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Volumn 6, Issue 6, 2012, Pages 620-636

Epigenetic alterations involved in cancer stem cell reprogramming

Author keywords

Cancer stem cells; DNA methylation; Epigenetics; Histone modifications; MicroRNAs

Indexed keywords

BETA CATENIN; BONE MORPHOGENETIC PROTEIN; MICRORNA; NOTCH RECEPTOR; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

EID: 84869880156     PISSN: 15747891     EISSN: 18780261     Source Type: Journal    
DOI: 10.1016/j.molonc.2012.10.006     Document Type: Review
Times cited : (164)

References (248)
  • 3
    • 0142182088 scopus 로고    scopus 로고
    • Cell-type-specific repression of the maspin gene is disrupted frequently by demethylation at the promoter region in gastric intestinal metaplasia and cancer cells
    • Akiyama Y., Maesawa C., Ogasawara S., Terashima M., Masuda T. Cell-type-specific repression of the maspin gene is disrupted frequently by demethylation at the promoter region in gastric intestinal metaplasia and cancer cells. Am. J. Pathol. 2003, 163:1911-1919.
    • (2003) Am. J. Pathol. , vol.163 , pp. 1911-1919
    • Akiyama, Y.1    Maesawa, C.2    Ogasawara, S.3    Terashima, M.4    Masuda, T.5
  • 5
    • 77951745289 scopus 로고    scopus 로고
    • Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF
    • Ali S., Ahmad A., Banerjee S., Padhye S., Dominiak K., Schaffert J.M., Wang Z., Philip P.A., Sarkar F.H. Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF. Cancer Res. 2010, 70:3606-3617.
    • (2010) Cancer Res. , vol.70 , pp. 3606-3617
    • Ali, S.1    Ahmad, A.2    Banerjee, S.3    Padhye, S.4    Dominiak, K.5    Schaffert, J.M.6    Wang, Z.7    Philip, P.A.8    Sarkar, F.H.9
  • 7
    • 40149092689 scopus 로고    scopus 로고
    • Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo
    • Ateeq B., Unterberger A., Szyf M., Rabbani S.A. Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo. Neoplasia 2008, 10:266-278.
    • (2008) Neoplasia , vol.10 , pp. 266-278
    • Ateeq, B.1    Unterberger, A.2    Szyf, M.3    Rabbani, S.A.4
  • 9
    • 84866447416 scopus 로고    scopus 로고
    • The evolving concept of cancer and metastasis stem cells
    • Baccelli I., Trumpp A. The evolving concept of cancer and metastasis stem cells. J. Cell. Biol. 2012, 198:281-293.
    • (2012) J. Cell. Biol. , vol.198 , pp. 281-293
    • Baccelli, I.1    Trumpp, A.2
  • 11
    • 84855405573 scopus 로고    scopus 로고
    • Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression
    • Bao B., Ali S., Banerjee S., Wang Z., Logna F., Azmi A.S., Kong D., Ahmad A., Li Y., Padhye S., Sarkar F.H. Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression. Cancer Res. 2012, 72:335-345.
    • (2012) Cancer Res. , vol.72 , pp. 335-345
    • Bao, B.1    Ali, S.2    Banerjee, S.3    Wang, Z.4    Logna, F.5    Azmi, A.S.6    Kong, D.7    Ahmad, A.8    Li, Y.9    Padhye, S.10    Sarkar, F.H.11
  • 12
    • 77956503727 scopus 로고    scopus 로고
    • Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres
    • Bar E.E., Lin A., Mahairaki V., Matsui W., Eberhart C.G. Hypoxia increases the expression of stem-cell markers and promotes clonogenicity in glioblastoma neurospheres. Am. J. Pathol. 2010, 177:1491-1502.
    • (2010) Am. J. Pathol. , vol.177 , pp. 1491-1502
    • Bar, E.E.1    Lin, A.2    Mahairaki, V.3    Matsui, W.4    Eberhart, C.G.5
  • 13
    • 33751530490 scopus 로고    scopus 로고
    • Mining the Wnt pathway for cancer therapeutics
    • Barker N., Clevers H. Mining the Wnt pathway for cancer therapeutics. Nat. Rev. Drug Discov. 2006, 5:997-1014.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 997-1014
    • Barker, N.1    Clevers, H.2
  • 15
    • 0029951738 scopus 로고    scopus 로고
    • E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain
    • Berx G., Cleton-Jansen A.M., Strumane K., de Leeuw W.J., Nollet F., van Roy F., Cornelisse C. E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. Oncogene 1996, 13:1919-1925.
