메뉴 건너뛰기




Volumn 5, Issue 6, 2005, Pages 436-446

Tumour vascular targeting

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; FIBRONECTIN; INTEGRIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY LM 609; TENASCIN; VASCULOTROPIN ANTIBODY;

EID: 20344367537     PISSN: 1474175X     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrc1627     Document Type: Review
Times cited : (555)

References (159)
  • 1
    • 0035906856 scopus 로고    scopus 로고
    • 3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon
    • Konerding, M. A., Fait, E. & Gaumann, A. 3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon. Br. J. Cancer 84, 1354-1362 (2001).
    • (2001) Br. J. Cancer , vol.84 , pp. 1354-1362
    • Konerding, M.A.1    Fait, E.2    Gaumann, A.3
  • 2
    • 0034161989 scopus 로고    scopus 로고
    • Heterogeneity of angiogenesis and blood vessel maturation in human tumors: Implications for antiangiogenic tumor therapies
    • Eberhard, A. et al. Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies. Cancer Res. 60, 1388-1393 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 1388-1393
    • Eberhard, A.1
  • 3
    • 0038376001 scopus 로고    scopus 로고
    • Imaging of angiogenesis: From microscope to clinic
    • McDonald, D. M. & Choyke, P. L. Imaging of angiogenesis: from microscope to clinic. Nature Med 9, 713-725 (2003). A comprehensive review of the tumour vasculature and ways to image it.
    • (2003) Nature Med , vol.9 , pp. 713-725
    • McDonald, D.M.1    Choyke, P.L.2
  • 4
    • 7044233257 scopus 로고    scopus 로고
    • Intravital imaging of tumour vascular networks using multi-photon fluorescence microscopy
    • Tozer, G. M. et al. Intravital imaging of tumour vascular networks using multi-photon fluorescence microscopy. Adv. Drug Deliv. Rev. 57, 135-152 (2005).
    • (2005) Adv. Drug Deliv. Rev. , vol.57 , pp. 135-152
    • Tozer, G.M.1
  • 5
    • 0025122289 scopus 로고
    • The relationship between regional variations in blood flow and histology in a transplanted rat fibrosarcoma
    • Tozer, G. M., Lewis, S., Michalowski, A. & Aber, V. The relationship between regional variations in blood flow and histology in a transplanted rat fibrosarcoma. Br. J. Cancer 61, 250-257 (1990).
    • (1990) Br. J. Cancer , vol.61 , pp. 250-257
    • Tozer, G.M.1    Lewis, S.2    Michalowski, A.3    Aber, V.4
  • 6
    • 0030614893 scopus 로고    scopus 로고
    • 2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
    • 2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nature Med. 3, 177-182 (1997).
    • (1997) Nature Med. , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4
  • 7
    • 0020449692 scopus 로고
    • Endothelial-cell proliferation in experimental tumours
    • Denekamp, J. & Hobson, B. Endothelial-cell proliferation in experimental tumours. Br. J. Cancer 46, 711-720 (1982).
    • (1982) Br. J. Cancer , vol.46 , pp. 711-720
    • Denekamp, J.1    Hobson, B.2
  • 8
    • 0034855105 scopus 로고    scopus 로고
    • Hypoxia and oxidative stress in breast cancer. Oxidative stress: Its effects on the growth, metastatic potential and response to therapy of breast cancer
    • Brown, N. S. & Bicknell, R. Hypoxia and oxidative stress in breast cancer. Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer. Breast Cancer Res. 3, 323-327 (2001).
    • (2001) Breast Cancer Res. , vol.3 , pp. 323-327
    • Brown, N.S.1    Bicknell, R.2
  • 10
    • 0035753241 scopus 로고    scopus 로고
    • Delta4, an endothelial specific Notch ligand expressed at sites of physiological and tumor angiogenesis
    • Mailhos, C. et al. Delta4, an endothelial specific Notch ligand expressed at sites of physiological and tumor angiogenesis. Differentiation 89, 135-144 (2001).
    • (2001) Differentiation , vol.89 , pp. 135-144
    • Mailhos, C.1
  • 11
    • 0025093973 scopus 로고
    • Vascular attack as a therapeutic strategy for cancer
    • Denekamp, J. Vascular attack as a therapeutic strategy for cancer. Cancer Metastasis Rev. 9, 267-282 (1990).
    • (1990) Cancer Metastasis Rev. , vol.9 , pp. 267-282
    • Denekamp, J.1
  • 12
    • 0000742387 scopus 로고
    • A critique of tumor resistance
    • Woglom, W. A critique of tumor resistance. J. Cancer Res. 7, 283-309 (1923).
    • (1923) J. Cancer Res. , vol.7 , pp. 283-309
    • Woglom, W.1
  • 13
    • 0027368441 scopus 로고
    • Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature
    • Burrows, F. J. & Thorpe, P. E. Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature. Proc. Natl Acad. Sci. USA 90, 8996-9000 (1993). The first proof that targeted anti-vascular therapy can eradicate solid tumours.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8996-9000
    • Burrows, F.J.1    Thorpe, P.E.2
  • 14
    • 0031026481 scopus 로고    scopus 로고
    • Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature
    • Huang, X. et al. Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature. Science 275, 547-550 (1997).
    • (1997) Science , vol.275 , pp. 547-550
    • Huang, X.1
  • 15
    • 0025884892 scopus 로고
    • The identification of proliferation and tumour-induced proteins in human endothelial cells: A possible target for tumour therapy
    • Clarke, M. S. & West, D. C. The identification of proliferation and tumour-induced proteins in human endothelial cells: a possible target for tumour therapy. Electrophoresis 12, 500-508 (1991).
    • (1991) Electrophoresis , vol.12 , pp. 500-508
    • Clarke, M.S.1    West, D.C.2
  • 16
    • 0029653613 scopus 로고
    • Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence
    • Adams, M. D. et al. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. Nature 377, 3-174 (1995).
    • (1995) Nature , vol.377 , pp. 3-174
    • Adams, M.D.1
  • 17
    • 11144356184 scopus 로고    scopus 로고
    • The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation
    • Parker, L. H. et al. The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature 426, 754-758 (2004).
    • (2004) Nature , vol.426 , pp. 754-758
    • Parker, L.H.1
  • 18
    • 0033669849 scopus 로고    scopus 로고
    • In silico cloning of novel endothelial-specific genes
    • Huminiecki, L. & Bicknell, R. In silico cloning of novel endothelial-specific genes. Genome Res. 10, 1796-1806 (2000).
    • (2000) Genome Res. , vol.10 , pp. 1796-1806
    • Huminiecki, L.1    Bicknell, R.2
  • 19
    • 0036209165 scopus 로고    scopus 로고
    • Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis
    • Huminiecki, L., Gorn, M., Suchting, S., Poulsom, R. & Bicknell, R. Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. Genomics 79, 547-552 (2002).
    • (2002) Genomics , vol.79 , pp. 547-552
    • Huminiecki, L.1    Gorn, M.2    Suchting, S.3    Poulsom, R.4    Bicknell, R.5
  • 20
    • 0344443678 scopus 로고    scopus 로고
    • EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor
    • Sullivan, D. C. et al. EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor. J. Biol. Chem. 278, 47079-47088 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 47079-47088
    • Sullivan, D.C.1
  • 21
    • 0042663890 scopus 로고    scopus 로고
    • Robo4 is a vascular-specific receptor that inhibits endothelial migration
    • Park, K. W. et al. Robo4 is a vascular-specific receptor that inhibits endothelial migration. Dev. Biol. 261, 251-267 (2003).
    • (2003) Dev. Biol. , vol.261 , pp. 251-267
    • Park, K.W.1
  • 22
    • 0038387504 scopus 로고    scopus 로고
    • Identification of endothelial cell genes by combined database mining and microarray analysis
    • Ho, M, et al. Identification of endothelial cell genes by combined database mining and microarray analysis. Physiol. Genomes 13, 249-262 (2003).
