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Volumn 45, Issue 1, 2013, Pages 2-10

SREBP: A novel therapeutic target

Author keywords

cAMP; insulin; miRNA; SREBP; therapeutic target; vitamin A

Indexed keywords

CYCLIC AMP; INSULIN; MESSENGER RNA; RETINOL; STEROL REGULATORY ELEMENT BINDING PROTEIN;

EID: 84871757651     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gms112     Document Type: Review
Times cited : (115)

References (84)
  • 1
    • 0036853543 scopus 로고    scopus 로고
    • Atherogenesis in perspective: Hypercholesterolemia and inflammation as partners in crime
    • DOI 10.1038/nm1102-1211
    • Steinberg D. Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime. Nat Med 2002, 8:1211-1217. (Pubitemid 35373551)
    • (2002) Nature Medicine , vol.8 , Issue.11 , pp. 1211-1217
    • Steinberg, D.1
  • 2
    • 0032913707 scopus 로고    scopus 로고
    • Dyslipidemia of central obesity and insulin resistance
    • Brunzell JD and Hokanson JE. Dyslipidemia of central obesity and insulin resistance. Diabetes Care 1999, 22(Suppl 3): C10-13. (Pubitemid 29164911)
    • (1999) Diabetes Care , vol.22 , Issue.SUPPL. 3
    • Brunzell, J.D.1    Hokanson, J.E.2
  • 3
    • 72749086098 scopus 로고    scopus 로고
    • Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: What a long, strange tRIP it's been
    • Osborne TF and Espenshade PJ. Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been. Genes Dev 2009, 23:2578-2591.
    • (2009) Genes Dev , vol.23 , pp. 2578-2591
    • Osborne, T.F.1    Espenshade, P.J.2
  • 5
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • DOI 10.1016/S0092-8674(00)80213-5
    • Brown MS and Goldstein JL. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 1997, 89:331-340. (Pubitemid 27220877)
    • (1997) Cell , vol.89 , Issue.3 , pp. 331-340
    • Brown, M.S.1    Goldstein, J.L.2
  • 7
    • 0027490174 scopus 로고
    • SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene
    • DOI 10.1016/0092-8674(93)90690-R
    • Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X and Goldstein JL, et al. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell 1993, 75:187-197. (Pubitemid 23306032)
    • (1993) Cell , vol.75 , Issue.1 , pp. 187-197
    • Yokoyama, C.1    Wang, X.2    Briggs, M.R.3    Admon, A.4    Wu, J.5    Hua, X.6    Goldstein, J.L.7    Brown, M.S.8
  • 8
    • 0028360111 scopus 로고
    • Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1)
    • Sato R, Yang J, Wang X, Evans MJ, Ho YK, Goldstein JL and Brown MS. Assignment of the membrane attachment, DNA binding, and transcription-al activation domains of sterol regulatory element-binding protein-1 (SREBP-1). J Biol Chem 1994, 269:17267-17273. (Pubitemid 24204053)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.25 , pp. 17267-17273
    • Sato, R.1    Yang, J.2    Wang, X.3    Evans, M.J.4    Ho, Y.K.5    Goldstein, J.L.6    Brown, M.S.7
  • 9
    • 77956176288 scopus 로고    scopus 로고
    • Sterol metabolism and SREBP activation
    • Sato R. Sterol metabolism and SREBP activation. Arch Biochem Biophys 2010, 501:177-181.
    • (2010) Arch Biochem Biophys , vol.501 , pp. 177-181
    • Sato, R.1
  • 10
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • DOI 10.1172/JCI200215593
    • Horton JD, Goldstein JL and Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002, 109:1125-1131. (Pubitemid 34496588)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.9 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 11
    • 0032892175 scopus 로고    scopus 로고
    • Sterol regulatory element-binding proteins: Activators of cholesterol and fatty acid biosynthesis
    • DOI 10.1097/00041433-199904000-00008
    • Horton JD and Shimomura I. Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis. Curr Opin Lipidol 1999, 10:143-150. (Pubitemid 29187097)
    • (1999) Current Opinion in Lipidology , vol.10 , Issue.2 , pp. 143-150
    • Horton, J.D.1    Shimomura, L.2
  • 13
    • 84856471735 scopus 로고    scopus 로고
    • SREBPs: Metabolic integrators in physiology and metabolism
    • Jeon TI and Osborne TF. SREBPs: metabolic integrators in physiology and metabolism. Trends Endocrinol Metab 2012, 23:65-72.
