Delivery of molecular and cellular medicine to solid tumors

Journal of Controlled Release

Volumn 53, Issue 1-3, 1998, Pages 49-67

  Jain, Rakesh K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Angiogenesis; Blood flow; Cancer detection and treatment; Cell adhesion and deformation; Diffusion and convection; Interstitial pressure; Lymphatics; Receptor ligand binding; Tumor microcirculation; Vascular permeability

Indexed keywords

ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY;

ANGIOGENESIS; BLOOD VESSEL PERMEABILITY; CANCER CELL; CANCER CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER IMMUNOTHERAPY; CELL ADHESION; CONFERENCE PAPER; DIFFUSION; DRUG DELIVERY SYSTEM; DRUG TRANSPORT; GENE THERAPY; HUMAN; INTERSTITIUM; NONHUMAN; PRIORITY JOURNAL; SOLID TUMOR; TUMOR BLOOD FLOW;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT; BLOOD VESSELS; HUMANS; LYMPHATIC SYSTEM; MODELS, BIOLOGICAL; NEOPLASMS;

EID: 0032580493     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(97)00237-X     Document Type: Conference Paper

References (151)

1. Beardsley T. Trends in cancer epidemiology: A war not won. Sci. Am. 270:1994;118-126.
2. Jain R.K. Barriers to drug delivery in solid tumors. Sci. Am. 271:1994;58-65.
3. Jain R.K. Transport phenomena in tumors. Adv. Chem. Eng. 20:1994;129-200.
4. Sevick E.M., Jain R.K. Blood flow and venous pH of tissue-isolated Walker 256 carcinoma during hyperglycemia. Cancer Res. 48:1988;1201-1207.
5. Sevick E.M., Jain R.K. Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure. Cancer Res. 49:1989;3506-3512.
6. P.M. Gullino, Techniques in tumor pathophysiology, in: H. Busch (Ed.), Methods in Cancer Research, Academic Press, New York, 1970, pp. 45-92.
7. Kristjansen P.E., Roberge S., Lee I., Jain R.K. Tissue-isolated human tumor xenografts in athymic nude mice. Microvasc. Res. 48:1994;389-402.
8. Kristjansen P.E.G., Brown T.J., Shipley L.A., Jain R.K. Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer. Clin. Cancer Res. 2:1996;359-367.
9. Less J.R., Posner M.C., Skalak T., Wolmark N., Jain R.K. Geometric resistance to blood flow and vascular network architecture in human colorectal carcinoma. Microcirculation. 4:1997;25-33.
10. Dudar T.E., Jain R.K. Microcirculatory flow changes during tissue growth. Microvasc. Res. 25:1983;1-21.
11. Zawicki D.F., Jain R.K., Schmid-Schoenbein G.W., Chien S. Dynamics of neovascularization in normal tissue. Microvasc. Res. 21:1981;27-47.
12. Leunig M., Yuan F., Berk D.A., Gerweck L.E., Jain R.K. Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice. Lab. Invest. 71:1994;300-307.
13. Leunig M., Yuan F., Menger M.D., Boucher Y., Goetz A.E., Messmer K., Jain R.K. Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Res. 52:1992;6553-6560.
14. Yuan F., Salehi H.A., Boucher Y., Vasthare U.S., Tuma R.F., Jain R.K. Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. Cancer Res. 54:1994;4564-4568.
15. Yamada S., Mayadas T., Yuan F., Wagner D., Hynes R., Melder R., Jain R.K. Rolling in P-selectin deficient mice is reduced but not eliminated in the dorsal skin. Blood. 86:1995;3487-3492.
16. D.S. Milstone, D. Fukumura, R.C. Padget, P.E. O'Donnell, V.M. Davis, O.J. Benavidez, R.J. Melder, R.K. Jain, M.A. Gimbrone, Mice lacking E-selectin show normal rolling but reduced arrest of leukocytes on cytokine-activated microvascular endothelium, Microcirculation (1998) in press.
17. Dellian M., Witwer B.P., Salehi H.A., Yuan F., Jain R.K. Quantitation and physiological characterization of bFGF and VEGF/VPF induced vessels in mice: Effect of microenvironment on angiogenesis. Am. J. Pathol. 149:1996;59-72.
