메뉴 건너뛰기




Volumn 21, Issue 1, 2013, Pages 1-26

Biological rationale for the design of polymeric anti-cancer nanomedicines

Author keywords

Cancer heterogeneity; Cancer stem cells; EPR effect; Metastasis; Nanomedicines; Polymer conjugates; Targeting; Tumor microenvironment

Indexed keywords

ALENDRONIC ACID; AMINOGLUTETHIMIDE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CYCLOPAMINE; CYTARABINE; DAUNORUBICIN; DOCETAXEL; DOXORUBICIN; FLOXURIDINE; GADOLINIUM; GAMMA SECRETASE INHIBITOR; GEMCITABINE; GONADORELIN; IMATINIB; IRINOTECAN; LIPOSOME; MACROGOL; NANOCARRIER; PACLITAXEL; PLATINUM; SALINOMYCIN; TRANSFORMING GROWTH FACTOR BETA; TRASTUZUMAB;

EID: 84872036618     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2012.723213     Document Type: Review
Times cited : (58)

References (227)
  • 2
    • 30744477450 scopus 로고    scopus 로고
    • Lymphangiogenesis in development and human disease
    • Alitalo K, Tammela T, Petrova T V. (2005). Lymphangiogenesis in development and human disease. Nature, 438, 946-953.
    • (2005) Nature , vol.438 , pp. 946-953
    • Alitalo, K.1    Tammela, T.2    Petrova, T.V.3
  • 3
    • 0036781811 scopus 로고    scopus 로고
    • Ligand-targeted therapeutics in anticancer therapy
    • Allen TM. (2002). Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer, 2, 750-763.
    • (2002) Nat Rev Cancer , vol.2 , pp. 750-763
    • Allen, T.M.1
  • 4
    • 0032535999 scopus 로고    scopus 로고
    • Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
    • Arap W, Pasqualini R, Ruoslahti E. (1998). Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science, 279, 377-380.
    • (1998) Science , vol.279 , pp. 377-380
    • Arap, W.1    Pasqualini, R.2    Ruoslahti, E.3
  • 10
    • 34848918210 scopus 로고    scopus 로고
    • Impact of tumor-specifc targeting on the biodistribution and efcacy of siRNA nanoparticles measured by multimodality in vivo imaging
    • Bartlett DW, Su H, Hildebrandt IJ, Weber WA, Davis ME. (2007). Impact of tumor-specifc targeting on the biodistribution and efcacy of siRNA nanoparticles measured by multimodality in vivo imaging. Proc Natl Acad Sci USA, 104, 15549-15554.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15549-15554
    • Bartlett, D.W.1    Su, H.2    Hildebrandt, I.J.3    Weber, W.A.4    Davis, M.E.5
  • 12
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D, Dick JE. (1997). Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med, 3, 730-737.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 14
    • 25444495269 scopus 로고    scopus 로고
    • Opinion: Migrating cancer stem cells-an integrated concept of malignant tumour progression
    • Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T. (2005). Opinion: migrating cancer stem cells-an integrated concept of malignant tumour progression. Nat Rev Cancer, 5, 744-749.
    • (2005) Nat Rev Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3    Hlubek, F.4    Kirchner, T.5
  • 15
    • 70349826431 scopus 로고    scopus 로고
    • Understanding the causes of multidrug resistance in cancer: A comparison of doxorubicin and sunitinib
    • Broxterman HJ, Gotink KJ, Verheul HM. (2009). Understanding the causes of multidrug resistance in cancer: a comparison of doxorubicin and sunitinib. Drug Resist Updat, 12, 114-126.
    • (2009) Drug Resist Updat , vol.12 , pp. 114-126
    • Broxterman, H.J.1    Gotink, K.J.2    Verheul, H.M.3
  • 16
    • 0002740313 scopus 로고
    • A quantitative assay for the number of murine lymphoma cells capable of proliferation in vivo
    • Bruce WR, Van Der Gaag H. (1963). A quantitative assay for the number of murine lymphoma cells capable of proliferation in vivo. Nature, 199, 79-80.
    • (1963) Nature , vol.199 , pp. 79-80
    • Bruce, W.R.1    Van Der Gaag, H.2
  • 17
  • 18
    • 82755193748 scopus 로고    scopus 로고
    • Polymer-drug conjugates as nano-sized medicines
    • Canal F, Sanchis J, Vicent MJ. (2011). Polymer-drug conjugates as nano-sized medicines. Curr Opin Biotechnol, 22, 894-900.
    • (2011) Curr Opin Biotechnol , vol.22 , pp. 894-900
    • Canal, F.1    Sanchis, J.2    Vicent, M.J.3
  • 19
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers AF, Groom AC, MacDonald IC. (2002). Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer, 2, 563-572.
    • (2002) Nat Rev Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 20
    • 78549294156 scopus 로고    scopus 로고
    • Multifunctional tumor-targeted polymer-peptide-drug delivery system for treatment of primary and metastatic cancers
    • Chandna P, Khandare JJ, Ber E, Rodriguez-Rodriguez L, Minko T. (2010). Multifunctional tumor-targeted polymer-peptide-drug delivery system for treatment of primary and metastatic cancers. Pharm Res, 27, 2296-2306.
    • (2010) Pharm Res , vol.27 , pp. 2296-2306
    • Chandna, P.1    Khandare, J.J.2    Ber, E.3    Rodriguez-Rodriguez, L.4    Minko, T.5
  • 21
    • 40949127319 scopus 로고    scopus 로고
    • Terapeutic nanoparticles for drug delivery in cancer
    • Cho K, Wang X, Nie S, Chen ZG, Shin DM. (2008). Terapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res, 14, 1310-1316.
    • (2008) Clin Cancer Res , vol.14 , pp. 1310-1316
    • Cho, K.1    Wang, X.2    Nie, S.3    Chen, Z.G.4    Shin, D.M.5
  • 23
    • 33645693408 scopus 로고    scopus 로고
    • Intraperitoneal immunotherapy for metastatic ovarian carcinoma: Resistance of intratumoral collagen to antibody penetration
    • Choi J, Credit K, Henderson K, Deverkadra R, He Z, Wiig H, Vanpelt H, Flessner MF. (2006). Intraperitoneal immunotherapy for metastatic ovarian carcinoma: Resistance of intratumoral collagen to antibody penetration. Clin Cancer Res, 12, 1906-1912.
    • (2006) Clin Cancer Res , vol.12 , pp. 1906-1912
    • Choi, J.1    Credit, K.2    Henderson, K.3    Deverkadra, R.4    He, Z.5    Wiig, H.6    Vanpelt, H.7    Flessner, M.F.8
  • 24
    • 33646720082 scopus 로고    scopus 로고
    • Sublethal irradiation induces vascular endothelial growth factor and promotes growth of hepatoma cells: Implications for radiotherapy of hepatocellular carcinoma
    • Chung YL, Jian JJ, Cheng SH, Tsai SY, Chuang V P, Soong T, Lin YM, Horng C F. (2006). Sublethal irradiation induces vascular endothelial growth factor and promotes growth of hepatoma cells: implications for radiotherapy of hepatocellular carcinoma. Clin Cancer Res, 12, 2706-2715.
    • (2006) Clin Cancer Res , vol.12 , pp. 2706-2715
    • Chung, Y.L.1    Jian, J.J.2    Cheng, S.H.3    Tsai, S.Y.4    Chuang, V.P.5    Soong, T.6    Lin, Y.M.7    Horng, C.F.8
  • 25
    • 77957259799 scopus 로고    scopus 로고
    • N-(2-Hydroxypropyl) methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specifc or passive tumour targeting. Synthesis by RAFT polymerisation and physicochemical characterisation
    • Chytil P, Etrych T, Kríž J, Šubr V, Ulbrich K. (2010). N-(2-Hydroxypropyl) methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specifc or passive tumour targeting. Synthesis by RAFT polymerisation and physicochemical characterisation. Eur J Pharm Sci, 41, 473-482.
    • (2010) Eur J Pharm Sci , vol.41 , pp. 473-482
    • Chytil, P.1    Etrych, T.2    Kríž, J.3    Šubr, V.4    Ulbrich, K.5
  • 26
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: Premises, promises and challenges
    • Clevers H. (2011). The cancer stem cell: premises, promises and challenges. Nat Med, 17, 313-319.
    • (2011) Nat Med , vol.17 , pp. 313-319
    • Clevers, H.1
  • 27
    • 76449108068 scopus 로고    scopus 로고
    • Prostate cancer: Regeneration of interest in the prostate
    • Collins AT, Maitland NJ. (2009). Prostate cancer: regeneration of interest in the prostate. Nat Rev Urol, 6, 184-186.
    • (2009) Nat Rev Urol , vol.6 , pp. 184-186
    • Collins, A.T.1    Maitland, N.J.2
  • 28
    • 33751106653 scopus 로고    scopus 로고
    • New approaches to molecular cancer therapeutics
    • Collins I, Workman P. (2006). New approaches to molecular cancer therapeutics. Nat Chem Biol, 2, 689-700.
    • (2006) Nat Chem Biol , vol.2 , pp. 689-700
    • Collins, I.1    Workman, P.2
  • 30
    • 0035206993 scopus 로고    scopus 로고
    • Enhanced biorecognition and internalization of HPMA copolymers containing multiple or multivalent carbohydrate side-chains by human hepatocarcinoma cells
    • David A, Kopecková P, Rubinstein A, Kopecek J. (2001). Enhanced biorecognition and internalization of HPMA copolymers containing multiple or multivalent carbohydrate side-chains by human hepatocarcinoma cells. Bioconjug Chem, 12, 890-899.
