메뉴 건너뛰기




Volumn 5, Issue 6, 2011, Pages 492-503

Molecular-targeted nanotherapies in cancer: Enabling treatment specificity

Author keywords

Cancer; Liposomes; Molecular therapeutics; Nanomedicine; Polymer micelles; SiRNA

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; DOCETAXEL; DOXORUBICIN; LIPOSOME; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; NANOPARTICLE; NK 012; POLYMER; SMALL INTERFERING RNA; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 81855198905     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1016/j.molonc.2011.10.005     Document Type: Review
Times cited : (42)

References (78)
  • 2
  • 4
    • 34548609979 scopus 로고    scopus 로고
    • Beta-lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells
    • Blanco E., Bey E.A., Dong Y., Weinberg B.D., Sutton D.M., Boothman D.A., Gao J. Beta-lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells. J. Control Release 2007, 122:365-374.
    • (2007) J. Control Release , vol.122 , pp. 365-374
    • Blanco, E.1    Bey, E.A.2    Dong, Y.3    Weinberg, B.D.4    Sutton, D.M.5    Boothman, D.A.6    Gao, J.7
  • 7
    • 77951058617 scopus 로고    scopus 로고
    • Trastuzumab-based therapy for patients with HER2-positive breast cancer: from early scientific development to foundation of care
    • Brufsky A. Trastuzumab-based therapy for patients with HER2-positive breast cancer: from early scientific development to foundation of care. Am. J. Clin. Oncol. 2010, 33:186-195.
    • (2010) Am. J. Clin. Oncol. , vol.33 , pp. 186-195
    • Brufsky, A.1
  • 12
    • 1542269161 scopus 로고    scopus 로고
    • Progress in antisense technology
    • Crooke S.T. Progress in antisense technology. Annu. Rev. Med. 2004, 55:61-95.
    • (2004) Annu. Rev. Med. , vol.55 , pp. 61-95
    • Crooke, S.T.1
  • 13
  • 14
    • 67249128859 scopus 로고    scopus 로고
    • The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic
    • Davis M.E. The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic. Mol. Pharm. 2009, 6:659-668.
    • (2009) Mol. Pharm. , vol.6 , pp. 659-668
    • Davis, M.E.1
  • 17
    • 57749207052 scopus 로고    scopus 로고
    • Intravascular delivery of particulate systems: does geometry really matter?
    • Decuzzi P., Pasqualini R., Arap W., Ferrari M. Intravascular delivery of particulate systems: does geometry really matter?. Pharm. Res. 2009, 26:235-243.
    • (2009) Pharm. Res. , vol.26 , pp. 235-243
    • Decuzzi, P.1    Pasqualini, R.2    Arap, W.3    Ferrari, M.4
  • 21
    • 81855170441 scopus 로고    scopus 로고
    • Nanomedicine(s) under the microscope
    • In Press
    • Duncan R., Gaspar R. Nanomedicine(s) under the microscope. Mol. Pharm. 2011, In Press.
    • (2011) Mol. Pharm.
    • Duncan, R.1    Gaspar, R.2
  • 22
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir S.M., Harborth J., Lendeckel W., Yalcin A., Weber K., Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001, 411:494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 23
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara N., Hillan K.J., Gerber H.P., Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat. Rev. Drug Discov. 2004, 3:391-400.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.P.3    Novotny, W.4
  • 24
    • 14644439267 scopus 로고    scopus 로고
    • Cancer nanotechnology: opportunities and challenges
    • Ferrari M. Cancer nanotechnology: opportunities and challenges. Nat. Rev. Cancer 2005, 5:161-171.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 161-171
    • Ferrari, M.1
  • 25
    • 40449092935 scopus 로고    scopus 로고
    • Beyond drug delivery
    • Ferrari M. Beyond drug delivery. Nat. Nanotechnology 2008, 3:131-132.
