-
1
-
-
0034077041
-
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
-
Abeliovich A, Schmitz Y, Farinãs I, Choi-Lundberg D, Ho WH, Castillo PE, Shinsky N, Verdugo JM, Armanini M, Ryan A, Hynes M, Phillips H, Sulzer D, Rosenthal A (2000) Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25:239-252.
-
(2000)
Neuron
, vol.25
, pp. 239-252
-
-
Abeliovich, A.1
Schmitz, Y.2
Farinãs, I.3
Choi-Lundberg, D.4
Ho, W.H.5
Castillo, P.E.6
Shinsky, N.7
Verdugo, J.M.8
Armanini, M.9
Ryan, A.10
Hynes, M.11
Phillips, H.12
Sulzer, D.13
Rosenthal, A.14
-
2
-
-
41149108952
-
Alpha-synuclein aggregation alters tyrosine hydroxylase phos-phorylation and immunore activity: Lessons from viral transduction of knock-out mice
-
Alerte TN, Akinfolarin AA, Friedrich EE, Mader SA, Hong CS, Perez RG (2008) Alpha-synuclein aggregation alters tyrosine hydroxylase phos-phorylation and immunore activity: lessons from viral transduction of knock-out mice. Neurosci Lett 435:24-29.
-
(2008)
Neurosci Lett
, vol.435
, pp. 24-29
-
-
Alerte, T.N.1
Akinfolarin, A.A.2
Friedrich, E.E.3
Mader, S.A.4
Hong, C.S.5
Perez, R.G.6
-
3
-
-
33749570292
-
Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease
-
Anderson JP, Walker DE, Goldstein JM, de Laat R, Banducci K, Caccavello RJ, Barbour R, Huang J, Kling K, Lee M, Diep L, Keim PS, Shen X, Chataway T, Schlossmacher MG, Seubert P, Schenk D, Sinha S, Gai WP, Chilcote TJ (2006) Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease. J Biol Chem 281:29739-29752.
-
(2006)
J Biol Chem
, vol.281
, pp. 29739-29752
-
-
Anderson, J.P.1
Walker, D.E.2
Goldstein, J.M.3
de Laat, R.4
Banducci, K.5
Caccavello, R.J.6
Barbour, R.7
Huang, J.8
Kling, K.9
Lee, M.10
Diep, L.11
Keim, P.S.12
Shen, X.13
Chataway, T.14
Schlossmacher, M.G.15
Seubert, P.16
Schenk, D.17
Sinha, S.18
Gai, W.P.19
Chilcote, T.J.20
more..
-
4
-
-
79956296370
-
Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family
-
Anwar S, Peters O, Millership S, Ninkina N, Doig N, Connor-Robson N, Threlfell S, Kooner G, Deacon RM, Bannerman DM, Bolam JP, Chandra SS, Cragg SJ, Wade-Martins R, Buchman VL (2011) Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family. J Neurosci 31:7264-7274.
-
(2011)
J Neurosci
, vol.31
, pp. 7264-7274
-
-
Anwar, S.1
Peters, O.2
Millership, S.3
Ninkina, N.4
Doig, N.5
Connor-Robson, N.6
Threlfell, S.7
Kooner, G.8
Deacon, R.M.9
Bannerman, D.M.10
Bolam, J.P.11
Chandra, S.S.12
Cragg, S.J.13
Wade-Martins, R.14
Buchman, V.L.15
-
5
-
-
0031941058
-
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
-
Baba M, Nakajo S, Tu PH, Tomita T, Nakaya K, Lee VM, Trojanowski JQ, Iwatsubo T (1998) Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. AmJ Pathol 152:879-884.
-
(1998)
AmJ Pathol
, vol.152
, pp. 879-884
-
-
Baba, M.1
Nakajo, S.2
Tu, P.H.3
Tomita, T.4
Nakaya, K.5
Lee, V.M.6
Trojanowski, J.Q.7
Iwatsubo, T.8
-
6
-
-
84863010985
-
Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease: A 3 year longitudinal study
-
Baba T, Kikuchi A, Hirayama K, Nishio Y, Hosokai Y, Kanno S, Hasegawa T, Sugeno N, Konno M, Suzuki K, Takahashi S, Fukuda H, Aoki M, Itoyama Y, Mori E, Takeda A (2012) Severe olfactory dysfunction is a prodromal symptom of dementia associated with Parkinson's disease: a 3 year longitudinal study. Brain 135:161-169.
-
(2012)
Brain
, vol.135
, pp. 161-169
-
-
Baba, T.1
Kikuchi, A.2
Hirayama, K.3
Nishio, Y.4
Hosokai, Y.5
Kanno, S.6
Hasegawa, T.7
Sugeno, N.8
Konno, M.9
Suzuki, K.10
Takahashi, S.11
Fukuda, H.12
Aoki, M.13
Itoyama, Y.14
Mori, E.15
Takeda, A.16
-
7
-
-
33747769942
-
Alpha-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers
-
Beyer K (2006) Alpha-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers. Acta Neuropathol 112: 237-251.
-
(2006)
Acta Neuropathol
, vol.112
, pp. 237-251
-
-
Beyer, K.1
-
8
-
-
11844251247
-
A topological model of the interaction between alpha-synuclein and sodium dodecyl sulfate micelles
-
Bisaglia M, Tessari I, Pinato L, Bellanda M, Giraudo S, Fasano M, Bergantino E, Bubacco L, Mammi S (2005) A topological model of the interaction between alpha-synuclein and sodium dodecyl sulfate micelles. Biochemistry 44:329-339.