    • (2001) Bioconjug Chem , vol.12 , pp. 890-899
    • David, A.1    Kopecková, P.2    Rubinstein, A.3    Kopecek, J.4
  • 32
    • 67249128859 scopus 로고    scopus 로고
    • The frst targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: From concept to clinic
    • Davis ME. (2009). The frst targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic. Mol Pharm, 6, 659-668.
    • (2009) Mol Pharm , vol.6 , pp. 659-668
    • Davis, M.E.1
  • 33
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • Dean M, Fojo T, Bates S. (2005). Tumour stem cells and drug resistance. Nat Rev Cancer, 5, 275-284.
    • (2005) Nat Rev Cancer , vol.5 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 34
    • 58149380742 scopus 로고    scopus 로고
    • Stem cell concepts renew cancer research
    • Dick JE. (2008). Stem cell concepts renew cancer research. Blood, 112, 4793-4807.
    • (2008) Blood , vol.112 , pp. 4793-4807
    • Dick, J.E.1
  • 35
    • 60149109533 scopus 로고    scopus 로고
    • Looking ahead in cancer stem cell research
    • Dick JE. (2009). Looking ahead in cancer stem cell research. Nat Biotechnol, 27, 44-46.
    • (2009) Nat Biotechnol , vol.27 , pp. 44-46
    • Dick, J.E.1
  • 36
    • 81855170441 scopus 로고    scopus 로고
    • Nanomedicine(s) under the microscope
    • Duncan R, Gaspar R. (2011). Nanomedicine(s) under the microscope. Mol Pharm, 8, 2101-2141.
    • (2011) Mol Pharm , vol.8 , pp. 2101-2141
    • Duncan, R.1    Gaspar, R.2
  • 37
    • 0041461026 scopus 로고    scopus 로고
    • High-molecular weight HPMA copolymer-adriamycin conjugates
    • Dvorák M, Kopecková P, Kopecek J. (1999). High-molecular weight HPMA copolymer-adriamycin conjugates. J Control Release, 60, 321-332.
    • (1999) J Control Release , vol.60 , pp. 321-332
    • Dvorák, M.1    Kopecková, P.2    Kopecek, J.3
  • 38
    • 6344250414 scopus 로고    scopus 로고
    • Modulation of prostate cancer growth in bone microenvironments
    • Edlund M, Sung SY, Chung LW. (2004). Modulation of prostate cancer growth in bone microenvironments. J Cell Biochem, 91, 686-705.
    • (2004) J Cell Biochem , vol.91 , pp. 686-705
    • Edlund, M.1    Sung, S.Y.2    Chung, L.W.3
  • 40
    • 63549094211 scopus 로고    scopus 로고
    • Tumor-targeted nanomedicines: Enhanced antitumor efcacy in vivo of doxorubicin-loaded, long-circulating liposomes modifed with cancer-specifc monoclonal antibody
    • ElBayoumi TA, Torchilin VP. (2009). Tumor-targeted nanomedicines: enhanced antitumor efcacy in vivo of doxorubicin-loaded, long-circulating liposomes modifed with cancer-specifc monoclonal antibody. Clin Cancer Res, 15, 1973-1980.
    • (2009) Clin Cancer Res , vol.15 , pp. 1973-1980
    • Elbayoumi, T.A.1    Torchilin, V.P.2
  • 42
    • 84870252834 scopus 로고    scopus 로고
    • HPMA copolymer-doxorubicin conjugates: The efects of molecular weight and architecture on biodistribution and in vivo activity
    • DOI: 10.1016/j.jconrel.2012.06.029
    • Etrych T, Šubr V, Strohalm J, Šírová M, Ríhová B, Ulbrich K. (2012). HPMA copolymer-doxorubicin conjugates: The efects of molecular weight and architecture on biodistribution and in vivo activity. J Control Release, DOI: 10.1016/j.jconrel.2012.06.029.
    • (2012) J Control Release
    • Etrych, T.1    Šubr, V.2    Strohalm, J.3    Šírová, M.4    Ríhová, B.5    Ulbrich, K.6
  • 43
    • 79953054576 scopus 로고    scopus 로고
    • The EPR efect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the efect
    • Fang J, Nakamura H, Maeda H. (2011). The EPR efect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the efect. Adv Drug Deliv Rev, 63, 136-151.
    • (2011) Adv Drug Deliv Rev , vol.63 , pp. 136-151
    • Fang, J.1    Nakamura, H.2    Maeda, H.3
  • 44
    • 0037508920 scopus 로고    scopus 로고
    • Factors and mechanism of "ePR" efect and the enhanced antitumor efects of macromolecular drugs including SMANCS
    • Fang J, Sawa T, Maeda H. (2003). Factors and mechanism of "EPR" efect and the enhanced antitumor efects of macromolecular drugs including SMANCS. Adv Exp Med Biol, 519, 29-49.
    • (2003) Adv Exp Med Biol , vol.519 , pp. 29-49
    • Fang, J.1    Sawa, T.2    Maeda, H.3
  • 45
    • 0021674404 scopus 로고
    • Sites of recurrence in resected stage i non-small-cell lung cancer: A guide for future studies
    • Feld R, Rubinstein LV, Weisenberger TH. (1984). Sites of recurrence in resected stage I non-small-cell lung cancer: a guide for future studies. J Clin Oncol, 2, 1352-1358.
    • (1984) J Clin Oncol , vol.2 , pp. 1352-1358
    • Feld, R.1    Rubinstein, L.V.2    Weisenberger, T.H.3
  • 46
    • 0028929803 scopus 로고
    • Angiogenesis in cancer, vascular, rheumatoid and other disease
    • Folkman J. (1995). Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med, 1, 27-31.
    • (1995) Nat Med , vol.1 , pp. 27-31
    • Folkman, J.1
  • 47
    • 81855169565 scopus 로고    scopus 로고
    • Cancer invasion and the microenvironment: Plasticity and reciprocity
    • Friedl P, Alexander S. (2011). Cancer invasion and the microenvironment: plasticity and reciprocity. Cell, 147, 992-1009.
    • (2011) Cell , vol.147 , pp. 992-1009
    • Friedl, P.1    Alexander, S.2
  • 48
    • 84965820581 scopus 로고
    • The transmission of leukemia of mice with a single cell
    • Furth J, Kahn M. (1937). The transmission of leukemia of mice with a single cell. Am J Cancer, 31, 276-282.
    • (1937) Am J Cancer , vol.31 , pp. 276-282
    • Furth, J.1    Kahn, M.2
  • 52
    • 29244439607 scopus 로고    scopus 로고
    • Colon-specifc 9-aminocamptothecin-HPMA copolymer conjugates containing a 1, 6-elimination spacer
    • Gao SQ, Lu ZR, Petri B, Kopecková P, Kopecek J. (2006). Colon-specifc 9-aminocamptothecin-HPMA copolymer conjugates containing a 1, 6-elimination spacer. J Control Release, 110, 323-331.
    • (2006) J Control Release , vol.110 , pp. 323-331
    • Gao, S.Q.1    Lu, Z.R.2    Petri, B.3    Kopecková, P.4    Kopecek, J.5
  • 53
    • 33846536256 scopus 로고    scopus 로고
    • Biodistribution and pharmacokinetics of colon-specifc HPMA copolymer-9-aminocamptothecin conjugate in mice
    • Gao SQ, Lu ZR, Kopecková P, Kopecek J. (2007). Biodistribution and pharmacokinetics of colon-specifc HPMA copolymer-9-aminocamptothecin conjugate in mice. J Control Release, 117, 179-185.
    • (2007) J Control Release , vol.117 , pp. 179-185
    • Gao, S.Q.1    Lu, Z.R.2    Kopecková, P.3    Kopecek, J.4
  • 54
    • 38049165649 scopus 로고    scopus 로고
    • Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specifc HPMA copolymer-9-AC conjugate in rats
    • Gao SQ, Sun Y, Kopecková P, Peterson CM, Kopecek J. (2008). Pharmacokinetic modeling of absorption behavior of 9-aminocamptothecin (9-AC) released from colon-specifc HPMA copolymer-9-AC conjugate in rats. Pharm Res, 25, 218-226.
    • (2008) Pharm Res , vol.25 , pp. 218-226
    • Gao, S.Q.1    Sun, Y.2    Kopecková, P.3    Peterson, C.M.4    Kopecek, J.5
  • 55
    • 70449686361 scopus 로고    scopus 로고
    • Antitumor efcacy of colon-specifc HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts
    • Gao SQ, Sun Y, Kopecková P, Peterson CM, Kopecek J. (2009). Antitumor efcacy of colon-specifc HPMA copolymer/9-aminocamptothecin conjugates in mice bearing human-colon carcinoma xenografts. Macromol Biosci, 9, 1135-1142.
    • (2009) Macromol Biosci , vol.9 , pp. 1135-1142
    • Gao, S.Q.1    Sun, Y.2    Kopecková, P.3    Peterson, C.M.4    Kopecek, J.5
  • 58
    • 0035879099 scopus 로고    scopus 로고
    • Recurrent epithelial ovarian carcinoma: A randomized phase III study of pegylated liposomal doxorubicin versus topotecan
    • Gordon AN, Fleagle JT, Guthrie D, Parkin DE, Gore ME, Lacave AJ. (2001). Recurrent epithelial ovarian carcinoma: a randomized phase III study of pegylated liposomal doxorubicin versus topotecan. J Clin Oncol, 19, 3312-3322.
    • (2001) J Clin Oncol , vol.19 , pp. 3312-3322
    • Gordon, A.N.1    Fleagle, J.T.2    Guthrie, D.3    Parkin, D.E.4    Gore, M.E.5    Lacave, A.J.6
  • 59
    • 32944482677 scopus 로고    scopus 로고
    • Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer
    • Gradishar WJ, Tjulandin S, Davidson N, Shaw H, Desai N, Bhar P, Hawkins M, O'Shaughnessy J. (2005). Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J Clin Oncol, 23, 7794-7803.