    • (1996) Oncogene , vol.13 , pp. 1919-1925
    • Berx, G.1    Cleton-Jansen, A.M.2    Strumane, K.3    de Leeuw, W.J.4    Nollet, F.5    van Roy, F.6    Cornelisse, C.7
  • 16
    • 0033910994 scopus 로고    scopus 로고
    • Mutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous system
    • Biegel J.A., Fogelgren B., Zhou J.Y., James C.D., Janss A.J., Allen J.C., Zagzag D., Raffel C., Rorke L.B. Mutations of the INI1 rhabdoid tumor suppressor gene in medulloblastomas and primitive neuroectodermal tumors of the central nervous system. Clin. Cancer Res. 2000, 6:2759-2763.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2759-2763
    • Biegel, J.A.1    Fogelgren, B.2    Zhou, J.Y.3    James, C.D.4    Janss, A.J.5    Allen, J.C.6    Zagzag, D.7    Raffel, C.8    Rorke, L.B.9
  • 17
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird A. DNA methylation patterns and epigenetic memory. Genes Dev. 2002, 16(1):6-21.
    • (2002) Genes Dev. , vol.16 , Issue.1 , pp. 6-21
    • Bird, A.1
  • 18
    • 79952392467 scopus 로고    scopus 로고
    • Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
    • Bissell M.J., Hines W.C. Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat. Med. 2011, 17:320-329.
    • (2011) Nat. Med. , vol.17 , pp. 320-329
    • Bissell, M.J.1    Hines, W.C.2
  • 22
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
    • Bonnet D., Dick J.E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 1997, 3:730-737.
    • (1997) Nat. Med. , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 23
    • 78449297894 scopus 로고    scopus 로고
    • The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network
    • Boominathan L. The guardians of the genome (p53, TA-p73, and TA-p63) are regulators of tumor suppressor miRNAs network. Cancer Metastasis Rev. 2010, 29:613-639.
    • (2010) Cancer Metastasis Rev. , vol.29 , pp. 613-639
    • Boominathan, L.1
  • 24
    • 33646870495 scopus 로고    scopus 로고
    • Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
    • Bracken A.P., Dietrich N., Pasini D., Hansen K.H., Helin K. Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev. 2006, 20:1123-1136.
    • (2006) Genes Dev. , vol.20 , pp. 1123-1136
    • Bracken, A.P.1    Dietrich, N.2    Pasini, D.3    Hansen, K.H.4    Helin, K.5
  • 25
    • 54049084380 scopus 로고    scopus 로고
    • A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    • Bracken C.P., Gregory P.A., Kolesnikoff N., Bert A.G., Wang J., Shannon M.F., Goodall G.J. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res. 2008, 68:7846-7854.
    • (2008) Cancer Res. , vol.68 , pp. 7846-7854
    • Bracken, C.P.1    Gregory, P.A.2    Kolesnikoff, N.3    Bert, A.G.4    Wang, J.5    Shannon, M.F.6    Goodall, G.J.7
  • 27
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    • Burk U., Schubert J., Wellner U., Schmalhofer O., Vincan E., Spaderna S., Brabletz T. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 2008, 9:582-589.
    • (2008) EMBO Rep. , vol.9 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Wellner, U.3    Schmalhofer, O.4    Vincan, E.5    Spaderna, S.6    Brabletz, T.7
  • 33
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in development and disease
    • Clevers H. Wnt/beta-catenin signaling in development and disease. Cell 2006, 127:469-480.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 35
    • 78149234118 scopus 로고    scopus 로고
    • MiR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells
    • Cottonham C.L., Kaneko S., Xu L. miR-21 and miR-31 converge on TIAM1 to regulate migration and invasion of colon carcinoma cells. J. Biol. Chem. 2010, 285:35293-35302.
    • (2010) J. Biol. Chem. , vol.285 , pp. 35293-35302
    • Cottonham, C.L.1    Kaneko, S.2    Xu, L.3
  • 36
    • 0346100567 scopus 로고    scopus 로고
    • Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors
    • Cozzio A., Passegue E., Ayton P.M., Karsunky H., Cleary M.L., Weissman I.L. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 2003, 17:3029-3035.
    • (2003) Genes Dev. , vol.17 , pp. 3029-3035
    • Cozzio, A.1    Passegue, E.2    Ayton, P.M.3    Karsunky, H.4    Cleary, M.L.5    Weissman, I.L.6
  • 38
    • 79955119487 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer
    • Crea F., Hurt E.M., Mathews L.A., Cabarcas S.M., Sun L., Marquez V.E., Danesi R., Farrar W.L. Pharmacologic disruption of Polycomb Repressive Complex 2 inhibits tumorigenicity and tumor progression in prostate cancer. Mol. Cancer 2012, 10:40.
