Post-transcriptional regulation of low density lipoprotein receptor protein by proprotein convertase subtilisin/kexin type 9a in mouse liver

Journal of Biological Chemistry

Volumn 279, Issue 48, 2004, Pages 50630-50638

  Sahng, Wook Park ^a   Moon, Young Ah ^a   Horton, Jay D ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CHOLESTEROL; GENES; RNA;

CLEAVAGE-ACTIVATING PROTEINS; ELEMENT-BINDING PROTEINS; LIPID HOMEOSTASIS; LIPOPROTEINS;

PROTEINS;

APOLIPOPROTEIN B; KEIN 9A; KEXIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PROPROTEIN CONVERTASE SUBTILISIN; SUBTILISIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE CONTROL; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HYPERCHOLESTEROLEMIA; INTERMETHOD COMPARISON; KNOCKOUT MOUSE; LIVER CELL; MOLECULAR BIOLOGY; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN SYNTHESIS; REDUCTION KINETICS; TRANSCRIPTION INITIATION; TRANSGENE; WILD TYPE;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; CHO CELLS; CRICETINAE; DNA-BINDING PROTEINS; LIVER; MICE; MUTATION; RECEPTORS, LDL; SERINE ENDOPEPTIDASES; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TIME FACTORS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 9644266673     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M410077200     Document Type: Article

References (46)

