메뉴 건너뛰기




Volumn 69, Issue 6, 2009, Pages 2400-2407

Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway

Author keywords

[No Author keywords available]

Indexed keywords

GEMCITABINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JAGGED1; NOTCH RECEPTOR; NOTCH2 RECEPTOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; VIMENTIN; ANTINEOPLASTIC ANTIMETABOLITE; CALCIUM BINDING PROTEIN; DEOXYCYTIDINE; DRUG DERIVATIVE; MEMBRANE PROTEIN; MESSENGER RNA; NOTCH2 PROTEIN, HUMAN; NOTCH4 PROTEIN, HUMAN; ONCOPROTEIN; SERRATE PROTEINS; SIGNAL PEPTIDE;

EID: 65549141305     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-4312     Document Type: Article
Times cited : (558)

References (39)
  • 2
    • 42549085643 scopus 로고    scopus 로고
    • Stathopoulos GP, Androulakis N, Souglakos J, Stathopoulos j, Georgoulias V. Present treatment and future expectations in advanced pancreatic cancer. Anticancer Res 2008;28:1303-8.
    • Stathopoulos GP, Androulakis N, Souglakos J, Stathopoulos j, Georgoulias V. Present treatment and future expectations in advanced pancreatic cancer. Anticancer Res 2008;28:1303-8.
  • 3
    • 35148825636 scopus 로고    scopus 로고
    • Chemo- resistance to paclitaxel induces epithelial-mesenchy- mal transition and enhances metastatic potential for epithelial ovarian carcinoma cells
    • Kajiyama H, Shibata K, Terauchi M, et al. Chemo- resistance to paclitaxel induces epithelial-mesenchy- mal transition and enhances metastatic potential for epithelial ovarian carcinoma cells. Int j Oncol 2007;31: 277-83.
    • (2007) Int j Oncol , vol.31 , pp. 277-283
    • Kajiyama, H.1    Shibata, K.2    Terauchi, M.3
  • 4
    • 33847327128 scopus 로고    scopus 로고
    • Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines
    • Yang AD, Fan F, Camp ER, et al. Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines. Clin Cancer Res 2006;12: 4147-53.
    • (2006) Clin Cancer Res , vol.12 , pp. 4147-4153
    • Yang, A.D.1    Fan, F.2    Camp, E.R.3
  • 5
    • 28844494352 scopus 로고    scopus 로고
    • Tamoxifen resistance in MCF7 cells promotes EMT4ike behaviour and involves modulation of [V-catenin phosphorylation
    • Hiscox S, Jiang WG, Obermeier K, et al. Tamoxifen resistance in MCF7 cells promotes EMT4ike behaviour and involves modulation of [V-catenin phosphorylation. Int j Cancer 2006;118:290-301.
    • (2006) Int j Cancer , vol.118 , pp. 290-301
    • Hiscox, S.1    Jiang, W.G.2    Obermeier, K.3
  • 6
    • 4344705051 scopus 로고    scopus 로고
    • Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: Inhibition by gefitinib ("Iressa," ZD1839)
    • Hiscox S, Morgan L, Barrow D, Dutkowskil C, Wakeling A, Nicholson RI. Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: inhibition by gefitinib ("Iressa," ZD1839). Clin Exp Metastasis 2004;21:201-12.
    • (2004) Clin Exp Metastasis , vol.21 , pp. 201-212
    • Hiscox, S.1    Morgan, L.2    Barrow, D.3    Dutkowskil, C.4    Wakeling, A.5    Nicholson, R.I.6
  • 7
    • 42349093952 scopus 로고    scopus 로고
    • Cancer stem cells: Implications for the progression and treatment of metastatic disease
    • Croker AK, Allan AL. Cancer stem cells: implications for the progression and treatment of metastatic disease, J Cell Mol Med 2008;12:374-90.
    • (2008) J Cell Mol Med , vol.12 , pp. 374-390
    • Croker, A.K.1    Allan, A.L.2
  • 8
    • 33646916614 scopus 로고    scopus 로고
    • Brain cancer stem-like cells
    • Kondo T. Brain cancer stem-like cells. Eur j Cancer 2006;42:1237-42.
    • (2006) Eur j Cancer , vol.42 , pp. 1237-1242
    • Kondo, T.1
  • 11
    • 34848826864 scopus 로고    scopus 로고