    • (2003) Physiol. Genomes , vol.13 , pp. 249-262
    • Ho, M.1
  • 23
    • 15444354665 scopus 로고    scopus 로고
    • Cloning and characterization of developmental endothelial locus-1: An embryonic endothelial cell protein that binds the αvβ 3 integrin receptor
    • Hidai, C. et al. Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the αvβ3 integrin receptor. Genes Dev. 12, 21-33 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 21-33
    • Hidai, C.1
  • 24
    • 19044379387 scopus 로고    scopus 로고
    • In silico data filtering to identify new angiogenesis targets from a large in vitro gene profiling data set
    • Gerritsen, M. E. et al. In silico data filtering to identify new angiogenesis targets from a large in vitro gene profiling data set. Physiol. Genomics 10, 13-20 (2002).
    • (2002) Physiol. Genomics , vol.10 , pp. 13-20
    • Gerritsen, M.E.1
  • 25
    • 0033869721 scopus 로고    scopus 로고
    • Gene expression profiling in an in vitro model of angiogenesis
    • Kahn, J. et al. Gene expression profiling in an in vitro model of angiogenesis. Am. J. Pathol. 156, 1887-1900 (2000).
    • (2000) Am. J. Pathol. , vol.156 , pp. 1887-1900
    • Kahn, J.1
  • 26
    • 10744232662 scopus 로고    scopus 로고
    • Stanniocalcin 1 is an autocrine modulator of endothelial angiogenic responses to hepatocyte growth factor
    • Zlot, C. et al. Stanniocalcin 1 is an autocrine modulator of endothelial angiogenic responses to hepatocyte growth factor. J. Biol. Chem. 278, 47654-47659 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 47654-47659
    • Zlot, C.1
  • 27
    • 0034682892 scopus 로고    scopus 로고
    • Genes expressed in human tumor endothelium
    • St Croix, B. et al. Genes expressed in human tumor endothelium. Science 289, 1197-1202 (2000). The identification of tumour endothelial markers by isolation of endothelium from normal and tumour tissue followed by construction of SAGE libraries and a comparison of gene expression.
    • (2000) Science , vol.289 , pp. 1197-1202
    • St Croix, B.1
  • 28
    • 0035884593 scopus 로고    scopus 로고
    • Cell surface tumor endothelial markers are conserved in mice and humans
    • Carson-Walter, E. B. et al. Cell surface tumor endothelial markers are conserved in mice and humans. Cancer Res. 61, 6649-6655 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 6649-6655
    • Carson-Walter, E.B.1
  • 29
    • 2442620564 scopus 로고    scopus 로고
    • Tumor endothelial markers: New targets for cancer therapy
    • Nanda, A. & St Croix, B. Tumor endothelial markers: new targets for cancer therapy. Curr. Opin. Oncol. 16, 44-49 (2004).
    • (2004) Curr. Opin. Oncol. , vol.16 , pp. 44-49
    • Nanda, A.1    St Croix, B.2
  • 30
    • 2942590647 scopus 로고    scopus 로고
    • The human and mouse repertoire of the adhesion family of G-protein-coupled receptors
    • Bjarnadottir, T. K. et al. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics 84, 23-33 (2004).
    • (2004) Genomics , vol.84 , pp. 23-33
    • Bjarnadottir, T.K.1
  • 31
    • 1642303225 scopus 로고    scopus 로고
    • Murine endothelial cell lines as models of tumor endothelial cells
    • Walter-Yohriing, J. et al. Murine endothelial cell lines as models of tumor endothelial cells. Clin. Cancer Res. 10, 2179-2189 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 2179-2189
    • Walter-Yohriing, J.1
  • 32
    • 0035831506 scopus 로고    scopus 로고
    • Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium
    • Christian, S. et al. Molecular cloning and characterization of endosialin, a C-type lectin-like cell surface receptor of tumor endothelium. J. Biol. Chem. 276, 7408-7414 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 7408-7414
    • Christian, S.1
  • 33
    • 0026469991 scopus 로고
    • Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer
    • Rettig, W. J. et al. Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer. Proc. Natl Acad. Sci. USA 89, 10832-10836 (1992).
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 10832-10836
    • Rettig, W.J.1
  • 34
    • 20944451492 scopus 로고    scopus 로고
    • Endosialin (TEM1, CD284) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium
    • MacFadyen, J. R. et al. Endosialin (TEM1, CD284) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium. FEBS Lett. 570, 2569-2575 (2005).
    • (2005) FEBS Lett. , vol.570 , pp. 2569-2575
    • MacFadyen, J.R.1
  • 35
    • 0035957358 scopus 로고    scopus 로고
    • Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways
    • Duesbery, N. S. et al. Suppression of ras-mediated transformation and inhibition of tumor growth and angiogenesis by anthrax lethal factor, a proteolytic inhibitor of multiple MEK pathways. Proc. Natl Acad. Sci. USA 98, 4089-4094 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 4089-4094
    • Duesbery, N.S.1
  • 36
    • 0034195220 scopus 로고    scopus 로고
    • DII4, a novel Notch ligand expressed in arterial endothelium
    • Shutter, J. R. et al. DII4, a novel Notch ligand expressed in arterial endothelium. Genes Dev. 14, 1313-1318 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 1313-1318
    • Shutter, J.R.1
  • 37
    • 0034329423 scopus 로고    scopus 로고
    • Isolation and characterization of the Notch ligand Delta4
    • Rao, P. K. et al. Isolation and characterization of the Notch ligand Delta4. Exp. Cell Res. 260, 379-386 (2000).
    • (2000) Exp. Cell Res. , vol.260 , pp. 379-386
    • Rao, P.K.1
  • 38
    • 0037216703 scopus 로고    scopus 로고
    • Regulation of Notch1 and DII4 by vascular endothelial growth factor in arterial endothelial cells: Implications for modulating arteriogenesis and angiogenesis
    • Liu, Z. J. et al. Regulation of Notch1 and DII4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol. Cell Biol. 23, 14-25 (2003).
    • (2003) Mol. Cell Biol. , vol.23 , pp. 14-25
    • Liu, Z.J.1
  • 39
    • 0032913318 scopus 로고    scopus 로고
    • Biochemical characterization and molecular cloning of a novel endothelial-specific sialomucin
    • Morgan, S. M., Samulowitz, U., Darley, L., Simmons, D. L. & Vestweber, D. Biochemical characterization and molecular cloning of a novel endothelial-specific sialomucin. Blood 93, 165-175 (1999).
    • (1999) Blood , vol.93 , pp. 165-175
    • Morgan, S.M.1    Samulowitz, U.2    Darley, L.3    Simmons, D.L.4    Vestweber, D.5
  • 40
    • 0035914127 scopus 로고    scopus 로고
    • Human endomucin is an endothelial marker
    • Liu, C. et al. Human endomucin is an endothelial marker. Biochem. Biophys. Res. Commun. 288, 129-136 (2001).
    • (2001) Biochem. Biophys. Res. Commun. , vol.288 , pp. 129-136
    • Liu, C.1
  • 41
    • 2942557164 scopus 로고    scopus 로고
    • Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: A transcriptomic and proteomic study
    • Scheurer, S. B., Raybak, J. N., Rosli, C., Neri, D. & Elia, G. Modulation of gene expression by hypoxia in human umbilical cord vein endothelial cells: a transcriptomic and proteomic study. Proteomics 4, 1737-1760 (2004).
    • (2004) Proteomics , vol.4 , pp. 1737-1760
    • Scheurer, S.B.1    Raybak, J.N.2    Rosli, C.3    Neri, D.4    Elia, G.5
  • 42
    • 0029962505 scopus 로고    scopus 로고
    • Molecular characterization of a novel human hybrid-type receptor that binds the α2- macroglobulin receptor-associated protein
    • Jacobsen, L. et al. Molecular characterization of a novel human hybrid-type receptor that binds the α2- macroglobulin receptor-associated protein. J. Biol. Chem. 271, 31379-31383 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 31379-31383
    • Jacobsen, L.1
  • 43
    • 2942529235 scopus 로고    scopus 로고
    • Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy
    • Oh, P. et al. Subtractive proteomic mapping of the endothelial surface in lung and solid tumours for tissue-specific therapy. Nature 429, 629-635 (2004). A comprehensive proteomic analysis identifying tumour endothelial markers.
