake, R. J. (1999). Notch signaling: cell fate control and signal integration in development. Science 284, 770-776.
2. Blair, S. S. (2000). Notch signaling: Fringe really is a glycosyltransferase. Curr. Biol. 10, R608-R612.
3. Boulianne, G. L., de la Concha, A., Campos-Ortega, J. A., Jan, L. Y. and Jan, Y. N. (1991). The Drosophila neurogenic gene neuralized encodes a novel protein and is expressed in precursors of larval and adult neurons. EMBO J. 10, 2975-2983.
4. Brand, A. H. and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.
5. Cadavid, A. L., Ginzel, A. and Fischer, J. A. (2000). The function of the Drosophila fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis. Development 127, 1727-1736.
6. Calleja, M., Moreno, E., Pelaz, S. and Morata, G. (1996). Visualization of gene expression in living adult Drosophila. Science 274, 252-255.
7. Chen, H. and De Camilli, P. (2005). From the Cover: The association of epsin with ubiquitinated cargo along the endocytic pathway is negatively regulated by its interaction with clathrin. Proc. Natl. Acad. Sci. USA 102, 2766-2771.
8. Chen, H., Fre, S., Slepnev, V. I., Capua, M. R., Takei, K., Butler, M. H., Di Fiore, P. P. and De Camilli, P. (1998). Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. Nature 394, 793-797.
9. Chen, W. and Casey Corliss, D. (2004). Three modules of zebrafish Mind bomb work cooperatively to promote Delta ubiquitination and endocytosis. Dev. Biol. 267, 361-373.
10. Corbin, V., Michelson, A. M., Abmayr, S. M., Neel, V., Alcamo, E., Maniatis, T. and Young, M. W. (1991). A role for the Drosophila neurogenic genes in mesoderm differentiation. Cell 67, 311-323.
11. De Celis, J. F. (2003). Pattern formation in the Drosophila wing: the development of the veins. Bioessays 25, 443-451.
12. Deblandre, G. A., Lai, E. C. and Kintner, C. (2001). Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling. Dev. Cell 1, 795-806.
13. Fleming, R. J., Gu, Y. and Hukriede, N. A. (1997). Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc. Development 124, 2973-2981.
14. Greenwald, I. (1998). LIN-12/Notch signaling: lessons from worms and flies. Genes Dev. 12, 1751-1762.
15. Hartenstein, A. Y., Rugendorff, A., Tepass, U. and Hartenstein, V. (1992). The function of the neurogenic genes during epithelial development in the Drosophila embryo. Development 116, 1203-1220.
16. Hofmann, K. and Falquet, L. (2001). A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems. Trends Biochem. Sci. 26, 347-350.
17. Itoh, M., Kim, C. H., Palardy, G., Oda, T., Jiang, Y. J., Maust, D., Yeo, S. Y., Lorick, K., Wright, G. J., Ariza-McNaughton, L. et al. (2003). Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev. Cell 4, 67-82.
18. Jiang, J. and Struhl, G. (1995). Protein kinase A and hedgehog signaling in Drosophila limb development. Cell 80, 563-572.
19. Jiang, Y. J., Brand, M., Heisenberg, C. P., Beuchle, D., Furutani-Seiki, M., Kelsh, R. N., Warga, R. M., Granato, M., Haffter, P., Hammerschmidt, M. et al. (1996). Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. Development 123, 205-216.
20. Lai, E. C. and Rubin, G. M. (2001). Drosophila neuralized functions cell-autonomously to regulate a subset of notch-dependent processes during adult development. Dev. Biol. 231, 217-233.
21. Lai, E. C., Deblandre, G. A., Kintner, C. and Rubin, G. M. (2001). Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta. Dev. Cell 1, 783-794.
22. Lai, E. C., Roegiers, F., Qin, X., Jan, Y.-N. and Rubin, G. M. (2005). The ubiqitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. Development 132, 2319-2332.
23. Le Borgne, R. and Schweisguth, F. (2003a). Notch signaling: endocytosis makes delta signal better. Curr. Biol. 13, R273-R275.
24. Le Borgne, R. and Schweisguth, F. (2003b). Unequal segregation of Neuralized biases Notch activation during asymmetric cell division. Dev. Cell. 5, 139-148.
