-
1
-
-
0035409575
-
α-synuclein and neurodegenerative diseases
-
Goedert, M. (2001) α-Synuclein and neurodegenerative diseases, Nat. Rev. Neurosci. 2, 492-501.
-
(2001)
Nat. Rev. Neurosci.
, vol.2
, pp. 492-501
-
-
Goedert, M.1
-
2
-
-
0030882856
-
α-synuclein in Lewy bodies
-
Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., and Goedert, M. (1997) α-Synuclein in Lewy bodies, Nature 388, 839-840.
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.-Y.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
3
-
-
0031941058
-
Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
-
Baba, M., Nakajo, S., Tu, P.-H., Tomita, T., Nakaya, K., Lee, V. M.-Y., Trojanowski, J. Q., and Iwatsubo, T. (1998) Aggregation of α-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies, Am. J. Pathol. 152, 879-884.
-
(1998)
Am. J. Pathol.
, vol.152
, pp. 879-884
-
-
Baba, M.1
Nakajo, S.2
Tu, P.-H.3
Tomita, T.4
Nakaya, K.5
Lee, V.M.-Y.6
Trojanowski, J.Q.7
Iwatsubo, T.8
-
4
-
-
0032568534
-
α-synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
-
Spillantini, M. G., Crowther, R. A., Jakes, R., Hasegawa, M., and Goedert, M. (1998) α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies, Proc. Natl. Acad. Sci. U.S.A. 95, 6469-6473.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 6469-6473
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Hasegawa, M.4
Goedert, M.5
-
5
-
-
0032546895
-
α-synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy
-
Wakabayashi, K., Yoshimoto, M., Tsuji, S., and Takahashi, H. (1998) α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophy, Neurosci. Lett. 249, 180-182.
-
(1998)
Neurosci. Lett.
, vol.249
, pp. 180-182
-
-
Wakabayashi, K.1
Yoshimoto, M.2
Tsuji, S.3
Takahashi, H.4
-
6
-
-
0032584686
-
Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies
-
Spillantini, M. G., Crowther, R. A., Jakes, R., Cairns, N. J., Lantos, P. L., and Goedert, M. (1998) Filamentous α-synuclein inclusions link multiple system atrophy with Parkinson's disease and dementia with Lewy bodies, Neurosci. Lett. 251, 205-208.
-
(1998)
Neurosci. Lett.
, vol.251
, pp. 205-208
-
-
Spillantini, M.G.1
Crowther, R.A.2
Jakes, R.3
Cairns, N.J.4
Lantos, P.L.5
Goedert, M.6
-
7
-
-
0031713491
-
Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein
-
Tu, P. H., Galvin, J. E., Baba, M., Giasson, B., Tomita, T., Leight, S., Nakajo, S., Iwatsubo, T., and Trojanowski, J. Q. (1988) Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α-synuclein, Ann. Neurol. 44, 415-422.
-
(1988)
Ann. Neurol.
, vol.44
, pp. 415-422
-
-
Tu, P.H.1
Galvin, J.E.2
Baba, M.3
Giasson, B.4
Tomita, T.5
Leight, S.6
Nakajo, S.7
Iwatsubo, T.8
Trojanowski, J.Q.9
-
8
-
-
0036174010
-
α-synuclein is phosphorylated in synucleinopathy lesions
-
Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M. S., Shen, J., Takio, K., and Iwatsubo, T. (2002) α-Synuclein is phosphorylated in synucleinopathy lesions, Nat. Cell Biol. 4, 160-164.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 160-164
-
-
Fujiwara, H.1
Hasegawa, M.2
Dohmae, N.3
Kawashima, A.4
Masliah, E.5
Goldberg, M.S.6
Shen, J.7
Takio, K.8
Iwatsubo, T.9
-
9
-
-
0030744876
-
Mutation in the α-synuclein gene identified in families with Parkinson's disease
-
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S., Athanassiadou, A., Papapetropoulos, T., Johnson, W. G., Lazzarini, A. M., Duvoisin, R. C., Di Iorio, G., Golbe, L. I., and Nussbaum, R. L. (1997) Mutation in the α-synuclein gene identified in families with Parkinson's disease, Science 276, 2045-2047.
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
Stenroos, E.S.11
Chandrasekharappa, S.12
Athanassiadou, A.13
Papapetropoulos, T.14
Johnson, W.G.15
Lazzarini, A.M.16
Duvoisin, R.C.17
Di Iorio, G.18
Golbe, L.I.19
Nussbaum, R.L.20
more..
-
10
-
-
0031990490
-
Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
-
Krüger, R., Kuhn, W., Müller, T., Woitalla, D., Graeber, M., Kösel, S., Przuntek, H., Epplen, J. T., Schöls, L., and Riess, O. (1998) Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease, Nat. Genet. 18, 106-108.
-
(1998)
Nat. Genet.