1. Goldstein, J. L., and Brown, M. S. (1977) Annu. Rev. Biochem. 46, 897-930
2. Dietschy, J. M., Turley, S. D., and Spady, D. K. (1993) J. Lipid Res. 34, 1637-1659
3. Horton, J. D., Goldstein, J. L., and Brown, M. S. (2002) J. Clin. Invest. 109, 1125-1131
4. Brown, M. S., and Goldstein, J. L. (1997) Cell 89, 331-340
5. Horton, J. D., Shah, N. A., Warrington, J. A., Anderson, N. N., Park, S. W., Brown, M. S., and Goldstein, J. L. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 12027-12032
6. Seidah, N. G., Benjannet, S., Wickham, L., Marcinkiewicz, J., Jasmin, S. B., Stifani, S., Baaak, A., Prat, A., and Chretien, M. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 928-933
7. Abifadel, M., Varret, M., Rabès, J.-P., Ouguerram, K., Devillers, M., Cruaud, C., Benjannet, S., Wickham, L., Erlich, D., Villéger, L., Farnier, M., Beucler, I., Bruckert, E., Chambaz, J., Chanu, B., Lecerf, J.-M., Luc, G., Moulin, P., Weissenbach, J., Prat, A., Krempf, M., Junien, C., Seidah, N. G., and Boileau, C. (2003) Nat. Genet. 34, 154-156
8. Leren, T. P. (2004) Clin. Genet. 65, 419-422
9. Timms, K. M., Wagner, S., Samuels, M. E., Forbey, K., Goldfine, H., Jammulapati, S., Skolnick, M. H., Hopkins, P. N., Hunt, S. C., and Shattuck, D. M. (2004) Hum. Genet. 114, 349-353
10. Rader, D. J., Cohen, J., and Hobbs, H. H. (2003) J. Clin. Invest. 111, 1795-1803
11. Sambrook, J., and Russell, D. W. (2001) Molecular Cloning: A Laboratory Manual, 3rd Ed., Cold Spring Harbor Laboratory Press, New York
12. Shimano, H., Horton, J. D., Hammer, R. E., Shimomura, I., Brown, M. S., and Goldstein, J. L. (1996) J. Clin. Invest. 98, 1575-1584
13. Yokode, M., Hammer, R. E., Ishibashi, S., Brown, M. S., and Goldstein, J. L. (1990) Science 250, 1273-1275
14. Horton, J. D., Shimano, H., Hamilton, R. L., Brown, M. S., and Goldstein, J. L. (1999) J. Clin. Invest. 103, 1067-1076
15. Goldstein, J. L., Basu, S. K., and Brown, M. S. (1983) Methods Enzymol. 98, 241-260
16. Hua, X., Sakai, J., Brown, M. S., and Goldstein, J. L. (1996) J. Biol. Chem. 271, 10379-10384
17. Espenshade, P. J., Cheng, D., Goldstein, J. L., and Brown, M. S. (1999) J. Biol. Chem. 274, 22795-22804
18. Russell, D. W., Schneider, W. J., Yamamoto, T., Luskey, K. L., Brown, M. S., and Goldstein, J. L. (1984) Cell 37, 577-585
19. Herz, J., Hamann, U., Rogne, S., Myklebost, O., Gausepohl, H., and Stanley, K. K. (1988) EMBO J. 7, 4119-4127
20. Herz, J., Goldstein, J. L., Strickland, D. K., Ho, Y. K., and Brown, M. S. (1991) J. Biol. Chem. 266, 21232-21238
21. Jones, C., Hammer, R. E., Li, W.-P., Cohen, J. C., Hobbs, H. H., and Herz, J. (2003) J. Biol. Chem. 278, 29024-29030.
22. Wang, X., Sato, R., Brown, M. S., Hua, X., and Goldstein, J. L. (1994) Cell 77, 53-62
23. Shimano, H., Shimomura, I., Hammer, R. E., Goldstein, J. L., Brown, M. S., and Horton, J. D. (1997) J. Clin. Invest. 100, 2115-2124
24. Moon, Y.-A., and Horton, J. D. (2003) J. Biol. Chem. 278, 7335-7343
25. Rawaon, R. B., Cheng, D., Brown, M. S., and Goldstein, J. L. (1998) J. Biol. Chem. 273, 28261-28269
26. Rawson, R. B., DeBose-Boyd, R., Goldstein, J. L., and Brown, M. S. (1999) J. Biol. Chem. 274, 28549-28556
27. DeBose-Boyd, R. A., Brown, M. S., Li, W. P., Nohturfft, A., Goldstein, J. L., and Espenshade, P. J. (1999) Cell 99, 703-712
28. Green, M., and Wold, W. S. (1979) Methods Enzymol. 58, 425-435
29. Nyberg-Hoffman, C., and Aguilar-Cordova, E. (1999) Nat. Med. 5, 955-957
30. Engelking, L. J., Kuriyama, H., Hammer, R. E., Horton, J. D., Brown, M. S., Goldstein, J. L., and Liang, G. (2004) J. Clin. Invest. 113, 1168-1175
31. Liang, G., Yang, J., Horton, J. D., Hammer, R. E., Goldstein, J. L., and Brown, M. S. (2002) J. Biol. Chem. 277, 9520-9528
32. Ishibashi, S., Brown, M. S., Goldstein, J. L., Gerard, R. D., Hammer, R. E., and Herz, J. (1993) J. Clin. Invest. 92, 883-893
33. Shimomura, I., Hammer, R. E., Richardson, J. A., Ikemoto, S., Bashmakov, Y., Goldstein, J. L., and Brown, M. S. (1998) Genes Dev. 12, 3182-3194
34. Yang, J., Goldstein, J. L., Hammer, R. E., Moon, Y.-A., Brown, M. S., and Horton, J. D. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 13607-13612
35. Goldstein, J. L., Rawson, R. B., and Brown, M. S. (2002) Arch. Biochem. Biophys. 397, 139-148
36. Goldstein, J. L., Brown, M. S., Anderson, R. G., Russell, D. W., and Schneider, W. J. (1985) Annu. Rev. Cell Biol. 1, 1-39
37. Garcia, C. K., Wilund, K., Arca, M., Zuliani, G., Fellin, R., Maioli, M., Calandra, S., Bertolini, S., Cossu, F., Grishin, N., Barnes, R., Cohen, J. C., and Hobbs, H. H. (2001) Science 292, 1394-1398
38. Norman, D., Sun, X.-M., Bourbon, M., Knight, B. L., Naoumova, R. P., and Soutar, A. K. (1999) J. Clin. Invest. 104, 619-628
39. Wilund, K. R., Yi, M., Campagna, F., Arca, M., Zuliani, G., Fellin, R., Ho, Y. K., Garcia, J. V., Hobbs, H. H., and Cohen, J. C. (2002) Hum. Mol. Genet. 11, 3019-3030
40. Herz, J. (2001) Neuron 29, 571-581
41. He, G., Gupta, S., Yi, M., Michaely, P., Hobbs, H. H., and Cohen, J. C. (2002) J. Biol. Chem. 277, 44044-44049
42. Michaely, P., Li, W.-P., Anderson, R. G., Cohen, J. C., and Hobbs, H. H. (2004) J. Biol. Chem. 279, 34023-34031
43. Ouguerrram, K., Chetiveaux, M., Zair, Y., Costet, P., Abifadel, M., Varret, M., Boileau, C., Magot, T., and Krempf, M. (2004) Arterioscler. Thromb. Vasc. Biol. 8, 1448-1453
44. Maxwell, K. N., and Breslow, J. L. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 7100-7105
45. Brown, M. S., and Goldstein, J. L. (1975) Cell 6, 307-316
46. Applied Biosystems (2001) User Bulletin 2, Foster City, CA