    • (2005) J Clin Oncol , vol.23 , pp. 7794-7803
    • Gradishar, W.J.1    Tjulandin, S.2    Davidson, N.3    Shaw, H.4    Desai, N.5    Bhar, P.6    Hawkins, M.7    O'Shaughnessy, J.8
  • 60
    • 33846549188 scopus 로고    scopus 로고
    • Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells
    • Greco F, Vicent MJ, Gee S, Jones AT, Gee J, Nicholson RI, Duncan R. (2007). Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells. J Control Release, 117, 28-39.
    • (2007) J Control Release , vol.117 , pp. 28-39
    • Greco, F.1    Vicent, M.J.2    Gee, S.3    Jones, A.T.4    Gee, J.5    Nicholson, R.I.6    Duncan, R.7
  • 61
  • 62
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • Gupta PB, Fillmore CM, Jiang G, Shapira SD, Tao K, Kuperwasser C, Lander ES. (2011). Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell, 146, 633-644.
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3    Shapira, S.D.4    Tao, K.5    Kuperwasser, C.6    Lander, E.S.7
  • 63
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan D, Coussens LM. (2012). Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell, 21, 309-322.
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 64
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. (2000). The hallmarks of cancer. Cell, 100, 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 65
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. (2011). Hallmarks of cancer: the next generation. Cell, 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 68
    • 79952487130 scopus 로고    scopus 로고
    • Clinical developments in nanotechnology for cancer therapy
    • Heidel JD, Davis ME. (2011). Clinical developments in nanotechnology for cancer therapy. Pharm Res, 28, 187-199.
    • (2011) Pharm Res , vol.28 , pp. 187-199
    • Heidel, J.D.1    Davis, M.E.2
  • 69
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fuid pressure-an obstacle in cancer therapy
    • Heldin CH, Rubin K, Pietras K, Ostman A. (2004). High interstitial fuid pressure-an obstacle in cancer therapy. Nat Rev Cancer, 4, 806-813.
    • (2004) Nat Rev Cancer , vol.4 , pp. 806-813
    • Heldin, C.H.1    Rubin, K.2    Pietras, K.3    Ostman, A.4
  • 73
    • 56049117207 scopus 로고    scopus 로고
    • Combination chemotherapy and photodynamic therapy with fab' fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells
    • Hongrapipat J, Kopecková P, Liu J, Prakongpan S, Kopecek J. (2008a). Combination chemotherapy and photodynamic therapy with fab' fragment targeted HPMA copolymer conjugates in human ovarian carcinoma cells. Mol Pharm, 5, 696-709.
    • (2008) Mol Pharm , vol.5 , pp. 696-709
    • Hongrapipat, J.1    Kopecková, P.2    Liu, J.3    Prakongpan, S.4    Kopecek, J.5
  • 74
    • 38749144812 scopus 로고    scopus 로고
    • Enhanced antitumor activity of combinations of free and HPMA copolymer-bound drugs
    • Hongrapipat J, Kopecková P, Prakongpan S, Kopecek J. (2008b). Enhanced antitumor activity of combinations of free and HPMA copolymer-bound drugs. Int J Pharm, 351, 259-270.
    • (2008) Int J Pharm , vol.351 , pp. 259-270
    • Hongrapipat, J.1    Kopecková, P.2    Prakongpan, S.3    Kopecek, J.4
  • 75
    • 14144249536 scopus 로고    scopus 로고
    • Efcacy and safety of tositumomab and iodine-131 tositumomab (Bexxar) in B-cell lymphoma, progressive after rituximab
    • Horning SJ, Younes A, Jain V, Kroll S, Lucas J, Podolof D, Goris M. (2005). Efcacy and safety of tositumomab and iodine-131 tositumomab (Bexxar) in B-cell lymphoma, progressive after rituximab. J Clin Oncol, 23, 712-719.
    • (2005) J Clin Oncol , vol.23 , pp. 712-719
    • Horning, S.J.1    Younes, A.2    Jain, V.3    Kroll, S.4    Lucas, J.5    Podolof, D.6    Goris, M.7
  • 76
    • 0020488877 scopus 로고
    • Interactions of liposomes with the reticuloendothelial system. II: Nonspecifc and receptor-mediated uptake of liposomes by mouse peritoneal macrophages
    • Hsu MJ, Juliano RL. (1982). Interactions of liposomes with the reticuloendothelial system. II: Nonspecifc and receptor-mediated uptake of liposomes by mouse peritoneal macrophages. Biochim Biophys Acta, 720, 411-419.
    • (1982) Biochim Biophys Acta , vol.720 , pp. 411-419
    • Hsu, M.J.1    Juliano, R.L.2
  • 77
    • 80052509765 scopus 로고    scopus 로고
    • Gemtuzumab ozogamicin in non-acute promyelocytic acute myeloid leukemia
    • Hütter ML, Schlenk RF. (2011). Gemtuzumab ozogamicin in non-acute promyelocytic acute myeloid leukemia. Expert Opin Biol Ter, 11, 1369-1380.
    • (2011) Expert Opin Biol ter , vol.11 , pp. 1369-1380
    • Hütter, M.L.1    Schlenk, R.F.2
  • 78
    • 79952121979 scopus 로고    scopus 로고
    • Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
    • Iliopoulos D, Hirsch HA, Wang G, Struhl K. (2011). Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc Natl Acad Sci USA, 108, 1397-1402.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 1397-1402
    • Iliopoulos, D.1    Hirsch, H.A.2    Wang, G.3    Struhl, K.4
  • 79
    • 0023481357 scopus 로고
    • Transport of molecules across tumor vasculature
    • Jain RK. (1987). Transport of molecules across tumor vasculature. Cancer Metastasis Rev, 6, 559-593.
    • (1987) Cancer Metastasis Rev , vol.6 , pp. 559-593
    • Jain, R.K.1
  • 80
    • 0023909330 scopus 로고
    • Determinants of tumor blood fow: A review
    • Jain RK. (1988). Determinants of tumor blood fow: a review. Cancer Res, 48, 2641-2658.
    • (1988) Cancer Res , vol.48 , pp. 2641-2658
    • Jain, R.K.1
  • 81
    • 0032580493 scopus 로고    scopus 로고
    • Delivery of molecular and cellular medicine to solid tumors
    • Jain RK. (1998). Delivery of molecular and cellular medicine to solid tumors. J Control Release, 53, 49-67.
    • (1998) J Control Release , vol.53 , pp. 49-67
    • Jain, R.K.1
  • 82
    • 0036548794 scopus 로고    scopus 로고
    • Dissecting tumour pathophysiology using intravital microscopy
    • Jain RK, Munn LL, Fukumura D. (2002). Dissecting tumour pathophysiology using intravital microscopy. Nat Rev Cancer, 2, 266-276.
    • (2002) Nat Rev Cancer , vol.2 , pp. 266-276
    • Jain, R.K.1    Munn, L.L.2    Fukumura, D.3
  • 83
    • 34047260282 scopus 로고    scopus 로고
    • Efect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: Insights from a mathematical model
    • Jain RK, Tong RT, Munn LL. (2007). Efect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. Cancer Res, 67, 2729-2735.
    • (2007) Cancer Res , vol.67 , pp. 2729-2735
    • Jain, R.K.1    Tong, R.T.2    Munn, L.L.3
  • 84
    • 78049452610 scopus 로고    scopus 로고
    • Delivering nanomedicine to solid tumors
    • Jain RK, Stylianopoulos T. (2010). Delivering nanomedicine to solid tumors. Nat Rev Clin Oncol, 7, 653-664.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 653-664
    • Jain, R.K.1    Stylianopoulos, T.2
  • 86
    • 61849184284 scopus 로고    scopus 로고
    • Synthesis and evaluation of multivalent branched HPMA copolymer-Fab' conjugates targeted to the B-cell antigen CD20
    • Johnson RN, Kopecková P, Kopecek J. (2009). Synthesis and evaluation of multivalent branched HPMA copolymer-Fab' conjugates targeted to the B-cell antigen CD20. Bioconjug Chem, 20, 129-137.
    • (2009) Bioconjug Chem , vol.20 , pp. 129-137
    • Johnson, R.N.1    Kopecková, P.2    Kopecek, J.3
  • 87
    • 0026739369 scopus 로고
    • Micropharmacology of monoclonal antibodies in solid tumors: Direct experimental evidence for a binding site barrier
    • Juweid M, Neumann R, Paik C, Perez-Bacete MJ, Sato J, van Osdol W, Weinstein JN. (1992). Micropharmacology of monoclonal antibodies in solid tumors: direct experimental evidence for a binding site barrier. Cancer Res, 52, 5144-5153.
    • (1992) Cancer Res , vol.52 , pp. 5144-5153
    • Juweid, M.1    Neumann, R.2    Paik, C.3    Perez-Bacete, M.J.4    Sato, J.5    Van Osdol, W.6    Weinstein, J.N.7
  • 91
    • 33746172167 scopus 로고    scopus 로고
    • Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models
    • Kirpotin DB, Drummond DC, Shao Y, Shalaby MR, Hong K, Nielsen UB, Marks JD, Benz CC, Park JW. (2006). Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res, 66, 6732-6740.
    • (2006) Cancer Res , vol.66 , pp. 6732-6740
    • Kirpotin, D.B.1    Drummond, D.C.2    Shao, Y.3    Shalaby, M.R.4    Hong, K.5    Nielsen, U.B.6    Marks, J.D.7    Benz, C.C.8    Park, J.W.9
  • 92
    • 63049102497 scopus 로고    scopus 로고
    • Parallel progression of primary tumours and metastases
    • Klein CA. (2009). Parallel progression of primary tumours and metastases. Nat Rev Cancer, 9, 302-312.