    • (2012) Trends Endocrinol Metab , vol.23 , pp. 65-72
    • Jeon, T.I.1    Osborne, T.F.2
  • 15
    • 22544466429 scopus 로고    scopus 로고
    • Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro
    • DOI 10.1074/jbc.M504041200
    • Sun LP, Li L, Goldstein JL and Brown MS. Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro. J Biol Chem 2005, 280:26483-26490. (Pubitemid 41022245)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.28 , pp. 26483-26490
    • Sun, L.-P.1    Li, L.2    Goldstein, J.L.3    Brown, M.S.4
  • 16
    • 0036671360 scopus 로고    scopus 로고
    • Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism
    • DOI 10.1016/S1097-2765(02)00591-9
    • Brown AJ, Sun L, Feramisco JD, Brown MS and Goldstein JL. Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism. Mol Cell 2002, 10:237-245. (Pubitemid 35007339)
    • (2002) Molecular Cell , vol.10 , Issue.2 , pp. 237-245
    • Brown, A.J.1    Sun, L.2    Feramisco, J.D.3    Brown, M.S.4    Goldstein, J.L.5
  • 18
    • 79955973156 scopus 로고    scopus 로고
    • Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis
    • Motamed M, Zhang Y, Wang ML, Seemann J, Kwon HJ, Goldstein JL and Brown MS. Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis. J Biol Chem 2011, 286:18002-18012.
    • (2011) J Biol Chem , vol.286 , pp. 18002-18012
    • Motamed, M.1    Zhang, Y.2    Wang, M.L.3    Seemann, J.4    Kwon, H.J.5    Goldstein, J.L.6    Brown, M.S.7
  • 19
    • 0037245750 scopus 로고    scopus 로고
    • Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain
    • DOI 10.1016/S1097-2765(02)00822-5
    • Sever N, Yang T, Brown MS, Goldstein JL and DeBose-Boyd RA. Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. Mol Cell 2003, 11:25-33. (Pubitemid 36126588)
    • (2003) Molecular Cell , vol.11 , Issue.1 , pp. 25-33
    • Sever, N.1    Yang, T.2    Brown, M.S.3    Goldstein, J.L.4    DeBose-Boyd, R.A.5
  • 21
    • 0037162719 scopus 로고    scopus 로고
    • Crucial step in cholesterol homeostasis: Sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER
    • DOI 10.1016/S0092-8674(02)00872-3
    • Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R and Goldstein JL, et al. Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Cell 2002, 110:489-500. (Pubitemid 35232292)
    • (2002) Cell , vol.110 , Issue.4 , pp. 489-500
    • Yang, T.1    Espenshade, P.J.2    Wright, M.E.3    Yabe, D.4    Gong, Y.5    Aebersold, R.6    Goldstein, J.L.7    Brown, M.S.8
  • 22
    • 0036792050 scopus 로고    scopus 로고
    • Insig-2, a second endoplasmic re-ticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
    • Yabe D, Brown MS and Goldstein JL. Insig-2, a second endoplasmic re-ticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci USA 2002, 99:12753-12758.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12753-12758
    • Yabe, D.1    Brown, M.S.2    Goldstein, J.L.3
  • 23
    • 77957843089 scopus 로고    scopus 로고
    • Insulin-induced gene: A new regulator in lipid metabolism
    • Dong XY and Tang SQ. Insulin-induced gene: a new regulator in lipid metabolism. Peptides 2010, 31:2145-2150.
    • (2010) Peptides , vol.31 , pp. 2145-2150
    • Dong, X.Y.1    Tang, S.Q.2
  • 24
    • 79961118496 scopus 로고    scopus 로고
    • Regulation of HMG-CoA reductase in mammals and yeast
    • Burg JS and Espenshade PJ. Regulation of HMG-CoA reductase in mammals and yeast. Prog Lipid Res 2011, 50:403-410.