, vol.18
, pp. 106-108
-
-
Krüger, R.1
Kuhn, W.2
Müller, T.3
Woitalla, D.4
Graeber, M.5
Kösel, S.6
Przuntek, H.7
Epplen, J.T.8
Schöls, L.9
Riess, O.10
-
11
-
-
10744230149
-
The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia
-
Zarranz, J. J., Alegre, J., Gómez-Esteban, J. C., Lezcano, E., Ros, R., Ampuero, I., Vidal, L., Hoenicka, J., Rodriguez, O., Atarés, B., Llorens, V., Gomez Tortosa, E., del Ser, T., Munoz, D. G., and de Yebenes, J. G. (2004) The new mutation, E46K, of α-synuclein causes Parkinson and Lewy body dementia, Ann. Neurol. 55, 164-173.
-
(2004)
Ann. Neurol.
, vol.55
, pp. 164-173
-
-
Zarranz, J.J.1
Alegre, J.2
Gómez-Esteban, J.C.3
Lezcano, E.4
Ros, R.5
Ampuero, I.6
Vidal, L.7
Hoenicka, J.8
Rodriguez, O.9
Atarés, B.10
Llorens, V.11
Gomez Tortosa, E.12
Del Ser, T.13
Munoz, D.G.14
De Yebenes, J.G.15
-
12
-
-
0242300619
-
α-synuclein locus triplication causes Parkinson's disease
-
Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., Lincoln, S., Crawley, A., Hanson, M., Maraganore, D., Adler, C., Cookson, M. R., Muenter, M., Baptista, M., Miller, D., Blancato, J., Hardy, J., and Gwinn-Hardy, K. (2003) α-Synuclein locus triplication causes Parkinson's disease, Science 302, 841.
-
(2003)
Science
, vol.302
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
Lincoln, S.11
Crawley, A.12
Hanson, M.13
Maraganore, D.14
Adler, C.15
Cookson, M.R.16
Muenter, M.17
Baptista, M.18
Miller, D.19
Blancato, J.20
Hardy, J.21
Gwinn-Hardy, K.22
more..
-
13
-
-
4644290985
-
α-synuclein locus duplication as a cause of familial Parkinson's disease
-
Chartier-Harlin, M. C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., Levecque, C., Lavor, L., Andrieux, J., Hulihan, M., Waucquier, N., Defebre, L., Amouyel, P., Farreer, M., and Destée, A. (2004) α-Synuclein locus duplication as a cause of familial Parkinson's disease, Lancet 364, 1167-1169.
-
(2004)
Lancet
, vol.364
, pp. 1167-1169
-
-
Chartier-Harlin, M.C.1
Kachergus, J.2
Roumier, C.3
Mouroux, V.4
Douay, X.5
Lincoln, S.6
Levecque, C.7
Lavor, L.8
Andrieux, J.9
Hulihan, M.10
Waucquier, N.11
Defebre, L.12
Amouyel, P.13
Farreer, M.14
Destée, A.15
-
14
-
-
4644236043
-
Causal relation between α-synuclein gene duplication and familial Parkinson's disease
-
Ibanez, P., Bonnet, A.-M., Débarges, B., Lohmann, E., Tison, F., Pollak, P., Agid, Y., Dürr, A., and Brice, A. (2004) Causal relation between α-synuclein gene duplication and familial Parkinson's disease, Lancet 364, 1169-1171.
-
(2004)
Lancet
, vol.364
, pp. 1169-1171
-
-
Ibanez, P.1
Bonnet, A.-M.2
Débarges, B.3
Lohmann, E.4
Tison, F.5
Pollak, P.6
Agid, Y.7
Dürr, A.8
Brice, A.9
-
15
-
-
0027489773
-
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease
-
Ueda, K., Fukushima, H., Masliah, E., Xia, Y., Iwai, A., Yoshimoto, M., Otero, D. A., Kondo, J., Ihara, Y., and Saitoh, T. (1993) Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease, Proc. Natl. Acad. Sci. U.S.A. 90, 11282-11286.
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 11282-11286
-
-
Ueda, K.1
Fukushima, H.2
Masliah, E.3
Xia, Y.4
Iwai, A.5
Yoshimoto, M.6
Otero, D.A.7
Kondo, J.8
Ihara, Y.9
Saitoh, T.10
-
16
-
-
0028277520
-
Identification of two distinct synucleins from human brain
-
Jakes, R., Spillantini, M. G., and Goedert, M. (1994) Identification of two distinct synucleins from human brain, FEBS Lett. 345, 27-32.
-
(1994)
FEBS Lett.
, vol.345
, pp. 27-32
-
-
Jakes, R.1
Spillantini, M.G.2
Goedert, M.3
-
17
-
-
0029904487
-
NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded
-
Weinreb, P. H., Zhen, W., Poon, A. W., Conway, K. A., and Lansbury, P. T. (1996) NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded, Biochemistry 35, 13709-13715.
