Phosphorylation of Ser-129 is the dominant pathological modification of α-synuclein in familial and sporadic lewy body disease

Journal of Biological Chemistry

Volumn 281, Issue 40, 2006, Pages 29739-29752

  Anderson, John P ^a   Walker, Donald E ^a   Goldstein, Jason M ^a   De Laat, Rian ^a   Banducci, Kelly ^a   Caccavello, Russell J ^a   Barbour, Robin ^a   Huang, Jiping ^a   Kling, Kristin ^a   Lee, Michael ^a   Diep, Linnea ^a   Keim, Pamela S ^a   Shen, Xiaofeng ^b   Chataway, Tim ^b   Schlossmacher, Michael G ^c   Seubert, Peter ^a   Schenk, Dale ^a   Sinha, Sukanto ^a   Gai, Wei Ping ^b   Chilcote, Tamie J ^a,d  

^a ELAN PHARMACEUTICALS   (United States)

^b FLINDERS UNIVERSITY   (Australia)

^c HARVARD MEDICAL SCHOOL   (United States)

^d ActiveSite Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; BIOASSAY; BRAIN; IMMUNOLOGY; MASS SPECTROMETRY; MATHEMATICAL MODELS; PATHOLOGY;

IMMUNOBLOT ANALYSIS; PHOSPHORYLATED SYNUCLEIN; SER-129;

ENZYME KINETICS;

ALPHA SYNUCLEIN; ASPARAGINE; ASPARTIC ACID; LYSINE; SERINE; TYROSINE;

ARTICLE; CONTROLLED STUDY; DIFFUSE LEWY BODY DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN TISSUE; MASS SPECTROMETRY; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; UBIQUITINATION;

EID: 33749570292     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M600933200     Document Type: Article

References (35)