    • (2011) Prog Lipid Res , vol.50 , pp. 403-410
    • Burg, J.S.1    Espenshade, P.J.2
  • 25
    • 36248988054 scopus 로고    scopus 로고
    • Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation
    • DOI 10.1016/j.semcdb.2007.09.002, PII S1084952107001486, Degredation of Misfolded Glycoproteins
    • Kostova Z, Tsai YC and Weissman AM. Ubiquitin ligases, critical mediators of endoplasmic reticulum-associated degradation. Semin Cell Dev Biol 2007, 18:770-779. (Pubitemid 350138452)
    • (2007) Seminars in Cell and Developmental Biology , vol.18 , Issue.6 , pp. 770-779
    • Kostova, Z.1    Tsai, Y.C.2    Weissman, A.M.3
  • 26
    • 77952860536 scopus 로고    scopus 로고
    • Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase
    • Jo Y and Debose-Boyd RA. Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase. Crit Rev Biochem Mol Biol 2010, 45:185-198.
    • (2010) Crit Rev Biochem Mol Biol , vol.45 , pp. 185-198
    • Jo, Y.1    Debose-Boyd, R.A.2
  • 27
    • 0346101770 scopus 로고    scopus 로고
    • Insig-dependent Ubiquitination and Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-CoA Reductase Stimulated by Sterols and Geranylgeraniol
    • DOI 10.1074/jbc.M310053200
    • Sever N, Song BL, Yabe D, Goldstein JL, Brown MS and DeBose-Boyd RA. Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3- methylglutaryl-CoA reductase stimulated by sterols and gera-nylgeraniol. J Biol Chem 2003, 278:52479-52490. (Pubitemid 38035841)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.52 , pp. 52479-52490
    • Sever, N.1    Song, B.-L.2    Yabe, D.3    Goldstein, J.L.4    Brown, M.S.5    DeBose-Boydb, R.A.6
  • 28
    • 24944591120 scopus 로고    scopus 로고
    • Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase
    • DOI 10.1016/j.molcel.2005.08.009, PII S1097276505015273
    • Song BL, Sever N and DeBose-Boyd RA. Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubi-quitination to degradation of HMG CoA reductase. Mol Cell 2005, 19:829-840. (Pubitemid 41316676)
    • (2005) Molecular Cell , vol.19 , Issue.6 , pp. 829-840
    • Song, B.-L.1    Sever, N.2    DeBose-Boyd, R.A.3
  • 29
    • 79955406213 scopus 로고    scopus 로고
    • Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase
    • Jo Y, Sguigna PV and DeBose-Boyd RA. Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem 2011, 286:15022-15031.
    • (2011) J Biol Chem , vol.286 , pp. 15022-15031
    • Jo, Y.1    Sguigna, P.V.2    Debose-Boyd, R.A.3
  • 30
    • 77953530388 scopus 로고    scopus 로고
    • Sterol-induced dislocation of 3-hydroxy-3-methylglu-taryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets
    • Hartman IZ, Liu P, Zehmer JK, Luby-Phelps K, Jo Y, Anderson RG and DeBose-Boyd RA. Sterol-induced dislocation of 3-hydroxy-3-methylglu-taryl coenzyme A reductase from endoplasmic reticulum membranes into the cytosol through a subcellular compartment resembling lipid droplets. J Biol Chem 2010, 285:19288-19298.
    • (2010) J Biol Chem , vol.285 , pp. 19288-19298
    • Hartman, I.Z.1    Liu, P.2    Zehmer, J.K.3    Luby-Phelps, K.4    Jo, Y.5    Anderson, R.G.6    Debose-Boyd, R.A.7
  • 31
    • 77649264504 scopus 로고    scopus 로고
    • Bifurcation of insulin signaling pathway in rat liver: MTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
    • Li S, Brown MS and Goldstein JL. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci USA 2010, 107:3441-3446.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 3441-3446
    • Li, S.1    Brown, M.S.2    Goldstein, J.L.3
  • 33
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB Signaling: Navigating Downstream
    • DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
    • Manning BD and Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007, 129:1261-1274. (Pubitemid 46962095)
    • (2007) Cell , vol.129 , Issue.7 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 34
    • 65549171104 scopus 로고    scopus 로고
    • Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles
    • Yellaturu CR, Deng X, Cagen LM, Wilcox HG, Mansbach CM, 2nd, Siddiqi SA and Park EA, et al. Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles. J Biol Chem 2009, 284:7518-7532.
