Combination chemotherapy and photodynamic therapy of targetable N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin/mesochlorin e6-OV-TL 16 antibody immunoconjugates

Journal of Controlled Release

Volumn 74, Issue 1-3, 2001, Pages 249-253

  Shiah, J G ^a   Sun, Y ^a   Kopeckova P ^a   Peterson, C M ^b   Straight, R C ^a   Kopecek J ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Doxorubicin (adriamycin); EPR effect; Mesochlorin e6 monoethylenediamine; N (2 Hydroxypropyl)methacrylamide copolymer; OV TL 16 immunoconjugate

Indexed keywords

ANTIBODY CONJUGATE; ANTINEOPLASTIC AGENT; DIAMINE DERIVATIVE; DOXORUBICIN; MESOCHLORIN E6 MONOETHYLENEDIAMINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY OV TL16; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER DOXORUBICIN OV TL16 MONOCLONAL ANTIBODY CONJUGATE; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER MESOCHLORIN E6 MONOETHYLENEDIAMINE OV TL16 MONOCLONAL ANTIBODY CONJUGATE; UNCLASSIFIED DRUG;

ANIMAL MODEL; CANCER COMBINATION CHEMOTHERAPY; CONFERENCE PAPER; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG PENETRATION; DRUG PURIFICATION; DRUG RETENTION; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; FLUORESCENCE ANALYSIS; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; IRRADIATION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OVARY CARCINOMA; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIBODIES, MONOCLONAL; DOXORUBICIN; FEMALE; HALF-LIFE; IMMUNOCONJUGATES; MESOPORPHYRINS; METHACRYLATES; MICE; MICE, NUDE; PHOTOCHEMOTHERAPY; PORPHYRINS; TISSUE DISTRIBUTION;

EID: 0035816192     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00325-X     Document Type: Conference Paper

References (7)

1. HPMA copolymer-anticancer drug conjugates: Design, activity, and mechanism of action
2. Combination chemotherapy and photodynamic therapy with N-(2-hydroxypropyl)methacrylamide copolymer-bound anticancer drugs inhibit human ovarian carcinoma heterotransplanted in nude mice
3. HPMA copolymer-anticancer drug-OV-TL 16 antibody conjugates. I. Influence of the method of synthesis on the binding affinity to OVCAR-3 ovarian carcinoma cells in vitro
4. 6 and adriamycin in nude mice bearing human ovarian carcinoma OVCAR-3 xenografts
5. 6 and adriamycin conjugates in combination treatments
6. Conjugates of anticancer agents and polymers: Advantages of macromolecular therapeutics in vivo
7. Biodistribution and antitumor efficacy of long-circulating N-(2-hydroxypropyl)methacrylamide copolymer-doxorubicin conjugates in nude mice