-
(2005)
Biochemistry
, vol.44
, pp. 329-339
-
-
Bisaglia, M.1
Tessari, I.2
Pinato, L.3
Bellanda, M.4
Giraudo, S.5
Fasano, M.6
Bergantino, E.7
Bubacco, L.8
Mammi, S.9
-
9
-
-
33746894560
-
Inter-helix distances in lysophospholipid micelle-bound alpha-synuclein from pulsed ESR measurements
-
Borbat P, Ramlall TF, Freed JH, Eliezer D (2006) Inter-helix distances in lysophospholipid micelle-bound alpha-synuclein from pulsed ESR measurements. J Am Chem Soc 128:10004-10005.
-
(2006)
J Am Chem Soc
, vol.128
, pp. 10004-10005
-
-
Borbat, P.1
Ramlall, T.F.2
Freed, J.H.3
Eliezer, D.4
-
10
-
-
44349100972
-
Broken helix in vesicle and micelle-bound alpha-synuclein: Insights from site-directed spin labeling-EPR experiments and MD simulation
-
Bortolus M, Tombolato F, Tessari I, Bisaglia M, Mammi S, Bubacco L, Ferrarini A, Maniero AL (2008) Broken helix in vesicle and micelle-bound alpha-synuclein: insights from site-directed spin labeling-EPR experiments and MD simulation. J Am Chem Soc 130:6690-6691.
-
(2008)
J Am Chem Soc
, vol.130
, pp. 6690-6691
-
-
Bortolus, M.1
Tombolato, F.2
Tessari, I.3
Bisaglia, M.4
Mammi, S.5
Bubacco, L.6
Ferrarini, A.7
Maniero, A.L.8
-
11
-
-
34547727312
-
Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease
-
Braak H, Sastre M, Del Tredici K (2007) Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease. Acta Neuropathol 114: 231-241.
-
(2007)
Acta Neuropathol
, vol.114
, pp. 231-241
-
-
Braak, H.1
Sastre, M.2
Del Tredici, K.3
-
12
-
-
77957347060
-
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro
-
Burré J, Sharma M, Tsetsenis T, Buchman V, Etherton MR, Südhof TC (2010) Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. Science 329:1663-1667.
-
(2010)
Science
, vol.329
, pp. 1663-1667
-
-
Burré, J.1
Sharma, M.2
Tsetsenis, T.3
Buchman, V.4
Etherton, M.R.5
Südhof, T.C.6
-
13
-
-
1942534598
-
Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein
-
Bussell R Jr, Eliezer D (2004) Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein. Biochemistry 43:4810-4818.
-
(2004)
Biochemistry
, vol.43
, pp. 4810-4818
-
-
Bussell Jr., R.1
Eliezer, D.2
-
14
-
-
69249213380
-
Neu N is not a reliable marker of dopamine neurons in rat substantia nigra
-
Cannon JR, Greenamyre JT (2009) Neu N is not a reliable marker of dopamine neurons in rat substantia nigra. Neurosci Lett 464:14-17.
-
(2009)
Neurosci Lett
, vol.464
, pp. 14-17
-
-
Cannon, J.R.1
Greenamyre, J.T.2
-
15
-
-
0038341134
-
A broken alpha-helix in folded alpha-synuclein
-
Chandra S, Chen X, Rizo J, Jahn R, Südhof TC (2003) A broken alpha-helix in folded alpha-synuclein. J Biol Chem 278:15313-15318.
-
(2003)
J Biol Chem
, vol.278
, pp. 15313-15318
-
-
Chandra, S.1
Chen, X.2
Rizo, J.3
Jahn, R.4
Südhof, T.C.5
-
16
-
-
27544507306
-
Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration
-
Chandra S, Gallardo G, Fernández-Chacnó R, Schlüter OM, Südhof TC (2005) Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123:383-396.
-
(2005)
Cell
, vol.123
, pp. 383-396
-
-
Chandra, S.1
Gallardo, G.2
Fernández-Chacnó, R.3
Schlüter, O.M.4
Südhof, T.C.5
-
17
-
-
84863229691
-
Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo
-
Colla E, Jensen PH, Pletnikova O, Troncoso JC, Glabe C, Lee MK (2012) Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo. J Neurosci 32:3301-3305.
-
(2012)
J Neurosci
, vol.32
, pp. 3301-3305
-
-
Colla, E.1
Jensen, P.H.2
Pletnikova, O.3
Troncoso, J.C.4
Glabe, C.5
Lee, M.K.6
-
18
-
-
0031787871
-
Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease
-
Conway KA, Harper JD, Lansbury PT (1998) Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat Med 4:1318-1320.
-
(1998)
Nat Med
, vol.4
, pp. 1318-1320
-
-
Conway, K.A.1
Harper, J.D.2
Lansbury, P.T.3
-
19
-
-
0034528027
-
Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants
-
Conway KA, Lee SJ, Rochet JC, Ding TT, Harper JD, Williamson RE, Lansbury PT Jr (2000) Accelerated oligomerization by Parkinson's disease linked alpha-synuclein mutants. Ann N Y Acad Sci 920:42-45.
-
(2000)
Ann N Y Acad Sci
, vol.920
, pp. 42-45
-
-
Conway, K.A.1
Lee, S.J.2
Rochet, J.C.3
Ding, T.T.4
Harper, J.D.5
Williamson, R.E.6
Lansbury Jr., P.T.7
-
20
-
-
0242363670
-
Molecular pathways of neurodegeneration in Parkinson's disease
-
Dawson TM, Dawson VL (2003) Molecular pathways of neurodegeneration in Parkinson's disease. Science 302:819-822.
-
(2003)
Science
, vol.302
, pp. 819-822
-
-
Dawson, T.M.1
Dawson, V.L.2
-
21
-
-
54349110912
-
Spin-label EPR on alpha-synuclein reveals differences in the membrane binding affinity of the two antiparallel helices
-
Drescher M, Godschalk F, Veldhuis G, van Rooijen BD, Subramaniam V, Huber M (2008) Spin-label EPR on alpha-synuclein reveals differences in the membrane binding affinity of the two antiparallel helices. Chembiochem 13:2411-2416.