    • (2012) Mol. Cancer , vol.10 , pp. 40
    • Crea, F.1    Hurt, E.M.2    Mathews, L.A.3    Cabarcas, S.M.4    Sun, L.5    Marquez, V.E.6    Danesi, R.7    Farrar, W.L.8
  • 43
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • Chen J., Li Y., Yu T.S., McKay R.M., Burns D.K., Kernie S.G., Parada L.F. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 2012, 488:522-526.
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.S.3    McKay, R.M.4    Burns, D.K.5    Kernie, S.G.6    Parada, L.F.7
  • 44
    • 78650389774 scopus 로고    scopus 로고
    • Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation
    • Chiou S.H., Wang M.L., Chou Y.T., Chen C.J., Hong C.F., Hsieh W.J., Chang H.T., Chen Y.S., Lin T.W., Hsu H.S., Wu C.W. Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation. Cancer Res. 2010, 70:10433-10444.
    • (2010) Cancer Res. , vol.70 , pp. 10433-10444
    • Chiou, S.H.1    Wang, M.L.2    Chou, Y.T.3    Chen, C.J.4    Hong, C.F.5    Hsieh, W.J.6    Chang, H.T.7    Chen, Y.S.8    Lin, T.W.9    Hsu, H.S.10    Wu, C.W.11
  • 45
    • 62449205665 scopus 로고    scopus 로고
    • Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition
    • Dallas N.A., Xia L., Fan F., Gray M.J., Gaur P., van Buren G., Samuel S., Kim M.P., Lim S.J., Ellis L.M. Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition. Cancer Res. 2009, 69:1951-1957.
    • (2009) Cancer Res. , vol.69 , pp. 1951-1957
    • Dallas, N.A.1    Xia, L.2    Fan, F.3    Gray, M.J.4    Gaur, P.5    van Buren, G.6    Samuel, S.7    Kim, M.P.8    Lim, S.J.9    Ellis, L.M.10
  • 48
    • 33744925683 scopus 로고    scopus 로고
    • Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer
    • Dohadwala M., Yang S.C., Luo J., Sharma S., Batra R.K., Huang M., Lin Y., Goodglick L., Krysan K., Fishbein M.C., et al. Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. Cancer Res. 2006, 66:5338-5345.
    • (2006) Cancer Res. , vol.66 , pp. 5338-5345
    • Dohadwala, M.1    Yang, S.C.2    Luo, J.3    Sharma, S.4    Batra, R.K.5    Huang, M.6    Lin, Y.7    Goodglick, L.8    Krysan, K.9    Fishbein, M.C.10
  • 50
    • 64149085515 scopus 로고    scopus 로고
    • BMP-6 inhibits microRNA-21 expression in breast cancer through repressing deltaEF1 and AP-1
    • Du J., Yang S., An D., Hu F., Yuan W., Zhai C., Zhu T. BMP-6 inhibits microRNA-21 expression in breast cancer through repressing deltaEF1 and AP-1. Cell. Res. 2009, 19:487-496.
    • (2009) Cell. Res. , vol.19 , pp. 487-496
    • Du, J.1    Yang, S.2    An, D.3    Hu, F.4    Yuan, W.5    Zhai, C.6    Zhu, T.7
  • 51
    • 54449085718 scopus 로고    scopus 로고
    • Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers
    • Dumont N., Wilson M.B., Crawford Y.G., Reynolds P.A., Sigaroudinia M., Tlsty T.D. Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:14867-14872.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 14867-14872
    • Dumont, N.1    Wilson, M.B.2    Crawford, Y.G.3    Reynolds, P.A.4    Sigaroudinia, M.5    Tlsty, T.D.6
  • 52
    • 0034800271 scopus 로고    scopus 로고
    • Hereditary diffuse gastric cancer
    • Dunbier A., Guilford P. Hereditary diffuse gastric cancer. Adv. Cancer Res. 2001, 83:55-65.
    • (2001) Adv. Cancer Res. , vol.83 , pp. 55-65
    • Dunbier, A.1    Guilford, P.2
  • 54
    • 77956505309 scopus 로고    scopus 로고
    • Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells
    • Eberle I., Pless B., Braun M., Dingermann T., Marschalek R. Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells. Nucleic Acids Res. 2010, 38:5384-5395.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 5384-5395
    • Eberle, I.1    Pless, B.2    Braun, M.3    Dingermann, T.4    Marschalek, R.5
  • 55
    • 0242584454 scopus 로고    scopus 로고
    • Chromosomal instability and tumors promoted by DNA hypomethylation
    • Eden A., Gaudet F., Waghmare A., Jaenisch R. Chromosomal instability and tumors promoted by DNA hypomethylation. Science 2003, 300:455.
