HPMA copolymer-bound doxorubicin induces apoptosis in ovarian carcinoma cells by the disruption of mitochondrial function

Molecular Pharmaceutics

Volumn 3, Issue 3, 2006, Pages 351-361

  Malugin, Alexander ^a   Kopečková, Pavla ^a,b   Kopeček, Jindřich ^a,b  

^a UNIVERSITY OF UTAH   (United States)

^b Department of Electrical and Computer Engineering   (United States)

Author keywords

Anticancer agents; Apoptosis; Cell culture; Doxorubicin; HPMA copolymer; Macromolecular therapeutics; Mitochondria

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE; CYTOCHROME C; DOXORUBICIN; MITOCHONDRIAL PROTEIN; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL;

APOPTOSIS; ARTICLE; CANCER CELL; CELL SURVIVAL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; DNA DAMAGE; DOSE RESPONSE; DRUG BINDING; DRUG CONJUGATION; DRUG EXPOSURE; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPECTROFLUOROMETRY;

ACRYLAMIDES; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DOXORUBICIN; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MEMBRANE POTENTIALS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; OVARIAN NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION;

EID: 33745782940     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp050065e     Document Type: Article

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