    • (2009) Nat Rev Cancer , vol.9 , pp. 302-312
    • Klein, C.A.1
  • 93
    • 75749149269 scopus 로고    scopus 로고
    • HPMA copolymers: Origins, early developments, present, and future
    • Kopecek J, Kopecková P. (2010). HPMA copolymers: origins, early developments, present, and future. Adv Drug Deliv Rev, 62, 122-149.
    • (2010) Adv Drug Deliv Rev , vol.62 , pp. 122-149
    • Kopecek, J.1    Kopecková, P.2
  • 95
    • 84869496001 scopus 로고    scopus 로고
    • Analysis on the current status of targeted drug delivery to tumors
    • DOI: 10.1016/j. jconrel.2012.07.010
    • Kwon IK, Lee SC, Han B, Park K. (2012). Analysis on the current status of targeted drug delivery to tumors. J Control Release, DOI: 10.1016/j. jconrel.2012.07.010.
    • (2012) J Control Release
    • Kwon, I.K.1    Lee, S.C.2    Han, B.3    Park, K.4
  • 97
    • 75749134040 scopus 로고    scopus 로고
    • Improving the efcacy of combined modality anticancer therapy using HPMA copolymer-based nanomedicine formulations
    • Lammers T. (2010). Improving the efcacy of combined modality anticancer therapy using HPMA copolymer-based nanomedicine formulations. Adv Drug Deliv Rev, 62, 203-230.
    • (2010) Adv Drug Deliv Rev , vol.62 , pp. 203-230
    • Lammers, T.1
  • 99
    • 48349107149 scopus 로고    scopus 로고
    • Tumour-targeted nanomedicines: Principles and practice
    • Lammers T, Hennink WE, Storm G. (2008). Tumour-targeted nanomedicines: principles and practice. Br J Cancer, 99, 392-397.
    • (2008) Br J Cancer , vol.99 , pp. 392-397
    • Lammers, T.1    Hennink, W.E.2    Storm, G.3
  • 100
    • 67349283045 scopus 로고    scopus 로고
    • Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers
    • Lammers T, Šubr V, Ulbrich K, Peschke P, Huber PE, Hennink WE, Storm G. (2009). Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers. Biomaterials, 30, 3466-3475.
    • (2009) Biomaterials , vol.30 , pp. 3466-3475
    • Lammers, T.1    Šubr, V.2    Ulbrich, K.3    Peschke, P.4    Huber, P.E.5    Hennink, W.E.6    Storm, G.7
  • 101
    • 84862698355 scopus 로고    scopus 로고
    • Drug targeting to tumors: Principles, pitfalls and (pre-) clinical progress
    • Lammers T, Kiessling F, Hennink WE, Storm G. (2012). Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress. J Control Release, 161, 175-187.
    • (2012) J Control Release , vol.161 , pp. 175-187
    • Lammers, T.1    Kiessling, F.2    Hennink, W.E.3    Storm, G.4
  • 102
    • 0028793693 scopus 로고
    • Efect of ionizing radiation on AP-1 binding activity and basic fbroblast growth factor gene expression in drug-sensitive human breast carcinoma MCF-7 and multidrug-resistant MCF-7/ADR cells
    • Lee YJ, Galoforo SS, Berns CM, Erdos G, Gupta AK, Ways DK, Corry PM. (1995). Efect of ionizing radiation on AP-1 binding activity and basic fbroblast growth factor gene expression in drug-sensitive human breast carcinoma MCF-7 and multidrug-resistant MCF-7/ADR cells. J Biol Chem, 270, 28790-28796.
    • (1995) J Biol Chem , vol.270 , pp. 28790-28796
    • Lee, Y.J.1    Galoforo, S.S.2    Berns, C.M.3    Erdos, G.4    Gupta, A.K.5    Ways, D.K.6    Corry, P.M.7
  • 103
    • 0034662608 scopus 로고    scopus 로고
    • Absence of functional lymphatics within a murine sarcoma: A molecular and functional evaluation
    • Leu AJ, Berk DA, Lymboussaki A, Alitalo K, Jain RK. (2000). Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation. Cancer Res, 60, 4324-4327.
    • (2000) Cancer Res , vol.60 , pp. 4324-4327
    • Leu, A.J.1    Berk, D.A.2    Lymboussaki, A.3    Alitalo, K.4    Jain, R.K.5
  • 104
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung DW, Cachianes G, Kuang WJ, Goeddel DV, Ferrara N. (1989). Vascular endothelial growth factor is a secreted angiogenic mitogen. Science, 246, 1306-1309.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.J.3    Goeddel, D.V.4    Ferrara, N.5
  • 105
    • 0026459493 scopus 로고
    • Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fuid pressure during early growth of human adenocarcinoma LS174T in SCID mice
    • Leunig M, Yuan F, Menger MD, Boucher Y, Goetz AE, Messmer K, Jain RK. (1992). Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fuid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Res, 52, 6553-6560.
    • (1992) Cancer Res , vol.52 , pp. 6553-6560
    • Leunig, M.1    Yuan, F.2    Menger, M.D.3    Boucher, Y.4    Goetz, A.E.5    Messmer, K.6    Jain, R.K.7
  • 106
    • 0033927015 scopus 로고    scopus 로고
    • Tumor irradiation enhances the tumor-specifc distribution of poly(L-glutamic acid)-conjugated paclitaxel and its antitumor efcacy
    • Li C, Ke S, Wu QP, Tansey W, Hunter N, Buchmiller LM, Milas L, Charnsangavej C, Wallace S. (2000). Tumor irradiation enhances the tumor-specifc distribution of poly(L-glutamic acid)-conjugated paclitaxel and its antitumor efcacy. Clin Cancer Res, 6, 2829-2834.
    • (2000) Clin Cancer Res , vol.6 , pp. 2829-2834
    • Li, C.1    Ke, S.2    Wu, Q.P.3    Tansey, W.4    Hunter, N.5    Buchmiller, L.M.6    Milas, L.7    Charnsangavej, C.8    Wallace, S.9
  • 107
    • 51049104302 scopus 로고    scopus 로고
    • Pharmacokinetics and biodistribution of nanoparticles
    • Li SD, Huang L. (2008). Pharmacokinetics and biodistribution of nanoparticles. Mol Pharm, 5, 496-504.
    • (2008) Mol Pharm , vol.5 , pp. 496-504
    • Li, S.D.1    Huang, L.2
  • 108
    • 79952341098 scopus 로고    scopus 로고
    • A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors
    • Lim KJ, Bisht S, Bar EE, Maitra A, Eberhart CG. (2011). A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors. Cancer Biol Ter, 11, 464-473.
    • (2011) Cancer Biol ter , vol.11 , pp. 464-473
    • Lim, K.J.1    Bisht, S.2    Bar, E.E.3    Maitra, A.4    Eberhart, C.G.5
  • 109
    • 67249102448 scopus 로고    scopus 로고
    • Biorecognition and subcellular trafcking of HPMA copolymer-anti-PSMA antibody conjugates by prostate cancer cells
    • Liu J, Kopecková P, Bühler P, Wolf P, Pan H, Bauer H, Elsässer-Beile U, Kopecek J. (2009). Biorecognition and subcellular trafcking of HPMA copolymer-anti-PSMA antibody conjugates by prostate cancer cells. Mol Pharm, 6, 959-970.
    • (2009) Mol Pharm , vol.6 , pp. 959-970
    • Liu, J.1    Kopecková, P.2    Bühler, P.3    Wolf, P.4    Pan, H.5    Bauer, H.6    Elsässer-Beile, U.7    Kopecek, J.8
  • 110
    • 0344146604 scopus 로고    scopus 로고
    • Polymerizable Fab' antibody fragments for targeting of anticancer drugs
    • Lu ZR, Kopecková P, Kopecek J. (1999). Polymerizable Fab' antibody fragments for targeting of anticancer drugs. Nat Biotechnol, 17, 1101-1104.
    • (1999) Nat Biotechnol , vol.17 , pp. 1101-1104
    • Lu, Z.R.1    Kopecková, P.2    Kopecek, J.3
  • 111
    • 79955017504 scopus 로고    scopus 로고
    • Biodegradable Multiblock Poly[N-(2-hydroxypropyl)methacrylamide] via Reversible Addition-Fragmentation Chain Transfer Polymerization and Click Chemistry
    • Luo K, Yang J, Kopecková P, Kopecek J. (2011). Biodegradable Multiblock Poly[N-(2-hydroxypropyl)methacrylamide] via Reversible Addition-Fragmentation Chain Transfer Polymerization and Click Chemistry. Macromolecules, 44, 2481-2488.
    • (2011) Macromolecules , vol.44 , pp. 2481-2488
    • Luo, K.1    Yang, J.2    Kopecková, P.3    Kopecek, J.4
  • 112
    • 0242392015 scopus 로고    scopus 로고
    • Acute and long-term toxicity following radiotherapy alone or in combination with chemotherapy for locally advanced cervical cancer
    • Maduro JH, Pras E, Willemse PH, de Vries EG. (2003). Acute and long-term toxicity following radiotherapy alone or in combination with chemotherapy for locally advanced cervical cancer. Cancer Treat Rev, 29, 471-488.
    • (2003) Cancer Treat Rev , vol.29 , pp. 471-488
    • Maduro, J.H.1    Pras, E.2    Willemse, P.H.3    De Vries, E.G.4
  • 113
    • 0023821387 scopus 로고
    • Purifcation and identifcation of [hydroxyprolyl3]bradykinin in ascitic fuid from a patient with gastric cancer
    • Maeda H, Matsumura Y, Kato H. (1988). Purifcation and identifcation of [hydroxyprolyl3]bradykinin in ascitic fuid from a patient with gastric cancer. J Biol Chem, 263, 16051-16054.