    • (2009) J Biol Chem , vol.284 , pp. 7518-7532
    • Yellaturu, C.R.1    Deng, X.2    Cagen, L.M.3    Wilcox, H.G.4    Mansbach II, C.M.5    Siddiqi, S.A.6    Park, E.A.7
  • 36
    • 0032104180 scopus 로고    scopus 로고
    • Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2
    • Horton JD, Shimomura I, Brown MS, Hammer RE, Goldstein JL and Shimano H. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J Clin Invest 1998, 101:2331-2339. (Pubitemid 28270427)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.11 , pp. 2331-2339
    • Norton, J.D.1    Shimomura, I.2    Brown, M.S.3    Hammer, R.E.4    Goldstein, J.L.5    Shimano, H.6
  • 39
    • 38349056675 scopus 로고    scopus 로고
    • Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
    • DeYoung MP, Horak P, Sofer A, Sgroi D and Ellisen LW. Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev 2008, 22:239-251.
    • (2008) Genes Dev , vol.22 , pp. 239-251
    • Deyoung, M.P.1    Horak, P.2    Sofer, A.3    Sgroi, D.4    Ellisen, L.W.5
  • 40
    • 0042701991 scopus 로고    scopus 로고
    • Tuberous Sclerosis Complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
    • DOI 10.1016/S0960-9822(03)00506-2
    • Tee AR, Manning BD, Roux PP, Cantley LC and Blenis J. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 2003, 13:1259-1268. (Pubitemid 36953298)
    • (2003) Current Biology , vol.13 , Issue.15 , pp. 1259-1268
    • Tee, A.R.1    Manning, B.D.2    Roux, P.P.3    Cantley, L.C.4    Blenis, J.5
  • 41
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTpase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • DOI 10.1101/gad.1110003
    • Inoki K, Li Y, Xu T and Guan KL. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 2003, 17:1829-1834. (Pubitemid 36944560)
    • (2003) Genes and Development , vol.17 , Issue.15 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.-L.4
  • 43
    • 84863858371 scopus 로고    scopus 로고
    • Regulation of cholesterol and fatty acid synthesis
    • pii: a004754
    • Ye J and DeBose-Boyd RA. Regulation of cholesterol and fatty acid synthesis. Cold Spring Harb Perspect Biol 2011, 3: pii: a004754.
    • (2011) Cold Spring Harb Perspect Biol , vol.3
    • Ye, J.1    Debose-Boyd, R.A.2
  • 44
    • 84864684825 scopus 로고    scopus 로고
    • Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis
    • Liu TF, Tang JJ, Li PS, Shen Y, Li JG, Miao HH and Li BL, et al. Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis. Cell Metab 2012, 16:213-225.
    • (2012) Cell Metab , vol.16 , pp. 213-225
    • Liu, T.F.1    Tang, J.J.2    Li, P.S.3    Shen, Y.4    Li, J.G.5    Miao, H.H.6    Li, B.L.7
  • 45
    • 33748751591 scopus 로고    scopus 로고
    • Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding
    • DOI 10.1074/jbc.M604983200
    • Punga T, Bengoechea-Alonso MT and Ericsson J. Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding. J Biol Chem 2006, 281:25278-25286. (Pubitemid 44401915)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.35 , pp. 25278-25286
    • Punga, T.1    Bengoechea-Alonso, M.T.2    Ericsson, J.3
  • 46
    • 65549140251 scopus 로고    scopus 로고
    • A phosphorylation cascade controls the degradation of active SREBP1
    • Bengoechea-Alonso MT and Ericsson J. A phosphorylation cascade controls the degradation of active SREBP1. J Biol Chem 2009, 284:5885-5895.