    • (2004) Nature , vol.429 , pp. 629-635
    • Oh, P.1
  • 44
    • 0033761517 scopus 로고    scopus 로고
    • Analysis of endoglin expression in normal brain tissue and in cerebral arteriovenous malformations
    • Matsubara, S., Bourdeau, A., terBrugge, K. G., Wallace, C. & Letarte, M. Analysis of endoglin expression in normal brain tissue and in cerebral arteriovenous malformations. Stroke 31, 2653-2660 (2000).
    • (2000) Stroke , vol.31 , pp. 2653-2660
    • Matsubara, S.1    Bourdeau, A.2    TerBrugge, K.G.3    Wallace, C.4    Letarte, M.5
  • 45
    • 0344304541 scopus 로고    scopus 로고
    • Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels
    • Christian, S. et al. Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels. J. Cell Biol. 163, 871-878 (2003).
    • (2003) J. Cell Biol. , vol.163 , pp. 871-878
    • Christian, S.1
  • 46
    • 18744399322 scopus 로고    scopus 로고
    • In vivo protein biotinylation for identification of organ-specific antigens accessible from the vasculature
    • Rybak, J. N. et al. In vivo protein biotinylation for identification of organ-specific antigens accessible from the vasculature. Nature Methods 23, 291-298 (2005).
    • (2005) Nature Methods , vol.23 , pp. 291-298
    • Rybak, J.N.1
  • 47
    • 0032535384 scopus 로고    scopus 로고
    • Expression trapping: Identification of novel genes expressed in hematopoietic and endothelial lineages by gene trapping in ES cells
    • Stanford, W. L. et al. Expression trapping: identification of novel genes expressed in hematopoietic and endothelial lineages by gene trapping in ES cells. Blood 92, 4622-4631 (1998).
    • (1998) Blood , vol.92 , pp. 4622-4631
    • Stanford, W.L.1
  • 48
    • 3242768444 scopus 로고    scopus 로고
    • Gene-trap expression screening to identify endothelial-specific genes
    • Hirashima, M., Bernstein, A., Stanford, W. L. & Rossant, J. Gene-trap expression screening to identify endothelial-specific genes. Blood 104, 711-718 (2004).
    • (2004) Blood , vol.104 , pp. 711-718
    • Hirashima, M.1    Bernstein, A.2    Stanford, W.L.3    Rossant, J.4
  • 49
    • 0023392493 scopus 로고
    • Transformed human cells produce a new fibronectin isoform by preferential alternative splicing of a previously unobserved exon
    • Zardi, L. et al. Transformed human cells produce a new fibronectin isoform by preferential alternative splicing of a previously unobserved exon. EMBO J. 6, 2337-2342 (1987).
    • (1987) EMBO J. , vol.6 , pp. 2337-2342
    • Zardi, L.1
  • 50
    • 0024594936 scopus 로고
    • A tumor-associated fibronectin isoform generated by alternative splicing of messenger RNA precursors
    • Carnemolla, B. et al. A tumor-associated fibronectin isoform generated by alternative splicing of messenger RNA precursors. J. Cell Biol. 108, 1139-1148 (1989).
    • (1989) J. Cell Biol. , vol.108 , pp. 1139-1148
    • Carnemolla, B.1
  • 51
    • 0028131531 scopus 로고
    • Distribution of oncofetal fibronectin isoforms in normal, hyperplastic and neoplastic human breast tissues
    • Kaczmarek, J. et al. Distribution of oncofetal fibronectin isoforms in normal, hyperplastic and neoplastic human breast tissues. Int. J. Cancer 59, 11-16(1994).
    • (1994) Int. J. Cancer , vol.59 , pp. 11-16
    • Kaczmarek, J.1
  • 52
    • 0028116528 scopus 로고
    • The fibronectin isoform containing the ED-B oncofetal domain: A marker of angiogenesis
    • Castellani, P. et al. The fibronectin isoform containing the ED-B oncofetal domain: a marker of angiogenesis. Int. J. Cancer 59, 612-618 (1994).
    • (1994) Int. J. Cancer , vol.59 , pp. 612-618
    • Castellani, P.1
  • 53
    • 0029802551 scopus 로고    scopus 로고
    • Phage antibodies with pan-species recognition of the oncofoetal angiogenesis marker fibronectin ED-B domain
    • Carnemolla, B. et al. Phage antibodies with pan-species recognition of the oncofoetal angiogenesis marker fibronectin ED-B domain. Int. J. Cancer 68, 397-405 (1996).
    • (1996) Int. J. Cancer , vol.68 , pp. 397-405
    • Carnemolla, B.1
  • 54
    • 0036841992 scopus 로고    scopus 로고
    • Differentiation between high- and low- grade astrocytoma using a human recombinant antibody to the extra domain-B of fibronectin
    • Castellani, P. et al. Differentiation between high- and low- grade astrocytoma using a human recombinant antibody to the extra domain-B of fibronectin. Am. J. Pathol. 161, 1695-1700 (2002). The article convincingly demonstrates that EDB is a marker of angiogenesis for brain tumours, and suggests innovative approaches for the differential diagnosis of high-grade and low-grade astrocytomas.
    • (2002) Am. J. Pathol. , vol.161 , pp. 1695-1700
    • Castellani, P.1
  • 55
    • 3242664404 scopus 로고    scopus 로고
    • mRNA expression and protein distribution of the unspliced tenascin-C isoform in prostatic adenocarcinoma
    • Katenkamp, K. et al. mRNA expression and protein distribution of the unspliced tenascin-C isoform in prostatic adenocarcinoma. J. Pathol. 203, 771-779 (2004).
    • (2004) J. Pathol. , vol.203 , pp. 771-779
    • Katenkamp, K.1
  • 56
    • 0029119763 scopus 로고
    • Extracellular matrix proteins in colorectal carcinomas. Expression of tenascin and fibronectin isoforms
    • Hauptmann, S. et al. Extracellular matrix proteins in colorectal carcinomas. Expression of tenascin and fibronectin isoforms. Lab. Invest. 73, 172-182 (1995).
    • (1995) Lab. Invest. , vol.73 , pp. 172-182
    • Hauptmann, S.1
  • 57
    • 0037827261 scopus 로고    scopus 로고
    • Expression of the extra domain B of fibronectin, a marker of angiogenesis, in head and neck tumors
    • Birchler, M. T. et al. Expression of the extra domain B of fibronectin, a marker of angiogenesis, in head and neck tumors. Laryngoscope 113, 1231-1237 (2003).
    • (2003) Laryngoscope , vol.113 , pp. 1231-1237
    • Birchler, M.T.1
  • 58
    • 20344395758 scopus 로고    scopus 로고
    • Differential in vivo and in vitro expression of ED-B+ fibronectin in adult human hematopoiesis
    • Vogel, W. et al. Differential in vivo and in vitro expression of ED-B+ fibronectin in adult human hematopoiesis. Int. J. Mol. Med. 12, 831-837 (2003).
    • (2003) Int. J. Mol. Med. , vol.12 , pp. 831-837
    • Vogel, W.1
  • 59
    • 0029961423 scopus 로고    scopus 로고
    • Fibronectin isoform distribution in the mouse. II. Differential distribution of the alternatively spliced EIIIB, EIIIA, and V segments in the adult mouse
    • Peters, J. H., Chen, G. E. & Hynes, R. O. Fibronectin isoform distribution in the mouse. II. Differential distribution of the alternatively spliced EIIIB, EIIIA, and V segments in the adult mouse. Cell Adhes. Commun. 4, 127-148 (1996).
    • (1996) Cell Adhes. Commun. , vol.4 , pp. 127-148
    • Peters, J.H.1    Chen, G.E.2    Hynes, R.O.3
  • 60
    • 0029862310 scopus 로고    scopus 로고
    • Fibronectin isoform distribution in the mouse. I. The alternatively spliced EIIIB, EIIIA, and V segments show widespread codistribution in the developing mouse embryo
    • Peters, J. H. & Hynes, R. O. Fibronectin isoform distribution in the mouse. I. The alternatively spliced EIIIB, EIIIA, and V segments show widespread codistribution in the developing mouse embryo. Cell Adhes. Commun. 4, 103-125 (1996).