    • (1988) J Biol Chem , vol.263 , pp. 16051-16054
    • Maeda, H.1    Matsumura, Y.2    Kato, H.3
  • 114
    • 0034000453 scopus 로고    scopus 로고
    • Tumor vascular permeability and the EPR efect in macromolecular therapeutics: A review
    • Maeda H, Wu J, Sawa T, Matsumura Y, Hori K. (2000). Tumor vascular permeability and the EPR efect in macromolecular therapeutics: a review. J Control Release, 65, 271-284.
    • (2000) J Control Release , vol.65 , pp. 271-284
    • Maeda, H.1    Wu, J.2    Sawa, T.3    Matsumura, Y.4    Hori, K.5
  • 115
    • 33745782940 scopus 로고    scopus 로고
    • HPMA copolymer-bound doxorubicin induces apoptosis in ovarian carcinoma cells by the disruption of mitochondrial function
    • Malugin A, Kopecková P, Kopecek J. (2006). HPMA copolymer-bound doxorubicin induces apoptosis in ovarian carcinoma cells by the disruption of mitochondrial function. Mol Pharm, 3, 351-361.
    • (2006) Mol Pharm , vol.3 , pp. 351-361
    • Malugin, A.1    Kopecková, P.2    Kopecek, J.3
  • 117
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Matsumura Y, Maeda H. (1986). A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res, 46, 6387-6392.
    • (1986) Cancer Res , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 118
    • 67449084321 scopus 로고    scopus 로고
    • Preclinical and clinical studies of anticancer agent-incorporating polymer micelles
    • Matsumura Y, Kataoka K. (2009). Preclinical and clinical studies of anticancer agent-incorporating polymer micelles. Cancer Sci, 100, 572-579.
    • (2009) Cancer Sci , vol.100 , pp. 572-579
    • Matsumura, Y.1    Kataoka, K.2
  • 120
    • 8444247084 scopus 로고    scopus 로고
    • Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage diferentiation
    • Milano J, McKay J, Dagenais C, Foster-Brown L, Pognan F, Gadient R, Jacobs RT, Zacco A, Greenberg B, Ciaccio PJ. (2004). Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage diferentiation. Toxicol Sci, 82, 341-358.
    • (2004) Toxicol Sci , vol.82 , pp. 341-358
    • Milano, J.1    McKay, J.2    Dagenais, C.3    Foster-Brown, L.4    Pognan, F.5    Gadient, R.6    Jacobs, R.T.7    Zacco, A.8    Greenberg, B.9    Ciaccio, P.J.10
  • 121
    • 79961079796 scopus 로고    scopus 로고
    • Antiangiogenic antitumor activity of HPMA copolymer-paclitaxel- alendronate conjugate on breast cancer bone metastasis mouse model
    • Miller K, Eldar-Boock A, Polyak D, Segal E, Benayoun L, Shaked Y, Satchi-Fainaro R. (2011). Antiangiogenic antitumor activity of HPMA copolymer-paclitaxel-alendronate conjugate on breast cancer bone metastasis mouse model. Mol Pharm, 8, 1052-1062.
    • (2011) Mol Pharm , vol.8 , pp. 1052-1062
    • Miller, K.1    Eldar-Boock, A.2    Polyak, D.3    Segal, E.4    Benayoun, L.5    Shaked, Y.6    Satchi-Fainaro, R.7
  • 122
  • 123
    • 0344142519 scopus 로고    scopus 로고
    • Chronic exposure to HPMA copolymer-bound adriamycin does not induce multidrug resistance in a human ovarian carcinoma cell line
    • Minko T, Kopecková P, Kopecek J. (1999). Chronic exposure to HPMA copolymer-bound adriamycin does not induce multidrug resistance in a human ovarian carcinoma cell line. J Control Release, 59, 133-148.
    • (1999) J Control Release , vol.59 , pp. 133-148
    • Minko, T.1    Kopecková, P.2    Kopecek, J.3
  • 124
    • 0034049291 scopus 로고    scopus 로고
    • Efcacy of the chemotherapeutic action of HPMA copolymer-bound doxorubicin in a solid tumor model of ovarian carcinoma
    • Minko T, Kopecková P, Kopecek J. (2000). Efcacy of the chemotherapeutic action of HPMA copolymer-bound doxorubicin in a solid tumor model of ovarian carcinoma. Int J Cancer, 86, 108-117.
    • (2000) Int J Cancer , vol.86 , pp. 108-117
    • Minko, T.1    Kopecková, P.2    Kopecek, J.3
  • 125
    • 0035962380 scopus 로고    scopus 로고
    • Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells
    • Minko T, Kopecková P, Kopecek J. (2001). Preliminary evaluation of caspases-dependent apoptosis signaling pathways of free and HPMA copolymer-bound doxorubicin in human ovarian carcinoma cells. J Control Release, 71, 227-237.
    • (2001) J Control Release , vol.71 , pp. 227-237
    • Minko, T.1    Kopecková, P.2    Kopecek, J.3
  • 126
    • 0036675220 scopus 로고    scopus 로고
    • Metastasis to bone: Causes, consequences and therapeutic opportunities
    • Mundy GR. (2002). Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer, 2, 584-593.
    • (2002) Nat Rev Cancer , vol.2 , pp. 584-593
    • Mundy, G.R.1
  • 129
    • 20344367537 scopus 로고    scopus 로고
    • Tumour vascular targeting
    • Neri D, Bicknell R. (2005). Tumour vascular targeting. Nat Rev Cancer, 5, 436-446.
    • (2005) Nat Rev Cancer , vol.5 , pp. 436-446
    • Neri, D.1    Bicknell, R.2
  • 130
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: From dissemination to organ-specifc colonization
    • Nguyen DX, Bos PD, Massagué J. (2009). Metastasis: from dissemination to organ-specifc colonization. Nat Rev Cancer, 9, 274-284.
    • (2009) Nat Rev Cancer , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massagué, J.3
  • 131
    • 77749254873 scopus 로고    scopus 로고
    • Surgery with molecular fuorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival
    • Nguyen QT, Olson ES, Aguilera TA, Jiang T, Scadeng M, Ellies LG, Tsien RY. (2010). Surgery with molecular fuorescence imaging using activatable cell-penetrating peptides decreases residual cancer and improves survival. Proc Natl Acad Sci USA, 107, 4317-4322.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4317-4322
    • Nguyen, Q.T.1    Olson, E.S.2    Aguilera, T.A.3    Jiang, T.4    Scadeng, M.5    Ellies, L.G.6    Tsien, R.Y.7
  • 132
    • 0344412936 scopus 로고    scopus 로고
    • Free and N-(2-hydroxypropyl)methacrylamide copolymer-bound geldanamycin derivative induce diferent stress responses in A2780 human ovarian carcinoma cells
    • Nishiyama N, Nori A, Malugin A, Kasuya Y, Kopecková P, Kopecek J. (2003). Free and N-(2-hydroxypropyl)methacrylamide copolymer-bound geldanamycin derivative induce diferent stress responses in A2780 human ovarian carcinoma cells. Cancer Res, 63, 7876-7882.
    • (2003) Cancer Res , vol.63 , pp. 7876-7882
    • Nishiyama, N.1    Nori, A.2    Malugin, A.3    Kasuya, Y.4    Kopecková, P.5    Kopecek, J.6
  • 133
    • 0031959490 scopus 로고    scopus 로고
    • Early phase tumor accumulation of macromolecules: A great diference in clearance rate between tumor and normal tissues
    • Noguchi Y, Wu J, Duncan R, Strohalm J, Ulbrich K, Akaike T, Maeda H. (1998). Early phase tumor accumulation of macromolecules: a great diference in clearance rate between tumor and normal tissues. Jpn J Cancer Res, 89, 307-314.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 307-314
    • Noguchi, Y.1    Wu, J.2    Duncan, R.3    Strohalm, J.4    Ulbrich, K.5    Akaike, T.6    Maeda, H.7
  • 134
    • 0031861021 scopus 로고    scopus 로고
    • Pegylated-liposomal doxorubicin versus doxorubicin, bleomycin, and vincristine in the treatment of AIDS-related Kaposi's sarcoma: Results of a randomized phase III clinical trial
    • Northfelt DW, Dezube BJ, Tommes JA, Miller BJ, Fischl MA, Friedman-Kien A, Kaplan LD, Du Mond C, Mamelok RD, Henry DH. (1998). Pegylated-liposomal doxorubicin versus doxorubicin, bleomycin, and vincristine in the treatment of AIDS-related Kaposi's sarcoma: results of a randomized phase III clinical trial. J Clin Oncol, 16, 2445-2451.
    • (1998) J Clin Oncol , vol.16 , pp. 2445-2451
    • Northfelt, D.W.1    Dezube, B.J.2    Tommes, J.A.3    Miller, B.J.4    Fischl, M.A.5    Friedman-Kien, A.6    Kaplan, L.D.7    Du Mond, C.8    Mamelok, R.D.9    Henry, D.H.10
  • 135
    • 0017167185 scopus 로고
    • The clonal evolution of tumor cell populations
    • Nowell PC. (1976). The clonal evolution of tumor cell populations. Science, 194, 23-28.
    • (1976) Science , vol.194 , pp. 23-28
    • Nowell, P.C.1
  • 136
    • 70350070378 scopus 로고    scopus 로고
    • ProLindac (AP5346): A review of the development of an HPMA DACH platinum Polymer Terapeutic
    • Nowotnik DP, Cvitkovic E. (2009). ProLindac (AP5346): a review of the development of an HPMA DACH platinum Polymer Terapeutic. Adv Drug Deliv Rev, 61, 1214-1219.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 1214-1219
    • Nowotnik, D.P.1    Cvitkovic, E.2
  • 137
    • 0021355544 scopus 로고
    • Extravascular difusion in normal and neoplastic tissues
    • Nugent LJ, Jain RK. (1984). Extravascular difusion in normal and neoplastic tissues. Cancer Res, 44, 238-244.