-
(1996)
Biochemistry
, vol.35
, pp. 13709-13715
-
-
Weinreb, P.H.1
Zhen, W.2
Poon, A.W.3
Conway, K.A.4
Lansbury, P.T.5
-
18
-
-
0032540327
-
Stabilization of α-synuclein secondary structure upon binding to synthetic membranes
-
Davidson, W. S., Jonas, A., Clayton, D. F., and George, J. M. (1998) Stabilization of α-synuclein secondary structure upon binding to synthetic membranes, J. Biol. Chem. 273, 9443-9449.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 9443-9449
-
-
Davidson, W.S.1
Jonas, A.2
Clayton, D.F.3
George, J.M.4
-
19
-
-
0032500599
-
Binding of α-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation
-
Jensen, P. H., Nielsen, M. H., Jakes, R., Dotti, C. G., and Goedert, M. (1998) Binding of α-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation, J. Biol. Chem. 273, 26292-26294.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 26292-26294
-
-
Jensen, P.H.1
Nielsen, M.H.2
Jakes, R.3
Dotti, C.G.4
Goedert, M.5
-
20
-
-
0034602296
-
α-synuclein membrane interactions and lipid specificity
-
Jo, E., McLaurin, J. A., Yip, C. M., St George-Hyslop, P., and Fraser, P. E. (2000) α-Synuclein membrane interactions and lipid specificity, J. Biol. Chem. 275, 34328-34334.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 34328-34334
-
-
Jo, E.1
McLaurin, J.A.2
Yip, C.M.3
St. George-Hyslop, P.4
Fraser, P.E.5
-
21
-
-
0034602271
-
Interaction of human α-synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis
-
Perrin, R. J., Woods, W. S., Clayton, D. F., and George, J. M. (2000) Interaction of human α-synuclein and Parkinson's disease variants with phospholipids. Structural analysis using site-directed mutagenesis, J. Biol. Chem. 275, 34393-34398.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 34393-34398
-
-
Perrin, R.J.1
Woods, W.S.2
Clayton, D.F.3
George, J.M.4
-
22
-
-
0035815115
-
Conformational properties of α-synuclein in its free and lipid-associated states
-
Eliezer, D., Kutluay, E., Bussell, R., and Browne, G. (2001) Conformational properties of α-synuclein in its free and lipid-associated states, J. Mol. Biol. 307, 1061-1073.
-
(2001)
J. Mol. Biol.
, vol.307
, pp. 1061-1073
-
-
Eliezer, D.1
Kutluay, E.2
Bussell, R.3
Browne, G.4
-
23
-
-
0038341134
-
A broken α-helix in folded α-synuclein
-
Chandra, S., Chen, X., Rizo, J., Jahn, R., and Südhof, T. (2003) A broken α-helix in folded α-synuclein, J. Biol. Chem. 278, 15313-15318.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 15313-15318
-
-
Chandra, S.1
Chen, X.2
Rizo, J.3
Jahn, R.4
Südhof, T.5
-
24
-
-
2942555022
-
Structure of membrane-bound α-synuclein studied by site-directed spin labeling
-
Jao, C. C., Der-Sarkissian, A., Chen, J., and Langen, R. (2004) Structure of membrane-bound α-synuclein studied by site-directed spin labeling, Proc. Natl. Acad. Sci. U.S.A. 101, 8331-8336.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 8331-8336
-
-
Jao, C.C.1
Der-Sarkissian, A.2
Chen, J.3
Langen, R.4
-
25
-
-
15744362063
-
Structure and dynamics of micelle-bound human α-synuclein
-
Ulmer, T. S., Bax, A., Cole, N. B., and Nussbaum, R. L. (2005) Structure and dynamics of micelle-bound human α-synuclein, J. Biol. Chem. 280, 9595-9603.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 9595-9603
-
-
Ulmer, T.S.1
Bax, A.2
Cole, N.B.3
Nussbaum, R.L.4
-
26
-
-
0031728689
-
Synthetic filaments assembled from C-terminally truncated α-synuclein
-
Crowther, R. A., Jakes, R., Spillantini, M. G., and Goedert, M. (1998) Synthetic filaments assembled from C-terminally truncated α-synuclein, FEBS Lett. 436, 309-312.
-
(1998)
FEBS Lett.
, vol.436
, pp. 309-312
-
-
Crowther, R.A.1
Jakes, R.2
Spillantini, M.G.3
Goedert, M.4
-
27
-
-
0032573289
-
Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of α-synuclein protein implicated in Parkinson's disease
-
El-Agnaf, O. M. A., Jakes, R., Curran, M. D., and Wallace, A. (1998) Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of α-synuclein protein implicated in Parkinson's disease, FEBS Lett. 440, 67-70.
-
(1998)
FEBS Lett.
, vol.440
, pp. 67-70
-
-
El-Agnaf, O.M.A.1
Jakes, R.2
Curran, M.D.3
Wallace, A.4
-
28
-
-
0031787871
-
Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease
-
Conway, K. A., Harper, J. D., and Lansbury, P. T. (1998) Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease, Nat. Med. 4, 1318-1320.
-
(1998)
Nat. Med.
