Retinoids synergized with insulin to induce Srebp-1c expression and activated its promoter via the two liver X receptor binding sites that mediate insulin action

Biochemical and Biophysical Research Communications

Volumn 406, Issue 2, 2011, Pages 268-272

  Li, Rui ^a   Chen, Wei ^a   Li, Yang ^a   Zhang, Yan ^a   Chen, Guoxun ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Insulin; LE; LXR; LXRE; Metabolism; Primary hepatocytes; RAR; RARE; Retinoid X receptor; Retinoids; RXR; SREBP 1c; Srebp 1c expression; TTNPB; VA; VAD; VAS

Indexed keywords

FAS LIGAND; FATTY ACID SYNTHASE; GCK PROTEIN; INSULIN; PROTEIN; RETINAL; RETINOIC ACID; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; RETINOL; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSCRIPTION; HORMONE ACTION; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE;

ANIMALS; ANTIGENS, CD95; BINDING SITES; HEPATOCYTES; INSULIN; ORPHAN NUCLEAR RECEPTORS; PROMOTER REGIONS, GENETIC; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, RETINOIC ACID; RESPONSE ELEMENTS; RETINALDEHYDE; RETINOID X RECEPTORS; RETINOIDS; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION, GENETIC; TRETINOIN;

RATTUS;

EID: 79952450716     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.02.031     Document Type: Article

References (26)

1. Moore T. Vitamin A and carotene: the vitamin A reserve of the adult human being in health and disease. Biochem. J. 1937, 31:155-164.
2. Wolf G., Lane M.D., Johnson B.C. Studies on the function of vitamin A in metabolism. J. Biol. Chem. 1957, 225:995-1008.
3. Bershad S., Rubinstein A., Paterniti J.R., Le N.A., Poliak S.C., Heller B., Ginsberg H.N., Fleischmajer R., Brown W.V. Changes in plasma lipids and lipoproteins during isotretinoin therapy for acne. N. Engl. J. Med. 1985, 313:981-985.
4. Sporn M., Robers A., Goodman D. The Retinoids, Biology, Chemistry, and Medicine 1994, Raven Press, New York. second ed.
5. Moise A.R., Noy N., Palczewski K., Blaner W.S. Delivery of retinoid-based therapies to target tissues. Biochemistry 2007, 46:4449-4458.
6. Ross A.C. Retinoid production and catabolism: role of diet in regulating retinol esterification and retinoic acid oxidation. J. Nutr. 2003, 133:291S-296.
7. Napoli J.L. Interactions of retinoid binding proteins and enzymes in retinoid metabolism. Biochim. Biophys. Acta, Mol. Cell Biol. Lipids 1999, 1440:139-162.
8. Shimomura I., Matsuda M., Hammer R.E., Bashmakov Y., Brown M.S., Goldstein J.L. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol. Cell 2000, 6:77-86.
9. Cagen L.M., Deng X., Wilcox H.G., Park E.A., Raghow R., Elam M.B. Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements. Biochem. J. 2005, 385:207-216.
10. Chen G., Liang G., Ou J., Goldstein J.L., Brown M.S. Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver. PNAS 2004, 101:11245-11250.
11. Chen G., Zhang Y., Lu D., Li N., Ross A.C. Retinoids synergize with insulin to induce hepatic Gck expression. Biochem. J. 2009, 419:645-653.
12. Roder K., Zhang L., Schweizer M. SREBP-1c mediates the retinoid-dependent increase in fatty acid synthase promoter activity in HepG2. FEBS Lett. 2007, 581:2715-2720.
13. Chen G. Liver lipid molecules induce PEPCK-C gene transcription and attenuate insulin action. Biochem. Biophys. Res. Commun. 2007, 361:805-810.
14. Wang Y., Zolfaghari R., Ross A.C. Cloning of rat cytochrome P450RAI (CYP26) cDNA and regulation of its gene expression by all-trans-retinoic acid in vivo. Arch. Biochem. Biophys. 2002, 401:235-243.
15. Chen G., Hohmeier H.E., Gasa R., Tran V.V., Newgard C.B. Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity. Diabetes 2000, 49:562-570.
16. Horton J.D., Goldstein J.L., Brown M.S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 2002, 109:1125-1131.
17. Haq R., Pfahl M., Chytil F. Retinoic acid affects the expression of nuclear retinoic acid receptors in tissues of retinol-deficient rats. Proc. Natl. Acad. Sci. USA 1991, 88:8272-8276.
18. Repa J.J., Liang G., Ou J., Bashmakov Y., Lobaccaro J.M., Shimomura I., Shan B., Brown M.S., Goldstein J.L., Mangelsdorf D.J. Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ. Genes Dev. 2000, 14:2819-2830.
19. Yoshikawa T., Shimano H., Amemiya-Kudo M., Yahagi N., Hasty A.H., Matsuzaka T., Okazaki H., Tamura Y., Iizuka Y., Ohashi K., Osuga J.I., Harada K., Gotoda T., Kimura S., Ishibashi S., Yamada N. Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. Mol. Cell. Biol. 2001, 21:2991-3000.
20. DeBose-Boyd R.A., Ou J., Goldstein J.L., Brown M.S. Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. Proc. Natl. Acad. Sci. 2001, 98:1477-1482.
21. Howell G., Deng X., Yellaturu C., Park E.A., Wilcox H.G., Raghow R., Elam M.B. N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXR[alpha]. Biochim. Biophys. Acta, Mol. Cell Biol. Lipids 2009, 1791:1190-1196.
22. Clarke S.D. The multi-dimensional regulation of gene expression by fatty acids: polyunsaturated fats as nutrient sensors. Curr. Opin. Lipidol. 2004, 15:13-18.
23. Wan Y.J.Y., Han G., Cai Y., Dai T., Konishi T., Leng A.S. Hepatocyte retinoid X receptor-{alpha}-deficient mice have reduced food intake, increased body weight, and improved glucose tolerance. Endocrinology 2003, 144:605-611.
24. Wang Q., Carroll J.S., Brown M. Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking. Mol. Cell 2005, 19:631-642.
25. Evans R.M. The nuclear receptor superfamily: a rosetta stone for physiology. Mol. Endocrinol. 2005, 19:1429-1438.
26. Oliveros L.B., Domeniconi M.A., Vega V.A., Gatica L.V., Brigada A.M., Gimenez M.S. Vitamin A deficiency modifies lipid metabolism in rat liver. Br. J. Nutr. 2007, 97:263-272.