18. Lichtenbeld H.C., Yuan F., Michel C.C., Jain R.K. Perfusion of single tumor microvessels: Application to vascular permeability measurement. Microcirculation. 3:1996;349-357.
19. Melder R.J., Brownell A.L., Shoup T.M., Brownell G.L., Jain R.K. Imaging of activated natural killer cells in mice by positron emission tomography: preferential uptake in tumors. Cancer Res. 53:1993;5867-5871.
20. Munn L.L., Melder R.J., Jain R.K. Analysis of cell flux in the parallel plate flow chamber: implications for cell capture studies. Biophys. J. 67:1994;889-895.
21. Sasaki A., Jain R.K., Maghazachi A.A., Goldfarb R.H., Herberman R.B. Low deformability of lymphokine-activated killer cells as a possible determinant of in vivo distribution. Cancer Res. 49:1989;3742-3746.
22. Traykov T.T., Jain R.K. Effect of glucose and galactose on red blood cell membrane deformability. Int. J. Microcirc.: Clin. Exp. 6:1987;35-44.
23. Munn L., Koenig G.C., Jain R.K., Melder R. Kinetics of adhesion molecule expression and spatial organization using targeted sampling fluorometry. Biotechniques. 19:1995;622-631.
24. Baxter L.T., Jain R.K. Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection. Microvasc. Res. 37:1989;77-104.
25. Baxter L.T., Jain R.K. Transport of fluid and macromolecules in tumors. II. Role of heterogeneous perfusion and lymphatics. Microvasc. Res. 40:1990;246-263.
26. Baxter L.T., Jain R.K. Transport of fluid and macromolecules in tumors. III. Role of binding and metabolism. Microvasc. Res. 41:1991;5-23.
27. Baxter L.T., Jain R.K. Transport of fluid and macromolecules in tumors. IV. A microscopic model of the perivascular distribution. Microvasc. Res. 41:1991;252-272.
28. Baxter L.T., Zhu H., Mackensen D.G., Butler W.F., Jain R.K. Biodistribution of monoclonal antibodies: Scale-up from mouse to man using a physiologically based pharmacokinetic model. Cancer Res. 55:1995;4611-4622.
29. Baxter L.T., Zhu H., Mackensen D.G., Jain R.K. Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice. Cancer Res. 54:1994;1517-1528.
30. Eskey C.J., Wolmark N., McDowell C.L., Domach M.M., Jain R.K. Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurement. J. Natl. Canc. Inst. 86:1994;293-299.
31. Jain R.K., Baxter L.T. Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure. Cancer Res. 48:1988;7022-7032.
32. Jain R.K., Wei J. Dynamics of drug transport in solid tumors: Distributed parameter model. J. Bioeng. 1:1977;313-329.
33. Jain R.K., Wei J., Gullino P.M. Pharmacokinetics of methotrexate in solid tumors. J. Pharmacokin. Biopharm. 7:1979;181-194.
34. Netti P.A., Roberge S., Boucher Y., Baxter L.T., Jain R.K. Effect of transvascular fluid exchange on arterio-venous pressure relationship: Implication for temporal and spatial heterogeneities in tumor blood flow. Microvasc. Res. 52:1996;27-46.
35. Netti P.A., Baxter L.T., Boucher Y., Skalak R., Jain R.K. Time dependent behavior of interstitial pressure in solid tumors: Implications for drug delivery. Cancer Res. 55:1995;5451-5458.
36. Pierson R.N., Price D.C., Wang J., Jain R.K. Extracellular water measurements: Organ tracer kinetics of bromide and sucrose in rats and man. Am. J. Physiol. 235:1978;254-264.
37. Yuan F., Baxter L.T., Jain R.K. Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies. Cancer Res. 51:1991;3119-3130.
38. J. Folkman, Tumor angiogenesis, in: P.M. Mendelsohn, M.A.P. Howley, L.A. Liotta (Eds.), The Molecular Basis of Cancer, W.B. Saunders, Philadephia, 1995, pp. 206-232.
39. Jain R.K. Determinants of tumor blood flow: a review. Cancer Res. 48:1988;2641-2658.
40. Baish J.W., Gazit Y., Berk D.A., Nozue M., Baxter L.T., Jain R.K. A novel approach to examine the role of vascular heterogeneity in nutrient and drug delivery for tumors: An invasion percolation model. Microvasc. Res. 51:1996;327-346.