    • (1984) Cancer Res , vol.44 , pp. 238-244
    • Nugent, L.J.1    Jain, R.K.2
  • 138
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodefcient mice
    • O'Brien CA, Pollett A, Gallinger S, Dick JE. (2007). A human colon cancer cell capable of initiating tumour growth in immunodefcient mice. Nature, 445, 106-110.
    • (2007) Nature , vol.445 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 139
    • 11144357506 scopus 로고    scopus 로고
    • Reduced cardiotoxicity and comparable efcacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for frst-line treatment of metastatic breast cancer
    • O'Brien ME, Wigler N, Inbar M, Rosso R, Grischke E, Santoro A, Catane R, Kieback DG, Tomczak P, Ackland SP, Orlandi F, Mellars L, Alland L, Tendler C; CAELYX Breast Cancer Study Group. (2004). Reduced cardiotoxicity and comparable efcacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for frst-line treatment of metastatic breast cancer. Ann Oncol, 15, 440-449.
    • (2004) Ann Oncol , vol.15 , pp. 440-449
    • O'Brien, M.E.1    Wigler, N.2    Inbar, M.3    Rosso, R.4    Grischke, E.5    Santoro, A.6    Catane, R.7    Kieback, D.G.8    Tomczak, P.9    Ackland, S.P.10    Orlandi, F.11    Mellars, L.12    Alland, L.13    Tendler, C.14
  • 142
    • 77749297971 scopus 로고    scopus 로고
    • Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fuorescence and MR imaging of proteases
    • Olson ES, Jiang T, Aguilera TA, Nguyen QT, Ellies LG, Scadeng M, Tsien RY. (2010). Activatable cell penetrating peptides linked to nanoparticles as dual probes for in vivo fuorescence and MR imaging of proteases. Proc Natl Acad Sci USA, 107, 4311-4316.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4311-4316
    • Olson, E.S.1    Jiang, T.2    Aguilera, T.A.3    Nguyen, Q.T.4    Ellies, L.G.5    Scadeng, M.6    Tsien, R.Y.7
  • 143
    • 0032580444 scopus 로고    scopus 로고
    • Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate
    • Omelyanenko V, Kopecková P, Gentry C, Kopecek J. (1998a). Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate. J Control Release, 53, 25-37.
    • (1998) J Control Release , vol.53 , pp. 25-37
    • Omelyanenko, V.1    Kopecková, P.2    Gentry, C.3    Kopecek, J.4
  • 144
    • 0032498552 scopus 로고    scopus 로고
    • HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. II. Processing in epithelial ovarian carcinoma cells in vitro
    • Omelyanenko V, Gentry C, Kopecková P, Kopecek J. (1998b). HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. II. Processing in epithelial ovarian carcinoma cells in vitro. Int J Cancer, 75, 600-608.
    • (1998) Int J Cancer , vol.75 , pp. 600-608
    • Omelyanenko, V.1    Gentry, C.2    Kopecková, P.3    Kopecek, J.4
  • 148
    • 51049117949 scopus 로고    scopus 로고
    • Biodistribution and pharmacokinetic studies of bone-targeting N-(2-hydroxypropyl)methacrylamide copolymer-alendronate conjugates
    • Pan H, Sima M, Kopecková P, Wu K, Gao S, Liu J, Wang D, Miller SC, Kopecek J. (2008). Biodistribution and pharmacokinetic studies of bone-targeting N-(2-hydroxypropyl)methacrylamide copolymer-alendronate conjugates. Mol Pharm, 5, 548-558.
    • (2008) Mol Pharm , vol.5 , pp. 548-558
    • Pan, H.1    Sima, M.2    Kopecková, P.3    Wu, K.4    Gao, S.5    Liu, J.6    Wang, D.7    Miller, S.C.8    Kopecek, J.9
  • 149
    • 78651333306 scopus 로고    scopus 로고
    • Backbone degradable multiblock N-(2-hydroxypropyl)methacrylamide copolymer conjugates via reversible addition-fragmentation chain transfer polymerization and thiol-ene coupling reaction
    • Pan H, Yang J, Kopecková P, Kopecek J. (2011). Backbone degradable multiblock N-(2-hydroxypropyl)methacrylamide copolymer conjugates via reversible addition-fragmentation chain transfer polymerization and thiol-ene coupling reaction. Biomacromolecules, 12, 247-252.
    • (2011) Biomacromolecules , vol.12 , pp. 247-252
    • Pan, H.1    Yang, J.2    Kopecková, P.3    Kopecek, J.4
  • 150
    • 0033651234 scopus 로고    scopus 로고
    • The molecular and cellular biology of HER2/neu gene amplifcation/ overexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer
    • Pegram MD, Konecny G, Slamon DJ. (2000). The molecular and cellular biology of HER2/neu gene amplifcation/overexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer. Cancer Treat Res, 103, 57-75.
    • (2000) Cancer Treat Res , vol.103 , pp. 57-75
    • Pegram, M.D.1    Konecny, G.2    Slamon, D.J.3
  • 151
    • 0032899915 scopus 로고    scopus 로고
    • Morphometric analysis of bromodeoxyuridine distribution and cell density in the rat Dunning prostate tumor R3327-AT1 following treatment with radiation and/or hyperthermia
    • Peschke P, Klein V, Wolber G, Friedrich E, Hahn EW. (1999). Morphometric analysis of bromodeoxyuridine distribution and cell density in the rat Dunning prostate tumor R3327-AT1 following treatment with radiation and/or hyperthermia. Histol Histopathol, 14, 461-469.
    • (1999) Histol Histopathol , vol.14 , pp. 461-469
    • Peschke, P.1    Klein, V.2    Wolber, G.3    Friedrich, E.4    Hahn, E.W.5
  • 152
    • 0015014839 scopus 로고
    • Diferentiation of malignant to benign cells
    • Pierce GB, Wallace C. (1971). Diferentiation of malignant to benign cells. Cancer Res, 31, 127-134.
    • (1971) Cancer Res , vol.31 , pp. 127-134
    • Pierce, G.B.1    Wallace, C.2
  • 153
    • 0032978690 scopus 로고    scopus 로고
    • Difusion of macromolecules in agarose gels: Comparison of linear and globular confgurations
    • Pluen A, Netti PA, Jain RK, Berk DA. (1999). Difusion of macromolecules in agarose gels: comparison of linear and globular confgurations. Biophys J, 77, 542-552.
    • (1999) Biophys J , vol.77 , pp. 542-552
    • Pluen, A.1    Netti, P.A.2    Jain, R.K.3    Berk, D.A.4
  • 154
    • 29344443251 scopus 로고    scopus 로고
    • The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors
    • Primeau AJ, Rendon A, Hedley D, Lilge L, Tannock IF. (2005). The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors. Clin Cancer Res, 11, 8782-8788.
    • (2005) Clin Cancer Res , vol.11 , pp. 8782-8788
    • Primeau, A.J.1    Rendon, A.2    Hedley, D.3    Lilge, L.4    Tannock, I.F.5
  • 155
    • 84858602107 scopus 로고    scopus 로고
    • Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma
    • Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hof DD, Hingorani SR. (2012). Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell, 21, 418-429.
    • (2012) Cancer Cell , vol.21 , pp. 418-429
    • Provenzano, P.P.1    Cuevas, C.2    Chang, A.E.3    Goel, V.K.4    Von Hof, D.D.5    Hingorani, S.R.6
  • 156
    • 0019364294 scopus 로고
    • Biochemical, morphological, and ultrastructural studies on the uptake of liposomes by murine macrophages
    • Raz A, Bucana C, Fogler WE, Poste G, Fidler IJ. (1981). Biochemical, morphological, and ultrastructural studies on the uptake of liposomes by murine macrophages. Cancer Res, 41, 487-494.
    • (1981) Cancer Res , vol.41 , pp. 487-494
    • Raz, A.1    Bucana, C.2    Fogler, W.E.3    Poste, G.4    Fidler, I.J.5
  • 157
    • 0000859980 scopus 로고
    • Polymers containing enzymatically degradable bonds. 8. Degradation of oligopeptide sequences in N-(2-hydroxypropyl)methacrylamide copolymers by bovine spleen cathepsin B
    • Rejmanová P, Pohl J, Baudyš M, Kostka V, Kopecek J. (1983). Polymers containing enzymatically degradable bonds. 8. Degradation of oligopeptide sequences in N-(2-hydroxypropyl)methacrylamide copolymers by bovine spleen cathepsin B. Makromol Chem, 184, 2009-2020.
    • (1983) Makromol Chem , vol.184 , pp. 2009-2020
    • Rejmanová, P.1    Pohl, J.2    Baudyš, M.3    Kostka, V.4    Kopecek, J.5
  • 158
    • 51049115157 scopus 로고    scopus 로고
    • Overcoming multidrug resistance in human carcinoma cells by an antisense oligodeoxynucleotide-doxorubicin conjugate in vitro and in vivo
    • Ren Y, Wang Y, Zhang Y, Wei D. (2008). Overcoming multidrug resistance in human carcinoma cells by an antisense oligodeoxynucleotide-doxorubicin conjugate in vitro and in vivo. Mol Pharm, 5, 579-587.
    • (2008) Mol Pharm , vol.5 , pp. 579-587
    • Ren, Y.1    Wang, Y.2    Zhang, Y.3    Wei, D.4
  • 162
    • 0023930539 scopus 로고
    • Antibody-directed afnity therapy applied to the immune system: In vivo efectiveness and limited toxicity of daunomycin conjugated to HPMA copolymers and targeting antibody
    • Ríhová B, Kopecková P, Strohalm J, Rossmann P, Vetvicka V, Kopecek J. (1988). Antibody-directed afnity therapy applied to the immune system: in vivo efectiveness and limited toxicity of daunomycin conjugated to HPMA copolymers and targeting antibody. Clin Immunol Immunopathol, 46, 100-114.