    • Epithelial- mesenchymal and mesenchymal-epithelial transitions in carcinoma progression.)
    • Hugo H, Ackland ML, Blick T, et al. Epithelial- mesenchymal and mesenchymal-epithelial transitions in carcinoma progression.) Cell Physiol 2007;213:374-83.
    • (2007) Cell Physiol , vol.213 , pp. 374-383
    • Hugo, H.1    Ackland, M.L.2    Blick, T.3
  • 12
    • 45149092780 scopus 로고    scopus 로고
    • NF-kB and epithelial to mesenchymal transition of cancer
    • Min C, Eddy SF, Sherr DH, Sonenshein GE. NF-kB and epithelial to mesenchymal transition of cancer, J Cell Biochem 2008;104:733-44.
    • (2008) J Cell Biochem , vol.104 , pp. 733-744
    • Min, C.1    Eddy, S.F.2    Sherr, D.H.3    Sonenshein, G.E.4
  • 13
    • 48649098427 scopus 로고    scopus 로고
    • Platelet-derived growth factor-D overexpression contributes to epitheli- al-mesenchymal transition of PC3 prostate cancer cells
    • Kong D, Wang Z, Sarkar SH, et al. Platelet-derived growth factor-D overexpression contributes to epitheli- al-mesenchymal transition of PC3 prostate cancer cells. Stem Cells 2008;26:1425-35.
    • (2008) Stem Cells , vol.26 , pp. 1425-1435
    • Kong, D.1    Wang, Z.2    Sarkar, S.H.3
  • 14
    • 27844461512 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in development and cancer: Role of phosphatidy- linositol 3′ kinase/AKT pathways
    • Larue L, Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidy- linositol 3′ kinase/AKT pathways. Oncogene 2005;24: 7443-54.
    • (2005) Oncogene , vol.24 , pp. 7443-7454
    • Larue, L.1    Bellacosa, A.2
  • 15
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeh and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • Peinado H, Olmeda D, Cano A, Snail, Zeh and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 2007;7:415-28.
    • (2007) Nat Rev Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 16
    • 47549098328 scopus 로고    scopus 로고
    • Mew insights of epithelial-mesenchymal transition in cancer metastasis
    • Wu Y, Zhou BP. Mew insights of epithelial-mesenchymal transition in cancer metastasis. Acta Biochim Biophys Sin (Shanghai) 2008;40:643-50.
    • (2008) Acta Biochim Biophys Sin (Shanghai) , vol.40 , pp. 643-650
    • Wu, Y.1    Zhou, B.P.2
  • 17
    • 58049200145 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line
    • Rho JK, Choi Yj, Lee JK, et al. Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line. Lung Cancer 2009;63:219-26.
    • (2009) Lung Cancer , vol.63 , pp. 219-226
    • Rho, J.K.1    Choi, Y.2    Lee, J.K.3
  • 18
    • 36349006961 scopus 로고    scopus 로고
    • Shah AN, Summy JM, Zhang j, Park SI, Parikh NU, Gallick GE. Development and characterization of gemcitabine-resistant pancreatic tumor cells. Ann Surg Oncol 2007;14:3629-37.
    • Shah AN, Summy JM, Zhang j, Park SI, Parikh NU, Gallick GE. Development and characterization of gemcitabine-resistant pancreatic tumor cells. Ann Surg Oncol 2007;14:3629-37.
  • 19
    • 33645049305 scopus 로고    scopus 로고
    • Down-regulation of Notch-1 inhibits invasion by inactivation of nuclear factor-κB, vascular endothelial growth factor, and matrix metal loproteinase-9 in pancreatic cancer cells
    • Wang Z, Banerjee S, Li Y, Rahman KM, Zhang Y, Sarkar FH. Down-regulation of Notch-1 inhibits invasion by inactivation of nuclear factor-κB, vascular endothelial growth factor, and matrix metal loproteinase-9 in pancreatic cancer cells. Cancer Res 2006;66: 2778-84.
    • (2006) Cancer Res , vol.66 , pp. 2778-2784
    • Wang, Z.1    Banerjee, S.2    Li, Y.3    Rahman, K.M.4    Zhang, Y.5    Sarkar, F.H.6
  • 20
    • 34548588406 scopus 로고    scopus 로고