41. Gazit Y., Berk D.A., Leunig M., Baxter L.T., Jain R.K. Scale-invariant behavior and vascular network formation in normal and tumor tissue. Phys. Rev. Lett. 75:1995;2428-2431.
42. Less J.R., Skalak T.C., Sevick E.M., Jain R.K. Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions. Cancer Res. 51:1991;265-273.
43. Patan S., Munn L., Jain R.K. Intussusceptive microvascular growth in solid tumors: A novel mechanism of tumor angiogenesis. Microvasc. Res. 51:1996;260-272.
44. Jain R.K., Ward-Hartley K.A. Tumor blood flow: Characterization, modifications and role in hyperthermia. IEEE Trans. Sonics and Ultrasonics. 31:1984;504-526.
45. Sevick E.M., Jain R.K. Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity. Cancer Res. 49:1989;3513-3519.
46. Sevick E.M., Jain R.K. Effect of red blood cell rigidity on tumor blood flow: increase in viscous resistance during hyperglycemia. Cancer Res. 51:1991;2727-2730.
47. Endrich B., Reinhold H.S., Gross J.F., Intaglietta M. Tissue perfusion inhomogeneity during early tumor growth in rats. J. Natl. Cancer Inst. 62:1979;387-395.
48. 2H Nuclear magnetic resonance imaging of tumor blood flow: spatial and temporal heterogeneity in a tissue-isolated mammary adenocarcinoma. Cancer Res. 52:1992;6010-6019.
49. Hamberg L.M., Kristjansen P.E., Hunter G.J., Wolf G.L., Jain R.K. Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution. Cancer Res. 54:1994;6032-6036.
50. P. Vaupel, R.K. Jain, Tumor Blood Supply and Metabolic Microenvironment: Characterization and Therapeutic Implications, Gustav Fischer Publications, Stuttgart, 1991.
51. Dellian M., Helmlinger G., Yuan F., Jain R.K. Fluorescence ratio imaging and optical sectioning: Effect of glucose on spatial and temporal gradients. Br. J. Cancer. 74:1996;1206-1215.
52. 2 gradients in solid tumors in vivo: Simultaneous high-resolution measurements reveal a lack of correlation. Nature Med. 3:1997;177-182.
53. Martin G.R., Jain R.K. Fluorescence ratio imaging measurement of pH gradients: calibration and application in normal and tumor tissues. Microvasc. Res. 46:1993;216-230.
54. Martin G.R., Jain R.K. Noninvasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy. Cancer Res. 54:1994;5670-5674.
55. Torres-Filho I.P., Leunig M., Yuan F., Intaglietta M., Jain R.K. Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice. Proc. Natl. Acad. Sci. USA. 91:1994;2081-2085.
56. Jain R.K., Shah S.A., Finney P.L. Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia. J. Natl. Canc. Inst. 73:1984;429-436.
57. Nozue M., Lee I., Manning J.M., Manning L.R., Jain R.K. Oxygenation in tumors by modified hemoglobins. J. Surg. Oncol. 62:1996;109-114.
58. Ward K.A., Jain R.K. Response of tumours to hyperglycaemia: characterization, significance and role in hyperthermia. Int. J. Hyperthermia. 4:1988;223-250.
59. 31P NMR. Proc. Natl. Acad. Sci. USA. 90:1993;2646-2650.
60. Jain R.K. Transport of molecules across tumor vasculature. Cancer Metastasis Rev. 6:1987;559-593.
61. Dvorak H.F., Brown L.F., Detmar M., Dvorak A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 146:1995;1029-1039.
62. Gerlowski L.E., Jain R.K. Microvascular permeability of normal and neoplastic tissues. Microvasc. Res. 31:1986;288-305.
63. Sevick E.M., Jain R.K. Measurement of capillary filtration coefficient in a solid tumor. Cancer Res. 51:1991;1352-1355.
64. Yuan F., Leunig M., Berk D.A., Jain R.K. Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice. Microvasc. Res. 45:1993;269-289.
65. Yuan F., Leunig M., Huang S.K., Berk D.A., Papahadjopoulos D., Jain R.K. Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. Cancer Res. 54:1994;3352-3356.
