Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells

Journal of Clinical Investigation

Volumn 121, Issue 3, 2011, Pages 1207-1216

  Varnum Finney, Barbara ^a   Halasz, Lia M ^a,d   Sun, Mingyi ^a,e   Gridley, Thomas ^b   Radtke, Freddy ^c   Bernstein, Irwin D ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

^b JACKSON LABORATORY   (United States)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

^d HARVARD RADIATION ONCOLOGY PROGRAM   (United States)

^e SIBS Novo Nordisk Translational Research Centre for PreDiabetes   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; JAGGED1; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; STEM CELL FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL POPULATION; CELL RENEWAL; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; IRRADIATION; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROGENY;

ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; LIGANDS; MICE; MICE, TRANSGENIC; MICROSCOPY, FLUORESCENCE; RECEPTOR, NOTCH1; RECEPTOR, NOTCH2; REGENERATION; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 79952217210     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI43868     Document Type: Article

References (38)

1. Wilson A, Laurenti E, Trumpp A. Balancing dormant and self-renewing hematopoietic stem cells. Curr Opin Genet Dev. 2009;19(5):461-468.
2. Li L, Clevers H. Coexistence of quiescent and active adult stem cells in mammals. Science. 2010;327(5965):542-545.
3. Chiba S. Notch signaling in stem cell systems. Stem Cells. 2006;24(11):2437-2447. (Pubitemid 44674304)
4. Mercher T, et al. Notch signaling specifies megakaryocyte development from hematopoietic stem cells. Cell Stem Cell. 2008;3(3):314-326.
5. Pui JC, et al. Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity. 1999;11(3):299-308. (Pubitemid 29463238)
6. Radtke F, et al. Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity. 1999;10(5):547-558. (Pubitemid 29262657)
7. Witt CM, Hurez V, Swindle CS, Hamada Y, Klug CA. Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1 B cells. Mol Cell Biol. 2003;23(23):8637-8650. (Pubitemid 37433368)
8. Witt CM, Won WJ, Hurez V, Klug CA. Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells. J Immunol. 2003;171(6):2783-2788. (Pubitemid 37093496)
9. Saito T, et al. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity. 2003;18(5):675-685. (Pubitemid 36588584)
10. Mancini SJ, Mantei N, Dumortier A, Suter U, MacDonald HR, Radtke F. Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood. 2005;105(6):2340-2342. (Pubitemid 40387028)
11. Duncan AW, et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol. 2005;6(3):314-322. (Pubitemid 41724769)
12. Maillard I, et al. Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell. 2008;2(4):356-366. (Pubitemid 351455243)
13. Burns CE, Traver D, Mayhall E, Shepard JL, Zon LI. Hematopoietic stem cell fate is established by the Notch-Runx pathway. Genes Dev. 2005;19(19):2331-2342. (Pubitemid 41396910)
14. Kunisato A, et al. HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo. Blood. 2003;101(5):1777- 1783. (Pubitemid 36237573)
15. Stier S, Cheng T, Dombkowski D, Carlesso N, Scadden DT. Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood. 2002;99(7):2369-2378. (Pubitemid 34525422)
16. Varnum-Finney B, et al. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med. 2000;6(11):1278-1281.
17. Yu X, et al. HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding. Stem Cells. 2006;24(4):876-888. (Pubitemid 44464721)
18. Butler JM, et al. Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell. 2010;6(3):251-264.
19. Dallas MH, Varnum-Finney B, Delaney C, Kato K, Bernstein ID. Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells. J Exp Med. 2005;201(9):1361-1366. (Pubitemid 40664080)
20. Ong CT, et al. Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem. 2006;281(8):5106-5119.
21. Hicks C, Johnston SH, di Sibio G, Collazo A, Vogt TF, Weinmaster G. Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2. Nat Cell Biol. 2000;2(8):515-520.
22. Milan M, Cohen SM. A re-evaluation of the contributions of Apterous and Notch to the dorsoventral lineage restriction boundary in the Drosophila wing. Development. 2003;130(3):553-562. (Pubitemid 36231274)
23. Okajima T, Matsuura A, Matsuda T. Biological functions of glycosyltransferase genes involved in Ofucose glycan synthesis. J Biochem. 2008;144(1):1-6. (Pubitemid 351957471)
24. Yang LT, Nichols JT, Yao C, Manilay JO, Robey EA, Weinmaster G. Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol Biol Cell. 2005;16(2):927-942. (Pubitemid 40173985)
25. Visan I, Tan JB, Yuan JS, Harper JA, Koch U, Guidos CJ. Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches. Nat Immunol. 2006;7(6):634-643. (Pubitemid 43797345)
26. Varnum-Finney B, Brashem-Stein C, Bernstein ID. Combined effects of Notch signaling and cytokines induce a multiple log increase in precursors with lymphoid and myeloid reconstituting ability. Blood. 2003;101(5):1784-1789. (Pubitemid 36237574)
27. Jaleco AC, et al. Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. J Exp Med. 2001;194(7):991-1002.
28. Lehar SM, Dooley J, Farr AG, Bevan MJ. Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors. Blood. 2005;105(4):1440-1447. (Pubitemid 40223659)
29. Calvi LM, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature. 2003;425(6960):841-846. (Pubitemid 37351468)
30. Maeda T, et al. Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science. 2007;316(5826):860-866. (Pubitemid 46764272)
31. Chiang MY, Shestove O, Childs ME, Romany C, Aster J, Pear WS. Divergent effects of Notch signaling on Leukemia Stem Cells and Hematotopoitic Stem Cells. ASH Annual Meeting Abstracts. December 5-8, 2009. New Orleans, Lousiana, USA.
32. Lee SU, Maeda M, Sakurai N, Radtke F, Maeda, T. LRF is Indispensable for Hematopoietic Stem Cell Function Via Blocking Notch1-Mediated T Cell-Instructive Signals in the Bone Marrow Niche. ASH Annual Meeting Abstracts. December 5-8, 2009. New Orleans, Lousiana, USA.
33. Neves H, et al. Effects of Delta1 and Jagged1 on early human hematopoiesis: correlation with expression of notch signaling-related genes in CD34+ cells. Stem Cells. 2006;24(5):1328-1337.
34. Wilson A, MacDonald HR, Radtke F. Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J Exp Med. 2001;194(7):1003-1012. (Pubitemid 32953268)
35. Delaney C, Heimfeld S, Brashem-Stein C, Voorhies H, Manger RL, Bernstein ID. Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med. 2010;16(2):232-236.
36. Varnum-Finney B, et al. Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling. J Cell Sci. 2000;113 pt 23:4313-4318. (Pubitemid 32000694)
37. Varnum-Finney B, et al. The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells. Blood. 1998;91(11):4084-4091. (Pubitemid 28261969)
38. Lin KK, Goodell MA. Purification of hematopoietic stem cells using the side population. Methods Enzymol. 2006;420:255-264. (Pubitemid 44855867)