    • (1988) Clin Immunol Immunopathol , vol.46 , pp. 100-114
    • Ríhová, B.1    Kopecková, P.2    Strohalm, J.3    Rossmann, P.4    Vetvicka, V.5    Kopecek, J.6
  • 164
    • 0031045279 scopus 로고    scopus 로고
    • Neovasculature induced by vascular endothelial growth factor is fenestrated
    • Roberts WG, Palade GE. (1997). Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Res, 57, 765-772.
    • (1997) Cancer Res , vol.57 , pp. 765-772
    • Roberts, W.G.1    Palade, G.E.2
  • 165
    • 67649939163 scopus 로고    scopus 로고
    • The increasing complexity of the cancer stem cell paradigm
    • Rosen JM, Jordan CT. (2009). The increasing complexity of the cancer stem cell paradigm. Science, 324, 1670-1673.
    • (2009) Science , vol.324 , pp. 1670-1673
    • Rosen, J.M.1    Jordan, C.T.2
  • 167
    • 84864125045 scopus 로고    scopus 로고
    • Peptides as targeting elements and tissue penetration devices for nanoparticles
    • Ruoslahti E. (2012). Peptides as targeting elements and tissue penetration devices for nanoparticles. Adv Mater, 24, 3747-3756.
    • (2012) Adv Mater , vol.24 , pp. 3747-3756
    • Ruoslahti, E.1
  • 171
    • 0023450012 scopus 로고
    • Efect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats
    • Seymour LW, Duncan R, Strohalm J, Kopecek J. (1987). Efect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats. J Biomed Mater Res, 21, 1341-1358.
    • (1987) J Biomed Mater Res , vol.21 , pp. 1341-1358
    • Seymour, L.W.1    Duncan, R.2    Strohalm, J.3    Kopecek, J.4
  • 172
    • 0029039418 scopus 로고
    • Infuence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier
    • Seymour LW, Miyamoto Y, Maeda H, Brereton M, Strohalm J, Ulbrich K, Duncan R. (1995). Infuence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier. Eur J Cancer, 31A, 766-770.
    • (1995) Eur J Cancer , vol.31 A , pp. 766-770
    • Seymour, L.W.1    Miyamoto, Y.2    Maeda, H.3    Brereton, M.4    Strohalm, J.5    Ulbrich, K.6    Duncan, R.7
  • 174
    • 69449096005 scopus 로고    scopus 로고
    • Heterogeneity in cancer: Cancer stem cells versus clonal evolution
    • Shackleton M, Quintana E, Fearon ER, Morrison SJ. (2009). Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell, 138, 822-829.
    • (2009) Cell , vol.138 , pp. 822-829
    • Shackleton, M.1    Quintana, E.2    Fearon, E.R.3    Morrison, S.J.4
  • 175
    • 34848911943 scopus 로고    scopus 로고
    • Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency
    • Shah N P, Skaggs BJ, Branford S, Hughes TP, Nicoll JM, Paquette RL, Sawyers CL. (2007). Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency. J Clin Invest, 117, 2562-2569.
    • (2007) J Clin Invest , vol.117 , pp. 2562-2569
    • Shah, N.P.1    Skaggs, B.J.2    Branford, S.3    Hughes, T.P.4    Nicoll, J.M.5    Paquette, R.L.6    Sawyers, C.L.7
  • 177
    • 33746836894 scopus 로고    scopus 로고
    • Targeted therapy of cancer: New prospects for antibodies and immunoconjugates
    • Sharkey RM, Goldenberg DM. (2006). Targeted therapy of cancer: new prospects for antibodies and immunoconjugates. CA Cancer J Clin, 56, 226-243.
    • (2006) CA Cancer J Clin , vol.56 , pp. 226-243
    • Sharkey, R.M.1    Goldenberg, D.M.2
  • 178
  • 180
    • 0035145742 scopus 로고    scopus 로고
    • Biodistribution and antitumour efcacy of long-circulating N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in nude mice
    • Shiah JG, Dvorák M, Kopecková P, Sun Y, Peterson CM, Kopecek J. (2001a). Biodistribution and antitumour efcacy of long-circulating N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in nude mice. Eur J Cancer, 37, 131-139.
    • (2001) Eur J Cancer , vol.37 , pp. 131-139
    • Shiah, J.G.1    Dvorák, M.2    Kopecková, P.3    Sun, Y.4    Peterson, C.M.5    Kopecek, J.6
  • 181
    • 0035816192 scopus 로고    scopus 로고
    • Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin/mesochlorin e(6)-OV-TL 16 antibody immunoconjugates
    • Shiah JG, Sun Y, Kopecková P, Peterson CM, Straight RC, Kopecek J. (2001b). Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin/mesochlorin e(6)-OV-TL 16 antibody immunoconjugates. J Control Release, 74, 249-253.
    • (2001) J Control Release , vol.74 , pp. 249-253
    • Shiah, J.G.1    Sun, Y.2    Kopecková, P.3    Peterson, C.M.4    Straight, R.C.5    Kopecek, J.6
  • 183
    • 0032997033 scopus 로고    scopus 로고
    • Oncolytic, antiarthritic, matrix metalloproteinase inhibitor
    • Sorbera LA, Graul A, Silvestre J, Castañer J. (1999). Oncolytic, antiarthritic, matrix metalloproteinase inhibitor. Drugs Fut, 24, 16.
    • (1999) Drugs Fut , vol.24 , pp. 16
    • Sorbera, L.A.1    Graul, A.2    Silvestre, J.3    Castañer, J.4
  • 184
    • 84859715721 scopus 로고    scopus 로고
    • Tumor microenvironment: A main actor in the metastasis process
    • Spano D, Zollo M. (2012). Tumor microenvironment: a main actor in the metastasis process. Clin Exp Metastasis, 29, 381-395.
    • (2012) Clin Exp Metastasis , vol.29 , pp. 381-395
    • Spano, D.1    Zollo, M.2
  • 185
    • 0032508627 scopus 로고    scopus 로고
    • Reversal of intrinsic and acquired forms of drug resistance by hyaluronidase treatment of solid tumors
    • St Croix B, Man S, Kerbel RS. (1998). Reversal of intrinsic and acquired forms of drug resistance by hyaluronidase treatment of solid tumors. Cancer Lett, 131, 35-44.
    • (1998) Cancer Lett , vol.131 , pp. 35-44
    • St Croix, B.1    Man, S.2    Kerbel, R.S.3
  • 189
    • 76749083490 scopus 로고    scopus 로고
    • Lymphangiogenesis: Molecular mechanisms and future promise
    • Tammela T, Alitalo K. (2010). Lymphangiogenesis: Molecular mechanisms and future promise. Cell, 140, 460-476.
    • (2010) Cell , vol.140 , pp. 460-476
    • Tammela, T.1    Alitalo, K.2
  • 190
    • 36849083949 scopus 로고    scopus 로고
    • Cancer stem cell: Target for anti-cancer therapy
    • Tang C, Ang BT, Pervaiz S. (2007). Cancer stem cell: target for anti-cancer therapy. FASEB J, 21, 3777-3785.
    • (2007) FASEB J , vol.21 , pp. 3777-3785
    • Tang, C.1    Ang, B.T.2    Pervaiz, S.3
  • 191
    • 33847049076 scopus 로고    scopus 로고
    • Coencapsulation of irinotecan and foxuridine into low cholesterol-containing liposomes that coordinate drug release in vivo
    • Tardi PG, Gallagher RC, Johnstone S, Harasym N, Webb M, Bally MB, Mayer LD. (2007). Coencapsulation of irinotecan and foxuridine into low cholesterol-containing liposomes that coordinate drug release in vivo. Biochim Biophys Acta, 1768, 678-687.
    • (2007) Biochim Biophys Acta , vol.1768 , pp. 678-687
    • Tardi, P.G.1    Gallagher, R.C.2    Johnstone, S.3    Harasym, N.4    Webb, M.5    Bally, M.B.6    Mayer, L.D.7
  • 193
    • 80054727258 scopus 로고    scopus 로고
    • Dextran-coated iron oxide nanoparticles: A versatile platform for targeted molecular imaging, molecular diagnostics, and therapy
    • Tassa C, Shaw SY, Weissleder R. (2011). Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy. Acc Chem Res, 44, 842-852.
    • (2011) Acc Chem Res , vol.44 , pp. 842-852
    • Tassa, C.1    Shaw, S.Y.2    Weissleder, R.3
  • 194
    • 84870236985 scopus 로고    scopus 로고
    • Anticancer nanomedicine and tumor vascular permeability; Where is the missing link?
    • DOI: 10.1016/j.jconrel.2012.07.013
    • Taurin S, Nehof H, Greish K. (2012). Anticancer nanomedicine and tumor vascular permeability; Where is the missing link? J Control Release, DOI: 10.1016/j.jconrel.2012.07.013.
    • (2012) J Control Release
    • Taurin, S.1    Nehof, H.2    Greish, K.3
  • 195
    • 76349104842 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer A549 cells
    • Teng Y, Wang X, Wang Y, Ma D. (2010). Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer A549 cells. Biochem Biophys Res Commun, 392, 373-379.
    • (2010) Biochem Biophys Res Commun , vol.392 , pp. 373-379
    • Teng, Y.1    Wang, X.2    Wang, Y.3    Ma, D.4
  • 198
    • 0019430432 scopus 로고
    • Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil
    • Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y. (1981). Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res, 41, 1967-1972.