-
(2008)
Chembiochem
, vol.13
, pp. 2411-2416
-
-
Drescher, M.1
Godschalk, F.2
Veldhuis, G.3
van Rooijen, B.D.4
Subramaniam, V.5
Huber, M.6
-
22
-
-
0042848693
-
A peptide motif consisting of glycine, alanine, and valine is required for the fibrillizationand cytotoxicity of human alpha-synuclein
-
Du HN, Tang L, Luo XY, Li HT, Hu J, Zhou JW, Hu HY (2003) A peptide motif consisting of glycine, alanine, and valine is required for the fibrillizationand cytotoxicity of human alpha-synuclein. Biochemistry 42: 8870-8878.
-
(2003)
Biochemistry
, vol.42
, pp. 8870-8878
-
-
Du, H.N.1
Tang, L.2
Luo, X.Y.3
Li, H.T.4
Hu, J.5
Zhou, J.W.6
Hu, H.Y.7
-
23
-
-
3543056130
-
Neurodegeneration and neuroprotection in Parkinson disease
-
Fahn S, Sulzer D (2004) Neurodegeneration and neuroprotection in Parkinson disease. NeuroRx 1:139-154.
-
(2004)
NeuroRx
, vol.1
, pp. 139-154
-
-
Fahn, S.1
Sulzer, D.2
-
24
-
-
0035972784
-
A force-plate actometer for quantitating rodent behaviors: Illustrative data on locomotion, rotation, spatial patterning, stereotypies,and tremor
-
Fowler SC, Birkestrand BR, Chen R, Moss SJ, Vorontsova E, Wang G, Zarcone TJ (2001) A force-plate actometer for quantitating rodent behaviors: illustrative data on locomotion, rotation, spatial patterning, stereotypies,and tremor. J Neurosci Methods 107:107-124.
-
(2001)
J Neurosci Methods
, vol.107
, pp. 107-124
-
-
Fowler, S.C.1
Birkestrand, B.R.2
Chen, R.3
Moss, S.J.4
Vorontsova, E.5
Wang, G.6
Zarcone, T.J.7
-
25
-
-
34250796802
-
The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states
-
Fredenburg RA, Rospigliosi C, Meray RK, Kessler JC, Lashuel HA, Eliezer D, Lansbury PT Jr (2007) The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states. Biochemistry 46:7107-7118.
-
(2007)
Biochemistry
, vol.46
, pp. 7107-7118
-
-
Fredenburg, R.A.1
Rospigliosi, C.2
Meray, R.K.3
Kessler, J.C.4
Lashuel, H.A.5
Eliezer, D.6
Lansbury Jr., P.T.7
-
26
-
-
0036174010
-
Alpha-synuclein is phosphorylated in synucleinopathy lesions
-
Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T (2002) Alpha-synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 4:160-164.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 160-164
-
-
Fujiwara, H.1
Hasegawa, M.2
Dohmae, N.3
Kawashima, A.4
Masliah, E.5
Goldberg, M.S.6
Shen, J.7
Takio, K.8
Iwatsubo, T.9
-
27
-
-
77956258196
-
The lipidbinding domain of wild type and mutant alpha-synuclein: Compactness and interconversion between the broken and extended helix forms
-
Georgieva ER, Ramlall TF, Borbat PP, Freed JH, Eliezer D (2010) The lipidbinding domain of wild type and mutant alpha-synuclein: compactness and interconversion between the broken and extended helix forms. J Biol Chem 285:28261-28274.
-
(2010)
J Biol Chem
, vol.285
, pp. 28261-28274
-
-
Georgieva, E.R.1
Ramlall, T.F.2
Borbat, P.P.3
Freed, J.H.4
Eliezer, D.5
-
28
-
-
0035951869
-
A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly
-
Giasson BI, Murray IV, Trojanowski JQ, Lee VM (2001) A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly. J Biol Chem 276:2380-2386.
-
(2001)
J Biol Chem
, vol.276
, pp. 2380-2386
-
-
Giasson, B.I.1
Murray, I.V.2
Trojanowski, J.Q.3
Lee, V.M.4
-
29
-
-
14844335694
-
The E46K mutation in alphasynuclein increases amyloid fibril formation
-
Greenbaum EA, Graves CL, Mishizen-Eberz AJ, Lupoli MA, Lynch DR, Englander SW, Axelsen PH, Giasson BI (2005) The E46K mutation in alphasynuclein increases amyloid fibril formation. J Biol Chem 280:7800-7807.
-
(2005)
J Biol Chem
, vol.280
, pp. 7800-7807
-
-
Greenbaum, E.A.1
Graves, C.L.2
Mishizen-Eberz, A.J.3
Lupoli, M.A.4
Lynch, D.R.5
Englander, S.W.6
Axelsen, P.H.7
Giasson, B.I.8
-
30
-
-
78650431984
-
αβα-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction
-
Greten-Harrison B, Polydoro M, Morimoto-Tomita M, Diao L, Williams AM, Nie EH, Makani S, Tian N, Castillo PE, Buchman VL, Chandra SS (2010) αβα-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction. Proc Natl Acad Sci U S A 107:19573-19578.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 19573-19578
-
-
Greten-Harrison, B.1
Polydoro, M.2
Morimoto-Tomita, M.3
Diao, L.4
Williams, A.M.5
Nie, E.H.6
Makani, S.7
Tian, N.8
Castillo, P.E.9
Buchman, V.L.10
Chandra, S.S.11
-
31
-
-
0028130728
-
Synaptic vesicle membrane fusion complex: Action of clostridial neurotoxins on assembly
-
Hayashi T, McMahon H, Yamasaki S, Binz T, Hata Y, Südhof TC, Niemann H (1994) Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly. EMBO J 13:5051-5061.