, vol.4
, pp. 1318-1320
-
-
Conway, K.A.1
Harper, J.D.2
Lansbury, P.T.3
-
29
-
-
0034712918
-
Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation
-
Serpell, L. C., Berriman, J., Jakes, R., Goedert, M., and Crowther, R. A. (2000) Fiber diffraction of synthetic α-synuclein filaments shows amyloid-like cross-β conformation, Proc. Natl. Acad. Sci. U.S.A. 97, 4897-4902.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 4897-4902
-
-
Serpell, L.C.1
Berriman, J.2
Jakes, R.3
Goedert, M.4
Crowther, R.A.5
-
30
-
-
0037166267
-
Biochemical characterization of the core structure of α-synuclein filaments
-
Miake, H., Mizusawa, H., Iwatsubo, T., and Hasegawa, M. (2002) Biochemical characterization of the core structure of α-synuclein filaments, J. Biol. Chem. 277, 19213-19219.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 19213-19219
-
-
Miake, H.1
Mizusawa, H.2
Iwatsubo, T.3
Hasegawa, M.4
-
31
-
-
0141733169
-
Structural organization of α-synuclein fibrils studied by site-directed spin labeling
-
Der-Sarkissian, A., Jao, C. J., Chen, J., and Langen, R. (2003) Structural organization of α-synuclein fibrils studied by site-directed spin labeling, J. Biol. Chem. 278, 37530-37535.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 37530-37535
-
-
Der-Sarkissian, A.1
Jao, C.J.2
Chen, J.3
Langen, R.4
-
32
-
-
0038116620
-
Role of α-synuclein carboxy-terminus on fibril formation in vitro
-
Murray, I. V., Giasson, B. I., Quinn, S. M., Koppaka, V., Axelsen, P. H., Ischiropoulos, H., Trojanowski, J. Q., and Lee, V. M.-Y. (2003) Role of α-synuclein carboxy-terminus on fibril formation in vitro, Biochemistry 42, 8530-8540.
-
(2003)
Biochemistry
, vol.42
, pp. 8530-8540
-
-
Murray, I.V.1
Giasson, B.I.2
Quinn, S.M.3
Koppaka, V.4
Axelsen, P.H.5
Ischiropoulos, H.6
Trojanowski, J.Q.7
Lee, V.M.-Y.8
-
33
-
-
12944304172
-
Mapping long-range interactions in α-synuclein using spin-label NMR and ensemble molecular dynamics simulations
-
Dedmon, M. K., Lindorff-Larsen, K., Christodoulou, J., Vendruscolo, M., and Dobson, C. M. (2005) Mapping long-range interactions in α-synuclein using spin-label NMR and ensemble molecular dynamics simulations, J. Am. Chem. Soc. 127, 476-477.
-
(2005)
J. Am. Chem. Soc.
, vol.127
, pp. 476-477
-
-
Dedmon, M.K.1
Lindorff-Larsen, K.2
Christodoulou, J.3
Vendruscolo, M.4
Dobson, C.M.5
-
34
-
-
15444373250
-
Structural characterization of copper(II) binding to α-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease
-
Bertoncini, C. W., Jung, Y.-S., Fernandez, C. O., Hoyer, W., Griesinger, C., Jovin, T. M., and Zweckstetter, M. (2005) Structural characterization of copper(II) binding to α-synuclein: Insights into the bioinorganic chemistry of Parkinson's disease, Proc. Natl. Acad. Sci. U.S.A. 102, 1430-1435.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 1430-1435
-
-
Bertoncini, C.W.1
Jung, Y.-S.2
Fernandez, C.O.3
Hoyer, W.4
Griesinger, C.5
Jovin, T.M.6
Zweckstetter, M.7
-
35
-
-
6344228684
-
Mutation E46K increases phospholipid binding and assembly into filaments of human α-synuclein
-
Choi, W., Zibaee, S., Jakes, R., Serpell, L. C., Davletov, B., Crowther, R. A., and Goedert, M. (2004) Mutation E46K increases phospholipid binding and assembly into filaments of human α-synuclein, FEBS Lett. 576, 363-368.
-
(2004)
FEBS Lett.
, vol.576
, pp. 363-368
-
-
Choi, W.1
Zibaee, S.2
Jakes, R.3
Serpell, L.C.4
Davletov, B.5
Crowther, R.A.6
Goedert, M.7
-
36
-
-
14844335694
-
The E46K mutation in α-synuclein increases amyloid fibril formation
-
Greenbaum, E. A., Graves, C. L., Mishizen-Eberz, A. J., Lupoli, M. A., Lynch, D. R., Englander, S. W., Axelsen, P. H., and Giasson, B. I. (2005) The E46K mutation in α-synuclein increases amyloid fibril formation, J. Biol. Chem. 280, 7800-7807.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 7800-7807
-
-
Greenbaum, E.A.1
Graves, C.L.2
Mishizen-Eberz, A.J.3
Lupoli, M.A.4
Lynch, D.R.5
Englander, S.W.6
Axelsen, P.H.7
Giasson, B.I.8
-
37
-
-
0033583215
-
Mutant and wild-type human α-synucleins assemble into elongated filaments with distinct morphologies in vitro
-
Giasson, B. I., Uryu, K., Trojanowski, J. Q., and Lee, V. M.-Y. (1999) Mutant and wild-type human α-synucleins assemble into elongated filaments with distinct morphologies in vitro, J. Biol. Chem. 274, 7619-7622.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 7619-7622
-
-
Giasson, B.I.1
Uryu, K.2
Trojanowski, J.Q.3
Lee, V.M.-Y.4
-
38
-
-
0033515471
-
Both familial Parkinson' s disease mutations accelerate α-synuclein aggregation
-
Narhi, L., Wood, S. J., Steavenson, S., Jiang, Y., Wu, G. M., Anafi, D., Kaufman, S. A., Martin, F., Sitney, K., Denis, P., Louis, J. C., Wypych, J., Biere, A. L., and Citron, M. (1999) Both familial Parkinson' s disease mutations accelerate α-synuclein aggregation, J. Biol. Chem. 274, 9843-9846.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 9843-9846
-
-
Narhi, L.1
Wood, S.J.2
Steavenson, S.3
Jiang, Y.4
Wu, G.M.5
Anafi, D.6
Kaufman, S.A.7
Martin, F.8
Sitney, K.9
Denis, P.10
Louis, J.C.11
Wypych, J.12
Biere, A.L.13
Citron, M.14
-
39
-
-
0035949542
-
Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human α-synuclein
-
Li, J., Uversky, V. N., and Fink, A. L. (2001) Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human α-synuclein, Biochemistry 40, 11604-11613.