    • (1996) Cell Adhes. Commun. , vol.4 , pp. 103-125
    • Peters, J.H.1    Hynes, R.O.2
  • 61
    • 0026476010 scopus 로고
    • The inclusion of the type III repeat ED-B in the fibronectin molecule generates confomnational modifications that unmask a cryptic sequence
    • Carnemolla, B., Leprini, A., Allemanni, G., Saginati, M. & Zardi, L. The inclusion of the type III repeat ED-B in the fibronectin molecule generates confomnational modifications that unmask a cryptic sequence. J. Biol. Chem. 267, 24689-24692 (1992).
    • (1992) J. Biol. Chem. , vol.267 , pp. 24689-24692
    • Carnemolla, B.1    Leprini, A.2    Allemanni, G.3    Saginati, M.4    Zardi, L.5
  • 62
    • 0035290720 scopus 로고    scopus 로고
    • Isolation of anti-angiogenesis antibodies from a large combinatorial repertoire by colony filter screening
    • Giovannoni, L., Viti, F., Zardi, L. & Neri, D. Isolation of anti-angiogenesis antibodies from a large combinatorial repertoire by colony filter screening. Nucleic Acids Res. 29, E27 (2001).
    • (2001) Nucleic Acids Res. , vol.29
    • Giovannoni, L.1    Viti, F.2    Zardi, L.3    Neri, D.4
  • 63
    • 0030700632 scopus 로고    scopus 로고
    • Targeting by affinity-matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform
    • Neri, D. et al. Targeting by affinity-matured recombinant antibody fragments of an angiogenesis associated fibronectin isoform. Nature Biotechnol. 15, 1271-1275 (1997).
    • (1997) Nature Biotechnol. , vol.15 , pp. 1271-1275
    • Neri, D.1
  • 64
    • 0032555478 scopus 로고    scopus 로고
    • Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel
    • Pini, A. et al. Design and use of a phage display library. Human antibodies with subnanomolar affinity against a marker of angiogenesis eluted from a two-dimensional gel. J. Biol. Chem. 273, 21769-21776 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 21769-21776
    • Pini, A.1
  • 65
    • 0033555628 scopus 로고    scopus 로고
    • Increased binding affinity and valence of recombinant antibody fragments lead to improved targeting of tumoral angiogenesis
    • Viti, F., Tarli, L., Giovannoni, L., Zardi, L. & Neri, D. Increased binding affinity and valence of recombinant antibody fragments lead to improved targeting of tumoral angiogenesis. Cancer Res. 59, 347-352 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 347-352
    • Viti, F.1    Tarli, L.2    Giovannoni, L.3    Zardi, L.4    Neri, D.5
  • 66
    • 0033168617 scopus 로고    scopus 로고
    • A high-affinity human antibody that targets tumoral blood vessels
    • Tarli, L. et al. A high-affinity human antibody that targets tumoral blood vessels. Blood 94, 192-198 (1999).
    • (1999) Blood , vol.94 , pp. 192-198
    • Tarli, L.1
  • 67
    • 0035096320 scopus 로고    scopus 로고
    • Selective targeting of tumour neovasculature by a radiohalogenated human antibody fragment specific for the ED-B domain of fibronectin
    • Demartis, S., Tarli, L., Borsi, L., Zardi, L. & Neri, D. Selective targeting of tumour neovasculature by a radiohalogenated human antibody fragment specific for the ED-B domain of fibronectin. Eur. J. Nucl. Med. 26, 534-539 (2001).
    • (2001) Eur. J. Nucl. Med. , vol.26 , pp. 534-539
    • Demartis, S.1    Tarli, L.2    Borsi, L.3    Zardi, L.4    Neri, D.5
  • 68
    • 0036837633 scopus 로고    scopus 로고
    • Selective targeting of tumoral vasculature: Comparison of different formats of an antibody (L19) to the ED-B domain of fibronectin
    • Borsi, L. et al. Selective targeting of tumoral vasculature: comparison of different formats of an antibody (L19) to the ED-B domain of fibronectin. Int. J. Cancer 102, 75-85 (2002).
    • (2002) Int. J. Cancer , vol.102 , pp. 75-85
    • Borsi, L.1
  • 69
    • 0037314650 scopus 로고    scopus 로고
    • Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer
    • Santimaria, M. et al. Immunoscintigraphic detection of the ED-B domain of fibronectin, a marker of angiogenesis, in patients with cancer. Clin. Cancer Res. 9, 571-579 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 571-579
    • Santimaria, M.1
  • 70
    • 0033560794 scopus 로고    scopus 로고
    • NMR structure of the human oncofoetal fibronectin ED-B domain, a specific marker for angiogenesis
    • Fattorusso, R. et al. NMR structure of the human oncofoetal fibronectin ED-B domain, a specific marker for angiogenesis. Structure Fold. Des. 7, 381-390 (1999).
    • (1999) Structure Fold. Des. , vol.7 , pp. 381-390
    • Fattorusso, R.1
  • 71
    • 0036790091 scopus 로고    scopus 로고
    • Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro
    • Fukuda, T. et al. Mice lacking the EDB segment of fibronectin develop normally but exhibit reduced cell growth and fibronectin matrix assembly in vitro. Cancer Res. 82, 5603-5610 (2002).
    • (2002) Cancer Res. , vol.82 , pp. 5603-5610
    • Fukuda, T.1
  • 72
    • 0033506053 scopus 로고    scopus 로고
    • Infrared photodetection for the in vivo localisation of phage-derived antibodies directed against angiogenic markers
    • Birchler, M. et al. Infrared photodetection for the in vivo localisation of phage-derived antibodies directed against angiogenic markers. J. Immunol. Methods 231, 239-248 (1999).
    • (1999) J. Immunol. Methods , vol.231 , pp. 239-248
    • Birchler, M.1
  • 73
    • 0032827243 scopus 로고    scopus 로고
    • Selective targeting and photocoagulation of ocular angiogenesis mediated by a phage-derived human antibody fragment
    • Birchler, M., Viti, F, Zardi, L., Spiess, B. & Neri, D. Selective targeting and photocoagulation of ocular angiogenesis mediated by a phage-derived human antibody fragment. Nature Biotechnol. 17, 984-988 (1999).
    • (1999) Nature Biotechnol. , vol.17 , pp. 984-988
    • Birchler, M.1    Viti, F.2    Zardi, L.3    Spiess, B.4    Neri, D.5
  • 74
    • 0036649819 scopus 로고    scopus 로고
    • Cytotoxic targeting of F9 teratocarcinoma tumours with anti-ED-B fibronectin scFv antibody modified liposomes
    • Marly, C. et al. Cytotoxic targeting of F9 teratocarcinoma tumours with anti-ED-B fibronectin scFv antibody modified liposomes. Br. J. Cancer 87, 106-112 (2002).
    • (2002) Br. J. Cancer , vol.87 , pp. 106-112
    • Marly, C.1
  • 75
    • 0035863566 scopus 로고    scopus 로고
    • Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice
    • Nilsson, F., Kosmehl, H., Zardi, L. & Neri, D. Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice. Cancer Res. 61, 711-716 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 711-716
    • Nilsson, F.1    Kosmehl, H.2    Zardi, L.3    Neri, D.4
  • 76
    • 0036493867 scopus 로고    scopus 로고
    • Enhancement of the antitumor properties of interteukin- 2 by its targeted delivery to the tumor blood vessel extracellular matrix
    • Carnemolla, B. et al. Enhancement of the antitumor properties of interteukin-2 by its targeted delivery to the tumor blood vessel extracellular matrix. Blood 99, 1659-1665 (2002).
    • (2002) Blood , vol.99 , pp. 1659-1665
    • Carnemolla, B.1
  • 77
    • 0037058313 scopus 로고    scopus 로고
    • Tumor-targeting properties of antibody-vascular endothelial growth factor fusion proteins
    • Halin, C., Niesner, U., Villani, M. E., Zardi, L. & Neri, D. Tumor-targeting properties of antibody-vascular endothelial growth factor fusion proteins. Int. J. Cancer 102, 109-116 (2002).
    • (2002) Int. J. Cancer , vol.102 , pp. 109-116
    • Halin, C.1    Niesner, U.2    Villani, M.E.3    Zardi, L.4    Neri, D.5
  • 78
    • 0036194917 scopus 로고    scopus 로고
    • Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature
    • Halin, C. et al. Enhancement of the antitumor activity of interleukin-12 by targeted delivery to neovasculature. Nature Biotechnol. 20, 264-269 (2002).
