Polymerizable Fab' antibody fragments for targeting of anticancer drugs

Nature Biotechnology

Volumn 17, Issue 11, 1999, Pages 1101-1104

  Lu, Zheng Rong ^a   Kopečková, Pavla ^a   Kopeček, Jindřich ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

Anticancer drug; Chlorin e6; Drug targeting; HPMA copolymer; Polymerizable Fab'

Indexed keywords

ANTINEOPLASTIC AGENT; IMMUNOGLOBULIN F(AB) FRAGMENT; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG TARGETING; MOUSE; NONHUMAN; OVARY CANCER; POLYMERIZATION; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; CARCINOMA; DRUG CARRIERS; FEMALE; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; METHACRYLATES; OVARIAN NEOPLASMS; POLYMERS; PORPHYRINS; TUMOR CELLS, CULTURED;

EID: 0344146604     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/15085     Document Type: Article

References (22)

1. Putnam, D. & Kopecek, J. Polymer conjugates with anticancer activity. Adv. Polym. Sci. 122, 55-123 (1995).
2. Maeda, H., Seymour, L.M. & Miyamoto, Y. Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vitro. Bioconjugate Chem. 3, 351-362 (1992).
3. Vasey, P.A. et al. Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin): first member of a new class of chemotherapeutic agents - drug-polymer conjugates. Clin. Cancer Res. 5, 63-94 (1999).
4. Caiolfa, V.R. et al. Novel perspectives in topoiosmerase-l inhibitor-based chemotherapy of solid tumors: MAG-camptothecin conjugates. Abstr. Ninth Intl. Symp. Recent Adv. Drug Delivery Systems. Salt Lake City, UT, February 22, 1999, p. 46.
5. Fritzberg, A.R. Biorecognition of antibodies in vivo: potential in drug targeting. J. Mol. Recognition 9, 309-315 (1996).
6. Omelyanenko, V., Kopecková, P., Gentry, C., Shiah, J.-G., & Kopecek, J. HPMA copolymer-anticancer drug-OV-TL 16 antibody conjugates. 1. Influence of the method of synthesis on the binding affinity to OVCAR-3 ovarian carcinoma cells in vitro. J. Drug Targeting 3, 357-373 (1996).
7. Rihová, B. et al. Antibody-directed affinity therapy applied to the immune system: in vivo effectiveness and limited toxicity of daunomycin conjugated to HPMA copolymers and targeting antibody. Clin. Immunol. Immunopathol. 46, 100-114 (1988).
8. Auditore-Hargreaves, K. et al. Phase-separation immunoassays. Clin. Chem. 33, 1509-1516 (1987).
9. Monji, N. & Hoffman, A.S. A novel immunoassay system and bioseparation process based on thermal phase separating polymers. Appl. Biochem. Biotech. 14, 107-119 (1987).
10. Fritzberg, A.R., Beaumier, P.L., Bottino, B.J. & Reno, J.R. Approaches to improved antibody-and peptide-mediated targeting for imaging and therapy of cancer. J. Controlled Release 28, 167-173 (1994).
11. Boerman, O. et al. Comparative in vitro binding and biodistribution in tumor-bearing athymic mice of anti-ovarian carcinoma monoclonal antibodies. Anticancer Res. 10, 1289-1296 (1990).
12. Boerman, O. et al. Monoclonal antibodies against ovarian carcinoma-associated antigens, raised by immunization with cyst fluids. Anticancer Res. 9, 551-558 (1989).
13. Lu, Z.-R., Kopecková, P. & Kopecek, J. Polymerizable Fab' antibody fragments. Proc. Intl. Symp. Controlled Release Bioactive Mater. 25, 788-789 (1998).
14. 2b from Balb/c mice. J. Immunol. 131, 2895-2902 (1993).
15. Parham, P., Androlewicz, M.J., Brodsky, F.M., Holmes, N.J. & Ways, J.P. Monoclonal antibodies: purification, fragmentation and application to structural and functional studies of class I MHC antigens. J. Immunol. Methods 53, 133-173 (1982).
16. Peterson, C.M. et al. Combination chemotherapy and photodynamic therapy with N-(2-hydroxypropyl)methacrylamide copolymer-bound anticancer drugs inhibit human ovarian carcinoma heterotransplanted in nude mice. Cancer Res. 56, 3980-3985 (1996).
17. Rejmanová, P., Pohl, J., Baudys, M., Kostka, V. & Kopecek, J. Polymers containing enzymatically degradable bonds. 8. Degradation of oligopeptide sequences in N-(2-hydroxypropyl)methacrylamide copolymers by bovine spleen cathepsin B. Makromol. Chem. 184, 2009-2020 (1983).
18. Omelyanenko, V., Gentry, C., Kopecková, P. & Kopecek, J. HPMA copolymer-anticancer drug-OV-TL16 antibody conjugates. II. Processing in epithelial ovarian carcinoma cells in vitro. Int. J. Cancer 75, 600-608 (1998).
19. Delgado, C. et al. Enhanced tumor specificity of an anticarcinoembrionic antigen Fab' fragment by poly(ethylene glycol) (PEG) modification. Br. J. Cancer 73, 175-182 (1996).
20. Drobník, J. et al. Enzymatic cleavage of side chains of synthetic water-soluble polymers. Makromol. Chem. 177, 2833-2848 (1976).
21. Kopecek, J. & Bazilová, H. Poly[N-(2-hydroxypropyl)methacrylamide]. 1. Radical polymerization and copolymerization. Eur. Polym. J. 9, 7-14 (1973).
22. Kopecek, J. et al. Synthetic polymeric drugs. U.S. Pat. 5, 037, 883 (Aug. 6, 1991).