    • (2003) Science , vol.300 , pp. 455
    • Eden, A.1    Gaudet, F.2    Waghmare, A.3    Jaenisch, R.4
  • 59
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - microRNAs with a role in cancer
    • Esquela-Kerscher A., Slack F.J. Oncomirs - microRNAs with a role in cancer. Nat. Rev. Cancer 2006, 6:259-269.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 60
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M. Epigenetics in cancer. N. Engl. J. Med. 2008, 358:1148-1159.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 61
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon E.R., Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990, 61:759-767.
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 64
    • 33847740988 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling in cancer stemness and malignant behavior
    • Fodde R., Brabletz T. Wnt/beta-catenin signaling in cancer stemness and malignant behavior. Curr. Opin. Cell. Biol. 2007, 19:150-158.
    • (2007) Curr. Opin. Cell. Biol. , vol.19 , pp. 150-158
    • Fodde, R.1    Brabletz, T.2
  • 66
    • 15844402009 scopus 로고    scopus 로고
    • Cell fate determination regulated by a transcriptional signal network in the developing mouse brain
    • Fukuda S., Taga T. Cell fate determination regulated by a transcriptional signal network in the developing mouse brain. Anat. Sci. Int. 2005, 80:12-18.
    • (2005) Anat. Sci. Int. , vol.80 , pp. 12-18
    • Fukuda, S.1    Taga, T.2
  • 67
    • 58849163959 scopus 로고    scopus 로고
    • MicroRNAs: key regulators of stem cell
    • Gangaraju V.K., Lin H. MicroRNAs: key regulators of stem cell. Nat. Rev. Mol. Cell. Biol. 2009, 10(2):116-125.
    • (2009) Nat. Rev. Mol. Cell. Biol. , vol.10 , Issue.2 , pp. 116-125
    • Gangaraju, V.K.1    Lin, H.2
  • 71
    • 77953169001 scopus 로고    scopus 로고
    • MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity
    • Giovannetti E., Funel N., Peters G.J., Del Chiaro M., Erozenci L.A., Vasile E., Leon L.G., Pollina L.E., Groen A., Falcone A., et al. MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity. Cancer Res. 2010, 70:4528-4538.
    • (2010) Cancer Res. , vol.70 , pp. 4528-4538
    • Giovannetti, E.1    Funel, N.2    Peters, G.J.3    Del Chiaro, M.4    Erozenci, L.A.5    Vasile, E.6    Leon, L.G.7    Pollina, L.E.8    Groen, A.9    Falcone, A.10
  • 72
    • 84879689573 scopus 로고    scopus 로고
    • Epigenetic regulation of CD133/PROM1 expression in glioma stem cells by Sp1/myc and promoter methylation. Oncogene
    • Gopisetty, G., Xu, J., Sampath, D., Colman, H., Puduvalli, V.K. Epigenetic regulation of CD133/PROM1 expression in glioma stem cells by Sp1/myc and promoter methylation. Oncogene, http://dx.doi.org/10.1038/onc.2012.331.
    • Gopisetty, G.1    Xu, J.2    Sampath, D.3    Colman, H.4    Puduvalli, V.K.5
  • 73
    • 0033566770 scopus 로고    scopus 로고
    • Frequent deletion of hSNF5/INI1, a component of the SWI/SNF complex, in chronic myeloid leukemia
    • Grand F., Kulkarni S., Chase A., Goldman J.M., Gordon M., Cross N.C. Frequent deletion of hSNF5/INI1, a component of the SWI/SNF complex, in chronic myeloid leukemia. Cancer Res. 1999, 59:3870-3874.
    • (1999) Cancer Res. , vol.59 , pp. 3870-3874
    • Grand, F.1    Kulkarni, S.2    Chase, A.3    Goldman, J.M.4    Gordon, M.5    Cross, N.C.6
  • 75
    • 34250174504 scopus 로고    scopus 로고
    • The role of epithelial-mesenchymal transition in cancer pathology
    • Guarino M., Rubino B., Ballabio G. The role of epithelial-mesenchymal transition in cancer pathology. Pathology 2007, 39:305-318.
    • (2007) Pathology , vol.39 , pp. 305-318
    • Guarino, M.1    Rubino, B.2    Ballabio, G.3
  • 76
    • 0036830198 scopus 로고    scopus 로고
    • Regulation of DNA methylation in human breast cancer. Effect on the urokinase-type plasminogen activator gene production and tumor invasion
    • Guo Y., Pakneshan P., Gladu J., Slack A., Szyf M., Rabbani S.A. Regulation of DNA methylation in human breast cancer. Effect on the urokinase-type plasminogen activator gene production and tumor invasion. J. Biol. Chem. 2002, 277:41571-41579.