-
(2001)
Biochemistry
, vol.40
, pp. 11604-11613
-
-
Li, J.1
Uversky, V.N.2
Fink, A.L.3
-
40
-
-
0034681163
-
Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy
-
Conway, K. A., Lee, S.-J., Rochet, J. C., Ding, T. T., Williamson, R. E., and Lansbury, P. T. (2000) Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy, Proc. Natl. Acad. Sci. U.S.A. 97, 571-576.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 571-576
-
-
Conway, K.A.1
Lee, S.-J.2
Rochet, J.C.3
Ding, T.T.4
Williamson, R.E.5
Lansbury, P.T.6
-
41
-
-
0032191105
-
Filamentous nerve cell inclusions in neurodegenerative diseases
-
Goedert, M., Spillantini, M. G., and Davies, S. W. (1998) Filamentous nerve cell inclusions in neurodegenerative diseases, Curr. Opin. Neurobiol. 8, 619-632.
-
(1998)
Curr. Opin. Neurobiol.
, vol.8
, pp. 619-632
-
-
Goedert, M.1
Spillantini, M.G.2
Davies, S.W.3
-
42
-
-
0035902194
-
Shattuck lecture: Neurodegenerative diseases and prions
-
Prusiner, S. B. (2001) Shattuck lecture: Neurodegenerative diseases and prions, N. Engl. J. Med. 344, 1516-1526.
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 1516-1526
-
-
Prusiner, S.B.1
-
43
-
-
0034718206
-
Approaches to discovery and characterization of inhibitors of amyloid β-peptide polymerization
-
Findeis, M. A. (2000) Approaches to discovery and characterization of inhibitors of amyloid β-peptide polymerization, Biochim. Biophys. Acta 1502, 76-84.
-
(2000)
Biochim. Biophys. Acta
, vol.1502
, pp. 76-84
-
-
Findeis, M.A.1
-
44
-
-
6444225674
-
Prion diseases: Close to effective therapy?
-
Cashman, N. R., and Caughey, B. (2004) Prion diseases: Close to effective therapy? Nat. Rev. Drug Discovery 3, 874-884.
-
(2004)
Nat. Rev. Drug Discovery
, vol.3
, pp. 874-884
-
-
Cashman, N.R.1
Caughey, B.2
-
45
-
-
18744369020
-
Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay
-
Heiser, V., Engemann, S., Bröcker, W., Dunkel, I., Boeddrich, A., Waelter, S., Nordhoff, E., Lurz, R., Schugardt, N., Rautenberg, S., Herhaus, C., Barnickel, G., Böttcher, H., Lehrach, H., and Wanker, E. E. (2002) Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by using an automated filter retardation assay, Proc. Natl. Acad. Sci. U.S.A. 99, 16400-16406.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 16400-16406
-
-
Heiser, V.1
Engemann, S.2
Bröcker, W.3
Dunkel, I.4
Boeddrich, A.5
Waelter, S.6
Nordhoff, E.7
Lurz, R.8
Schugardt, N.9
Rautenberg, S.10
Herhaus, C.11
Barnickel, G.12
Böttcher, H.13
Lehrach, H.14
Wanker, E.E.15
-
46
-
-
13544251748
-
Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells
-
Pickhardt, M., Gazova, Z., von Bergen, M., Khlistunova, I., Wang, Y., Hascher, A., Mandelkow, E. M., Biernat, J., and Mandelkow, E. (2005) Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells, J. Biol. Chem. 280, 3628-3635.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 3628-3635
-
-
Pickhardt, M.1
Gazova, Z.2
Von Bergen, M.3
Khlistunova, I.4
Wang, Y.5
Hascher, A.6
Mandelkow, E.M.7
Biernat, J.8
Mandelkow, E.9
-
47
-
-
14844303721
-
Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins
-
Taniguchi, S., Suzuki, N., Masuda, M., Hisanaga, S.-I., Iwatsubo, T., Goedert, M., and Hasegawa, M. (2005) Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins, J. Biol. Chem. 280, 7614-7623.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 7614-7623
-
-
Taniguchi, S.1
Suzuki, N.2
Masuda, M.3
Hisanaga, S.-I.4
Iwatsubo, T.5
Goedert, M.6
Hasegawa, M.7
-
48
-
-
0035834360
-
Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct
-
Conway, K. A., Rochet, J. C., Bieganski, R. M., and Lansbury, P. T. (2001) Kinetic stabilization of the α-synuclein protofibril by a dopamine-α-synuclein adduct, Science 294, 1346-1349.