    • (2008) Nat. Nanotechnology , vol.3 , pp. 131-132
    • Ferrari, M.1
  • 26
    • 77949632782 scopus 로고    scopus 로고
    • Frontiers in cancer nanomedicine: directing mass transport through biological barriers
    • Ferrari M. Frontiers in cancer nanomedicine: directing mass transport through biological barriers. Trends Biotechnol. 2010, 28:181-188.
    • (2010) Trends Biotechnol. , vol.28 , pp. 181-188
    • Ferrari, M.1
  • 27
    • 77956248928 scopus 로고    scopus 로고
    • Vectoring siRNA therapeutics into the clinic
    • Ferrari M. Vectoring siRNA therapeutics into the clinic. Nat. Rev. Clin. Oncol. 2010, 7:485-486.
    • (2010) Nat. Rev. Clin. Oncol. , vol.7 , pp. 485-486
    • Ferrari, M.1
  • 28
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391:806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 29
    • 0037681850 scopus 로고    scopus 로고
    • Pharmacokinetics of pegylated liposomal Doxorubicin: review of animal and human studies
    • Gabizon A., Shmeeda H., Barenholz Y. Pharmacokinetics of pegylated liposomal Doxorubicin: review of animal and human studies. Clin. Pharm. 2003, 42:419-436.
    • (2003) Clin. Pharm. , vol.42 , pp. 419-436
    • Gabizon, A.1    Shmeeda, H.2    Barenholz, Y.3
  • 30
    • 0035005359 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin: metamorphosis of an old drug into a new form of chemotherapy
    • Gabizon A.A. Pegylated liposomal doxorubicin: metamorphosis of an old drug into a new form of chemotherapy. Cancer Invest. 2001, 19:424-436.
    • (2001) Cancer Invest. , vol.19 , pp. 424-436
    • Gabizon, A.A.1
  • 31
    • 80255135728 scopus 로고    scopus 로고
    • Efficacy of taxanes as adjuvant treatment of breast cancer: a review and meta-analysis of randomised clinical trials
    • Gines J., Sabater E., Martorell C., Grau M., Monroy M., Casado M.A. Efficacy of taxanes as adjuvant treatment of breast cancer: a review and meta-analysis of randomised clinical trials. Clin. Transl. Oncol. 2011, 13:485-498.
    • (2011) Clin. Transl. Oncol. , vol.13 , pp. 485-498
    • Gines, J.1    Sabater, E.2    Martorell, C.3    Grau, M.4    Monroy, M.5    Casado, M.A.6
  • 32
    • 81855216513 scopus 로고    scopus 로고
    • Anticancer activity of bisphosphonates in breast cancer
    • Gnant M. Anticancer activity of bisphosphonates in breast cancer. Anticancer Agents Med. Chem. 2011.
    • (2011) Anticancer Agents Med. Chem.
    • Gnant, M.1
  • 34
    • 79958054544 scopus 로고    scopus 로고
    • Targeted therapies: peaking beneath the surface of recent bevacizumab trials
    • Gonzalez-Angulo A.M., Hortobagyi G.N., Ellis L.M. Targeted therapies: peaking beneath the surface of recent bevacizumab trials. Nat. Rev. Clin. Oncol. 2011, 8:319-320.
    • (2011) Nat. Rev. Clin. Oncol. , vol.8 , pp. 319-320
    • Gonzalez-Angulo, A.M.1    Hortobagyi, G.N.2    Ellis, L.M.3
  • 35
    • 52649150833 scopus 로고    scopus 로고
    • Targeting angiogenesis driven by vascular endothelial growth factors using antibody-based therapies
    • Grothey A., Ellis L.M. Targeting angiogenesis driven by vascular endothelial growth factors using antibody-based therapies. Cancer J. 2008, 14:170-177.