    • (2002) J. Biol. Chem. , vol.277 , pp. 41571-41579
    • Guo, Y.1    Pakneshan, P.2    Gladu, J.3    Slack, A.4    Szyf, M.5    Rabbani, S.A.6
  • 77
    • 69949129056 scopus 로고    scopus 로고
    • Cancer stem cells: mirage or reality?
    • Gupta P.B., Chaffer C.L., Weinberg R.A. Cancer stem cells: mirage or reality?. Nat. Med. 2009, 15:1010-1012.
    • (2009) Nat. Med. , vol.15 , pp. 1010-1012
    • Gupta, P.B.1    Chaffer, C.L.2    Weinberg, R.A.3
  • 78
    • 1842631408 scopus 로고    scopus 로고
    • Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer
    • Halkidou K., Gaughan L., Cook S., Leung H.Y., Neal D.E., Robson C.N. Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. Prostate 2004, 59:177-189.
    • (2004) Prostate , vol.59 , pp. 177-189
    • Halkidou, K.1    Gaughan, L.2    Cook, S.3    Leung, H.Y.4    Neal, D.E.5    Robson, C.N.6
  • 79
    • 84862638243 scopus 로고    scopus 로고
    • Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN
    • Han M., Liu M., Wang Y., Chen X., Xu J., Sun Y., Zhao L., Qu H., Fan Y., Wu C. Antagonism of miR-21 reverses epithelial-mesenchymal transition and cancer stem cell phenotype through AKT/ERK1/2 inactivation by targeting PTEN. PLoS One 2012, 7:e39520.
    • (2012) PLoS One , vol.7
    • Han, M.1    Liu, M.2    Wang, Y.3    Chen, X.4    Xu, J.5    Sun, Y.6    Zhao, L.7    Qu, H.8    Fan, Y.9    Wu, C.10
  • 80
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: functions of cells recruited to the tumor microenvironment
    • Hanahan D., Coussens L.M. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 2012, 21:309-322.
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 81
    • 77952297768 scopus 로고    scopus 로고
    • Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis
    • Hashimoto Y., Akiyama Y., Otsubo T., Shimada S., Yuasa Y. Involvement of epigenetically silenced microRNA-181c in gastric carcinogenesis. Carcinogenesis 2010, 31:777-784.
    • (2010) Carcinogenesis , vol.31 , pp. 777-784
    • Hashimoto, Y.1    Akiyama, Y.2    Otsubo, T.3    Shimada, S.4    Yuasa, Y.5
  • 83
    • 70350225829 scopus 로고    scopus 로고
    • The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype
    • Heddleston J.M., Li Z., McLendon R.E., Hjelmeland A.B., Rich J.N. The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype. Cell Cycle 2009, 8:3274-3284.
    • (2009) Cell Cycle , vol.8 , pp. 3274-3284
    • Heddleston, J.M.1    Li, Z.2    McLendon, R.E.3    Hjelmeland, A.B.4    Rich, J.N.5
  • 85
  • 87
    • 84856746717 scopus 로고    scopus 로고
    • Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease
    • Herrera-Merchan A., Arranz L., Ligos J.M., de Molina A., Dominguez O., Gonzalez S. Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease. Nat. Commun. 2012, 3:623.
    • (2012) Nat. Commun. , vol.3 , pp. 623
    • Herrera-Merchan, A.1    Arranz, L.2    Ligos, J.M.3    de Molina, A.4    Dominguez, O.5    Gonzalez, S.6
  • 89
    • 84857979406 scopus 로고    scopus 로고
    • MicroRNA-1826 directly targets beta-catenin (CTNNB1) and MEK1 (MAP2K1) in VHL-inactivated renal cancer
    • Hirata H., Hinoda Y., Ueno K., Nakajima K., Ishii N., Dahiya R. MicroRNA-1826 directly targets beta-catenin (CTNNB1) and MEK1 (MAP2K1) in VHL-inactivated renal cancer. Carcinogenesis 2012, 33:501-508.
    • (2012) Carcinogenesis , vol.33 , pp. 501-508
    • Hirata, H.1    Hinoda, Y.2    Ueno, K.3    Nakajima, K.4    Ishii, N.5    Dahiya, R.6
  • 90
    • 75749101495 scopus 로고    scopus 로고
    • Chromatin remodelling during development
    • Ho L., Crabtree G.R. Chromatin remodelling during development. Nature 2010, 463(7280):474-484.