-
(1994)
EMBO J
, vol.13
, pp. 5051-5061
-
-
Hayashi, T.1
McMahon, H.2
Yamasaki, S.3
Binz, T.4
Hata, Y.5
Südhof, T.C.6
Niemann, H.7
-
32
-
-
79551483725
-
The role of the C-terminus of human alpha-synuclein: Intra-disulfide bonds between the C-terminus and other regions stabilize non-fibrillar monomeric isomers
-
Hong DP, Xiong W, Chang JY, Jiang C (2011) The role of the C-terminus of human alpha-synuclein: intra-disulfide bonds between the C-terminus and other regions stabilize non-fibrillar monomeric isomers. FEBS Lett 585:561-566.
-
(2011)
FEBS Lett
, vol.585
, pp. 561-566
-
-
Hong, D.P.1
Xiong, W.2
Chang, J.Y.3
Jiang, C.4
-
33
-
-
8544264002
-
Impact of the acidic C-terminal region comprising amino acids 109-140 on alpha-synuclein aggregation in vitro
-
Hoyer W, Cherny D, Subramaniam V, Jovin TM (2004) Impact of the acidic C-terminal region comprising amino acids 109-140 on alpha-synuclein aggregation in vitro. Biochemistry 43:16233-16242.
-
(2004)
Biochemistry
, vol.43
, pp. 16233-16242
-
-
Hoyer, W.1
Cherny, D.2
Subramaniam, V.3
Jovin, T.M.4
-
34
-
-
4644236043
-
Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease
-
Ibánez P, Bonnet AM, Debarges B, Lohmann E, Tison F, Pollak P, Agid Y, Dürr A, Brice A (2004) Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease. Lancet 364:1169-1171.
-
(2004)
Lancet
, vol.364
, pp. 1169-1171
-
-
Ibánez, P.1
Bonnet, A.M.2
Debarges, B.3
Lohmann, E.4
Tison, F.5
Pollak, P.6
Agid, Y.7
Dürr, A.8
Brice, A.9
-
35
-
-
0028985267
-
The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system
-
Iwai A, Masliah E, Yoshimoto M, Ge N, Flanagan L, de Silva HA, Kittel A, Saitoh T (1995) The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. Neuron 14:467-475.
-
(1995)
Neuron
, vol.14
, pp. 467-475
-
-
Iwai, A.1
Masliah, E.2
Yoshimoto, M.3
Ge, N.4
Flanagan, L.5
de Silva, H.A.6
Kittel, A.7
Saitoh, T.8
-
36
-
-
0028277520
-
Identification of two distinct synucleins from human brain
-
Jakes R, Spillantini MG, Goedert M (1994) Identification of two distinct synucleins from human brain. FEBS Lett 345:27-32.
-
(1994)
FEBS Lett
, vol.345
, pp. 27-32
-
-
Jakes, R.1
Spillantini, M.G.2
Goedert, M.3
-
37
-
-
0036304315
-
Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes
-
Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin WB, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar HA, Haass C (2002) Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes. EMBO Rep 3:583-588.
-
(2002)
EMBO Rep
, vol.3
, pp. 583-588
-
-
Kahle, P.J.1
Neumann, M.2
Ozmen, L.3
Muller, V.4
Jacobsen, H.5
Spooren, W.6
Fuss, B.7
Mallon, B.8
Macklin, W.B.9
Fujiwara, H.10
Hasegawa, M.11
Iwatsubo, T.12
Kretzschmar, H.A.13
Haass, C.14
-
38
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300:486-489.
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
Glabe, C.G.7
-
39
-
-
0031990490
-
Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease
-
Krüger R, Kuhn W, Müller T, Woitalla D, Graeber M, Kösel S, Przuntek H, Epplen JT, Schöls L, Riess O (1998) Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease. Nat Genet 18:106-108.
-
(1998)
Nat Genet
, vol.18
, pp. 106-108
-
-
Krüger, R.1
Kuhn, W.2
Müller, T.3
Woitalla, D.4
Graeber, M.5
Kösel, S.6
Przuntek, H.7
Epplen, J.T.8
Schöls, L.9
Riess, O.10
-
40
-
-
33750361540
-
A century-old debate on protein aggregation and neurodegeneration enters the clinic
-
Lansbury PT, Lashuel HA (2006) A century-old debate on protein aggregation and neurodegeneration enters the clinic. Nature 443:774-779.
-
(2006)
Nature
, vol.443
, pp. 774-779
-
-
Lansbury, P.T.1
Lashuel, H.A.2
-
41
-
-
33845482072
-
Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression
-
Lauwers E, Bequé D, Van Laere K, Nuyts J, Bormans G, Mortelmans L, Casteels C, Vercammen L, Bockstael O, Nuttin B, Debyser Z, Baekelandt V (2007) Non-invasive imaging of neuropathology in a rat model of alpha-synuclein overexpression. Neurobiol Aging 28:248-257.
-
(2007)
Neurobiol Aging
, vol.28
, pp. 248-257
-
-
Lauwers, E.1
Bequé, D.2
van Laere, K.3
Nuyts, J.4
Bormans, G.5
Mortelmans, L.6
Casteels, C.7
Vercammen, L.8
Bockstael, O.9
Nuttin, B.10
Debyser, Z.11
Baekelandt, V.12
-
42
-
-
79960712793
-
Conserved C-terminal charge exerts a profound influence on the aggregation rate of alphasynuclein
-
Levitan K, Chereau D, Cohen SI, Knowles TP, Dobson CM, Fink AL, Anderson JP, Goldstein JM, Millhauser GL (2011) Conserved C-terminal charge exerts a profound influence on the aggregation rate of alphasynuclein. J Mol Biol 411:329-333.
