-
1
-
-
33747513134
-
Notch signalling regulates stem cell numbers in vitro and in vivo
-
DOI 10.1038/nature04940, PII NATURE04940
-
Androutsellis-Theotokis, A, Leker, RR, Soldner, F, Hoeppner, DJ, Ravin, R, Poser, SW et al. (2006). Notch signalling regulates stem cell numbers in vitro and in vivo. Nature 442: 823-826. (Pubitemid 44258913)
-
(2006)
Nature
, vol.442
, Issue.7104
, pp. 823-826
-
-
Androutsellis-Theotokis, A.1
Leker, R.R.2
Soldner, F.3
Hoeppner, D.J.4
Ravin, R.5
Poser, S.W.6
Rueger, M.A.7
Bae, S.-K.8
Kittappa, R.9
McKay, R.D.G.10
-
2
-
-
0033617522
-
Notch signaling: Cell fate control and signal integration in development
-
DOI 10.1126/science.284.5415.770
-
Artavanis-Tsakonas, S, Rand, MD and Lake, RJ (1999). Notch signaling: cell fate control and signal integration in development. Science 284: 770-776. (Pubitemid 29291335)
-
(1999)
Science
, vol.284
, Issue.5415
, pp. 770-776
-
-
Artavanis-Tsakonas, S.1
Rand, M.D.2
Lake, R.J.3
-
3
-
-
0142259346
-
The role of Notch in tumorigenesis: Oncogene or tumour suppressor
-
Radtke, F and Raj, K (2003). The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer 3: 756-767. (Pubitemid 37328814)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.10
, pp. 756-767
-
-
Radtke, F.1
Raj, K.2
-
4
-
-
50849111710
-
Rational targeting of Notch signaling in cancer
-
Rizzo, P, Osipo, C, Foreman, K, Golde, T, Osborne, B and Miele, L (2008). Rational targeting of Notch signaling in cancer. Oncogene 27: 5124-5131.
-
(2008)
Oncogene
, vol.27
, pp. 5124-5131
-
-
Rizzo, P.1
Osipo, C.2
Foreman, K.3
Golde, T.4
Osborne, B.5
Miele, L.6
-
5
-
-
54549107725
-
Rational targeting of Notch signaling in breast cancer
-
Miele, L (2008). Rational targeting of Notch signaling in breast cancer. Expert Rev Anticancer Ther 8: 1197-1202.
-
(2008)
Expert Rev Anticancer Ther
, vol.8
, pp. 1197-1202
-
-
Miele, L.1
-
6
-
-
48549103124
-
Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches
-
Rizzo, P, Miao, H, D'Souza, G, Osipo, C, Song, LL, Yun, J et al. (2008). Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res 68: 5226-5235.
-
(2008)
Cancer Res
, vol.68
, pp. 5226-5235
-
-
Rizzo, P.1
Miao, H.2
D'souza, G.3
Osipo, C.4
Song, L.L.5
Yun, J.6
-
7
-
-
33845907380
-
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
-
DOI 10.1038/nature05313, PII NATURE05313
-
Ridgway, J, Zhang, G, Wu, Y, Stawicki, S, Liang, WC, Chanthery, Y et al. (2006). Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444: 1083-1087. (Pubitemid 46018529)
-
(2006)
Nature
, vol.444
, Issue.7122
, pp. 1083-1087
-
-
Ridgway, J.1
Zhang, G.2
Wu, Y.3
Stawicki, S.4
Liang, W.-C.5
Chanthery, Y.6
Kowalski, J.7
Watts, R.J.8
Callahan, C.9
Kasman, I.10
Singh, M.11
Chien, M.12
Tan, C.13
Hongo, J.-A.S.14
De Sauvage, F.15
Plowman, G.16
Yan, M.17
-
8
-
-
64249172203
-
The canonical Notch signaling pathway: Unfolding the activation mechanism
-
Kopan, R and Ilagan, MX (2009). The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137: 216-233.