    • (2002) Nature Biotechnol. , vol.20 , pp. 264-269
    • Halin, C.1
  • 79
    • 10744221996 scopus 로고    scopus 로고
    • Selective targeted delivery of TNFα to tumor blood vessels
    • Borsi, L. et al. Selective targeted delivery of TNFα to tumor blood vessels. Blood 102, 4384-4392 (2003).
    • (2003) Blood , vol.102 , pp. 4384-4392
    • Borsi, L.1
  • 80
    • 2442710337 scopus 로고    scopus 로고
    • Engineering a thermostable human prolyl endopeptidase for antibody-directed enzyme prodrug therapy
    • Heinis, C., Alessi, P. & Neri, D. Engineering a thermostable human prolyl endopeptidase for antibody-directed enzyme prodrug therapy. Biochemistry 43, 6293-6303 (2004).
    • (2004) Biochemistry , vol.43 , pp. 6293-6303
    • Heinis, C.1    Alessi, P.2    Neri, D.3
  • 81
    • 0036891467 scopus 로고    scopus 로고
    • An antibody-calmodulin fusion protein reveals a functional dependence between macromolecular isoelectric point and tumor targeting performance
    • Melkko, S., Halin, C., Borsi, L., Zardi, L. & Neri, D. An antibody-calmodulin fusion protein reveals a functional dependence between macromolecular isoelectric point and tumor targeting performance. Int. J. Radiat. Oncol. Biol. Phys. 54, 1485-1490 (2002).
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.54 , pp. 1485-1490
    • Melkko, S.1    Halin, C.2    Borsi, L.3    Zardi, L.4    Neri, D.5
  • 82
    • 0036074754 scopus 로고    scopus 로고
    • Quantitation of the tumor-targeting properties of antibody fragments conjugated to cell-permeating HIV-1 TAT peptides
    • Niesner, U. et al. Quantitation of the tumor-targeting properties of antibody fragments conjugated to cell-permeating HIV-1 TAT peptides. Bioconjug. Chem. 13, 729-736 (2002).
    • (2002) Bioconjug. Chem. , vol.13 , pp. 729-736
    • Niesner, U.1
  • 83
    • 0026457220 scopus 로고
    • Expression of different tenascin isoforms in normal, hyperplastic and neoplastic human breast tissues
    • Borsi, L. et al. Expression of different tenascin isoforms in normal, hyperplastic and neoplastic human breast tissues. Int. J. Cancer 52, 688-692 (1992).
    • (1992) Int. J. Cancer , vol.52 , pp. 688-692
    • Borsi, L.1
  • 84
    • 0032932980 scopus 로고    scopus 로고
    • Identification of a glioblastoma-associated tenascin-C isoform by a high affinity recombinant antibody
    • Carnemolla, B. et al. Identification of a glioblastoma-associated tenascin-C isoform by a high affinity recombinant antibody. Am. J. Pathol. 154, 1345-1352 (1999).
    • (1999) Am. J. Pathol. , vol.154 , pp. 1345-1352
    • Carnemolla, B.1
  • 85
    • 0032741275 scopus 로고    scopus 로고
    • Loco-regional radioimmunotherapy of high-grade malignant gliomas using specific monoclonal antibodies labeled with 90Y: A phase I study
    • Riva, P. et al. Loco-regional radioimmunotherapy of high-grade malignant gliomas using specific monoclonal antibodies labeled with 90Y: a phase I study. Clin. Cancer Res. 5, 3275s-3280s (1999).
    • (1999) Clin. Cancer Res. , vol.5
    • Riva, P.1
  • 86
    • 0032588925 scopus 로고    scopus 로고
    • 131I radioconjugated antibodies for the locoregional radioimmunotherapy of high-grade malignant glioma: Phase I and II study
    • 131I radioconjugated antibodies for the locoregional radioimmunotherapy of high-grade malignant glioma: phase I and II study. Acta Oncol. 38, 351-359 (1999).
    • (1999) Acta Oncol. , vol.38 , pp. 351-359
    • Riva, P.1
  • 87
    • 0032916670 scopus 로고    scopus 로고
    • Antibody-guided three-step therapy for high grade glioma with yttrium-90 biotin
    • Paganelli, G. et al. Antibody-guided three-step therapy for high grade glioma with yttrium-90 biotin. Eur. J. Nucl. Med. 26, 348-357 (1999). An ingenious pre-targeting approach leads to an impressive selectivity for trie targeting of gliomas with radiolabelled compounds and validates oncofetal tenascin-C as an attractive target antigen.
    • (1999) Eur. J. Nucl. Med. , vol.26 , pp. 348-357
    • Paganelli, G.1
  • 88
    • 3242798990 scopus 로고    scopus 로고
    • 131I-labeled chimeric 81C6 monoclonal antibody for the treatment of patients with non-Hodgkin lymphoma
    • 131I-labeled chimeric 81C6 monoclonal antibody for the treatment of patients with non-Hodgkin lymphoma. Blood 104, 642-648 (2004).
    • (2004) Blood , vol.104 , pp. 642-648
    • Rizzieri, D.A.1
  • 89
    • 0036498790 scopus 로고    scopus 로고
    • 131I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas
    • 131I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas. J. Clin. Oncol. 20, 1389-1397 (2002).
    • (2002) J. Clin. Oncol. , vol.20 , pp. 1389-1397
    • Reardon, D.A.1
  • 90
    • 0029610677 scopus 로고
    • Definition of two angiogenic pathways by distinct αv integrins
    • Friedlander, M. et al. Definition of two angiogenic pathways by distinct αv integrins. Science 270, 1500-1502 (1995).
    • (1995) Science , vol.270 , pp. 1500-1502
    • Friedlander, M.1
  • 91
    • 0037189380 scopus 로고    scopus 로고
    • Tumor regression by targeted gene delivery to the neovasculature
    • Hood, J. D. et al. Tumor regression by targeted gene delivery to the neovasculature. Science 296, 2404-2407 (2002).
    • (2002) Science , vol.296 , pp. 2404-2407
    • Hood, J.D.1
  • 93
    • 0035706407 scopus 로고    scopus 로고
    • 3) antibody in patients with metastatic cancer
    • 3) antibody in patients with metastatic cancer. Cancer Biother. Radiopharm. 16, 125-132 (2001).
    • (2001) Cancer Biother. Radiopharm. , vol.16 , pp. 125-132
    • Posey, J.A.1
  • 94
    • 0142151097 scopus 로고    scopus 로고
    • Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors
    • Baluk, P., Morikawa, S., Haskell, A., Mancuso, M. & McDonald, D. M. Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors. Am. J. Pathol. 163, 1801-1815 (2003).
    • (2003) Am. J. Pathol. , vol.163 , pp. 1801-1815
    • Baluk, P.1    Morikawa, S.2    Haskell, A.3    Mancuso, M.4    McDonald, D.M.5
  • 95
    • 0031862889 scopus 로고    scopus 로고
    • 3-targeted magnetic resonance imaging
    • 3-targeted magnetic resonance imaging. Nature Med. 4, 623-626 (1998).
    • (1998) Nature Med. , vol.4 , pp. 623-626
    • Sipkins, D.A.1
  • 96
    • 0030940283 scopus 로고    scopus 로고
    • αv integrins as receptors for tumor targeting by circulating ligands
    • Pasqualini, R., Koivunen, E. & Ruoslahti, E. αv integrins as receptors for tumor targeting by circulating ligands. Nature Biotechnol. 15, 542-546 (1997).
    • (1997) Nature Biotechnol. , vol.15 , pp. 542-546
    • Pasqualini, R.1    Koivunen, E.2    Ruoslahti, E.3
  • 97
    • 0036829759 scopus 로고    scopus 로고
    • 3 integrin binding peptides in a nude mouse model
    • 3 integrin binding peptides in a nude mouse model. Cancer Res. 62, 6146-6151 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 6146-6151
    • Janssen, M.L.1
  • 98
    • 4544387211 scopus 로고    scopus 로고
    • 64Cu-labeled dimeric RGD peptides
    • 64Cu-labeled dimeric RGD peptides. Mol. Imaging Biol. 6, 350-359 (2004).