1. Kuzuhara, S., Mori, H., Izumiyama, N., Yoshimura, M., and Ihara, Y. (1988) Acta Neuropathol. 75, 345-353
2. Pollanen, M. S., Dickson, D. W., and Bergeron, C. (1993) J. Neuropathol. Exp. Neurol. 52, 183-191
3. Spillantini, M. G., Schmidt, M. L., Lee, V. M., Trojanowski, J. Q., Jakes, R., and Goedert, M. (1997) Nature 388, 839-840
4. Sampathu, D. M., Giasson, B. I., Pawlyk, A. C., Trojanowski, J. Q., and Lee, V. M.-Y. (2003) Am. J. Pathol. 163, 91-100
5. Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, P., Root, H., Rubenstein, J., Boyer, R., Stenroos, E. S., Chandrasekharappa, S., Athanassiadou, A., Paparpetrpoulos, T., Johnson, W. G., Lazzarini, A. M., Duvoisin, R. C., Di Iorio, G., Golbe, L. I., and Nussbaum, R. L. (1997) Science 276, 2045-2047
6. Krueger, R., Kuhn, W., Muller, T., Woitalla, D., Graeber, M., Kosel, S., Przuntek, H., Epplen, J. T., Schlos, L., and Riess, O. (1998) Nat. Gen. 18, 106-108
7. Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., Lincoln, S., Crawley, A., Hanson, M., Maraganore, D., Adler, C., Cookson, M. R., Muenter, M., Baptista, M., Miller, D., Blancato, J., Hardy, J., and Gwinn-Hardy, K. (2003) Science 302, 841
8. Chartier-Harlin, M. C., Kachergus, J., Roumier, C., Mouroux, V., Douay, X., Lincoln, S., Levecque, C., Larvor, L., Andrieux, J., Hulihan, M., Waucquier, N., Defebvre, L., Amouyel, P., Farrer, M., and Destee, A. (2004) Lancet 364, 1167-1169
9. Ibanez, P., Bonnet, A. M., Debarges, B., Lohmann, E., Tison, F., Pollak, P., Agid, Y., Durr, A., and Brice, A. (2004) Lancet 364, 1169-1171
10. Fujiwara, H., Hasegawa, M., Dohmae, N., Kawashima, A., Masliah, E., Goldberg, M. S., Shen, J., Takio, K., and Iwatsubo, T. (2002) Nat. Cell Biol. 4, 160-164
11. Jakes, R., Spillantini, M. G., and Goedert, M. (1994) FEBS Lett. 345, 27-32
12. Jensen, P. H., Islam, K., Kenney, J., Nielsen, M. S., Power, J., and Gai, W. P. (2000) J. Biol. Chem. 275, 21500-21507
13. Gai, W. P., Power, J. H. T., Blumbergs, P. C., Culvenor, J. G., and Jensen, P. H. (1999) J. Neurochem. 73, 2093-2100
14. Golbe, L. I., Di Iorio, G., Sanges, G., Lazzarini, A. M., La Sala, S., Bonavita, V., and Duvoisin, R. C. (1996) Ann. Neurol. 40, 767-775
15. Schlossmacher, M. G., and Shimura, H. (2005) Methods Mol. Biol. 301, 351-369
16. Spira, P. J., Sharpe, D. M., Halliday, G., Cavanagh, J., and Nicholson, G. A. (2001) Ann. Neurol. 49, 313-319
17. Gai, W. P., Yuan, H. X., Li, X. Q., Power, T. H., Blumbergs, P. C., and Jensen, P. H. (2000) Exp. Neurol. 166, 324-333
18. Kahle, P. J., Neumann, M., Ozmen, L., Muller, V., Jacobson, H., Spooren, W., Fuss, B., Mallon, B., Macklin, W. B., Fujiwara, H., Hasegawa, M., Iwatsubo, T., Kretzschmar, H. A., and Haas, C. (2002) EMBO Rep. 3, 583-588
19. Duda, J., Giasson, B. I., Mabon, M. E., Miller, D. C., Golbe, L. I., Lee, V. M.-Y., and Trojanowski, J. (2002) Acta Neuropathol. 104, 7-11
20. Ciechanover, A., Heller, H., Elias, S., Haas, A. L., and Hershko, A. (1980) Proc. Natl. Acad. Sci. U. S. A. 77, 1365-1368
21. Pickart, C. M. (2000) Trends Biochem. Sci. 25, 544-548
22. Hicke, L. (2001) Nat. Rev. Mol. Cell Biol. 2, 195-201
23. Bradshaw, R. A. (1989) Trends Biochem. Sci. 14, 276-279
24. Smith, W. W., Margolis, R. L., Li, X., Troncoso, J. C., Lee, M. K., Dawson, V. L., Dawson, T. M., Iwatsubo, T., and Ross, C. A. (2005) J. Neurosci. 25, 5544-5552
25. Hasegawa, M., Fujiwara, H., Nonaka, T., Wakabayashi, K., Takahashi, H., Lee, V. M.-Y., Trojanowski, J. Q., Mann, D., and Iwatsubo, T. (2002) J. Biol. Chem. 277, 49071-49076
26. Nonaka, T., Iwatsubo, T., and Hasegawa, M. (2005) Biochem. 44, 361-368
27. Tofaris, G. K., Razzaq, A., Ghetti, B., Lilley, K. S., and Spillantini, M. G. (2003) J. Biol. Chem. 278, 44405-44411
28. Rideout, J. J., Dietrich, P., Wang, Q., Dauer, W. T., and Stefanis, L. (2004) J. Biol. Chem. 279, 46915-46920
29. Li, W., West, N., Colla, E., Pletnikova, O., Troncoso, J. C., Marsh, L., Dawson, T. M., Jakala, P., Hartmann, T., Price, D. L., and Lee, M. K. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 2162-2167
30. Mishizen-Eberz, A. J., Guttmann, R. P., Giasson, B. I., Day III, G. A., Hodara, R., Ischiropoulos, H., Lee, V. M.-Y., Trojanowski, J. Q., and Lynch, D. R. (2003) J. Neurochem. 86, 836-847
31. Miake, H., Mizusawa, H., Iwatsubo, T., and Hasegawa, M. (2002) J. Biol. Chem. 277, 19213-19219
32. Murray, I. V. J., Biasson, B. I., Quinn, S. M., Koppaka, V., Axelsen, P. H., Ischiropoulos, H., Trojanowski, J. Q., and Lee, V. M.-L. (2003) Biochemistry 42, 8530-8540
33. Serpell, L. C., Berruman, J., Jakes, R., Goedert, M., and Crowther, R. A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 4897-4902
34. Crowther, R. A., Jakes, R., Spillantini, M. G., and Goedert, M. (1998) FEBS Lett. 436, 309-312
35. Liu, C.-W., Giasson, B. I., Lewis, K. A., Lee, V. M., DeMartino, G. N., and Thomas, P. J. (2005) J. Biol. Chem. 280, 22670-22678