Identification of luminal loop 1 of scap protein as the sterol sensor that maintains cholesterol homeostasis

Journal of Biological Chemistry

Volumn 286, Issue 20, 2011, Pages 18002-18012

  Motamed, Massoud ^a   Zhang, Yinxin ^a   Wang, Michael L ^a   Seemann, Joachim ^a   Kwon, Hyock Joo ^a   Goldstein, Joseph L ^a   Brown, Michael S ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR CHOLESTEROL; CHOLESTEROL HOMEOSTASIS; CHOLESTEROL SYNTHESIS; CYTOSOLIC; ENDOPLASMIC RETICULUM; MEMBRANE DOMAIN; STEROL REGULATORY ELEMENT-BINDING PROTEINS; STEROL SENSORS; TRANSFECTED CELLS; TRANSMEMBRANE HELICES;

ALCOHOLS; AMINO ACIDS; BIOSYNTHESIS; GENES; PHYSIOLOGY; PROTEINS;

CHOLESTEROL;

ALANINE; CELL PROTEIN; CHOLESTEROL; SCAP PROTEIN; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CHO CELL; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM; GENETIC TRANSFECTION; HOMEOSTASIS; INSECT CELL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; PROTEIN PROCESSING; PROTEIN STRUCTURE; REGULATORY MECHANISM;

AMINO ACID SUBSTITUTION; ANIMALS; CHOLESTEROL; CRICETINAE; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; HOMEOSTASIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MUTATION, MISSENSE; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN TRANSPORT; STEROL REGULATORY ELEMENT BINDING PROTEINS;

EID: 79955973156     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.238311     Document Type: Article

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