66. Yuan F., Dellian M., Fukumura D., Leunig M., Berk D.A., Torchiliin V.P., Jain R.K. Vascular permeability in a human tumor xenograft: Molecular size-dependence and cut off size. Cancer Res. 55:1995;3752-3756.
67. Dellian M., Yuan F., Trubetskoy V., Torchilin V.P., Jain R.K. Dependence of microvascular permeability on molecular charge in a human tumor xenograft. Int. J. Microcirc.: Clin. Exp. 16(Supp. 1):1996;152.
68. Hobbs S.K., Yuan F., Cima L.G., Jain R.K. Tumor microvascular pore cutoff size: Implications for macromolecules and particle drug delivery. Int. J. Microcirc.: Clin. Exp. 16(1):1996;218.
69. Roberts W.G., Palade G. Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Res. 57:1997;1207-1211.
70. Yuan F., Chen Y., Dellian M., Safabakhsh N., Ferrara N., Jain R.K. Time-dependent changes in vascular permeability and morphology in established human tumor xenografts induced by an anti-VEGF/VPF antibody. Proc. Natl. Acad. Sci. 93:1996;14765-14770.
71. E. Arbit, J. Lee, G. DiResta, Interstitial hypertension in human brain tumors: possible role in peritumoral edema formulation, in: H. Nagai, K. Kamiya, S. Ishi (Eds.), Intracranial Pressure, Springer-Verlag, Tokyo, 1994, pp. 609-614.
72. Boucher Y., Baxter L.T., Jain R.K. Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy. Cancer Res. 50:1990;4478-4484.
73. Boucher Y., Jain R.K. Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse. Cancer Res. 52:1992;5110-5114.
74. 2 in tumors. Microvasc. Res. 50:1995;175-182.
75. Boucher Y., Kirkwood J.M., Opacic D., Desantis M., Jain R.K. Interstitial hypertension in superficial metastatic melanomas in humans. Cancer Res. 51:1991;6691-6694.
76. Boucher Y., Salehi H., Witwer B., Harsh G.R., Jain R.K. Interstitial fluid pressure in intracranial tumors in patients and in rodents: Effect of antiedema therapy. Br. J. Cancer. 75:1997;829-836.
77. Curti B.D., Urba W.J., Alvord W.G., Janik J.E., Smith J.W., Madara K., Longo D.L. Interstitial Pressure of subcutaneous nodules in melanoma and lymphoma patients: Changes during treatment. Cancer Res. 53:1993;2204-2207s.
78. Gutmann R., Leunig M., Feyh J., Goetz A.E., Messmer K., Kastenbauer E., Jain R.K. Interstitial hypertension in head and neck tumors in patients: correlation with tumor size. Cancer Res. 52:1992;1993-1995.
79. Jain R.K. Transport of molecules in the tumor interstitium: A review. Cancer Res. 47:1987;3039-3051.
80. Less J.R., Posner M.C., Boucher Y., Borochovitz D., Wolmark N., Jain R.K. Interstitial hypertension in human breast and colorectal tumors. Cancer Res. 52:1992;6371-6374.
81. Nathanson S.D., Nelson L. Interstitial fluid pressure in breast cancer, benign breast conditions, and breast parenchyma. Ann. Surg. Oncol. 1:1994;333-338.
82. Roh H.D., Boucher Y., Kalnicki S., Buchsbaum R., Bloomer W.D., Jain R.K. Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response. Cancer Res. 51:1991;6695-6698.
83. C.A. Znati, K. Karasek, C. Faul, H.-D. Roh, Y. Boucher, M. Rosenstein, S. Kalnicki, R. Buchsbaum, A. Chen, W.D. Bloomer, R.K. Jain, Interstitial fluid pressure changes in cervical carcinomas in patients undergoing radiation therapy: A potential prognostic factor, submitted (1997).
84. Znati C.A., Rosenstein M., Boucher Y., Epperly M.W., Bloomer W.D., Jain R.K. Effect of radiation on interstitial fluid pressure and oxygenation in a human colon carcinoma xenograft. Cancer Res. 56:1996;964-968.
85. M. Stohrer, Y. Boucher, M. Stangassinger, R.K. Jain, Oncotic pressure in human tumor xenografts, Proc. AACR, 1995.
86. Rippe B., Haraldsson B. Fluid and protein fluxes across small and large pores in the microvasculature: Application of two-pore equations. Acta Physiol. Scand. 131:1987;411.