-
(2009)
Cell
, vol.137
, pp. 216-233
-
-
Kopan, R.1
Ilagan, M.X.2
-
9
-
-
33845370048
-
Notch signaling in cancer
-
DOI 10.2174/156652406779010830
-
Miele, L, Golde, T and Osborne, B (2006). Notch signaling in cancer. Curr Mol Med 6: 905-918. (Pubitemid 44883940)
-
(2006)
Current Molecular Medicine
, vol.6
, Issue.8
, pp. 905-918
-
-
Miele, L.1
Golde, T.2
Osborne, B.3
-
10
-
-
76349113345
-
Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution
-
Delaney, C, Heimfeld, S, Brashem-Stein, C, Voorhies, H, Manger, RL and Bernstein, ID (2010). Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution. Nat Med 16: 232-236.
-
(2010)
Nat Med
, vol.16
, pp. 232-236
-
-
Delaney, C.1
Heimfeld, S.2
Brashem-Stein, C.3
Voorhies, H.4
Manger, R.L.5
Bernstein, I.D.6
-
11
-
-
70449671729
-
Direct inhibition of the NOTCH transcription factor complex
-
Moellering, RE, Cornejo, M, Davis, TN, Del Bianco, C, Aster, JC, Blacklow, SC et al. (2009). Direct inhibition of the NOTCH transcription factor complex. Nature 462: 182-188.
-
(2009)
Nature
, vol.462
, pp. 182-188
-
-
Moellering, R.E.1
Cornejo, M.2
Davis, T.N.3
Del Bianco, C.4
Aster, J.C.5
Blacklow, S.C.6
-
12
-
-
77951139188
-
Therapeutic antibody targeting of individual Notch receptors
-
Wu, Y, Cain-Hom, C, Choy, L, Hagenbeek, TJ, de Leon, GP, Chen, Y et al. (2010). Therapeutic antibody targeting of individual Notch receptors. Nature 464: 1052-1057.
-
(2010)
Nature
, vol.464
, pp. 1052-1057
-
-
Wu, Y.1
Cain-Hom, C.2
Choy, L.3
Hagenbeek, T.J.4
De Leon, G.P.5
Chen, Y.6
-
13
-
-
76749157186
-
Chronic DLL4 blockade induces vascular neoplasms
-
Yan, M, Callahan, CA, Beyer, JC, Allamneni, KP, Zhang, G, Ridgway, JB et al. (2010). Chronic DLL4 blockade induces vascular neoplasms. Nature 463: E6-E7.
-
(2010)
Nature
, vol.463
-
-
Yan, M.1
Callahan, C.A.2
Beyer, J.C.3
Allamneni, K.P.4
Zhang, G.5
Ridgway, J.B.6
-
14
-
-
20544460148
-
Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
-
DOI 10.1038/nature03659
-
van Es, JH, van Gijn ME, Riccio O, van den Born M, Vooijs M, Begthel H, et al. (2005). Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435, 959-963. (Pubitemid 40896322)
-
(2005)
Nature
, vol.435
, Issue.7044
, pp. 959-963
-
-
Van Es, J.H.1
Van Gijn, M.E.2
Riccio, O.3
Van Den Born, M.4
Vooijs, M.5
Begthel, H.6
Cozijnsen, M.7
Robine, S.8
Winton, D.J.9
Radtke, F.10
Clevers, H.11
-
15
-
-
11144355129
-
Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits γ-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation
-
DOI 10.1074/jbc.M311652200
-
Wong, GT, Manfra, D, Poulet, FM, Zhang, Q, Josien, H, Bara, T et al. (2004). Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem 279: 12876-12882. (Pubitemid 38445862)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.13
, pp. 12876-12882
-
-
Wong, G.T.1
Manfra, D.2
Poulet, F.M.3
Zhang, Q.4
Josien, H.5
Bara, T.6
Engstrom, L.7
Pinzon-Ortiz, M.8
Fine, J.S.9
Lee, H.-J.J.10
Zhang, L.11
Higgins, G.A.12
Parker, E.M.13
-
16
-
-
33747623018
-
Notch signalling: A simple pathway becomes complex
-
DOI 10.1038/nrm2009, PII NRM2009
-
Bray, SJ (2006). Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7: 678-689. (Pubitemid 44268213)
-
(2006)
Nature Reviews Molecular Cell Biology
, vol.7
, Issue.9
, pp. 678-689
-
-
Bray, S.J.1
-
17
-
-
67650389196
-
Targeting the Notch1 and mTOR pathways in a mouse T-ALL model
-
Cullion, K, Draheim, KM, Hermance, N, Tammam, J, Sharma, VM, Ware, C et al. (2009). Targeting the Notch1 and mTOR pathways in a mouse T-ALL model. Blood 113: 6172-6181.