-
(2001)
Science
, vol.294
, pp. 1346-1349
-
-
Conway, K.A.1
Rochet, J.C.2
Bieganski, R.M.3
Lansbury, P.T.4
-
49
-
-
20444401187
-
Reversible inhibition of α-synuclein fibrillization by dopaminochrome-mediated conformational alterations
-
Norris, E. H., Giasson, B. I., Hodara, R., Xu, S., Trojanowski, J. Q., Ischiropoulos, H., and Lee, V. M.-Y. (2005) Reversible inhibition of α-synuclein fibrillization by dopaminochrome-mediated conformational alterations, J. Biol. Chem. 280, 21212-21219.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 21212-21219
-
-
Norris, E.H.1
Giasson, B.I.2
Hodara, R.3
Xu, S.4
Trojanowski, J.Q.5
Ischiropoulos, H.6
Lee, V.M.-Y.7
-
50
-
-
23444455247
-
Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway
-
Cappai, R., Leek, S.-L., Tew, D. J., Williamson, N. A., Smith, D. P., Galatis, D., Sharples, R. A., Curtain, C. C., Ali, F. E., Cherny, R. A., Culvenor, J. G., Bottomley, S. P., Masters, C. L., Barnham, K. J., and Hill, A. F. (2005) Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway, FASEB J. 19, 1377-1379.
-
(2005)
FASEB J.
, vol.19
, pp. 1377-1379
-
-
Cappai, R.1
Leek, S.-L.2
Tew, D.J.3
Williamson, N.A.4
Smith, D.P.5
Galatis, D.6
Sharples, R.A.7
Curtain, C.C.8
Ali, F.E.9
Cherny, R.A.10
Culvenor, J.G.11
Bottomley, S.P.12
Masters, C.L.13
Barnham, K.J.14
Hill, A.F.15
-
51
-
-
3042547187
-
The flavonoid baicalein inhibits fibrillation of α-synuclein and disaggregates existing fibrils
-
Zhu, M., Rajamani, S., Kaylor, J., Han, S., Zhou, F., and Fink, A. L. (2004) The flavonoid baicalein inhibits fibrillation of α-synuclein and disaggregates existing fibrils, J. Biol. Chem. 279, 26846-26857.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 26846-26857
-
-
Zhu, M.1
Rajamani, S.2
Kaylor, J.3
Han, S.4
Zhou, F.5
Fink, A.L.6
-
52
-
-
1642372780
-
Phthalocyanine tetrasulfonates affect the amyloid formation and cytotoxicity of α-synuclein
-
Lee, E.-N., Cho, H.-J., Lee, C.-H., Lee, D., Chung, K. C., and Paik, S. R. (2004) Phthalocyanine tetrasulfonates affect the amyloid formation and cytotoxicity of α-synuclein, Biochemistry 43, 3704-3715.
-
(2004)
Biochemistry
, vol.43
, pp. 3704-3715
-
-
Lee, E.-N.1
Cho, H.-J.2
Lee, C.-H.3
Lee, D.4
Chung, K.C.5
Paik, S.R.6
-
53
-
-
8844224948
-
Rifampicin inhibits α-synuclein fibrillation and disaggregates fibrils
-
Li, J., Zhu, M., Rajamani, S., Uversky, V. N., and Fink, A. L. (2004) Rifampicin inhibits α-synuclein fibrillation and disaggregates fibrils, Chem. Biol. 11, 1513-1521.
-
(2004)
Chem. Biol.
, vol.11
, pp. 1513-1521
-
-
Li, J.1
Zhu, M.2
Rajamani, S.3
Uversky, V.N.4
Fink, A.L.5
-
54
-
-
11844306551
-
Ubiquitination of α-synuclein
-
Nonaka, T., Iwatsubo, T., and Hasegawa, M. (2005) Ubiquitination of α-synuclein, Biochemistry 44, 361-368.
-
(2005)
Biochemistry
, vol.44
, pp. 361-368
-
-
Nonaka, T.1
Iwatsubo, T.2
Hasegawa, M.3
-
55
-
-
33644911177
-
Cysteine misincorporation in bacterially expressed human α-synuclein
-
Masuda, M., Dohmae, N., Nonaka, T., Oikawa, T., Hisanaga, S. I., Goedert, M., and Hasegawa, M. (2006) Cysteine misincorporation in bacterially expressed human α-synuclein, FEBS Lett. 580, 1775-1779.
-
(2006)
FEBS Lett.
, vol.580
, pp. 1775-1779
-
-
Masuda, M.1
Dohmae, N.2
Nonaka, T.3
Oikawa, T.4
Hisanaga, S.I.5
Goedert, M.6
Hasegawa, M.7
-
56
-
-
0030030956
-
First-order kinetic model of Alzheimer's β-amyloid fibril extension in vitro
-
Naiki, H., and Nakakuki, K. (1996) First-order kinetic model of Alzheimer's β-amyloid fibril extension in vitro, Lab. Invest. 74, 374-383.