    • (2008) Cancer J. , vol.14 , pp. 170-177
    • Grothey, A.1    Ellis, L.M.2
  • 36
    • 0036597855 scopus 로고    scopus 로고
    • EORTC 10968: a phase I clinical and pharmacokinetic study of polyethylene glycol liposomal doxorubicin (Caelyx, Doxil) at a 6-week interval in patients with metastatic breast cancer. European Organization for Research and Treatment of Cancer
    • Hamilton A., Biganzoli L., Coleman R., Mauriac L., Hennebert P., Awada A., Nooij M., Beex L., Piccart M., Van Hoorebeeck I., Bruning P., de Valeriola D. EORTC 10968: a phase I clinical and pharmacokinetic study of polyethylene glycol liposomal doxorubicin (Caelyx, Doxil) at a 6-week interval in patients with metastatic breast cancer. European Organization for Research and Treatment of Cancer. Ann. Oncol. 2002, 13:910-918.
    • (2002) Ann. Oncol. , vol.13 , pp. 910-918
    • Hamilton, A.1    Biganzoli, L.2    Coleman, R.3    Mauriac, L.4    Hennebert, P.5    Awada, A.6    Nooij, M.7    Beex, L.8    Piccart, M.9    Van Hoorebeeck, I.10    Bruning, P.11    de Valeriola, D.12
  • 37
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 38
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 39
    • 34347272315 scopus 로고    scopus 로고
    • Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA
    • Heidel J.D., Yu Z., Liu J.Y., Rele S.M., Liang Y., Zeidan R.K., Kornbrust D.J., Davis M.E. Administration in non-human primates of escalating intravenous doses of targeted nanoparticles containing ribonucleotide reductase subunit M2 siRNA. Proc. Natl. Acad. Sci. U S A 2007, 104:5715-5721.
    • (2007) Proc. Natl. Acad. Sci. U S A , vol.104 , pp. 5715-5721
    • Heidel, J.D.1    Yu, Z.2    Liu, J.Y.3    Rele, S.M.4    Liang, Y.5    Zeidan, R.K.6    Kornbrust, D.J.7    Davis, M.E.8
  • 41
    • 74049119820 scopus 로고    scopus 로고
    • Combination chemotherapy of doxorubicin and paclitaxel for hepatocellular carcinoma in vitro and in vivo
    • Jin C., Li H., He Y., He M., Bai L., Cao Y., Song W., Dou K. Combination chemotherapy of doxorubicin and paclitaxel for hepatocellular carcinoma in vitro and in vivo. J. Cancer Res. Clin. Oncol. 2010, 136:267-274.
    • (2010) J. Cancer Res. Clin. Oncol. , vol.136 , pp. 267-274
    • Jin, C.1    Li, H.2    He, Y.3    He, M.4    Bai, L.5    Cao, Y.6    Song, W.7    Dou, K.8
  • 42
    • 83555173191 scopus 로고    scopus 로고
    • Cationic liposomal co-delivery of small interfering RNA and a MEK inhibitor for enhanced anticancer efficacy
    • In Press
    • Kang S.H., Cho H.J., Shim G., Lee S., Kim S.H., Choi H.G., Kim C.W., Oh Y.K. Cationic liposomal co-delivery of small interfering RNA and a MEK inhibitor for enhanced anticancer efficacy. Pharm. Res. 2011, In Press.
    • (2011) Pharm. Res.
    • Kang, S.H.1    Cho, H.J.2    Shim, G.3    Lee, S.4    Kim, S.H.5    Choi, H.G.6    Kim, C.W.7    Oh, Y.K.8
  • 43
    • 0035937592 scopus 로고    scopus 로고
    • Block copolymer micelles for drug delivery: design, characterization and biological significance
    • Kataoka K., Harada A., Nagasaki Y. Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv. Drug Deliv. Rev. 2001, 47:113-131.