-
(2011)
J Mol Biol
, vol.411
, pp. 329-333
-
-
Levitan, K.1
Chereau, D.2
Cohen, S.I.3
Knowles, T.P.4
Dobson, C.M.5
Fink, A.L.6
Anderson, J.P.7
Goldstein, J.M.8
Millhauser, G.L.9
-
43
-
-
78650221707
-
Abnormal neurites containing C-terminally truncated alpha-synuclein are present in Alzheimer's disease without conventional Lewy body pathology
-
Lewis KA, Su Y, Jou O, Ritchie C, Foong C, Hynan LS, White CL, Thomas PJ, Hatanpaa KJ (2010) Abnormal neurites containing C-terminally truncated alpha-synuclein are present in Alzheimer's disease without conventional Lewy body pathology. Am J Pathol 177:3037-3050.
-
(2010)
Am J Pathol
, vol.177
, pp. 3037-3050
-
-
Lewis, K.A.1
Su, Y.2
Jou, O.3
Ritchie, C.4
Foong, C.5
Hynan, L.S.6
White, C.L.7
Thomas, P.J.8
Hatanpaa, K.J.9
-
44
-
-
1842424791
-
Proteasomal inhibition by alpha-synuclein filaments and oligomers
-
Lindersson E, Beedholm R, Højrup P, Moos T, Gai W, Hendil KB, Jensen PH (2004) Proteasomal inhibition by alpha-synuclein filaments and oligomers. J Biol Chem 279:12924-12934.
-
(2004)
J Biol Chem
, vol.279
, pp. 12924-12934
-
-
Lindersson, E.1
Beedholm, R.2
Højrup, P.3
Moos, T.4
Gai, W.5
Hendil, K.B.6
Jensen, P.H.7
-
45
-
-
20744442130
-
A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: Implications for pathogenesis of Parkinson disease
-
Liu CW, Giasson BI, Lewis KA, Lee VM, Demartino GN, Thomas PJ (2005) A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease. J Biol Chem 280:22670-22678.
-
(2005)
J Biol Chem
, vol.280
, pp. 22670-22678
-
-
Liu, C.W.1
Giasson, B.I.2
Lewis, K.A.3
Lee, V.M.4
Demartino, G.N.5
Thomas, P.J.6
-
46
-
-
0036679197
-
α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease
-
Lo Bianco C, Ridet JL, Schneider BL, Deglon N, Aebischer P (2002) α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease. Proc Natl Acad Sci U S A 99:10813-10818.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 10813-10818
-
-
Lo Bianco, C.1
Ridet, J.L.2
Schneider, B.L.3
Deglon, N.4
Aebischer, P.5
-
47
-
-
79958727550
-
Alpha-synuclein populates both elongated and broken helix states on small unilamellar vesicles
-
Lokappa SB, Ulmer TS (2011) Alpha-synuclein populates both elongated and broken helix states on small unilamellar vesicles. J Biol Chem 286:21450-21457.
-
(2011)
J Biol Chem
, vol.286
, pp. 21450-21457
-
-
Lokappa, S.B.1
Ulmer, T.S.2
-
48
-
-
0023722437
-
Synuclein: A neuronspecific protein localized to the nucleus and presynaptic nerve terminal
-
Maroteaux L, Campanelli JT, Scheller RH (1988) Synuclein: a neuronspecific protein localized to the nucleus and presynaptic nerve terminal. J Neurosci 8:2804-2815.
-
(1988)
J Neurosci
, vol.8
, pp. 2804-2815
-
-
Maroteaux, L.1
Campanelli, J.T.2
Scheller, R.H.3
-
49
-
-
0035834076
-
Beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
-
Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, Mucke L (2001) Beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proc Natl Acad Sci U S A 98:12245-12250.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 12245-12250
-
-
Masliah, E.1
Rockenstein, E.2
Veinbergs, I.3
Sagara, Y.4
Mallory, M.5
Hashimoto, M.6
Mucke, L.7
-
50
-
-
33847352925
-
Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation
-
Maximov A, Pang ZP, Tervo DG, Südhof TC (2007) Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation. J Neurosci Methods 161:75-87.
-
(2007)
J Neurosci Methods
, vol.161
, pp. 75-87
-
-
Maximov, A.1
Pang, Z.P.2
Tervo, D.G.3
Südhof, T.C.4
-
51
-
-
57049151865
-
Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions
-
McFarland MA, Ellis CE, Markey SP, Nussbaum RL (2008) Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions. Mol Cell Proteomics 7:2123-2137.
-
(2008)
Mol Cell Proteomics
, vol.7
, pp. 2123-2137
-
-
McFarland, M.A.1
Ellis, C.E.2
Markey, S.P.3
Nussbaum, R.L.4
-
52
-
-
0027429156
-
A new brainspecific 14-kDa protein is a phosphoprotein. Its complete amino acid sequence and evidence for phosphorylation
-
Nakajo S, Tsukada K, Omata K, Nakamura Y, Nakaya K (1993) A new brainspecific 14-kDa protein is a phosphoprotein. Its complete amino acid sequence and evidence for phosphorylation. Eur J Biochem 217:1057-1063.
-
(1993)
Eur J Biochem
, vol.217
, pp. 1057-1063
-
-
Nakajo, S.1
Tsukada, K.2
Omata, K.3
Nakamura, Y.4
Nakaya, K.5
-
53
-
-
0033515471
-
Both familial Parkinson's disease mutations accelerate alphasynuclein aggregation
-
Narhi L, Wood SJ, Steavenson S, Jiang Y, Wu GM, Anafi D, Kaufman SA, Martin F, Sitney K, Denis P, Louis JC, Wypych J, Biere AL, Citron M (1999) Both familial Parkinson's disease mutations accelerate alphasynuclein aggregation. J Biol Chem 274:9843-9846.
