Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 16, 2007, Pages 6519-6526

  Sun, Li Ping ^a   Seemann, Joachim ^b   Goldstein, Joseph L ^a   Brown, Michael S ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cholesterol homeostasis; COPII vesicles; Oxysterols; SREBP pathway

Indexed keywords

BINDING PROTEIN; CELL RECEPTOR; CHOLESTEROL; COPOLYMER; CYSTEINE; HEXAPEPTIDE; IMMUNOGLOBULIN F(AB) FRAGMENT; MEMBRANE PROTEIN; METHIONYLGLUTAMYLLEUCYLALANYLASPARTYLLEUCINE; OXYSTEROL; PROTEIN COP II; PROTEIN INHIBITOR; PROTEIN INSIG; PROTEIN SCAP; STEROL; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG; BLOCKING ANTIBODY; SEC23A PROTEIN, HUMAN; SEC24 PROTEIN, HUMAN; SIGNAL PEPTIDE; SREBP CLEAVAGE ACTIVATING PROTEIN; SREBP CLEAVAGE-ACTIVATING PROTEIN; VESICULAR TRANSPORT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; ANIMAL; CELL CLONE; CHO CELL; COATED VESICLE; CRICETULUS; DRUG ANTAGONISM; GENETICS; HAMSTER; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BLOCKING; CHO CELLS; CLONE CELLS; COP-COATED VESICLES; CRICETINAE; CRICETULUS; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN SORTING SIGNALS; PROTEIN TRANSPORT; STEROL REGULATORY ELEMENT BINDING PROTEINS; VESICULAR TRANSPORT PROTEINS;

EID: 34249861927     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0700907104     Document Type: Article

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