87. Berk D.A., Yuan F., Leunig M., Jain R.K. Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media. Biophys. J. 65:1993;2428-2436.
88. Chary S.R., Jain R.K. Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching. Proc. Natl. Acad. Sci. USA. 86:1989;5385-5389.
89. Johnson E.M., Berk D.A., Jain R.K., Deen W.M. Diffusion and partitioning of proteins in charged agarose gels. Biophys. J. 68:1995;1561-1568.
90. Johnson E.M., Berk D.A., Jain R.K., Deen W.M. Hindered diffusion in agarose gels: Test of effective medium model. Biophys. J. 70:1996;1017-1026.
91. Johnson M.E., Berk D.A., Blankschtein D., Golan D.E., Jain R.K., Langer R. Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems. Biophys. J. 71:1996;2656-2668.
92. Nugent L.J., Jain R.K. Extravascular diffusion in normal and neoplastic tissues. Cancer Res. 44:1984;238-244.
93. Swabb E.A., Wei J., Gullino P.M. Diffusion and convection in normal and neoplastic tissues. Cancer Res. 34:1974;2814.
94. Berk D.A., Yuan F., Leunig M., Jain R.K. Direct in vivo measurement of targeted binding in a human tumor xenograft. Proceedings of the National Academy of Sciences. 94:1997;1785-1790.
95. Y. Boucher, C. Brekken, P.A. Netti, L.T. Baxter, R.K. Jain, Hydraulic conductivity of solid tumors: A novel in vivo measurement technique and implications for drug delivery, Br. J. Cancer (1998) in press.
96. C.A. Znati, Y. Boucher, M. Rosenstein, D. Turner, S. Watkins, R.K. Jain, Effect of radiation on the interstitial matrix and hydraulic conductivity of tumors, submitted, (1997).
97. Juweid M., Neumann R., Paik C., Perez-Bacete M.J., Sato J., Van Osdol W., Weinstein J.N. Micropharmacology of monoclonal antibodies in solid tumor: Direct experimental evidence for a binding site barrier. Cancer Res. 52:1992;5144.
98. Kaufman E.N., Jain R.K. Quantification of transport and binding parameters using fluorescence recovery after photobleaching: Potential for in vivo applications. Biophys. J. 58:1990;873-885.
99. Kaufman E.N., Jain R.K. Measurement of mass transport and reaction parameters in bulk solution using photobleaching: Reaction limited binding regime. Biophys. J. 60:1991;596-610.
100. Kaufman E.N., Jain R.K. Effect of bivalent interaction upon apparent antibody affinity: experimental confirmation of theory using fluorescence photobleaching and implications for antibody binding assays. Cancer Res. 52:1992;4157-4167.
101. Kaufman E.N., Jain R.K. In vitro measurement and screening of monoclonal antibody affinity using fluorescence photobleaching. J. Immunol. Methods. 155:1992;1-17.
102. Jain R.K. Delivery of novel therapeutic agents in tumors: Physiological barriers and strategies. J. Natl. Canc. Inst. 81:1989;570-576.
103. Leu A.J., Berk D.A., Yuan F., Jain R.K. Flow velocity in the superficial lymphatic network of the mouse tail. Am. J. Physiol. 267:1994;H1507-13.
104. Berk D.A., Swartz M.A., Leu A.J., Jain R.K. Transport in lymphatic capillaries: II. Microscopic velocity measurement with fluorescence recovery after photobleaching. Am. J. Physiol. 270:1996;H330-H337.
105. Swartz M.A., Berk D.A., Jain R.K. Transport in lymphatic capillaries: I. Macroscopic measurements using residence time distribution theory. Am. J. Physiol. 270:1996;H324-H329.
106. A. Leu, D. Berk, R.K. Jain, Search for initial lymphatics in solid tumors, submitted, (1997).
107. Melder R.J., Munn L.L., Yamada S., Ohkubo C., Jain R.K. Selectin and integrin mediated T lymphocyte rolling and arrest on TNFa-activated endothelium is augmented by erythrocytes. Biophys. J. 69:1995;2131-2138.
108. Munn L.L., Melder R.J., Jain R.K. Role of erythrocytes in leukocyte-endothelial interactions: Mathematical model and experimental validation. Biophys. J. 71:1996;466-478.