    • (2010) Nature , vol.463 , Issue.7280 , pp. 474-484
    • Ho, L.1    Crabtree, G.R.2
  • 92
    • 47049125858 scopus 로고    scopus 로고
    • Upregulation of miR-23a approximately 27a approximately 24 decreases transforming growth factor-beta-induced tumor-suppressive activities in human hepatocellular carcinoma cells
    • Huang S., He X., Ding J., Liang L., Zhao Y., Zhang Z., Yao X., Pan Z., Zhang P., Li J., et al. Upregulation of miR-23a approximately 27a approximately 24 decreases transforming growth factor-beta-induced tumor-suppressive activities in human hepatocellular carcinoma cells. Int. J. Cancer 2008, 123:972-978.
    • (2008) Int. J. Cancer , vol.123 , pp. 972-978
    • Huang, S.1    He, X.2    Ding, J.3    Liang, L.4    Zhao, Y.5    Zhang, Z.6    Yao, X.7    Pan, Z.8    Zhang, P.9    Li, J.10
  • 93
    • 77953674754 scopus 로고    scopus 로고
    • How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize
    • Hughes D.P. How the NOTCH pathway contributes to the ability of osteosarcoma cells to metastasize. Cancer Treat. Res. 2009, 152:479-496.
    • (2009) Cancer Treat. Res. , vol.152 , pp. 479-496
    • Hughes, D.P.1
  • 95
    • 79957613439 scopus 로고    scopus 로고
    • MiR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1
    • Hwang-Verslues W.W., Chang P.H., Wei P.C., Yang C.Y., Huang C.K., Kuo W.H., Shew J.Y., Chang K.J., Lee E.Y., Lee W.H. miR-495 is upregulated by E12/E47 in breast cancer stem cells, and promotes oncogenesis and hypoxia resistance via downregulation of E-cadherin and REDD1. Oncogene 2011, 30(21):2463-2474.
    • (2011) Oncogene , vol.30 , Issue.21 , pp. 2463-2474
    • Hwang-Verslues, W.W.1    Chang, P.H.2    Wei, P.C.3    Yang, C.Y.4    Huang, C.K.5    Kuo, W.H.6    Shew, J.Y.7    Chang, K.J.8    Lee, E.Y.9    Lee, W.H.10
  • 96
    • 77956296766 scopus 로고    scopus 로고
    • Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer
    • Hwang J.H., Voortman J., Giovannetti E., Steinberg S.M., Leon L.G., Kim Y.T., Funel N., Park J.K., Kim M.A., Kang G.H., et al. Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer. PLoS One 2010, 5:e10630.
    • (2010) PLoS One , vol.5
    • Hwang, J.H.1    Voortman, J.2    Giovannetti, E.3    Steinberg, S.M.4    Leon, L.G.5    Kim, Y.T.6    Funel, N.7    Park, J.K.8    Kim, M.A.9    Kang, G.H.10
  • 97
    • 77956547097 scopus 로고    scopus 로고
    • Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells
    • Iliopoulos D., Lindahl-Allen M., Polytarchou C., Hirsch H.A., Tsichlis P.N., Struhl K. Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol. Cell. 2010, 39:761-772.
    • (2010) Mol. Cell. , vol.39 , pp. 761-772
    • Iliopoulos, D.1    Lindahl-Allen, M.2    Polytarchou, C.3    Hirsch, H.A.4    Tsichlis, P.N.5    Struhl, K.6
  • 98
    • 33750200389 scopus 로고    scopus 로고
    • Orchestrating ontogenesis: variations on a theme by sonic hedgehog
    • Ingham P.W., Placzek M. Orchestrating ontogenesis: variations on a theme by sonic hedgehog. Nat. Rev. Genet. 2006, 7:841-850.
    • (2006) Nat. Rev. Genet. , vol.7 , pp. 841-850
    • Ingham, P.W.1    Placzek, M.2
  • 101
    • 68949170622 scopus 로고    scopus 로고
    • Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells
    • Ji J., Yamashita T., Budhu A., Forgues M., Jia H.L., Li C., Deng C., Wauthier E., Reid L.M., Ye Q.H., et al. Identification of microRNA-181 by genome-wide screening as a critical player in EpCAM-positive hepatic cancer stem cells. Hepatology 2009, 50:472-480.
    • (2009) Hepatology , vol.50 , pp. 472-480
    • Ji, J.1    Yamashita, T.2    Budhu, A.3    Forgues, M.4    Jia, H.L.5    Li, C.6    Deng, C.7    Wauthier, E.8    Reid, L.M.9    Ye, Q.H.10
  • 102
    • 53949090314 scopus 로고    scopus 로고
    • Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres
    • Ji Q., Hao X., Meng Y., Zhang M., Desano J., Fan D., Xu L. Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC Cancer 2008, 8:266.