-
(2009)
Blood
, vol.113
, pp. 6172-6181
-
-
Cullion, K.1
Draheim, K.M.2
Hermance, N.3
Tammam, J.4
Sharma, V.M.5
Ware, C.6
-
18
-
-
58149336788
-
Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
-
Real, PJ, Tosello, V, Palomero, T, Castillo, M, Hernando, E, de Stanchina, E et al. (2009). Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nat Med 15: 50-58.
-
(2009)
Nat Med
, vol.15
, pp. 50-58
-
-
Real, P.J.1
Tosello, V.2
Palomero, T.3
Castillo, M.4
Hernando, E.5
De Stanchina, E.6
-
19
-
-
51049090204
-
Nanoparticle therapeutics: An emerging treatment modality for cancer
-
Davis, ME, Chen, ZG and Shin, DM (2008). Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat Rev Drug Discov 7: 771-782.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 771-782
-
-
Davis, M.E.1
Chen, Z.G.2
Shin, D.M.3
-
20
-
-
14644439267
-
Cancer nanotechnology: Opportunities and challenges
-
DOI 10.1038/nrc1566
-
Ferrari, M (2005). Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer 5: 161-171. (Pubitemid 40314948)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.3
, pp. 161-171
-
-
Ferrari, M.1
-
21
-
-
77950118834
-
Cancer-cell targeting and cell-specific delivery by mesoporous silica nanoparticles
-
Rosenholm, JM, Sahlgren, C and Linden, M (2010). Cancer-cell targeting and cell-specific delivery by mesoporous silica nanoparticles. J Mater Chem 20: 2707-2713.
-
(2010)
J Mater Chem
, vol.20
, pp. 2707-2713
-
-
Rosenholm, J.M.1
Sahlgren, C.2
Linden, M.3
-
22
-
-
77957893294
-
Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles-opportunities & challenges
-
Rosenholm, JM, Sahlgren, C and Lindén, M (2010). Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles-opportunities & challenges. Nanoscale 2: 1870-1883.
-
(2010)
Nanoscale
, vol.2
, pp. 1870-1883
-
-
Rosenholm, J.M.1
Sahlgren, C.2
Lindén, M.3
-
23
-
-
61849185277
-
Targeting of porous hybrid silica nanoparticles to cancer cells
-
Rosenholm, JM, Meinander, A, Peuhu, E, Niemi, R, Eriksson, JE, Sahlgren, C et al. (2009). Targeting of porous hybrid silica nanoparticles to cancer cells. ACS Nano 3: 197-206.
-
(2009)
ACS Nano
, vol.3
, pp. 197-206
-
-
Rosenholm, J.M.1
Meinander, A.2
Peuhu, E.3
Niemi, R.4
Eriksson, J.E.5
Sahlgren, C.6
-
24
-
-
69249197816
-
Mesostructured multifunctional nanoparticles for imaging and drug delivery
-
Liong, M, Angelos, S, Choi, E, Patel, K, Stoddart, JF and Zink, JI (2009). Mesostructured multifunctional nanoparticles for imaging and drug delivery. J Mater Chem 19: 6251-6257.
-
(2009)
J Mater Chem
, vol.19
, pp. 6251-6257
-
-
Liong, M.1
Angelos, S.2
Choi, E.3
Patel, K.4
Stoddart, J.F.5
Zink, J.I.6
-
25
-
-
46749123819
-
Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers
-
Slowing, II, Vivero-Escoto, JL, Wu, CW and Lin, VS (2008). Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. Adv Drug Deliv Rev 60: 1278-1288.
-
(2008)
Adv Drug Deliv Rev
, vol.60
, pp. 1278-1288
-
-
Slowing, I.I.1
Vivero-Escoto, J.L.2
Wu, C.W.3
Lin, V.S.4
-
26
-
-
77953165953
-
Cancer-cell-specific induction of apoptosis using mesoporous silica nanoparticles as drug-delivery vectors
-
Rosenholm, JM, Peuhu, E, Bate-Eya, LT, Eriksson, JE, Sahlgren, C and Lindén, M (2010). Cancer-cell-specific induction of apoptosis using mesoporous silica nanoparticles as drug-delivery vectors. Small 6: 1234-1241.