109. Fukumura D., Salehi H., Witwer B., Tuma R.F., Melder R.J., Jain R.K. TNFα-induced leukocyte-adhesion in normal and tumor vessels: Effect of tumor type, transplantation site and host. Cancer Res. 55:1995;4824-4829.
110. Yamada S., Melder R.J., Leunig M., Ohkubo C., Jain R.K. Leukocyte-rolling increases with age. Blood. 86:1995;4707-4708.
111. Melder R.J., Elmaleh D., Brownell A.L., Brownell G.L., Jain R.K. A method for labeling cells for positron emission tomography (PET) studies. J. Immunol. Methods. 175:1994;79-87.
112. Melder R.J., Jain R.K. Kinetics of interleukin-2 induced changes in rigidity of human natural killer cells. Cell Biophys. 20:1992;161-176.
113. Jain R.K., Koenig G., Dellian M., Fukumura D., Munn L.L., Melder R.J. Leukocyte-endothelial adhesion and angiogenesis in tumors. Cancer Metastasis Rev. 15:1996;195-204.
114. Melder R.J., Jain R.K. Reduction of rigidity in human activated natural killer cells by thioglycollate treatment. J. Immunol. Methods. 175:1994;69-77.
115. Melder R.J., Salehi H.A., Jain R.K. Localization of activated natural killer cells in MCaIV mammary carcinoma grown in cranial windows in C3H mice. Microvasc. Res. 50:1995;35-44.
116. Sasaki A., Melder R.J., Whiteside T.L., Herberman R.B., Jain R.K. Preferential localization of human adherent lymphokine-activated killer cells in tumor microcirculation. J. Natl. Canc. Inst. 83:1991;433-437.
117. Ohkubo C., Bigos D., Jain R.K. Interleukin 2 induced leukocyte adhesion to the normal and tumor microvascular endothelium in vivo and its inhibition by dextran sulfate: implications for vascular leak syndrome. Cancer Res. 51:1991;1561-1563.
118. Melder R.J., Koenig G., Witwer B.P., Safabakhsh N., Munn L.L., Jain R.K. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Nature Med. 2:1996;992-997.
119. Jallal B., Powell F., Zachwieja J., Brakebusch C., Germain L., Jacobs J., Iacobelli S., Ullrich A. Suppression of tumor growth in vivo by local and systemic 90K level increase. Cancer Res. 55:1995;3223-3227.
120. Melder R.J., Koenig G., Munn L.L., Jain R.K. Adhesion of activated natural killer cells to TNF-alpha treated endothelium under physiological flow conditions. Natural Immunity. 15:1997;154-163.
121. Gamble J.R., Vadas M.A. Endothelial adhesiveness for blood neutrophils is inhibited by transforming growth factor-beta. Science. 242:1988;97-99.
122. Gamble J.R., Vadas M.A. Endothelial cell adhesiveness for human T lymphocytes is inhibited by transforming growth factor-beta. J. Immunol. 146:1991;1149-1154.
123. Gamble J.R., Khew-Goodall Y. Transforming growth factor-beta inhibits E-selectin expression on human endothelial cells. J. Immunol. 150:1993;4494-4503.
124. Fidler I.J. Modulation of the organ microenvironment for treatment of cancer metastasis. J. Natl. Canc. Inst. 87:1995;1588-1592.
125. Kitayama J., Nagawa J., Yasuhara H., Tsuno N., Kimura W., Shibata Y., Muto T. Suppressive effect of basic fibroblast growth factor on transendothelial emigration of CD4(+) T-lymphocyte. Cancer Res. 54:1994;4729-4733.
126. Haying J.B., Williams S.K. Reduced adhesion of human microvascular endothelial cells to collagen in response to basic FGF is mediated by β1 integrin. FASEB J. 8:1994;263.
127. Dedrick R.L. Animal scale-up. J. Pharmacokin. Biopharm. 1:1973;435-461.
128. Gerlowski L.E., Jain R.K. Physiologically based pharmacokinetic modeling: principles and applications. J. Pharmaceut. Sci. 72:1983;1103-1127.
129. Zhu H., Melder R., Baxter L., Jain R.K. Physiologically based kinetic model of effector cell biodistribution in mammals: Implications for adoptive immunotherapy. Cancer Res. 56:1996;3771-3781.