    • (2008) BMC Cancer , vol.8 , pp. 266
    • Ji, Q.1    Hao, X.2    Meng, Y.3    Zhang, M.4    Desano, J.5    Fan, D.6    Xu, L.7
  • 104
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • Jiang J., Hui C.C. Hedgehog signaling in development and cancer. Dev. Cell. 2008, 15:801-812.
    • (2008) Dev. Cell. , vol.15 , pp. 801-812
    • Jiang, J.1    Hui, C.C.2
  • 105
    • 44449134715 scopus 로고    scopus 로고
    • DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications
    • Jiang X., Tan J., Li J., Kivimae S., Yang X., Zhuang L., Lee P.L., Chan M.T., Stanton L.W., Liu E.T., et al. DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. Cancer Cell 2008, 13:529-541.
    • (2008) Cancer Cell , vol.13 , pp. 529-541
    • Jiang, X.1    Tan, J.2    Li, J.3    Kivimae, S.4    Yang, X.5    Zhuang, L.6    Lee, P.L.7    Chan, M.T.8    Stanton, L.W.9    Liu, E.T.10
  • 106
    • 79954575702 scopus 로고    scopus 로고
    • Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation
    • Jin X., Jeon H.Y., Joo K.M., Kim J.K., Jin J., Kim S.H., Kang B.G., Beck S., Lee S.J., Kim J.K., et al. Frizzled 4 regulates stemness and invasiveness of migrating glioma cells established by serial intracranial transplantation. Cancer Res. 2011, 71(8):3066-3075.
    • (2011) Cancer Res. , vol.71 , Issue.8 , pp. 3066-3075
    • Jin, X.1    Jeon, H.Y.2    Joo, K.M.3    Kim, J.K.4    Jin, J.5    Kim, S.H.6    Kang, B.G.7    Beck, S.8    Lee, S.J.9    Kim, J.K.10
  • 108
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones P.A., Baylin S.B. The epigenomics of cancer. Cell 2007, 128:683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 111
    • 34748837360 scopus 로고    scopus 로고
    • Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis
    • Katoh M. Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis. Stem Cell. Rev. 2007, 3:30-38.
    • (2007) Stem Cell. Rev. , vol.3 , pp. 30-38
    • Katoh, M.1
  • 114
    • 47149097853 scopus 로고    scopus 로고
    • Epigenetic gene silencing in the Wnt pathway in breast cancer
    • Klarmann G.J., Decker A., Farrar W.L. Epigenetic gene silencing in the Wnt pathway in breast cancer. Epigenetics 2008, 3:59-63.
    • (2008) Epigenetics , vol.3 , pp. 59-63
    • Klarmann, G.J.1    Decker, A.2    Farrar, W.L.3
  • 115
    • 32344450824 scopus 로고    scopus 로고
    • Genomic DNA methylation: the mark and its mediators
    • Klose R.J., Bird A.P. Genomic DNA methylation: the mark and its mediators. Trends Biochem. Sci. 2006, 31(2):89-97.
    • (2006) Trends Biochem. Sci. , vol.31 , Issue.2 , pp. 89-97
    • Klose, R.J.1    Bird, A.P.2
  • 116
    • 0036848385 scopus 로고    scopus 로고
    • Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells
    • Koizume S., Tachibana K., Sekiya T., Hirohashi S., Shiraishi M. Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells. Nucleic Acids Res. 2002, 30:4770-4780.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 4770-4780
    • Koizume, S.1    Tachibana, K.2    Sekiya, T.3    Hirohashi, S.4    Shiraishi, M.5
  • 117
    • 77957902732 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells
    • Kong D., Banerjee S., Ahmad A., Li Y., Wang Z., Sethi S., Sarkar F.H. Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells. PLoS One 2010, 5:e12445.
    • (2010) PLoS One , vol.5
    • Kong, D.1    Banerjee, S.2    Ahmad, A.3    Li, Y.4    Wang, Z.5    Sethi, S.6    Sarkar, F.H.7
  • 118
    • 84863343713 scopus 로고    scopus 로고
    • Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM
    • Kong D., Heath E., Chen W., Cher M.L., Powell I., Heilbrun L., Li Y., Ali S., Sethi S., Hassan O., et al. Loss of let-7 up-regulates EZH2 in prostate cancer consistent with the acquisition of cancer stem cell signatures that are attenuated by BR-DIM. PLoS One 2012, 7:e33729.