    • (1981) Cancer Res , vol.41 , pp. 1967-1972
    • Tsuruo, T.1    Iida, H.2    Tsukagoshi, S.3    Sakurai, Y.4
  • 199
    • 0037458920 scopus 로고    scopus 로고
    • HPMA copolymers with pH-controlled release of doxorubicin: In vitro cytotoxicity and in vivo antitumor activity
    • Ulbrich K, Etrych T, Chytil P, Jelínková M, Ríhová B. (2003). HPMA copolymers with pH-controlled release of doxorubicin: in vitro cytotoxicity and in vivo antitumor activity. J Control Release, 87, 33-47.
    • (2003) J Control Release , vol.87 , pp. 33-47
    • Ulbrich, K.1    Etrych, T.2    Chytil, P.3    Jelínková, M.4    Ríhová, B.5
  • 200
    • 75749144204 scopus 로고    scopus 로고
    • Structural and chemical aspects of HPMA copolymers as drug carriers
    • Ulbrich K, Šubr V. (2010). Structural and chemical aspects of HPMA copolymers as drug carriers. Adv Drug Deliv Rev, 62, 150-166.
    • (2010) Adv Drug Deliv Rev , vol.62 , pp. 150-166
    • Ulbrich, K.1    Šubr, V.2
  • 201
    • 79957794004 scopus 로고    scopus 로고
    • Cancer cell invasion: Treatment and monitoring opportunities in nanomedicine
    • Veiseh O, Kievit FM, Ellenbogen RG, Zhang M. (2011). Cancer cell invasion: treatment and monitoring opportunities in nanomedicine. Adv Drug Deliv Rev, 63, 582-596.
    • (2011) Adv Drug Deliv Rev , vol.63 , pp. 582-596
    • Veiseh, O.1    Kievit, F.M.2    Ellenbogen, R.G.3    Zhang, M.4
  • 205
    • 84859450097 scopus 로고    scopus 로고
    • Cancer stem cells and drug resistance: The potential of nanomedicine
    • Vinogradov S, Wei X. (2012). Cancer stem cells and drug resistance: the potential of nanomedicine. Nanomedicine (Lond), 7, 597-615.
    • (2012) Nanomedicine (Lond) , vol.7 , pp. 597-615
    • Vinogradov, S.1    Wei, X.2
  • 207
    • 0037268220 scopus 로고    scopus 로고
    • Paclitaxel at ultra low concentrations inhibits angiogenesis without afecting cellular microtubule assembly
    • Wang J, Lou P, Lesniewski R, Henkin J. (2003). Paclitaxel at ultra low concentrations inhibits angiogenesis without afecting cellular microtubule assembly. Anticancer Drugs, 14, 13-19.
    • (2003) Anticancer Drugs , vol.14 , pp. 13-19
    • Wang, J.1    Lou, P.2    Lesniewski, R.3    Henkin, J.4
  • 209
    • 77957682470 scopus 로고    scopus 로고
    • Current views on the function of the lymphatic vasculature in health and disease
    • Wang Y, Oliver G. (2010). Current views on the function of the lymphatic vasculature in health and disease. Genes Dev, 24, 2115-2126.
    • (2010) Genes Dev , vol.24 , pp. 2115-2126
    • Wang, Y.1    Oliver, G.2
  • 210
    • 65549141305 scopus 로고    scopus 로고
    • Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway
    • Wang Z, Li Y, Kong D, Banerjee S, Ahmad A, Azmi AS, Ali S, Abbruzzese JL, Gallick GE, Sarkar FH. (2009). Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res, 69, 2400-2407.
    • (2009) Cancer Res , vol.69 , pp. 2400-2407
    • Wang, Z.1    Li, Y.2    Kong, D.3    Banerjee, S.4    Ahmad, A.5    Azmi, A.S.6    Ali, S.7    Abbruzzese, J.L.8    Gallick, G.E.9    Sarkar, F.H.10
  • 211
    • 79952771880 scopus 로고    scopus 로고
    • Revisiting the concept of cancer stem cells in prostate cancer
    • Wang ZA, Shen MM. (2011). Revisiting the concept of cancer stem cells in prostate cancer. Oncogene, 30, 1261-1271.
    • (2011) Oncogene , vol.30 , pp. 1261-1271
    • Wang, Z.A.1    Shen, M.M.2
  • 214
    • 34547569807 scopus 로고    scopus 로고
    • Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
    • Wolf K, Wu YI, Liu Y, Geiger J, Tam E, Overall C, Stack MS, Friedl P. (2007). Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nat Cell Biol, 9, 893-904.
    • (2007) Nat Cell Biol , vol.9 , pp. 893-904
    • Wolf, K.1    Wu, Y.I.2    Liu, Y.3    Geiger, J.4    Tam, E.5    Overall, C.6    Stack, M.S.7    Friedl, P.8
  • 215
    • 0031964923 scopus 로고    scopus 로고
    • Modulation of enhanced vascular permeability in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger
    • Wu J, Akaike T, Maeda H. (1998). Modulation of enhanced vascular permeability in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger. Cancer Res, 58, 159-165.
    • (1998) Cancer Res , vol.58 , pp. 159-165
    • Wu, J.1    Akaike, T.2    Maeda, H.3
  • 216
    • 76649140507 scopus 로고    scopus 로고
    • Drug-free macromolecular therapeutics: Induction of apoptosis by coiled-coil-mediated cross-linking of antigens on the cell surface
    • Wu K, Liu J, Johnson RN, Yang J, Kopecek J. (2010). Drug-free macromolecular therapeutics: induction of apoptosis by coiled-coil-mediated cross-linking of antigens on the cell surface. Angew Chem Int Ed Engl, 49, 1451-1455.
    • (2010) Angew Chem Int Ed Engl , vol.49 , pp. 1451-1455
    • Wu, K.1    Liu, J.2    Johnson, R.N.3    Yang, J.4    Kopecek, J.5
  • 217
    • 84855852603 scopus 로고    scopus 로고
    • Coiled-coil based drug-free macromolecular therapeutics: In vivo efcacy
    • Wu K, Yang J, Liu J, Kopecek J. (2012). Coiled-coil based drug-free macromolecular therapeutics: In vivo efcacy. J Control Release, 157, 126-131.
    • (2012) J Control Release , vol.157 , pp. 126-131
    • Wu, K.1    Yang, J.2    Liu, J.3    Kopecek, J.4
  • 218
    • 84855858432 scopus 로고    scopus 로고
    • LyP-1-conjugated PEGylated liposomes: A carrier system for targeted therapy of lymphatic metastatic tumor
    • Yan Z, Wang F, Wen Z, Zhan C, Feng L, Liu Y, Wei X, Xie C, Lu W. (2012). LyP-1-conjugated PEGylated liposomes: A carrier system for targeted therapy of lymphatic metastatic tumor. J Control Release, 157, 118-125.
    • (2012) J Control Release , vol.157 , pp. 118-125
    • Yan, Z.1    Wang, F.2    Wen, Z.3    Zhan, C.4    Feng, L.5    Liu, Y.6    Wei, X.7    Xie, C.8    Lu, W.9
  • 219
    • 80053230454 scopus 로고    scopus 로고
    • LyP-1-conjugated doxorubicin-loaded liposomes suppress lymphatic metastasis by inhibiting lymph node metastases and destroying tumor lymphatics
    • Yan Z, Zhan C, Wen Z, Feng L, Wang F, Liu Y, Yang X, Dong Q, Liu M, Lu W. (2011). LyP-1-conjugated doxorubicin-loaded liposomes suppress lymphatic metastasis by inhibiting lymph node metastases and destroying tumor lymphatics. Nanotechnology, 22, 415103.
    • (2011) Nanotechnology , vol.22 , pp. 415103
    • Yan, Z.1    Zhan, C.2    Wen, Z.3    Feng, L.4    Wang, F.5    Liu, Y.6    Yang, X.7    Dong, Q.8    Liu, M.9    Lu, W.10
  • 220
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • Yang J, Weinberg RA. (2008). Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell, 14, 818-829.
    • (2008) Dev Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 221
    • 79551684989 scopus 로고    scopus 로고
    • Synthesis of biodegradable multiblock copolymers by click coupling of RAFT-generated heterotelechelicpolyHPMA conjugates
    • Yang J, Luo K, Pan H, Kopecková P, Kopecek J. (2011). Synthesis of Biodegradable Multiblock Copolymers by Click Coupling of RAFT-Generated HeterotelechelicPolyHPMA Conjugates. React Funct Polym, 71, 294-302.
    • (2011) React Funct Polym , vol.71 , pp. 294-302
    • Yang, J.1    Luo, K.2    Pan, H.3    Kopecková, P.4    Kopecek, J.5
  • 222
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    • Yilmaz OH, Valdez R, Teisen BK, Guo W, Ferguson DO, Wu H, Morrison SJ. (2006). Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature, 441, 475-482.
    • (2006) Nature , vol.441 , pp. 475-482
    • Yilmaz, O.H.1    Valdez, R.2    Teisen, B.K.3    Guo, W.4    Ferguson, D.O.5    Wu, H.6    Morrison, S.J.7
  • 223
  • 224
    • 0028025011 scopus 로고
    • Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows
    • Yuan F, Salehi HA, Boucher Y, Vasthare US, Tuma RF, Jain RK. (1994). Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. Cancer Res, 54, 4564-4568.
    • (1994) Cancer Res , vol.54 , pp. 4564-4568
    • Yuan, F.1    Salehi, H.A.2    Boucher, Y.3    Vasthare, U.S.4    Tuma, R.F.5    Jain, R.K.6
  • 227
    • 83555176260 scopus 로고    scopus 로고
    • Selective inhibitory efect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells
    • Zhou Y, Yang J, Kopecek J. (2012). Selective inhibitory efect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cells. Biomaterials, 33, 1863-1872.
    • (2012) Biomaterials , vol.33 , pp. 1863-1872
    • Zhou, Y.1    Yang, J.2    Kopecek, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.