-
(1999)
J Biol Chem
, vol.274
, pp. 9843-9846
-
-
Narhi, L.1
Wood, S.J.2
Steavenson, S.3
Jiang, Y.4
Wu, G.M.5
Anafi, D.6
Kaufman, S.A.7
Martin, F.8
Sitney, K.9
Denis, P.10
Louis, J.C.11
Wypych, J.12
Biere, A.L.13
Citron, M.14
-
54
-
-
0034614415
-
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein
-
Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle PJ, Haass C (2000) Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. J Biol Chem 275:390-397.
-
(2000)
J Biol Chem
, vol.275
, pp. 390-397
-
-
Okochi, M.1
Walter, J.2
Koyama, A.3
Nakajo, S.4
Baba, M.5
Iwatsubo, T.6
Meijer, L.7
Kahle, P.J.8
Haass, C.9
-
55
-
-
79960260042
-
Familial Parkinson disease mutations influence alpha-synuclein assembly
-
Ono K, Ikeda T, Takasaki J, Yamada M (2011) Familial Parkinson disease mutations influence alpha-synuclein assembly. Neurobiol Dis 43:715-724.
-
(2011)
Neurobiol Dis
, vol.43
, pp. 715-724
-
-
Ono, K.1
Ikeda, T.2
Takasaki, J.3
Yamada, M.4
-
56
-
-
47749107973
-
Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein
-
Paleologou KE, Schmid AW, Rospigliosi CC, Kim HY, Lamberto GR, Fredenburg RA, Lansbury PT Jr, Fernandez CO, Eliezer D, Zweckstetter M, Lashuel HA (2008) Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein. J Biol Chem 283:16895-16905.
-
(2008)
J Biol Chem
, vol.283
, pp. 16895-16905
-
-
Paleologou, K.E.1
Schmid, A.W.2
Rospigliosi, C.C.3
Kim, H.Y.4
Lamberto, G.R.5
Fredenburg, R.A.6
Lansbury Jr., P.T.7
Fernandez, C.O.8
Eliezer, D.9
Zweckstetter, M.10
Lashuel, H.A.11
-
57
-
-
77749341497
-
Phosphorylation at S87 is enhanced in synucleinopathies, inhibits α-synuclein oligomerization, and influences synuclein-membrane interactions
-
Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, Zweckstetter M, Masliah E, Lashuel HA (2010) Phosphorylation at S87 is enhanced in synucleinopathies, inhibits α-synuclein oligomerization, and influences synuclein-membrane interactions. J Neurosci 30:3184-3198.
-
(2010)
J Neurosci
, vol.30
, pp. 3184-3198
-
-
Paleologou, K.E.1
Oueslati, A.2
Shakked, G.3
Rospigliosi, C.C.4
Kim, H.Y.5
Lamberto, G.R.6
Fernandez, C.O.7
Schmid, A.8
Chegini, F.9
Gai, W.P.10
Chiappe, D.11
Moniatte, M.12
Schneider, B.L.13
Aebischer, P.14
Eliezer, D.15
Zweckstetter, M.16
Masliah, E.17
Lashuel, H.A.18
-
58
-
-
0034602271
-
Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis
-
Perrin RJ, Woods WS, Clayton DF, George JM (2000) Interaction of human alpha-Synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis. J BiolChem 275:34393-34398.
-
(2000)
J BiolChem
, vol.275
, pp. 34393-34398
-
-
Perrin, R.J.1
Woods, W.S.2
Clayton, D.F.3
George, J.M.4
-
59
-
-
0030744876
-
Mutation in the alphasynuclein gene identified in families with Parkinson's disease
-
Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL (1997) Mutation in the alphasynuclein gene identified in families with Parkinson's disease. Science 276:2045-2047.
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
Stenroos, E.S.11
Chandrasekharappa, S.12
Athanassiadou, A.13
Papapetropoulos, T.14
Johnson, W.G.15
Lazzarini, A.M.16
Duvoisin, R.C.17
Di Iorio, G.18
Golbe, L.I.19
Nussbaum, R.L.20
more..
-
60
-
-
0029024135
-
Essential functions of synapsins I and II in synaptic vesicle regulation
-
Rosahl TW, Spillane D, Missler M, Herz J, Selig DK, Wolff JR, Hammer RE, Malenka RC, Südhof TC (1995) Essential functions of synapsins I and II in synaptic vesicle regulation. Nature 375:488-493.
-
(1995)
Nature
, vol.375
, pp. 488-493
-
-
Rosahl, T.W.1
Spillane, D.2
Missler, M.3
Herz, J.4
Selig, D.K.5
Wolff, J.R.6
Hammer, R.E.7
Malenka, R.C.8
Südhof, T.C.9
-
61
-
-
0038404962
-
Role of alpha-synuclein in 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine-induced parkinsonism in mice
-
Schluter OM, Fornai F, Alessandrí MG, Takamori S, Geppert M, Jahn R, Südhof TC (2003) Role of alpha-synuclein in 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine-induced parkinsonism in mice. Neuroscience 118:985-1002.
-
(2003)
Neuroscience
, vol.118
, pp. 985-1002
-
-
Schluter, O.M.1
Fornai, F.2
Alessandrí, M.G.3
Takamori, S.4
Geppert, M.5
Jahn, R.6
Südhof, T.C.7
-
62
-
-
0035798088
-
SNARE function analyzed in synaptobrevin/VAMP knockout mice
-
Schoch S, Deák F, Königstorfer A, Mozhayeva M, Sara Y, Südhof TC, Kavalali ET (2001) SNARE function analyzed in synaptobrevin/VAMP knockout mice. Science 294:1117-1122.