    • (2001) Adv. Drug Deliv. Rev. , vol.47 , pp. 113-131
    • Kataoka, K.1    Harada, A.2    Nagasaki, Y.3
  • 44
    • 77957599889 scopus 로고    scopus 로고
    • The antitumor activity of NK012, an SN-38-incorporating micelle, in combination with bevacizumab against lung cancer xenografts
    • Kenmotsu H., Yasunaga M., Goto K., Nagano T., Kuroda J., Koga Y., Takahashi A., Nishiwaki Y., Matsumura Y. The antitumor activity of NK012, an SN-38-incorporating micelle, in combination with bevacizumab against lung cancer xenografts. Cancer 2010, 116:4597-4604.
    • (2010) Cancer , vol.116 , pp. 4597-4604
    • Kenmotsu, H.1    Yasunaga, M.2    Goto, K.3    Nagano, T.4    Kuroda, J.5    Koga, Y.6    Takahashi, A.7    Nishiwaki, Y.8    Matsumura, Y.9
  • 45
    • 80053948169 scopus 로고    scopus 로고
    • Targeting heat shock protein 90 induces apoptosis and inhibits critical survival and proliferation pathways in multiple myeloma
    • Khong T., Spencer A. Targeting heat shock protein 90 induces apoptosis and inhibits critical survival and proliferation pathways in multiple myeloma. Mol. Cancer Ther. 2011, 10:1909-1917.
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 1909-1917
    • Khong, T.1    Spencer, A.2
  • 46
    • 70349758510 scopus 로고    scopus 로고
    • Src kinases as therapeutic targets for cancer
    • Kim L.C., Song L., Haura E.B. Src kinases as therapeutic targets for cancer. Nat. Rev. Clin. Oncol. 2009, 6:587-595.
    • (2009) Nat. Rev. Clin. Oncol. , vol.6 , pp. 587-595
    • Kim, L.C.1    Song, L.2    Haura, E.B.3
  • 47
    • 46549085779 scopus 로고    scopus 로고
    • Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer
    • Kim S.H., Jeong J.H., Lee S.H., Kim S.W., Park T.G. Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer. J. Control Release 2008, 129:107-116.
    • (2008) J. Control Release , vol.129 , pp. 107-116
    • Kim, S.H.1    Jeong, J.H.2    Lee, S.H.3    Kim, S.W.4    Park, T.G.5
  • 48
    • 77952531028 scopus 로고    scopus 로고
    • Conjugation of bevacizumab to cationic liposomes enhances their tumor-targeting potential
    • Kuesters G.M., Campbell R.B. Conjugation of bevacizumab to cationic liposomes enhances their tumor-targeting potential. Nanomedicine (Lond) 2010, 5:181-192.
    • (2010) Nanomedicine (Lond) , vol.5 , pp. 181-192
    • Kuesters, G.M.1    Campbell, R.B.2
  • 49
    • 80054716147 scopus 로고    scopus 로고
    • Synthesis and evaluation of poly(styrene-co-maleic acid) micellar nanocarriers for the delivery of tanespimycin
    • Larson N., Greish K., Bauer H., Maeda H., Ghandehari H. Synthesis and evaluation of poly(styrene-co-maleic acid) micellar nanocarriers for the delivery of tanespimycin. Int. J. Pharm. 2011, 420:111-117.
    • (2011) Int. J. Pharm. , vol.420 , pp. 111-117
    • Larson, N.1    Greish, K.2    Bauer, H.3    Maeda, H.4    Ghandehari, H.5
  • 50
    • 39749178252 scopus 로고    scopus 로고
    • Multicenter phase II trial of Genexol-PM, a Cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer
    • Lee K.S., Chung H.C., Im S.A., Park Y.H., Kim C.S., Kim S.B., Rha S.Y., Lee M.Y., Ro J. Multicenter phase II trial of Genexol-PM, a Cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer. Breast Cancer Res. Treat. 2008, 108:241-250.