-
(2010)
Small
, vol.6
, pp. 1234-1241
-
-
Rosenholm, J.M.1
Peuhu, E.2
Bate-Eya, L.T.3
Eriksson, J.E.4
Sahlgren, C.5
Lindén, M.6
-
27
-
-
70349968163
-
Targeted intracellular delivery of hydrophobic agents using mesoporous hybrid silica nanoparticles as carrier systems
-
Rosenholm, JM, Peuhu, E, Eriksson, JE, Sahlgren, C and Lindén, M (2009). Targeted intracellular delivery of hydrophobic agents using mesoporous hybrid silica nanoparticles as carrier systems. Nano Lett 9: 3308-3311.
-
(2009)
Nano Lett
, vol.9
, pp. 3308-3311
-
-
Rosenholm, J.M.1
Peuhu, E.2
Eriksson, J.E.3
Sahlgren, C.4
Lindén, M.5
-
28
-
-
45749083773
-
Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery
-
Liong, M, Lu, J, Kovochich, M, Xia, T, Ruehm, SG, Nel, AE et al. (2008). Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery. ACS Nano 2: 889-896.
-
(2008)
ACS Nano
, vol.2
, pp. 889-896
-
-
Liong, M.1
Lu, J.2
Kovochich, M.3
Xia, T.4
Ruehm, S.G.5
Nel, A.E.6
-
29
-
-
77950292495
-
Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model
-
Efferson, CL, Winkelmann, CT, Ware, C, Sullivan, T, Giampaoli, S, Tammam, J et al. (2010). Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model. Cancer Res 70: 2476-2484.
-
(2010)
Cancer Res
, vol.70
, pp. 2476-2484
-
-
Efferson, C.L.1
Winkelmann, C.T.2
Ware, C.3
Sullivan, T.4
Giampaoli, S.5
Tammam, J.6
-
30
-
-
7244250027
-
Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis
-
DOI 10.1083/jcb.200406140
-
Pece, S, Serresi, M, Santolini, E, Capra, M, Hulleman, E, Galimberti, V et al. (2004). Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J Cell Biol 167: 215-221. (Pubitemid 39435065)
-
(2004)
Journal of Cell Biology
, vol.167
, Issue.2
, pp. 215-221
-
-
Pece, S.1
Serresi, M.2
Santolini, E.3
Capra, M.4
Hulleman, E.5
Galimberti, V.6
Zurrida, S.7
Maisonneuve, P.8
Viale, G.9
Di Fiore, P.P.10
-
31
-
-
44049090235
-
Notch signaling mediates hypoxia-induced tumor cell migration and invasion
-
DOI 10.1073/pnas.0802047105
-
Sahlgren, C, Gustafsson, MV, Jin, S, Poellinger, L and Lendahl, U (2008). Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci USA 105: 6392-6397. (Pubitemid 351758356)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.17
, pp. 6392-6397
-
-
Sahlgren, C.1
Gustafsson, M.V.2
Jin, S.3
Poellinger, L.4
Lendahl, U.5
-
32
-
-
77955613395
-
Biocompatibility, biodistribution, and drug-delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals
-
Lu, J, Liong, M, Li, Z, Zink, JI and Tamanoi, F (2010). Biocompatibility, biodistribution, and drug-delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals. Small 6: 1794-1805.
-
(2010)
Small
, vol.6
, pp. 1794-1805
-
-
Lu, J.1
Liong, M.2
Li, Z.3
Zink, J.I.4
Tamanoi, F.5
-
33
-
-
65549086537
-
Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine
-
Fre, S, Pallavi, SK, Huyghe, M, Laé, M, Janssen, KP, Robine, S et al. (2009). Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc Natl Acad Sci USA 106: 6309-6314.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 6309-6314
-
-
Fre, S.1
Pallavi, S.K.2
Huyghe, M.3
Laé, M.4
Janssen, K.P.5
Robine, S.6
-
34
-
-
20544447734
-
Notch signals control the fate of immature progenitor cells in the intestine
-
DOI 10.1038/nature03589
-
Fre, S, Huyghe, M, Mourikis, P, Robine, S, Louvard, D and Artavanis-Tsakonas, S (2005). Notch signals control the fate of immature progenitor cells in the intestine. Nature 435: 964-968. (Pubitemid 40896323)
-
(2005)
Nature
, vol.435
, Issue.7044
, pp. 964-968
-
-
Fre, S.1
Huyghe, M.2
Mourikis, P.3
Robine, S.4
Louvard, D.5
Artavanis-Tsakonas, S.6
-
35
-
-
77954351997
-
Synthetic lethality through combined Notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer
-
Dong, Y, Li, A, Wang, J, Weber, JD and Michel, LS (2010). Synthetic lethality through combined Notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer. Cancer Res 70: 5465-5474.