-
(2001)
Science
, vol.294
, pp. 1117-1122
-
-
Schoch, S.1
Deák, F.2
Königstorfer, A.3
Mozhayeva, M.4
Sara, Y.5
Südhof, T.C.6
Kavalali, E.T.7
-
63
-
-
78650505099
-
CSPalpha promotes SNAREcomplex assembly by chaperoning SNAP-25 during synaptic activity
-
Sharma M, Burré J, Südhof TC (2011a) CSPalpha promotes SNAREcomplex assembly by chaperoning SNAP-25 during synaptic activity. Nat Cell Biol 13:30-39.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 30-39
-
-
Sharma, M.1
Burré, J.2
Südhof, T.C.3
-
64
-
-
84857059950
-
CSPα knockout causes neurodegeneration by impairing SNAP-25 function
-
Sharma M, Burré J, Bronk P, Zhang Y, Xu W, Südhof TC (2011b) CSPα knockout causes neurodegeneration by impairing SNAP-25 function. EMBO J 31:829-841.
-
(2011)
EMBO J
, vol.31
, pp. 829-841
-
-
Sharma, M.1
Burré, J.2
Bronk, P.3
Zhang, Y.4
Xu, W.5
Südhof, T.C.6
-
65
-
-
0242300619
-
Alpha-Synuclein locus triplication causes Parkinson's disease
-
Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, Lincoln S, Crawley A, Hanson M, Maraganore D, Adler C, Cookson MR, Muenter M, Baptista M, Miller D, Blancato J, et al. (2003) Alpha-Synuclein locus triplication causes Parkinson's disease. Science 302:841.
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
Lincoln, S.11
Crawley, A.12
Hanson, M.13
Maraganore, D.14
Adler, C.15
Cookson, M.R.16
Muenter, M.17
Baptista, M.18
Miller, D.19
Blancato, J.20
more..
-
66
-
-
0034531475
-
The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy
-
Spillantini MG, Goedert M (2000) The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Ann N Y Acad Sci 920:16-27.
-
(2000)
Ann N Y Acad Sci
, vol.920
, pp. 16-27
-
-
Spillantini, M.G.1
Goedert, M.2
-
67
-
-
84867775447
-
Neuronal vulnerability, pathogenesis, and Parkinson's disease. Mov Disord. Advance online publication
-
Sulzer D, Surmeier DJ (2012) Neuronal vulnerability, pathogenesis, and Parkinson's disease. Mov Disord. Advance online publication. Retrieved September 17, 2012.
-
(2012)
Retrieved September
, vol.17
, pp. 2012
-
-
Sulzer, D.1
Surmeier, D.J.2
-
68
-
-
33748605056
-
A complexin/ synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
-
Tang J, Maximov A, Shin OH, Dai H, Rizo J, Südhof TC (2006) A complexin/ synaptotagmin 1 switch controls fast synaptic vesicle exocytosis. Cell 126:1175-1187.
-
(2006)
Cell
, vol.126
, pp. 1175-1187
-
-
Tang, J.1
Maximov, A.2
Shin, O.H.3
Dai, H.4
Rizo, J.5
Südhof, T.C.6
-
69
-
-
0242666359
-
Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function
-
Tofaris GK, Razzaq A, Ghetti B, Lilley KS, Spillantini MG (2003) Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function. J Biol Chem 278:44405-44411.
-
(2003)
J Biol Chem
, vol.278
, pp. 44405-44411
-
-
Tofaris, G.K.1
Razzaq, A.2
Ghetti, B.3
Lilley, K.S.4
Spillantini, M.G.5
-
70
-
-
33646097224
-
Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human α-synuclein(1-120): Implications for Lewy body disorders
-
Tofaris GK, Garcia Reitböck P, Humby T, Lambourne SL, O'Connell M, Ghetti B, Gossage H, Emson PC, Wilkinson LS, Goedert M, Spillantini MG (2006) Pathological changes in dopaminergic nerve cells of the substantia nigra and olfactory bulb in mice transgenic for truncated human α-synuclein(1-120): implications for Lewy body disorders. J Neurosci 26:3942-3950.
-
(2006)
J Neurosci
, vol.26
, pp. 3942-3950
-
-
Tofaris, G.K.1
Garcia, R.P.2
Humby, T.3
Lambourne, S.L.4
O'Connell, M.5
Ghetti, B.6
Gossage, H.7
Emson, P.C.8
Wilkinson, L.S.9
Goedert, M.10
Spillantini, M.G.11
-
71
-
-
77749341440
-
Distinct region-specific α-synuclein oligomers in A53T transgenic mice: Implications for neurodegeneration
-
Tsika E, Moysidou M, Guo J, Cushman M, Gannon P, Sandaltzopoulos R, Giasson BI, Krainc D, Ischiropoulos H, Mazzulli JR (2010) Distinct region-specific α-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration. J Neurosci 30:3409-3418.
-
(2010)
J Neurosci
, vol.30
, pp. 3409-3418
-
-
Tsika, E.1
Moysidou, M.2
Guo, J.3
Cushman, M.4
Gannon, P.5
Sandaltzopoulos, R.6
Giasson, B.I.7
Krainc, D.8
Ischiropoulos, H.9
Mazzulli, J.R.10
-
72
-
-
0027489773
-
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
-
Uéda K, Fukushima H, Masliah E, Xia Y, Iwai A, Yoshimoto M, Otero DA, Kondo J, Ihara Y, Saitoh T (1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proc Natl Acad Sci U S A 90:11282-11286.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 11282-11286
-
-
Uéda, K.1
Fukushima, H.2
Masliah, E.3
Xia, Y.4
Iwai, A.5
Yoshimoto, M.6
Otero, D.A.7
Kondo, J.8
Ihara, Y.9
Saitoh, T.10
-
73
-
-
30044450420
-
Comparison of structure and dynamics of micellebound human alpha-synuclein and Parkinson disease variants
-
Ulmer TS, Bax A (2005) Comparison of structure and dynamics of micellebound human alpha-synuclein and Parkinson disease variants. J Biol Chem 280:43179-43187.
