Efficacy of the chemotherapeutic action of HPMA copolymer-bound doxorubicin in a solid tumor model of ovarian carcinoma

International Journal of Cancer

Volumn 86, Issue 1, 2000, Pages 108-117

  Minko, Tamara ^a   Kopečková, Pavla ^a,b   Kopeček, Jindřich ^a,b  

^a UNIVERSITY OF UTAH   (United States)

^b Department of Electrical and Computer Engineering   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXORUBICIN; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MOUSE; OVARY CARCINOMA; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CAPILLARY PERMEABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA FRAGMENTATION; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIPID PEROXIDATION; MICE; MICE, NUDE; NECROSIS; NEOPLASM TRANSPLANTATION; OVARIAN NEOPLASMS; POLYMETHACRYLIC ACIDS; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 0034049291     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(20000401)86:1<108::AID-IJC17>3.0.CO;2-8     Document Type: Article

References (21)

1. DVORAK, H.F., NAGY, J.A., DVORAK, J.T. and DVORAK, A.M., Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. Am. J. Pathol., 133, 95-109 (1988).
2. HEIDEN, M.G.V., CHANDEL, N.S., WILLIAMSON, E.K., SCHUMACKER, P.T. and THOMPSON, C.B., Bel-xl regulates the membrane potential and volume homeoslasis of mitochondria. Cell. 91, 627-637 (1997).
3. KOPEČEK, J., REIMANOVÁ, P., STROHALM, J., ULBRICH, K., ŘÍHOVÁ, B., CHYTRÝ, V., LLOYD, J. B. and DUNCAN, R., Synthetic polymeric drugs, U.S. Pat. 5,037,883 (Aug. 6, 1991).
4. KUIDA, K., HAYDAR, T. F., KUAN, C.-Y., GU, Y., TAYA, C., KARASUYAMA, H., SU, M.S.-S., RAKIC, P. and FLAVELL, R.A., Reduced apoptosis and cytochrome-c - mediated caspase activation in mice lacking caspase 9. Cell, 94, 325-337 (1998).
5. LI, P., NIJHAWAN, D., BUDIHARDJO, I., SRINIVASULA, S.M., AHMAD, M., ALNEMRI, E.S. and WANG, X., Cytochrome-c and dATP-dependent formation of Apaf1/Caspase-9 complex initiates an apoptotic protease cascade. Cell, 91, 479-489 (1997).
6. LIU, X., KIM, C.N., YANG, J., JEMMERSON, R. and WANG, X., Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome-c. Cell, 86, 147-157 (1996).
7. MATSUMURA, Y. and MAEDA, H., A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent SMANCS. Cancer Res., 46, 6387-6392 (1986).
8. MINKO, T., KOPEČKOVÁ, P., POZHAROV, V. and KOPEČEK, J., HPMA copolymer bound adriamycin overcomes MDR1 gene encoded resistance in a human ovarian carcinoma cell line. J. Control. Rel., 54, 223-233 (1998).
9. MINKO, T., KOPEČKOVÁ, P. and KOPEČEK, J., Comparison of the anticancer effect of free and HPMA copolymer-bound adriamycin in human ovarian carcinoma calls. Pharm. Res., 16, 986-996 (1999a).
10. MINKO, T., KOPEČKOVÁ, P. and KOPEČEK, J., Chronic exposure to HPMA copolymer-bound adriamycin does not induce multidrug resistance in a human ovarian carcinoma cell line. J. Control. Rel., 59, 133-148 (1999b).
11. MINYAILENKO (MINKO), T., POZHAROV, V. and SEREDENKO, M., Oxygen supply-consumption ratio as the criterion of tissue hypoxia. Wiss. Zeit. Humboldt-Univ. Berlin, R. Medizin., 40, 97-102 (1991).
12. MINYAILENKO (MINKO), T.D., POZHAROV, V.P. and SEREDENKO, M.M., Severe hypoxia activates lipid peroxidation in the rat brain. Chem. Phys. Lipids, 55, 25-28 (1990).
13. NOGUCHI, Y., WU, J., DUNCAN, R., STROHALM, J., ULBRICH, K., AKAIKE, T. and MAEDA, H., Early phase tumor accumulation of macromolecules: A great difference in clearance rate between tumor and normal tissues. Jpn. J. Cancer Res., 89, 307-314 (1998).
14. OMELYANENKO, V., GENTRY, C., KOPEČKOVÁ, P. and KOPEČEK, J., HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. II. Processing in epithelial ovarian carcinoma cells in vitro. Int. J. Cancer, 75, 600-608 (1998a).
15. OMELYANENKO, V., KOPEČKOVÁ, P., GENTRY, C. and KOPEČEK, J., Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate. J. Contr. Rel., 53, 25-37 (1998b).
16. OMELYANENKO, V.G. KOPEČKOVÁ, P., GENTRY, C., SHIAH, J.-G. and KOPEČEK, J., HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. 1. Influence of the methods of synthesis on the binding affinity to OVCAR-3 ovarian carcinoma cells in vitro. J. Drug Targeting, 3, 357-373 (1996).
17. PUTNAM, D.A. and KOPEČEK. J., Polymer conjugates with anticancer activity. Adv. Polym. Sci., 122, 55-123 (1995).
18. REED, J.C., Cytochrome c: Can't live with it - can't live without it. Cell, 91, 559-562 (1997).
19. ŘÍHOVÁ, B., KOPEČKOVÁ, P., STROHALM, J., ROSSMANN, P., VETVIČKA, V. and KOPEČEK, J., Antibody-directed affinity therapy applied to the immune system: In vivo effectiveness and limited toxicity of daunomycin conjugates to HPMA copolymers and targeting antibody. Clin. Immunol. Immunopathol., 46, 100-114 (1988).
20. ŠT'ASTNÝ, M., STROHALM, J., PLOCOVÁ, D., ULBRICH, K. and ŘÍHOVÁ, B., A possibility to overcome P-glycoprotein (PGP)-mediated multidrug resistance by antibody-targeted drugs conjugated to N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymer carrier. Eur. J. Cancer, 35, 459-466 (1999).
21. VASEY, P.A., ET AL., Phase I clinical and pharmacokinetic study of PK1 [N-(2-Hydroxypropyl)methacrylamide copolymer doxoruhicin]: First member of a new class of chemotherapeutic agents-drug-polymer conjugates. Clin. Cancer Res., 5, 83-94 (1999).