    • (2004) Mol. Imaging Biol. , vol.6 , pp. 350-359
    • Chen, X.1
  • 99
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara, N., Hillan, K. J., Gerber, H. P. & Novotny, W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nature Rev. Drug Discov. 3, 391-400 (2004).
    • (2004) Nature Rev. Drug Discov. , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 100
    • 0037699955 scopus 로고    scopus 로고
    • Angiogenesis in health and disease
    • Carmeliet, P. Angiogenesis in health and disease. Nature Med. 9, 653-660 (2003).
    • (2003) Nature Med. , vol.9 , pp. 653-660
    • Carmeliet, P.1
  • 101
    • 1242269816 scopus 로고    scopus 로고
    • Role of lymphangiogenic factors in tumor metastasis
    • He, Y., Karpanen, T. & Alitalo, K. Role of lymphangiogenic factors in tumor metastasis. Biochim. Biophys. Acta 1654, 3-12 (2004).
    • (2004) Biochim. Biophys. Acta , vol.1654 , pp. 3-12
    • He, Y.1    Karpanen, T.2    Alitalo, K.3
  • 102
    • 0038456130 scopus 로고    scopus 로고
    • Angiogenesis, lymphangiogenesis, and melanoma metastasis
    • Streit, M. & Detmar, M. Angiogenesis, lymphangiogenesis, and melanoma metastasis. Oncogene 22, 3172-3179 (2003).
    • (2003) Oncogene , vol.22 , pp. 3172-3179
    • Streit, M.1    Detmar, M.2
  • 103
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • Ferrara, N. Vascular endothelial growth factor: basic science and clinical progress. Endocr. Rev. 25, 581-611 (2004).
    • (2004) Endocr. Rev. , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 104
    • 0032080427 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as a marker of tumor endothelium
    • Brekken, R. A., Huang, X., King, S. W. & Thorpe, P. E. Vascular endothelial growth factor as a marker of tumor endothelium. Cancer Res. 58, 1952-1959 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 1952-1959
    • Brekken, R.A.1    Huang, X.2    King, S.W.3    Thorpe, P.E.4
  • 105
    • 0035328576 scopus 로고    scopus 로고
    • A strategy for antitumor vascular therapy by targeting the vascular endothelial growth factor: Receptor complex
    • Cooke, S. P. et al. A strategy for antitumor vascular therapy by targeting the vascular endothelial growth factor: receptor complex. Cancer Res. 61, 3663-3659 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 3663-3659
    • Cooke, S.P.1
  • 106
    • 0030484706 scopus 로고    scopus 로고
    • Vascular targeting of solid and ascites tumours with antibodies to vascular endothelial growth factor
    • Ke, L. et al. Vascular targeting of solid and ascites tumours with antibodies to vascular endothelial growth factor. Eur. J. Cancer 32A, 2467-2473 (1996).
    • (1996) Eur. J. Cancer , vol.32 A , pp. 2467-2473
    • Ke, L.1
  • 107
    • 0032698140 scopus 로고    scopus 로고
    • Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors
    • Prewett, M. et al. Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res. 59, 5209-5218 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 5209-5218
    • Prewett, M.1
  • 108
    • 0033396950 scopus 로고    scopus 로고
    • Inhibition of tumor growth and metastasis by targeting tumor-associated angiogenesis with antagonists to the receptors of vascular endothelial growth factor
    • Zhu, Z. & Witte, L. Inhibition of tumor growth and metastasis by targeting tumor-associated angiogenesis with antagonists to the receptors of vascular endothelial growth factor. Invest. New Drugs 17, 195-212(1999).
    • (1999) Invest. New Drugs , vol.17 , pp. 195-212
    • Zhu, Z.1    Witte, L.2
  • 109
    • 0034665166 scopus 로고    scopus 로고
    • Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice
    • Brekken, R. A. et al. Selective inhibition of vascular endothelial growth factor (VEGF) receptor 2 (KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice. Cancer Res. 60, 5117-5124 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 5117-5124
    • Brekken, R.A.1
  • 110
    • 12944332009 scopus 로고    scopus 로고
    • Prognostic factors in prostate cancer. College of American Pathologists Consensus statement 1999
    • Bostwick, D. G. et al. Prognostic factors in prostate cancer. College of American Pathologists Consensus Statement 1999. Arch. Pathol. Lab. Med. 124, 995-1000 (2000).
    • (2000) Arch. Pathol. Lab. Med. , vol.124 , pp. 995-1000
    • Bostwick, D.G.1
  • 111
    • 0033168844 scopus 로고    scopus 로고
    • Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature
    • Chang, S. S. et al. Five different anti-prostate-specific membrane antigen (PSMA) antibodies confirm PSMA expression in tumor-associated neovasculature. Cancer Res. 59, 3192-3198 (1999).
    • (1999) Cancer Res. , vol.59 , pp. 3192-3198
    • Chang, S.S.1
  • 112
    • 0030866116 scopus 로고    scopus 로고
    • Monoclonal antibodies to the extracellular domain of prostate-specific membrane antigen also react with tumor vascular endothelium
    • Liu, H. et al. Monoclonal antibodies to the extracellular domain of prostate-specific membrane antigen also react with tumor vascular endothelium. Cancer Res. 57, 3629-3634 (1997). PSMA is shown to be an attractive marker of angiogenesis for antibody-based targeting approaches.
    • (1997) Cancer Res. , vol.57 , pp. 3629-3634
    • Liu, H.1
  • 113
    • 0142030952 scopus 로고    scopus 로고
    • Targeted systemic therapy of prostate cancer with a monoclonal antibody to prostate-specific membrane antigen
    • Bander, N. H. et al. Targeted systemic therapy of prostate cancer with a monoclonal antibody to prostate-specific membrane antigen. Semin. Oncol. 30, 667-676 (2003).
    • (2003) Semin. Oncol. , vol.30 , pp. 667-676
    • Bander, N.H.1
  • 114
    • 4344618391 scopus 로고    scopus 로고
    • Phase I trial of yttrium-90-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for androgen-independent prostate cancer
    • Milowsky, M. I. et al. Phase I trial of yttrium-90-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for androgen-independent prostate cancer. J. Clin. Oncol. 22, 2522-2531 (2004).
    • (2004) J. Clin. Oncol. , vol.22 , pp. 2522-2531
    • Milowsky, M.I.1
  • 115
    • 85047699075 scopus 로고    scopus 로고
    • In vitro and preclinical targeted alpha therapy of human prostate cancer with Bi-213 labeled J591 antibody against the prostate specific membrane antigen
    • Li, Y, Tian, Z., Rizvi, S. M., Bander, N. H. & Allen, B. J. In vitro and preclinical targeted alpha therapy of human prostate cancer with Bi-213 labeled J591 antibody against the prostate specific membrane antigen. Prostate Cancer Prostatic Dis. 5, 36-46 (2002).
    • (2002) Prostate Cancer Prostatic Dis. , vol.5 , pp. 36-46
    • Li, Y.1    Tian, Z.2    Rizvi, S.M.3    Bander, N.H.4    Allen, B.J.5
  • 117
    • 0027173613 scopus 로고
    • A monoclonal antibody detects heterogeneity in vascular endothelium of tumours and normal tissues
    • Wang, J. M. et al. A monoclonal antibody detects heterogeneity in vascular endothelium of tumours and normal tissues. Int. J. Cancer 54, 363-370 (1993).
    • (1993) Int. J. Cancer , vol.54 , pp. 363-370
    • Wang, J.M.1
  • 118
    • 0029611184 scopus 로고
    • Up-regulation of endoglin on vascular endothelial cells in human solid tumors: Implications for diagnosis and therapy
    • Burrows, F. J. et al. Up-regulation of endoglin on vascular endothelial cells in human solid tumors: implications for diagnosis and therapy. Clin. Cancer Res. 1, 1623-1634 (1995).
    • (1995) Clin. Cancer Res. , vol.1 , pp. 1623-1634
    • Burrows, F.J.1
  • 119
    • 0035889654 scopus 로고    scopus 로고
    • Lack of specificity of endoglin expression for tumor blood vessels
    • Balza, E. et al. Lack of specificity of endoglin expression for tumor blood vessels. Int. J. Cancer 94, 579-585 (2001).