    • (2009) J Biol Chem , vol.284 , pp. 5885-5895
    • Bengoechea-Alonso, M.T.1    Ericsson, J.2
  • 48
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • DOI 10.1038/378785a0
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M and Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995, 378:785-789. (Pubitemid 26004411)
    • (1995) Nature , vol.378 , Issue.6559 , pp. 785-789
    • Cross, D.A.E.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 51
    • 0034623288 scopus 로고    scopus 로고
    • Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
    • Costet P, Luo Y, Wang N and Tall AR. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor. J Biol Chem 2000, 275:28240-28245.
    • (2000) J Biol Chem , vol.275 , pp. 28240-28245
    • Costet, P.1    Luo, Y.2    Wang, N.3    Tall, A.R.4
  • 53
    • 0033997752 scopus 로고    scopus 로고
    • Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element
    • Luo Y and Tall AR. Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR element. J Clin Invest 2000, 105:513-520. (Pubitemid 30127252)
    • (2000) Journal of Clinical Investigation , vol.105 , Issue.4 , pp. 513-520
    • Luo, Y.1    Tall, A.R.2
  • 55
    • 0034518420 scopus 로고    scopus 로고
    • The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
    • DOI 10.1146/annurev.cellbio.16.1.459
    • Repa JJ and Mangelsdorf DJ. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu Rev Cell Dev Biol 2000, 16:459-481. (Pubitemid 32037514)
    • (2000) Annual Review of Cell and Developmental Biology , vol.16 , pp. 459-481
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 56
    • 84860548049 scopus 로고    scopus 로고
    • Liver LXRalpha expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice
    • Zhang Y, Breevoort SR, Angdisen J, Fu M, Schmidt DR, Holmstrom SR and Kliewer SA, et al. Liver LXRalpha expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice. J Clin Invest 2012, 122:1688-1699.
    • (2012) J Clin Invest , vol.122 , pp. 1688-1699
    • Zhang, Y.1    Breevoort, S.R.2    Angdisen, J.3    Fu, M.4    Schmidt, D.R.5    Holmstrom, S.R.6    Kliewer, S.A.7
  • 57
    • 12844271136 scopus 로고    scopus 로고
    • Differential regulation of sterol regulatory element-binding protein 1c transcriptional activity by insulin and liver X receptor during liver development
    • DOI 10.1074/jbc.M406522200
    • Bobard A, Hainault I, Ferre P, Foufelle F and Bossard P. Differential regulation of sterol regulatory element-binding protein 1c transcriptional activity by insulin and liver X receptor during liver development. J Biol Chem 2005, 280:199-206. (Pubitemid 40164981)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.1 , pp. 199-206
    • Bobard, A.1    Hainault, I.2    Ferre, P.3    Foufelle, F.4    Bossard, P.5
  • 59
  • 61
    • 73649120951 scopus 로고    scopus 로고
    • 0-monophosphate/protein kinase A signalling and suppresses sterol regulatory element-binding protein-1 expression in cultured primary chicken hepatocytes
    • 0-monophosphate/protein kinase A signalling and suppresses sterol regulatory element-binding protein-1 expression in cultured primary chicken hepatocytes. Br J Nutr 2009, 102:680-686.