    • Down-regulation of Forkhead Box Ml transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cells
    • Wang Z, Banerjee S, Kong D, Li Y, Sarkar FH. Down-regulation of Forkhead Box Ml transcription factor leads to the inhibition of invasion and angiogenesis of pancreatic cancer cells. Cancer Res 2007;67: 8293-300.
    • (2007) Cancer Res , vol.67 , pp. 8293-8300
    • Wang, Z.1    Banerjee, S.2    Kong, D.3    Li, Y.4    Sarkar, F.H.5
  • 21
    • 33748872289 scopus 로고    scopus 로고
    • Down-regulation of Jagged-1 induces cell growth inhibition and S phase arrest in prostate cancer cells
    • Zhang Y, Wang Z, Ahmed F, Banerjee S, Li Y, Sarkar FH. Down-regulation of Jagged-1 induces cell growth inhibition and S phase arrest in prostate cancer cells. Int J Cancer 2006;119:2071-7.
    • (2006) Int J Cancer , vol.119 , pp. 2071-2077
    • Zhang, Y.1    Wang, Z.2    Ahmed, F.3    Banerjee, S.4    Li, Y.5    Sarkar, F.H.6
  • 22
    • 43049103824 scopus 로고    scopus 로고
    • The miK-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    • Gregory PA, Bert AG, Paterson EL, et al. The miK-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008;10:593-601.
    • (2008) Nat Cell Biol , vol.10 , pp. 593-601
    • Gregory, P.A.1    Bert, A.G.2    Paterson, E.L.3
  • 23
    • 13244298117 scopus 로고    scopus 로고
    • Grego-Bessa j, Diez J, Timmerman L, de la Pompa JL. Notch and epithelial-mesenchyme transition in development and tumor progression: another turn of the screw. Cell Cycle 2004;3:718-21.
    • Grego-Bessa j, Diez J, Timmerman L, de la Pompa JL. Notch and epithelial-mesenchyme transition in development and tumor progression: another turn of the screw. Cell Cycle 2004;3:718-21.
  • 24
    • 36549010842 scopus 로고    scopus 로고
    • jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin
    • Leong KG, Niessen K, Kulic I, et al. jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J Exp Med 2007;204:2935-48.
    • (2007) J Exp Med , vol.204 , pp. 2935-2948
    • Leong, K.G.1    Niessen, K.2    Kulic, I.3
  • 25
    • 37549037911 scopus 로고    scopus 로고
    • Off the beaten pathway: The complex cross talk between Notch and NF-κB
    • Osipo C, Golde TE, Osborne BA, Miele LA. Off the beaten pathway: the complex cross talk between Notch and NF-κB. Lab Invest 2008;88:11-7.
    • (2008) Lab Invest , vol.88 , pp. 11-17
    • Osipo, C.1    Golde, T.E.2    Osborne, B.A.3    Miele, L.A.4
  • 26
    • 53949090765 scopus 로고    scopus 로고
    • NF-kB signaling pathway and its therapeutic implications in human diseases
    • Sarkar FH, Li Y, Wang Z, Kong D. NF-kB signaling pathway and its therapeutic implications in human diseases. Int Rev Immunol 2008;27:293-319.
    • (2008) Int Rev Immunol , vol.27 , pp. 293-319
    • Sarkar, F.H.1    Li, Y.2    Wang, Z.3    Kong, D.4
  • 27
    • 10744232549 scopus 로고    scopus 로고
    • Evaluation of urinary plasminogen activator, its receptor, matrix metalloproteinase-9, and von Willebrand factor in pancreatic cancer
    • Harvey SR, Hurd TC, Markus G, et al. Evaluation of urinary plasminogen activator, its receptor, matrix metalloproteinase-9, and von Willebrand factor in pancreatic cancer. Clin Cancer Res 2003;9:4935-43.
    • (2003) Clin Cancer Res , vol.9 , pp. 4935-4943
    • Harvey, S.R.1    Hurd, T.C.2    Markus, G.3
  • 30
    • 33644752839 scopus 로고    scopus 로고
    • Notch signaling
    • Miele L. Notch signaling. Clin Cancer Res 2006;12: 1074-9.
    • (2006) Clin Cancer Res , vol.12 , pp. 1074-1079
    • Miele, L.1
  • 31
    • 33645473185 scopus 로고    scopus 로고
    • Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells
    • Wang Z, Zhang Y, Li Y, Banerjee S, Liao J, Sarkar FH. Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther 2006;5:483-93.
    • (2006) Mol Cancer Ther , vol.5 , pp. 483-493
    • Wang, Z.1    Zhang, Y.2    Li, Y.3    Banerjee, S.4    Liao, J.5    Sarkar, F.H.6
  • 32
    • 48249103470 scopus 로고    scopus 로고
    • Slug is a direct Notch target required for initiation of cardiac cushion cellularization
    • Niessen K, Fu Y, Chang L, Hoodless PA, McFadden D, Karsan A. Slug is a direct Notch target required for initiation of cardiac cushion cellularization. j Cell Biol 2008;182:315-25.
    • (2008) j Cell Biol , vol.182 , pp. 315-325
    • Niessen, K.1    Fu, Y.2    Chang, L.3    Hoodless, P.A.4    McFadden, D.5    Karsan, A.6
  • 33
    • 2342471446 scopus 로고    scopus 로고
    • Notch-1 regulates cell death independently of differentiation in murine erythroleukemia cells through multiple apoptosis and cell cycle pathways
    • Jang MS, Miao H, Carlesso N, et al. Notch-1 regulates cell death independently of differentiation in murine erythroleukemia cells through multiple apoptosis and cell cycle pathways. J Cell Physiol 2004;199:418-33.
    • (2004) J Cell Physiol , vol.199 , pp. 418-433
    • Jang, M.S.1    Miao, H.2    Carlesso, N.3
  • 34
    • 0036024023 scopus 로고    scopus 로고
    • Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinoeytes through NF-kB and PPAR7
    • Nickoloff Bj, Qin JZ, Chaturvedi V, Denning MF, Bonish B, Miele L. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinoeytes through NF-kB and PPAR7. Cell Death Differ 2002;9:842-55.
    • (2002) Cell Death Differ , vol.9 , pp. 842-855
    • Nickoloff, B.1    Qin, J.Z.2    Chaturvedi, V.3    Denning, M.F.4    Bonish, B.5    Miele, L.6
  • 35
    • 3042634620 scopus 로고    scopus 로고
    • involvement of Notch signaling in hippocampal synaptic plasticity
    • Wang Y, Chan SL, Miele L, et al. involvement of Notch signaling in hippocampal synaptic plasticity. Proc Natl Acad Sci U S A 2004;101:9458-62.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 9458-9462
    • Wang, Y.1    Chan, S.L.2    Miele, L.3
  • 36
    • 53549111642 scopus 로고    scopus 로고
    • The association of Notch2 and NF-κB accelerates RANKL- induced osteoclastogenesis
    • Fukushima H, Nakao A, Okamoto F, et al. The association of Notch2 and NF-κB accelerates RANKL- induced osteoclastogenesis. Mol Cell Biol 2008;28: 6402-12.
    • (2008) Mol Cell Biol , vol.28 , pp. 6402-6412
    • Fukushima, H.1    Nakao, A.2    Okamoto, F.3
  • 37
    • 33846828787 scopus 로고    scopus 로고
    • NF-kB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: Potential involvement, of ZEB-1 and ZEB-2
    • Chua HL, Bhat-Nakshatri P, Clare SE, Morimiya A, Badve S, Nakshatri H. NF-kB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement, of ZEB-1 and ZEB-2. Oncogene 2007;26: 711-24.
    • (2007) Oncogene , vol.26 , pp. 711-724
    • Chua, H.L.1    Bhat-Nakshatri, P.2    Clare, S.E.3    Morimiya, A.4    Badve, S.5    Nakshatri, H.6
  • 38
    • 34248178375 scopus 로고    scopus 로고
    • Inhibition of angiogenesis and invasion by 3,3-diindolyl- methane is mediated by the nuclear factor-kb downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer
    • Kong D, Li Y, Wang Z, Banerjee S, Sarkar FH, Inhibition of angiogenesis and invasion by 3,3-diindolyl- methane is mediated by the nuclear factor-kb downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer. Cancer Res 2007;67:3310-9.
    • (2007) Cancer Res , vol.67 , pp. 3310-3319
    • Kong, D.1    Li, Y.2    Wang, Z.3    Banerjee, S.4    Sarkar, F.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.