    • (2001) Int. J. Cancer , vol.94 , pp. 579-585
    • Balza, E.1
  • 120
    • 0034060755 scopus 로고    scopus 로고
    • Imaging of tumour neovasculature by targeting the TGF-β binding receptor endoglin
    • Bredow, S., Lewin, M., Hofmann, B., Marecos, E. & Weissleder, R. Imaging of tumour neovasculature by targeting the TGF-β binding receptor endoglin. Eur. J. Cancer 38, 675-681 (2000).
    • (2000) Eur. J. Cancer , vol.38 , pp. 675-681
    • Bredow, S.1    Lewin, M.2    Hofmann, B.3    Marecos, E.4    Weissleder, R.5
  • 121
    • 0034027107 scopus 로고    scopus 로고
    • Endoglin is a suitable target for efficient imaging of solid tumors: In vivo evidence in a canine mammary carcinoma model
    • Fonsatti, E. et al. Endoglin is a suitable target for efficient imaging of solid tumors: in vivo evidence in a canine mammary carcinoma model. Clin. Cancer Res. 6, 2037-2043 (2000).
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2037-2043
    • Fonsatti, E.1
  • 122
    • 0034523979 scopus 로고    scopus 로고
    • Effective cancer targeting using an antitumor tissue vascular endothelium-specific monoclonal antibody (TES-23)
    • Wakai, Y. et al. Effective cancer targeting using an antitumor tissue vascular endothelium-specific monoclonal antibody (TES-23). Jpn. J. Cancer Res. 91, 1319-1325 (2000).
    • (2000) Jpn. J. Cancer Res. , vol.91 , pp. 1319-1325
    • Wakai, Y.1
  • 123
    • 10844290511 scopus 로고    scopus 로고
    • 186Relabeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with head and neck squamous cell carcinoma
    • 186Relabeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with head and neck squamous cell carcinoma. Clin. Cancer Res. 9, 3961S-3972S (2003).
    • (2003) Clin. Cancer Res. , vol.9
    • Borjesson, P.K.1
  • 124
    • 0037140958 scopus 로고    scopus 로고
    • Tumor targeting properties of monoclonal antibodies with different affinity for target antigen CD44V6 in nude mice bearing head-and-neck cancer xenografts
    • Verel, I. et al. Tumor targeting properties of monoclonal antibodies with different affinity for target antigen CD44V6 in nude mice bearing head-and-neck cancer xenografts. Int. J. Cancer 99, 396-402 (2002).
    • (2002) Int. J. Cancer , vol.99 , pp. 396-402
    • Verel, I.1
  • 125
    • 0033950895 scopus 로고    scopus 로고
    • Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis
    • Pasqualini, R. et al. Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. Cancer Res. 60, 722-727 (2000).
    • (2000) Cancer Res. , vol.60 , pp. 722-727
    • Pasqualini, R.1
  • 126
    • 0033764170 scopus 로고    scopus 로고
    • Enhancement of tumor necrosis factor α antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13)
    • Curnis, F. et al. Enhancement of tumor necrosis factor α antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13). Nature Biotechnol. 18, 1185-1190 (2000). A tumour-homing peptide, previously identified by in vivo peptide phage panning procedures, can be appended to TNF and increases the anticancer therapeutic index of this pro-inflammatory cytokine.
    • (2000) Nature Biotechnol. , vol.18 , pp. 1185-1190
    • Curnis, F.1
  • 127
    • 0036678474 scopus 로고    scopus 로고
    • Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration
    • Curnis, F., Sacchi, A. & Corti, A. Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration. J. Clin. Invest. 110, 475-482 (2002).
    • (2002) J. Clin. Invest. , vol.110 , pp. 475-482
    • Curnis, F.1    Sacchi, A.2    Corti, A.3
  • 128
    • 12544258353 scopus 로고    scopus 로고
    • Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine
    • Weller, G. E. et al. Ultrasonic imaging of tumor angiogenesis using contrast microbubbles targeted via the tumor-binding peptide arginine-arginine-leucine. Cancer Res. 65, 533-539 (2005).
    • (2005) Cancer Res. , vol.65 , pp. 533-539
    • Weller, G.E.1
  • 129
    • 0036829110 scopus 로고    scopus 로고
    • Increased exposure of anionic phospholipids on the surface of tumor blood vessels
    • Ran, S., Downes, A. & Thorpe, P. E. Increased exposure of anionic phospholipids on the surface of tumor blood vessels. Cancer Res. 62, 6132-6140 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 6132-6140
    • Ran, S.1    Downes, A.2    Thorpe, P.E.3
  • 130
    • 0035951092 scopus 로고    scopus 로고
    • Involvement of phosphatidylinositol 4,5-bisphosphate in phosphatidylserine exposure in platelets: Use of a permeant phosphoinositide- binding peptide
    • Bucki, R., Janmey, P. A., Vegners, R., Giraud, F. Sulpice, J. C. Involvement of phosphatidylinositol 4,5-bisphosphate in phosphatidylserine exposure in platelets: use of a permeant phosphoinositide-binding peptide. Biochemistry 40, 15752-15761 (2001).
    • (2001) Biochemistry , vol.40 , pp. 15752-15761
    • Bucki, R.1    Janmey, P.A.2    Vegners, R.3    Giraud, F.4    Sulpice, J.C.5
  • 131
    • 10744223801 scopus 로고    scopus 로고
    • 3 integrin
    • 3 integrin. Cancer Cell 3, 589-601 (2003).
    • (2003) Cancer Cell , vol.3 , pp. 589-601
    • Hamano, Y.1
  • 132
    • 3042815043 scopus 로고    scopus 로고
    • Combinatorial administration of molecules that simultaneously inhibit angiogenesis and invasion leads to increased therapeutic efficacy in mouse models of malignant glioma
    • Bello, L. et al. Combinatorial administration of molecules that simultaneously inhibit angiogenesis and invasion leads to increased therapeutic efficacy in mouse models of malignant glioma. Clin. Cancer Res. 10, 4527-4537 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , pp. 4527-4537
    • Bello, L.1
  • 133
    • 0035874887 scopus 로고    scopus 로고
    • High affinity restricts the localization and tumor penetration of single-chain Fv antibody molecules
    • Adams, G. P. et al. High affinity restricts the localization and tumor penetration of single-chain Fv antibody molecules. Cancer Res. 61, 4750-4755 (2001). This important article shows how low doses of high affinity antibodies specific to a tumour-cell marker tend to accumulate in the perivascular area of solid tumours.
    • (2001) Cancer Res. , vol.61 , pp. 4750-4755
    • Adams, G.P.1
  • 134
    • 0037499918 scopus 로고    scopus 로고
    • Neovascular targeting therapy: Paclitaxel encapsulated in cationic liposomes improves antitumoral efficacy
    • Schmitt-Sody, M. et al. Neovascular targeting therapy: paclitaxel encapsulated in cationic liposomes improves antitumoral efficacy. Clin. Cancer Res. 9, 2335-2341 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 2335-2341
    • Schmitt-Sody, M.1
  • 135
    • 0037124333 scopus 로고    scopus 로고
    • Active immunization against the vascular endothelial growth factor receptor flk 1 inhibits tumor angiogenesis and metastasis
    • Li, Y. et al. Active immunization against the vascular endothelial growth factor receptor flk1 inhibits tumor angiogenesis and metastasis. J. Exp. Med 195, 1575-1584 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 1575-1584
    • Li, Y.1
  • 136
    • 0037076297 scopus 로고    scopus 로고
    • Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors
    • Niederman, T. M. et al. Antitumor activity of cytotoxic T lymphocytes engineered to target vascular endothelial growth factor receptors. Proc. Natl Acad. Sci. USA 99, 7009-7014 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 7009-7014
    • Niederman, T.M.1
  • 137
    • 2942581320 scopus 로고    scopus 로고
    • DNA vaccines suppress tumor growth and metastases by the induction of anti-angiogenesis
    • Reisfeld, R. A., Niethammer, A. G., Luo, Y. & Xiang, R. DNA vaccines suppress tumor growth and metastases by the induction of anti-angiogenesis. Immunol. Rev. 199, 181-190 (2004).
    • (2004) Immunol. Rev. , vol.199 , pp. 181-190
    • Reisfeld, R.A.1    Niethammer, A.G.2    Luo, Y.3    Xiang, R.4
  • 138
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler, G. & Milstein, C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256, 495-497 (1975).