130. Zhu H., Baxter L., Jain R.K. Potential and limitations of radioimmunodetection and radioimmunotherapy with monoclonal antibodies: Evaluation using a physiologically-based pharmacokinetic model. J. Nucl. Med. 38:1997;731-741.
131. Zhu H., Jain R.K., Baxter L.T. Tumor pretargeting for radioimmunodetection and radioimmunotherapy: Evaluation using a physiologically-based pharmacokinetic model. J. Nucl. Med. 39:1997;65-76.
132. Jain R.K. Effect of inhomogeneities and finite boundaries on temperature distribution in a perfused medium with application to tumors. Trans. ASME J. Biomech. Eng. 100:1978;235-241.
133. Jain R.K. Transient temperature distributions in an infinite perfused medium due to a time-dependent, spherical heat source. Trans. ASME J. Biomech. Eng. 101:1979;82-86.
134. R.K. Jain, Y. Boucher, A. Stacey-Clear, R. Moore, D. Kopans, Method for locating tumors prior to needle biopsy, US Patent Number 5 396 897, March 14, 1995.
135. Boucher Y., Leunig M., Jain R.K. Tumor angiogenesis and interstitial hypertension. Cancer Res. 56:1996;4264-4266.
136. Dudar T.E., Jain R.K. Differential response of normal and tumor microcirculation to hyperthermia. Cancer Res. 44:1984;605-612.
137. Fukumura D., Yuan F., Endo M., Jain R.K. Role of nitric oxide in tumor microcirculation: Blood flow, vascular permeability, and leukocyte-endothelial interactions. Am. J. Pathol. 150:1997;713-725.
138. Gerlowski L.E., Jain R.K. Effect of hyperthermia on microvascular permeability to macromolecules in normal and tumor tissues. Int. J. Microcirc.: Clin. Exp. 4:1985;363-372.
139. Kristensen C.A., Nozue M., Boucher Y., Jain R.K. Reduction of interstitial fluid pressure after TNF-α treatment of human melanoma xenografts. Br. J. Cancer. 74:1996;533-536.
140. Kristensen C.A., Roberge S., Jain R.K. Effect of tumor necrosis factor-alpha on vascular resistance, nitric oxide production, glucose and oxygen consumption in perfused, tissue-isolated human melanoma xenografts. Clinical Cancer Research. 3:1997;319-324.
141. Baxter L.T., Jain R.K. Pharmacokinetic analysis of the microscopic distribution of enzyme-conjugated antibodies and prodrugs: Comparison with experimental data. Br. J. Cancer. 73:1996;447-456.
142. Baxter L.T., Yuan F., Jain R.K. Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data. Cancer Res. 52:1992;5838-5844.
143. Kristjansen P.E., Boucher Y., Jain R.K. Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft. Cancer Res. 53:1993;4764-4766.
144. Lee I., Boucher Y., Jain R.K. Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications. Cancer Res. 52:1992;3237-3240.
145. Lee I., Boucher Y., Demhartner T.J., Jain R.K. Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline. Br. J. Cancer. 69:1994;492-496.
146. Lee I., Demhartner T.J., Boucher Y., Jain R.K., Intaglietta M. Effect of hemodilution and resuscitation on tumor interstitial fluid pressure, blood flow, and oxygenation. Microvasc. Res. 48:1994;1-12.
147. Leunig M., Goetz A.E., Dellian M., Zetterer G., Gamarra F., Jain R.K., Messmer K. Interstitial fluid pressure in solid tumors following hyperthermia: possible correlation with therapeutic response. Cancer Res. 52:1992;487-490.
148. Leunig M., Goetz A.E., Gamarra F., Zetterer G., Messmer K., Jain R.K. Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster. Br. J. Cancer. 69:1994;101-103.
149. Zlotecki R.A., Baxter L.T., Boucher Y., Jain R.K. Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft: Network analysis and mechanistic interpretation. Microvasc. Res. 50:1995;429-443.
150. Zlotecki R.A., Boucher Y., Lee I., Baxter L.T., Jain R.K. Effect of angiotensin II induced hypertension on tumor blood flow and interstitial fluid pressure. Cancer Res. 53:1993;2466-2468.
151. Jain R.K. Delivery of molecular medicine to solid tumors. Science. 271:1996;1079-1080.