25. Le Borgne, R., Remaud, S., Hamel, S. and Schweisguth, F. (2005). Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila. PLoS Biol. 3, e96.
26. Lee, T. and Luo, L. (1999). Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron 22, 451-461.
27. Lee, Y. S. and Carthew, R. W. (2003). Making a better RNAi vector for Drosophila: use of intron spacers. Methods 30, 322-329.
28. Lehmann, R., Jimenez, F., Dietrich, U. and Campos-Ortega, J. (1983). On the phenotype and development of mutants of early neurogenesis in Drosophila melanogaster. Roux's Arch. Dev. Biol. 192, 62-74.
29. Lloyd, T. E., Atkinson, R., Wu, M. N., Zhou, Y., Pennetta, G. and Bellen, H. J. (2002). Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila. Cell 108, 261-269.
30. Martin-Bermudo, M. D., Carmena, A. and Jimenez, F. (1995). Neurogenic genes control gene expression at the transcriptional level in early neurogenesis and in mesectoderm specification. Development 121, 219-224.
31. Mumm, J. S. and Kopan, R. (2000). Notch signaling: from the outside in. Dev. Biol. 228, 151-165.
32. Overstreet, E., Fitch, E. and Fischer, J. A. (2004). Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells. Development 131, 5355-5366.
33. Panin, V. M., Papayannopoulos, V., Wilson, R. and Irvine, K. D. (1997). Fringe modulates Notch-ligand interactions. Nature 387, 908-912.
34. Parks, A. L., Klueg, K. M., Stout, J. R. and Muskavitch, M. A. (2000). Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. Development 127, 1373-1385.
35. Pavlopoulos, E., Pitsouli, C., Klueg, K. M., Muskavitch, M. A., Moschonas, N. K. and Delidakis, C. (2001). Neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis. Dev. Cell. 1, 807-816.
36. Rebay, I., Fehon, R. G. and Artavanis-Tsakonas, S. (1993). Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell 74, 319-329.
37. Schier, A. F., Neuhauss, S. C., Harvey, M., Malicki, J., Solnica-Krezel, L., Stainier, D. Y., Zwartkruis, F., Abdelilah, S., Stemple, D. L., Rangini, Z. et al. (1996). Mutations affecting the development of the embryonic zebrafish brain. Development 123, 165-178.
38. Schweisguth, F. (2004). Notch signaling activity. Curr. Biol. 14, R129-R138.
39. Sigismund, S., Woelk, T., Puri, C., Maspero, E., Tacchetti, C., Transidico, P., Di Fiore, P. P. and Polo, S. (2005). From the Cover: Clathrin-independent endocytosis of ubiquitinated cargos. Proc. Natl. Acad. Sci. USA 102, 2760-2765.
40. Simpson, P. (1997). Notch signalling in development: on equivalence groups and asymmetric developmental potential. Curr. Opin. Genet. Dev. 7, 537-542.
41. Struhl, G. and Adachi, A. (1998). Nuclear access and action of notch in vivo. Cell 93, 649-660.
42. Struhl, G. and Greenwald, I. (1999). Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398, 522-525.
43. Struhl, G. and Adachi, A. (2000). Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins. Mol. Cell. 6, 625-636.
44. Struhl, G. and Greenwald, I. (2001). Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila. Proc. Natl. Acad. Sci. USA 98, 229-234.
45. Tian, X., Hansen, D., Schedl, T. and Skeath, J. B. (2004). Epsin potentiates Notch pathway activity in Drosophila and C. elegans. Development 131, 5807-5815.
46. Wang, W. and Struhl, G. (2004). Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch. Development 131, 5367-5380.
47. Wendland, B. (2002). Epsins: adaptors in endocytosis? Nat. Rev. Mol. Cell. Biol. 3, 971-977.
48. Yeh, E., Zhou, L., Rudzik, N. and Boulianne, G. L. (2000). Neuralized functions cell autonomously to regulate Drosophila sense organ development. EMBO J. 19, 4827-4837.
49. Yeh, E., Dermer, M., Commisso, C., Zhou, L., McGlade, C. J. and Boulianne, G. L. (2001). Neuralized functions as an E3 ubiquitin ligase during Drosophila development. Curr. Biol. 11, 1675-1679.