    • (1975) Nature , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 140
    • 0033506261 scopus 로고    scopus 로고
    • Ribosome display: An in vitro method for selection and evolution of antibodies from libraries
    • Schaffitzel, C., Hanes, J., Jermutus, L. & Pluckthun, A. Ribosome display: an in vitro method for selection and evolution of antibodies from libraries. J. Immunol. Methods 231, 119-135 (1999).
    • (1999) J. Immunol. Methods , vol.231 , pp. 119-135
    • Schaffitzel, C.1    Hanes, J.2    Jermutus, L.3    Pluckthun, A.4
  • 141
    • 4143129879 scopus 로고    scopus 로고
    • Directed evolution of an anti-carcinoembryonic antigen scFv with a 4-day monovalent dissociation half-time at 37°C
    • Graff, C. P., Chester, K., Begent, R. & Wittrup, K. D. Directed evolution of an anti-carcinoembryonic antigen scFv with a 4-day monovalent dissociation half-time at 37°C. Protein Eng. Des. Sel. 17, 293-304 (2004).
    • (2004) Protein Eng. Des. Sel. , vol.17 , pp. 293-304
    • Graff, C.P.1    Chester, K.2    Begent, R.3    Wittrup, K.D.4
  • 142
    • 4143058066 scopus 로고    scopus 로고
    • Characterization of engineered anti-p185HER-2 (scFv-CH3)2 antibody fragments (minibodies) for tumor targeting
    • Olafsen, T. et al. Characterization of engineered anti-p185HER-2 (scFv-CH3)2 antibody fragments (minibodies) for tumor targeting. Protein Eng. Des. Sel. 17, 315-323 (2004).
    • (2004) Protein Eng. Des. Sel. , vol.17 , pp. 315-323
    • Olafsen, T.1
  • 143
    • 0025112794 scopus 로고
    • Searching for peptide ligands with an epitope library
    • Scott, J. K. & Smith, G. P. Searching for peptide ligands with an epitope library. Science 249, 386-390 (1990).
    • (1990) Science , vol.249 , pp. 386-390
    • Scott, J.K.1    Smith, G.P.2
  • 144
    • 0029418639 scopus 로고
    • Peptide and protein display on the surface of filamentous bacteriophage
    • Felici, F. et al. Peptide and protein display on the surface of filamentous bacteriophage. Biotechnol. Annu. Rev. 1, 149-183 (1995).
    • (1995) Biotechnol. Annu. Rev. , vol.1 , pp. 149-183
    • Felici, F.1
  • 145
    • 0035718639 scopus 로고    scopus 로고
    • Cosmix-plexing: A novel recombinatorial approach for evolutionary selection from combinatorial libraries
    • Collins, J., Horn, N., Wadenback, J. & Szardenings, M. Cosmix-plexing: a novel recombinatorial approach for evolutionary selection from combinatorial libraries. J. Biotechnol. 74, 317-338 (2001).
    • (2001) J. Biotechnol. , vol.74 , pp. 317-338
    • Collins, J.1    Horn, N.2    Wadenback, J.3    Szardenings, M.4
  • 146
    • 0036721834 scopus 로고    scopus 로고
    • The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports - Principles and applications
    • Frank, R. The SPOT-synthesis technique. Synthetic peptide arrays on membrane supports -principles and applications. J. Immunol. Methods 267, 13-26 (2002).
    • (2002) J. Immunol. Methods , vol.267 , pp. 13-26
    • Frank, R.1
  • 147
    • 0037231880 scopus 로고    scopus 로고
    • Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries
    • Pinilla, C., Appel, J. R., Borras, E. & Houghten, R. A. Advances in the use of synthetic combinatorial chemistry: mixture-based libraries. Nature Med. 9, 118-122 (2003).
    • (2003) Nature Med. , vol.9 , pp. 118-122
    • Pinilla, C.1    Appel, J.R.2    Borras, E.3    Houghten, R.A.4
  • 148
    • 0031049701 scopus 로고    scopus 로고
    • "Peptabody": A new type of high avidity binding protein
    • Terskikh, A. V. et al. "Peptabody": a new type of high avidity binding protein. Proc. Natl Acad. Sci. USA 94, 1663-1668 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 1663-1668
    • Terskikh, A.V.1
  • 149
    • 0030717635 scopus 로고    scopus 로고
    • Increased potency of an erythropoietin peptide mimetic through covalent dimerization
    • Wrighton, N. C. et al. Increased potency of an erythropoietin peptide mimetic through covalent dimerization. Nature Biotechnol. 15, 1261-1265 (1997).
    • (1997) Nature Biotechnol. , vol.15 , pp. 1261-1265
    • Wrighton, N.C.1
  • 150
    • 0026599465 scopus 로고
    • Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures
    • Ellington, A. D. & Szostak, J. W. Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures. Nafure 355, 850-652 (1992).
    • (1992) Nafure , vol.355 , pp. 850-652
    • Ellington, A.D.1    Szostak, J.W.2
  • 151
    • 0347364648 scopus 로고    scopus 로고
    • A tenascin-C aptamer identified by tumor cell SELEX: Systematic evolution of ligands by exponential enrichment
    • Daniels, D. A., Chen, H., Hicke, B. J., Swiderek, K. M. & Gold, L. A tenascin-C aptamer identified by tumor cell SELEX: systematic evolution of ligands by exponential enrichment. Proc. Natl Acad. Sci. USA 100, 15416-15421 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 15416-15421
    • Daniels, D.A.1    Chen, H.2    Hicke, B.J.3    Swiderek, K.M.4    Gold, L.5
  • 152
    • 4444260060 scopus 로고    scopus 로고
    • Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer
    • Helmling, S. et al. Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer. Proc. Natl Acad. Sci. USA 101, 13174-13179 (2004).
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 13174-13179
    • Helmling, S.1
  • 154
    • 0029836953 scopus 로고    scopus 로고
    • Discovering high-affinity ligands for proteins: SAR by NMR
    • Shuker, S. B., Hajduk, P. J., Meadows, R. P. & Fesik, S. W. Discovering high-affinity ligands for proteins: SAR by NMR. Science 274, 1531-1534 (1996).
    • (1996) Science , vol.274 , pp. 1531-1534
    • Shuker, S.B.1    Hajduk, P.J.2    Meadows, R.P.3    Fesik, S.W.4
  • 156
    • 4644350506 scopus 로고    scopus 로고
    • DNA-templated organic synthesis and selection of a library of macrocycles
    • Gartner, Z. J. et al. DNA-templated organic synthesis and selection of a library of macrocycles. Science 305, 1601-1605 (2004).
    • (2004) Science , vol.305 , pp. 1601-1605
    • Gartner, Z.J.1
  • 157
    • 0036047069 scopus 로고    scopus 로고
    • Drug discovery by dynamic combinatorial libraries
    • Ramstrom, O. & Lehn, J. M. Drug discovery by dynamic combinatorial libraries. Nature Rev. Drug Discov. 1, 26-36 (2002).
    • (2002) Nature Rev. Drug Discov. , vol.1 , pp. 26-36
    • Ramstrom, O.1    Lehn, J.M.2
  • 158
    • 3142781225 scopus 로고    scopus 로고
    • Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
    • Arkin, M. R. & Wells, J. A. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nature Rev. Drug Discov. 3, 301-317 (2004).
    • (2004) Nature Rev. Drug Discov. , vol.3 , pp. 301-317
    • Arkin, M.R.1    Wells, J.A.2
  • 159
    • 0347694626 scopus 로고    scopus 로고
    • SpeedScreen: Label-free liquid chromatography-mass speotrometry-based high-throughput screening for the discovery of orphan protein ligands
    • Muckenschnabel, I., Falchetto, R., Mayr, L. M. & Filipuzzi, I. SpeedScreen: label-free liquid chromatography-mass speotrometry-based high-throughput screening for the discovery of orphan protein ligands. Anal. Biochem. 324, 241-249 (2004).
    • (2004) Anal. Biochem. , vol.324 , pp. 241-249
    • Muckenschnabel, I.1    Falchetto, R.2    Mayr, L.M.3    Filipuzzi, I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.