-
(1996)
Lab. Invest.
, vol.74
, pp. 374-383
-
-
Naiki, H.1
Nakakuki, K.2
-
57
-
-
0024745894
-
Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
-
Goedert, M., Spillantini, M. G., Jakes, R., Rutherford, D., and Crowther, R. A. (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease, Neuron 3, 519-526.
-
(1989)
Neuron
, vol.3
, pp. 519-526
-
-
Goedert, M.1
Spillantini, M.G.2
Jakes, R.3
Rutherford, D.4
Crowther, R.A.5
-
58
-
-
0032561415
-
Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly
-
Hasegawa, M., Smith, M. J., and Goedert, M. (1998) Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly, FEBS Lett. 437, 207-210.
-
(1998)
FEBS Lett.
, vol.437
, pp. 207-210
-
-
Hasegawa, M.1
Smith, M.J.2
Goedert, M.3
-
59
-
-
0037072284
-
Annular α-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes
-
Ding, T. T., Lee, S.-J., Rochet, J. C., and Lansbury, P. T. (2002) Annular α-synuclein protofibrils are produced when spherical protofibrils are incubated in solution or bound to brain-derived membranes, Biochemistry 41, 10209-10217.
-
(2002)
Biochemistry
, vol.41
, pp. 10209-10217
-
-
Ding, T.T.1
Lee, S.-J.2
Rochet, J.C.3
Lansbury, P.T.4
-
60
-
-
3042667647
-
Catechin polyphenols: Neurodegeneration and neuroprotection in neurodegenerative diseases
-
Mandel, S., and Youdim, B. H. (2004) Catechin polyphenols: Neurodegeneration and neuroprotection in neurodegenerative diseases, Free Radical Biol. Med. 37, 304-317.
-
(2004)
Free Radical Biol. Med.
, vol.37
, pp. 304-317
-
-
Mandel, S.1
Youdim, B.H.2
-
61
-
-
0028172886
-
β-amyloid neurotoxicity requires fibril formation and is inhibited by congo red
-
Lorenzo, A., and Yankner, B. A. (1994) β-Amyloid neurotoxicity requires fibril formation and is inhibited by congo red, Proc. Natl. Acad. Sci. U.S.A. 91, 12243-12247.
-
(1994)
Proc. Natl. Acad. Sci. U.S.A.
, vol.91
, pp. 12243-12247
-
-
Lorenzo, A.1
Yankner, B.A.2
-
62
-
-
0030996676
-
Aβ deposition inhibitor screen using synthetic amyloid
-
Esler, W. P., Stimson, E. R., Ghilardi, J. R., Felix, A. M., Lu, Y.-A., Vinters, H. V., Mantyh, P. W., and Maggio, J. E. (1997) Aβ deposition inhibitor screen using synthetic amyloid, Nat. Biotechnol. 15, 258-263.
-
(1997)
Nat. Biotechnol.
, vol.15
, pp. 258-263
-
-
Esler, W.P.1
Stimson, E.R.2
Ghilardi, J.R.3
Felix, A.M.4
Lu, Y.-A.5
Vinters, H.V.6
Mantyh, P.W.7
Maggio, J.E.8
-
63
-
-
0026638150
-
Potent inhibition of scrapie-associated PrP accumulation by congo red
-
Caughey, B., and Race, R. E. (1992) Potent inhibition of scrapie-associated PrP accumulation by congo red, J. Neurochem. 59, 768-771.
-
(1992)
J. Neurochem.
, vol.59
, pp. 768-771
-
-
Caughey, B.1
Race, R.E.2
-
64
-
-
0027280172
-
Congo red inhibition of scrapie agent replication
-
Caughey, B., Ernest, D., and Race, R. E. (1993) Congo red inhibition of scrapie agent replication, J. Virol. 67, 6270-6272.
-
(1993)
J. Virol.
, vol.67
, pp. 6270-6272
-
-
Caughey, B.1
Ernest, D.2
Race, R.E.3
-
65
-
-
0034612220
-
Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: Implications for Huntington's disease therapy
-
Heiser, V., Scherzinger, E., Boeddrich, A., Nordhoff, E., Lurz, R., Schugardt, N., Lehrach, H., and Wanker, E. E. (2000) Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: Implications for Huntington's disease therapy, Proc. Natl. Acad. Sci. U.S.A. 97, 6739-6744.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 6739-6744
-
-
Heiser, V.1
Scherzinger, E.2
Boeddrich, A.3
Nordhoff, E.4
Lurz, R.5
Schugardt, N.6
Lehrach, H.7
Wanker, E.E.8
-
66
-
-
0037461730
-
Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders
-
Sánchez, I., Mahlke, C., and Yuan, J. (2003) Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders, Nature 421, 373-379.
-
(2003)
Nature
, vol.421
, pp. 373-379
-
-
Sánchez, I.1
Mahlke, C.2
Yuan, J.3
-
67
-
-
0034691124
-
In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease
-
Skovronsky, D. M., Zhang, B., Kung, M.-P., Kung, H. F., Trojanowski, J. Q., and Lee, V. M.-Y. (2000) In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease, Proc. Natl. Acad. Sci. U.S.A. 97, 7609-7614.