-
(2005)
J Biol Chem
, vol.280
, pp. 43179-43187
-
-
Ulmer, T.S.1
Bax, A.2
-
74
-
-
15744362063
-
Structure and dynamics of micelle-bound human alpha-synuclein
-
Ulmer TS, Bax A, Cole NB, Nussbaum RL (2005) Structure and dynamics of micelle-bound human alpha-synuclein. J Biol Chem 280:9595-9603.
-
(2005)
J Biol Chem
, vol.280
, pp. 9595-9603
-
-
Ulmer, T.S.1
Bax, A.2
Cole, N.B.3
Nussbaum, R.L.4
-
75
-
-
77955141273
-
Coexpression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology
-
Ulusoy A, Febbraro F, Jensen PH, Kirik D, Romero-Ramos M (2010) Coexpression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology. Eur J Neurosci 32:409-422.
-
(2010)
Eur J Neurosci
, vol.32
, pp. 409-422
-
-
Ulusoy, A.1
Febbraro, F.2
Jensen, P.H.3
Kirik, D.4
Romero-Ramos, M.5
-
76
-
-
0037014618
-
Amino acid determinants of alpha-synuclein aggregation: Putting together pieces of the puzzle
-
Uversky VN, Fink AL (2002) Amino acid determinants of alpha-synuclein aggregation: putting together pieces of the puzzle. FEBS Lett 522:9-13.
-
(2002)
FEBS Lett
, vol.522
, pp. 9-13
-
-
Uversky, V.N.1
Fink, A.L.2
-
77
-
-
0038386274
-
Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease
-
Volles MJ, Lansbury PT Jr (2003) Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease. Biochemistry 42:7871-7878.
-
(2003)
Biochemistry
, vol.42
, pp. 7871-7878
-
-
Volles, M.J.1
Lansbury Jr., P.T.2
-
78
-
-
39749196233
-
Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice
-
Wakamatsu M, Ishii A, Iwata S, Sakagami J, Ukai Y, Ono M, Kanbe D, Muramatsu S, Kobayashi K, Iwatsubo T, Yoshimoto M (2008) Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice. Neurobiol Aging 29:574-585.
-
(2008)
Neurobiol Aging
, vol.29
, pp. 574-585
-
-
Wakamatsu, M.1
Ishii, A.2
Iwata, S.3
Sakagami, J.4
Ukai, Y.5
Ono, M.6
Kanbe, D.7
Muramatsu, S.8
Kobayashi, K.9
Iwatsubo, T.10
Yoshimoto, M.11
-
79
-
-
43249108653
-
Specificity and regulation of casein kinasemediated phosphorylation of alpha-synuclein
-
Waxman EA, Giasson BI (2008) Specificity and regulation of casein kinasemediated phosphorylation of alpha-synuclein. J Neuropathol Exp Neurol 67:402-416.
-
(2008)
J Neuropathol Exp Neurol
, vol.67
, pp. 402-416
-
-
Waxman, E.A.1
Giasson, B.I.2
-
80
-
-
70350041314
-
Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization
-
Waxman EA, Mazzulli JR, Giasson BI (2009) Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization. Biochemistry 48:9427-9436.
-
(2009)
Biochemistry
, vol.48
, pp. 9427-9436
-
-
Waxman, E.A.1
Mazzulli, J.R.2
Giasson, B.I.3
-
81
-
-
84863393541
-
Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission
-
Xu W, Morishita W, Buckmaster PS, Pang ZP, Malenka RC, Südhof TC (2012) Distinct neuronal coding schemes in memory revealed by selective erasure of fast synchronous synaptic transmission. Neuron 73:990-1001.
-
(2012)
Neuron
, vol.73
, pp. 990-1001
-
-
Xu, W.1
Morishita, W.2
Buckmaster, P.S.3
Pang, Z.P.4
Malenka, R.C.5
Südhof, T.C.6
-
82
-
-
65549150887
-
Conversion of wild-type alpha-synuclein into mutanttype fibrils and its propagation in the presence of A30P mutant
-
Yonetani M, Nonaka T, Masuda M, Inukai Y, Oikawa T, Hisanaga S, Hasegawa M (2009) Conversion of wild-type alpha-synuclein into mutanttype fibrils and its propagation in the presence of A30P mutant. J Biol Chem 284:7940-7950.
-
(2009)
J Biol Chem
, vol.284
, pp. 7940-7950
-
-
Yonetani, M.1
Nonaka, T.2
Masuda, M.3
Inukai, Y.4
Oikawa, T.5
Hisanaga, S.6
Hasegawa, M.7
-
83
-
-
10744230149
-
The new mutation, E46K, of alphasynuclein causes Parkinson and Lewy body dementia
-
Zarranz JJ, Alegre J, Gómez-Esteban JC, Lezcano E, Ros R, Ampuero I, Vidal L, Hoenicka J, Rodriguez O, Atarés B, Llorens V, Gomez Tortosa E, del Ser T, Munoz DG, de Yebenes JG (2004) The new mutation, E46K, of alphasynuclein causes Parkinson and Lewy body dementia. Ann Neurol 55: 164-173.
-
(2004)
Ann Neurol
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gómez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
Vidal, L.7
Hoenicka, J.8
Rodriguez, O.9
Atarés, B.10
Llorens, V.11
Gomez, T.E.12
del Ser, T.13
Munoz, D.G.14
de Yebenes, J.G.15
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