    • (2009) Br J Nutr , vol.102 , pp. 680-686
    • Tang, X.1    Ma, H.2    Shen, Z.3    Zou, S.4    Xu, X.5    Lin, C.6
  • 63
    • 33744821064 scopus 로고    scopus 로고
    • Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation
    • DOI 10.1152/ajpcell.00374.2005
    • Lu M and Shyy JY. Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation. Am J Physiol Cell Physiol 2006, 290: C1477-1486. (Pubitemid 43830787)
    • (2006) American Journal of Physiology - Cell Physiology , vol.290 , Issue.6
    • Lu, M.1    Shyy, J.Y.-J.2
  • 64
    • 0037229271 scopus 로고    scopus 로고
    • Retinoid production and catabolism: Role of diet in regulating retinol esterification and retinoic acid oxidation
    • Ross AC. Retinoid production and catabolism: role of diet in regulating retinol esterification and retinoic acid oxidation. J Nutr 2003, 133:291S-296S. (Pubitemid 36070621)
    • (2003) Journal of Nutrition , vol.133 , Issue.1
    • Ross, A.C.1
  • 65
    • 0032831815 scopus 로고    scopus 로고
    • Interactions of retinoid binding proteins and enzymes in retinoid metabolism
    • DOI 10.1016/S1388-1981(99)00117-1, PII S1388198199001171
    • Napoli JL. Interactions of retinoid binding proteins and enzymes in retinoid metabolism. Biochim Biophys Acta 1999, 1440:139-162. (Pubitemid 29424180)
    • (1999) Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids , vol.1440 , Issue.2-3 , pp. 139-162
    • Napoli, J.L.1
  • 66
    • 84862991862 scopus 로고    scopus 로고
    • Vitamin A status affects obesity development and hepatic expression of key genes for fuel metabolism in Zucker fatty rats
    • Zhang Y, Li R, Li Y, Chen W, Zhao S and Chen G. Vitamin A status affects obesity development and hepatic expression of key genes for fuel metabolism in Zucker fatty rats. Biochem Cell Biol 2012, 90:548-557.
    • (2012) Biochem Cell Biol , vol.90 , pp. 548-557
    • Zhang, Y.1    Li, R.2    Li, Y.3    Chen, W.4    Zhao, S.5    Chen, G.6
  • 67
    • 79952450716 scopus 로고    scopus 로고
    • Retinoids synergized with insulin to induce Srebp-1c expression and activated its promoter via the two liver X receptor binding sites that mediate insulin action
    • Li R, Chen W, Li Y, Zhang Y and Chen G. Retinoids synergized with insulin to induce Srebp-1c expression and activated its promoter via the two liver X receptor binding sites that mediate insulin action. Biochem Biophys Res Commun 2011, 406:268-272.
    • (2011) Biochem Biophys Res Commun , vol.406 , pp. 268-272
    • Li, R.1    Chen, W.2    Li, Y.3    Zhang, Y.4    Chen, G.5
  • 68
    • 34249720160 scopus 로고    scopus 로고
    • SREBP-1c mediates the retinoid-dependent increase in fatty acid synthase promoter activity in HepG2
    • DOI 10.1016/j.febslet.2007.05.022, PII S0014579307005509
    • Roder K, Zhang L and Schweizer M. SREBP-1c mediates the retinoid-dependent increase in fatty acid synthase promoter activity in HepG2. FEBS Lett 2007, 581:2715-2720. (Pubitemid 46829116)
    • (2007) FEBS Letters , vol.581 , Issue.14 , pp. 2715-2720
    • Roder, K.1    Zhang, L.2    Schweizer, M.3
  • 71
    • 77955456415 scopus 로고    scopus 로고
    • MiR-33 links SREBP-2 induction to repression of sterol transporters
    • Marquart TJ, Allen RM, Ory DS and Baldan A. miR-33 links SREBP-2 induction to repression of sterol transporters. Proc Natl Acad Sci USA 2010, 107:12228-12232.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 12228-12232
    • Marquart, T.J.1    Allen, R.M.2    Ory, D.S.3    Baldan, A.4
  • 72
    • 77958553499 scopus 로고    scopus 로고
    • Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation
    • Gerin I, Clerbaux LA, Haumont O, Lanthier N, Das AK, Burant CF and Leclercq IA, et al. Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation. J Biol Chem 2010, 285:33652-33661.
    • (2010) J Biol Chem , vol.285 , pp. 33652-33661
    • Gerin, I.1    Clerbaux, L.A.2    Haumont, O.3    Lanthier, N.4    Das, A.K.5    Burant, C.F.6    Leclercq, I.A.7
  • 73
    • 0037197803 scopus 로고    scopus 로고
    • Identification of tissue-specific MicroRNAs from mouse
    • DOI 10.1016/S0960-9822(02)00809-6, PII S0960982202008096
    • Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W and Tuschl T. Identification of tissue-specific microRNAs from mouse. Curr Biol 2002, 12:735-739. (Pubitemid 34455427)
    • (2002) Current Biology , vol.12 , Issue.9 , pp. 735-739
    • Lagos-Quintana, M.1    Rauhut, R.2    Yalcin, A.3    Meyer, J.4    Lendeckel, W.5    Tuschl, T.6
  • 75
    • 33645075443 scopus 로고    scopus 로고
    • MiR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
    • Esau C, Davis S, Murray SF, Yu XX, Pandey SK, Pear M and Watts L, et al. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell Metab 2006, 3:87-98.