    • (2008) Breast Cancer Res. Treat. , vol.108 , pp. 241-250
    • Lee, K.S.1    Chung, H.C.2    Im, S.A.3    Park, Y.H.4    Kim, C.S.5    Kim, S.B.6    Rha, S.Y.7    Lee, M.Y.8    Ro, J.9
  • 51
    • 0034993240 scopus 로고    scopus 로고
    • The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting
    • Maeda H. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv. Enzyme. Regul. 2001, 41:189-207.
    • (2001) Adv. Enzyme. Regul. , vol.41 , pp. 189-207
    • Maeda, H.1
  • 53
    • 0034722889 scopus 로고    scopus 로고
    • The EGF receptor family as targets for cancer therapy
    • Mendelsohn J., Baselga J. The EGF receptor family as targets for cancer therapy. Oncogene 2000, 19:6550-6565.
    • (2000) Oncogene , vol.19 , pp. 6550-6565
    • Mendelsohn, J.1    Baselga, J.2
  • 55
    • 0142154204 scopus 로고    scopus 로고
    • Technology evaluation: LErafAON, NeoPharm
    • Moreira J.N., Simoes S. Technology evaluation: LErafAON, NeoPharm. Curr. Opin. Mol. Ther. 2003, 5:547-552.
    • (2003) Curr. Opin. Mol. Ther. , vol.5 , pp. 547-552
    • Moreira, J.N.1    Simoes, S.2
  • 56
    • 76549090842 scopus 로고    scopus 로고
    • Recent advances in systemic therapy: advances in systemic therapy for HER2-positive metastatic breast cancer
    • Morrow P.K., Zambrana F., Esteva F.J. Recent advances in systemic therapy: advances in systemic therapy for HER2-positive metastatic breast cancer. Breast Cancer Res. 2009, 11:207.
    • (2009) Breast Cancer Res. , vol.11 , pp. 207
    • Morrow, P.K.1    Zambrana, F.2    Esteva, F.J.3
  • 59
    • 77952585292 scopus 로고    scopus 로고
    • Targeted near-IR QDs-loaded micelles for cancer therapy and imaging
    • Nurunnabi M., Cho K.J., Choi J.S., Huh K.M., Lee Y.K. Targeted near-IR QDs-loaded micelles for cancer therapy and imaging. Biomaterials 2010, 31:5436-5444.
    • (2010) Biomaterials , vol.31 , pp. 5436-5444
    • Nurunnabi, M.1    Cho, K.J.2    Choi, J.S.3    Huh, K.M.4    Lee, Y.K.5
  • 62
    • 0033651234 scopus 로고    scopus 로고
    • The molecular and cellular biology of HER2/neu gene amplification/overexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer
    • Pegram M.D., Konecny G., Slamon D.J. The molecular and cellular biology of HER2/neu gene amplification/overexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer. Cancer Treat. Res. 2000, 103:57-75.
    • (2000) Cancer Treat. Res. , vol.103 , pp. 57-75
    • Pegram, M.D.1    Konecny, G.2    Slamon, D.J.3
  • 63
    • 79952180081 scopus 로고    scopus 로고
    • Promise and challenge of RNA interference-based therapy for cancer
    • Petrocca F., Lieberman J. Promise and challenge of RNA interference-based therapy for cancer. J. Clin. Oncol. 2011, 29:747-754.
    • (2011) J. Clin. Oncol. , vol.29 , pp. 747-754
    • Petrocca, F.1    Lieberman, J.2
  • 64
    • 0034009970 scopus 로고    scopus 로고
    • NAD(P)H: quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity
    • Pink J.J., Planchon S.M., Tagliarino C., Varnes M.E., Siegel D., Boothman D.A. NAD(P)H: quinone oxidoreductase activity is the principal determinant of beta-lapachone cytotoxicity. J. Biol. Chem. 2000, 275:5416-5424.