-
(2010)
Cancer Res
, vol.70
, pp. 5465-5474
-
-
Dong, Y.1
Li, A.2
Wang, J.3
Weber, J.D.4
Michel, L.S.5
-
36
-
-
77952575335
-
Tumor-selective delivery of macromolecular drugs via the EPR effect: Background and future prospects
-
Maeda, H (2010). Tumor-selective delivery of macromolecular drugs via the EPR effect: background and future prospects. Bioconjug Chem 21: 797-802.
-
(2010)
Bioconjug Chem
, vol.21
, pp. 797-802
-
-
Maeda, H.1
-
37
-
-
68349141561
-
Monoclonal antibody-functionalized mesoporous silica nanoparticles (MSN) for selective targeting breast cancer cells
-
Tsai, C-P, Chen, C-Y, Hung, Y, Chang, F-H and Mou, C-Y (2009). Monoclonal antibody-functionalized mesoporous silica nanoparticles (MSN) for selective targeting breast cancer cells. J Mater Chem 19: 5737-5743.
-
(2009)
J Mater Chem
, vol.19
, pp. 5737-5743
-
-
Tsai, C.-P.1
Chen, C.-Y.2
Hung, Y.3
Chang, F.-H.4
Mou, C.-Y.5
-
38
-
-
70350077671
-
An efficient cell-targeting and intracellular controlled-release drug delivery system based on MSN-PEM-aptamer conjugates
-
Zhu, C-L, Song, X-Y, Zhou, W-H, Yang, H-H, Wen, Y-H and Wang X-R (2009). An efficient cell-targeting and intracellular controlled-release drug delivery system based on MSN-PEM-aptamer conjugates. J Mater Chem 41: 7765-7770.
-
(2009)
J Mater Chem
, vol.41
, pp. 7765-7770
-
-
Zhu, C.-L.1
Song, X.-Y.2
Zhou, W.-H.3
Yang, H.-H.4
Wen, Y.-H.5
Wang, X.-R.6
-
39
-
-
61649102498
-
Fluorescent silica nanoparticles with efficient urinary excretion for nanomedicine
-
Burns, AA, Vider, J, Ow, H, Herz, E, Penate-Medina, O, Baumgart, M et al. (2009). Fluorescent silica nanoparticles with efficient urinary excretion for nanomedicine. Nano Lett 9: 442-448.
-
(2009)
Nano Lett
, vol.9
, pp. 442-448
-
-
Burns, A.A.1
Vider, J.2
Ow, H.3
Herz, E.4
Penate-Medina, O.5
Baumgart, M.6
-
40
-
-
77953020259
-
Surface charge-mediated rapid hepatobiliary excretion of mesoporous silica nanoparticles
-
Souris, JS, Lee, CH, Cheng, SH, Chen, CT, Yang, CS, Ho, JA et al. (2010). Surface charge-mediated rapid hepatobiliary excretion of mesoporous silica nanoparticles. Biomaterials 31: 5564-5574.
-
(2010)
Biomaterials
, vol.31
, pp. 5564-5574
-
-
Souris, J.S.1
Lee, C.H.2
Cheng, S.H.3
Chen, C.T.4
Yang, C.S.5
Ho, J.A.6
-
41
-
-
34548264586
-
Direct synthesis of monodispersed thiol-functionalized nanoporous silica spheres and their application to a colloidal crystal embedded with gold nanoparticles
-
DOI 10.1039/b705209j
-
Nakamura, T, Yamada, Y and Yano, K (2007). Direct synthesis of monodispersed thiolfunctionalized nanoporous silica spheres and their application to a colloidal crystal embedded with gold nanoparticles. J Mater Chem 17: 3726-3732. (Pubitemid 47330704)
-
(2007)
Journal of Materials Chemistry
, vol.17
, Issue.35
, pp. 3726-3732
-
-
Nakamura, T.1
Yamada, Y.2
Yano, K.3
|