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 7609-7614
-
-
Skovronsky, D.M.1
Zhang, B.2
Kung, M.-P.3
Kung, H.F.4
Trojanowski, J.Q.5
Lee, V.M.-Y.6
-
69
-
-
20044392910
-
1H MRI detection of amyloid β plaques in vivo
-
1H MRI detection of amyloid β plaques in vivo, Nat. Neurosci. 8, 527-533.
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 527-533
-
-
Higuchi, M.1
Iwata, N.2
Matsuba, Y.3
Sato, K.4
Sasamoto, K.5
Saido, T.C.6
-
70
-
-
0034858025
-
The fluorescent Congo red derivative, (trans,trans)-1-bromo-2,5-bis-(3- hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB), labels diverse β-pleated sheet structures in postmortem human neurodegenerative disease brains
-
Schmidt, M. L., Schuck, T., Sheridan, S., Kung, M.-P., Kung, H., Zhuang, Z.-P., Bergeron, C., Lamarche, J. S., Skovronsky, D., Giasson, B. I., Lee, V. M.-Y., and Trojanowski, J. Q. (2001) The fluorescent Congo red derivative, (trans,trans)-1-bromo-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB), labels diverse β-pleated sheet structures in postmortem human neurodegenerative disease brains, Am. J. Pathol. 159, 937-943.
-
(2001)
Am. J. Pathol.
, vol.159
, pp. 937-943
-
-
Schmidt, M.L.1
Schuck, T.2
Sheridan, S.3
Kung, M.-P.4
Kung, H.5
Zhuang, Z.-P.6
Bergeron, C.7
Lamarche, J.S.8
Skovronsky, D.9
Giasson, B.I.10
Lee, V.M.-Y.11
Trojanowski, J.Q.12
-
71
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., and Glabe, C. G. (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis, Science 300, 486-489.
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
Glabe, C.G.7
-
72
-
-
2642578354
-
Single chain variable fragments against β-amyloid (Aβ) can inhibit Aβ aggregation and prevent Aβ-induced neurotoxicity
-
Emadi, S., Liu, R., Yuan, B., Schulz, P., McAllister, C., Lyubchenko, Y., Messer, A., and Sierks, M. R. (2004) Single chain variable fragments against β-amyloid (Aβ) can inhibit Aβ aggregation and prevent Aβ-induced neurotoxicity, Biochemistry 43, 2871-2878.
-
(2004)
Biochemistry
, vol.43
, pp. 2871-2878
-
-
Emadi, S.1
Liu, R.2
Yuan, B.3
Schulz, P.4
McAllister, C.5
Lyubchenko, Y.6
Messer, A.7
Sierks, M.R.8
-
73
-
-
17644383748
-
Heat shock protein 70 inhibits α-synuclein fibril formation via preferential binding to prefibrillar species
-
Dedmon, M. W., Christodoulou, J., Wilson, M. R., and Dobson, C. M. (2005) Heat shock protein 70 inhibits α-synuclein fibril formation via preferential binding to prefibrillar species, J. Biol. Chem. 280, 14733-14740.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 14733-14740
-
-
Dedmon, M.W.1
Christodoulou, J.2
Wilson, M.R.3
Dobson, C.M.4
-
74
-
-
0032573597
-
Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments
-
El-Agnaf, O. M. A., Jakes, R., Curran, M. D., Middleton, D., Ingenito, R., Bianchi, E., Pessi, A., Neill, D., and Wallace, D. (1998) Aggregates from mutant and wild-type α-synuclein proteins and NAC peptide induce apoptotic cell death in human neuroblastoma cells by formation of β-sheet and amyloid-like filaments, FEBS Lett. 440, 71-75.
-
(1998)
FEBS Lett.
, vol.440
, pp. 71-75
-
-
El-Agnaf, O.M.A.1
Jakes, R.2
Curran, M.D.3
Middleton, D.4
Ingenito, R.5
Bianchi, E.6
Pessi, A.7
Neill, D.8
Wallace, D.9
-
75
-
-
0038386274
-
Zeroing in on the pathogenic form of α-synuclein and its mechanism of neurotoxicity in Parkinson's disease
-
Volles, M. J., and Lansbury, P. T. (2003) Zeroing in on the pathogenic form of α-synuclein and its mechanism of neurotoxicity in Parkinson's disease, Biochemistry 42, 7871-7878.
-
(2003)
Biochemistry
, vol.42
, pp. 7871-7878
-
-
Volles, M.J.1
Lansbury, P.T.2
-
76
-
-
0038784529
-
Are ubiquitination pathways central to Parkinson's disease?
-
Giasson, B. I., and Lee, V. M.-Y. (2003) Are ubiquitination pathways central to Parkinson's disease? Cell 114, 1-8.
-
(2003)
Cell
, vol.114
, pp. 1-8
-
-
Giasson, B.I.1
Lee, V.M.-Y.2
-
77
-
-
17844406856
-
α-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
-
Chen, L., and Feany, M. B. (2005) α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease, Nat. Neurosci. 8, 657-663.
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 657-663
-
-
Chen, L.1
Feany, M.B.2
|