    • (2006) Cell Metab , vol.3 , pp. 87-98
    • Esau, C.1    Davis, S.2    Murray, S.F.3    Yu, X.X.4    Pandey, S.K.5    Pear, M.6    Watts, L.7
  • 76
    • 37349113774 scopus 로고    scopus 로고
    • Inhibition of microRNA with antisense oligonucleotides
    • DOI 10.1016/j.ymeth.2007.11.001, PII S1046202307002095, MicroRNAs: Part B
    • Esau CC. Inhibition of microRNA with antisense oligonucleotides. Methods 2008, 44:55-60. (Pubitemid 350297990)
    • (2008) Methods , vol.44 , Issue.1 , pp. 55-60
    • Esau, C.C.1
  • 78
    • 77952983901 scopus 로고    scopus 로고
    • Antisense gets a grip on miR-122 in chimpanzees
    • Branch AD and Rice CM. Antisense gets a grip on miR-122 in chimpanzees. Sci Transl Med 2010, 2:13ps1.
    • (2010) Sci Transl Med , vol.2
    • Branch, A.D.1    Rice, C.M.2
  • 79
    • 77952707662 scopus 로고    scopus 로고
    • MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism
    • Iliopoulos D, Drosatos K, Hiyama Y, Goldberg IJ and Zannis VI. MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism. J Lipid Res 2010, 51:1513-1523.
    • (2010) J Lipid Res , vol.51 , pp. 1513-1523
    • Iliopoulos, D.1    Drosatos, K.2    Hiyama, Y.3    Goldberg, I.J.4    Zannis, V.I.5
  • 80
    • 78650861117 scopus 로고    scopus 로고
    • Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques
    • Tang JJ, Li JG, Qi W, Qiu WW, Li PS, Li BL and Song BL. Inhibition of SREBP by a small molecule, betulin, improves hyperlipidemia and insulin resistance and reduces atherosclerotic plaques. Cell Metab 2011, 13:44-56.
    • (2011) Cell Metab , vol.13 , pp. 44-56
    • Tang, J.J.1    Li, J.G.2    Qi, W.3    Qiu, W.W.4    Li, P.S.5    Li, B.L.6    Song, B.L.7
  • 81
    • 84863393589 scopus 로고    scopus 로고
    • The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglycer-idemia in animals
    • Moon YA, Liang G, Xie X, Frank-Kamenetsky M, Fitzgerald K, Koteliansky V and Brown MS, et al. The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglycer-idemia in animals. Cell Metab 2012, 15:240-246.
    • (2012) Cell Metab , vol.15 , pp. 240-246
    • Moon, Y.A.1    Liang, G.2    Xie, X.3    Frank-Kamenetsky, M.4    Fitzgerald, K.5    Koteliansky, V.6    Brown, M.S.7
  • 82
    • 9644266673 scopus 로고    scopus 로고
    • Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver
    • DOI 10.1074/jbc.M410077200
    • Park SW, Moon YA and Horton JD. Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver. J Biol Chem 2004, 279:50630-50638. (Pubitemid 39577880)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.48 , pp. 50630-50638
    • Sahng, W.P.1    Moon, Y.-A.2    Horton, J.D.3
  • 84
    • 38949137409 scopus 로고    scopus 로고
    • Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2
    • DOI 10.1194/jlr.M700443-JLR200
    • Jeong HJ, Lee HS, Kim KS, Kim YK, Yoon D and Park SW. Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2. J Lipid Res 2008, 49:399-409. (Pubitemid 351213625)
    • (2008) Journal of Lipid Research , vol.49 , Issue.2 , pp. 399-409
    • Hyun, J.J.1    Lee, H.-S.2    Kim, K.-S.3    Kim, Y.-K.4    Yoon, D.5    Sahng, W.P.6


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