    • (2000) J. Biol. Chem. , vol.275 , pp. 5416-5424
    • Pink, J.J.1    Planchon, S.M.2    Tagliarino, C.3    Varnes, M.E.4    Siegel, D.5    Boothman, D.A.6
  • 65
    • 79952914994 scopus 로고    scopus 로고
    • Zoledronic acid for adjuvant use in patients with breast cancer
    • Ressler S., Mlineritsch B., Greil R. Zoledronic acid for adjuvant use in patients with breast cancer. Expert Rev. Anticancer Ther. 2011, 11:333-349.
    • (2011) Expert Rev. Anticancer Ther. , vol.11 , pp. 333-349
    • Ressler, S.1    Mlineritsch, B.2    Greil, R.3
  • 67
    • 79952228437 scopus 로고    scopus 로고
    • How do you tell whether a breast cancer is HER2 positive? Ongoing studies keep debate in high gear
    • Schmidt C. How do you tell whether a breast cancer is HER2 positive? Ongoing studies keep debate in high gear. J. Natl. Cancer Inst. 2011, 103:87-89.
    • (2011) J. Natl. Cancer Inst. , vol.103 , pp. 87-89
    • Schmidt, C.1
  • 68
    • 60849117221 scopus 로고    scopus 로고
    • The association of silicon microparticles with endothelial cells in drug delivery to the vasculature
    • Serda R.E., Gu J., Bhavane R.C., Liu X., Chiappini C., Decuzzi P., Ferrari M. The association of silicon microparticles with endothelial cells in drug delivery to the vasculature. Biomaterials 2009, 30:2440-2448.
    • (2009) Biomaterials , vol.30 , pp. 2440-2448
    • Serda, R.E.1    Gu, J.2    Bhavane, R.C.3    Liu, X.4    Chiappini, C.5    Decuzzi, P.6    Ferrari, M.7
  • 69
    • 46749091612 scopus 로고    scopus 로고
    • Bioconjugated quantum dots for in vivo molecular and cellular imaging
    • Smith A.M., Duan H., Mohs A.M., Nie S. Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv. Drug Deliv. Rev. 2008, 60:1226-1240.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 1226-1240
    • Smith, A.M.1    Duan, H.2    Mohs, A.M.3    Nie, S.4
  • 70
    • 44449085539 scopus 로고    scopus 로고
    • Paul Ehrlich's magic bullet concept: 100 years of progress
    • Strebhardt K., Ullrich A. Paul Ehrlich's magic bullet concept: 100 years of progress. Nat. Rev. Cancer 2008, 8:473-480.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 473-480
    • Strebhardt, K.1    Ullrich, A.2
  • 71
    • 34249023676 scopus 로고    scopus 로고
    • Functionalized micellar systems for cancer targeted drug delivery
    • Sutton D., Nasongkla N., Blanco E., Gao J. Functionalized micellar systems for cancer targeted drug delivery. Pharm. Res. 2007, 24:1029-1046.
    • (2007) Pharm. Res. , vol.24 , pp. 1029-1046
    • Sutton, D.1    Nasongkla, N.2    Blanco, E.3    Gao, J.4
  • 74
    • 14144250911 scopus 로고    scopus 로고
    • Recent advances with liposomes as pharmaceutical carriers
    • Torchilin V.P. Recent advances with liposomes as pharmaceutical carriers. Nat. Rev. Drug Discov. 2005, 4:145-160.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 145-160
    • Torchilin, V.P.1
  • 76
  • 78
    • 33646144003 scopus 로고    scopus 로고
    • SiRNA-containing liposomes modified with polyarginine effectively silence the targeted gene
    • Zhang C., Tang N., Liu X., Liang W., Xu W., Torchilin V.P. siRNA-containing liposomes modified with polyarginine effectively silence the targeted gene. J. Control Release 2006, 112:229-239.
    • (2006) J. Control Release , vol.112 , pp. 229-239
    • Zhang, C.1    Tang, N.2    Liu, X.3    Liang, W.4    Xu, W.5    Torchilin, V.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.