    • (2012) PLoS One , vol.7
    • Kong, D.1    Heath, E.2    Chen, W.3    Cher, M.L.4    Powell, I.5    Heilbrun, L.6    Li, Y.7    Ali, S.8    Sethi, S.9    Hassan, O.10
  • 119
    • 55849123946 scopus 로고    scopus 로고
    • MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
    • Kong W., Yang H., He L., Zhao J.J., Coppola D., Dalton W.S., Cheng J.Q. MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol. Cell. Biol. 2008, 28:6773-6784.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 6773-6784
    • Kong, W.1    Yang, H.2    He, L.3    Zhao, J.J.4    Coppola, D.5    Dalton, W.S.6    Cheng, J.Q.7
  • 120
    • 47249091921 scopus 로고    scopus 로고
    • The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    • Korpal M., Lee E.S., Hu G., Kang Y. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J. Biol. Chem. 2008, 283:14910-14914.
    • (2008) J. Biol. Chem. , vol.283 , pp. 14910-14914
    • Korpal, M.1    Lee, E.S.2    Hu, G.3    Kang, Y.4
  • 121
    • 35548934558 scopus 로고    scopus 로고
    • MLL translocations, histone modifications and leukaemia stem-cell development
    • Krivtsov A.V., Armstrong S.A. MLL translocations, histone modifications and leukaemia stem-cell development. Nat. Rev. Cancer 2007, 7:823-833.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 823-833
    • Krivtsov, A.V.1    Armstrong, S.A.2
  • 123
    • 57149092998 scopus 로고    scopus 로고
    • Cyclic stretch induced miR-146a upregulation delays C2C12 myogenic differentiation through inhibition of Numb
    • Kuang W., Tan J., Duan Y., Duan J., Wang W., Jin F., Jin Z., Yuan X., Liu Y. Cyclic stretch induced miR-146a upregulation delays C2C12 myogenic differentiation through inhibition of Numb. Biochem. Biophys. Res. Commun. 2009, 378:259-263.
    • (2009) Biochem. Biophys. Res. Commun. , vol.378 , pp. 259-263
    • Kuang, W.1    Tan, J.2    Duan, Y.3    Duan, J.4    Wang, W.5    Jin, F.6    Jin, Z.7    Yuan, X.8    Liu, Y.9
  • 126
    • 33947532026 scopus 로고    scopus 로고
    • Hisotne acetyltransferase complex: one size doesn't fit all
    • Lee K.K., Workman J.L. Hisotne acetyltransferase complex: one size doesn't fit all. Nat. Rev. Mol. Cell. Biol. 2007, 8(4):284-295.
    • (2007) Nat. Rev. Mol. Cell. Biol. , vol.8 , Issue.4 , pp. 284-295
    • Lee, K.K.1    Workman, J.L.2
  • 127
    • 37349067098 scopus 로고    scopus 로고
    • Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
    • Lee J., Son M.J., Woolard K., Donin N.M., Li A., Cheng C.H., Kotliarova S., Kotliarov Y., Walling J., Ahn S., et al. Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell 2008, 13:69-80.
    • (2008) Cancer Cell , vol.13 , pp. 69-80
    • Lee, J.1    Son, M.J.2    Woolard, K.3    Donin, N.M.4    Li, A.5    Cheng, C.H.6    Kotliarova, S.7    Kotliarov, Y.8    Walling, J.9    Ahn, S.10
  • 129
    • 70349238717 scopus 로고    scopus 로고
    • Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia
    • Li X., Gonzalez M.E., Toy K., Filzen T., Merajver S.D., Kleer C.G. Targeted overexpression of EZH2 in the mammary gland disrupts ductal morphogenesis and causes epithelial hyperplasia. Am. J. Pathol. 2009, 175:1246-1254.
    • (2009) Am. J. Pathol. , vol.175 , pp. 1246-1254
    • Li, X.1    Gonzalez, M.E.2    Toy, K.3    Filzen, T.4    Merajver, S.D.5    Kleer, C.G.6
  • 130
    • 79951943718 scopus 로고    scopus 로고
    • Breast cancer resistance protein BCRP/ABCG2 regulatory microRNAs (hsa-miR-328, -519c and -520h) and their differential expression in stem-like ABCG2+ cancer cells
    • Li X., Pan Y.Z., Seigel G.M., Hu Z.H., Huang M., Yu A.M. Breast cancer resistance protein BCRP/ABCG2 regulatory microRNAs (hsa-miR-328, -519c and -520h) and their differential expression in stem-like ABCG2+ cancer cells. Biochem. Pharmacol. 2011, 81:783-792.
    • (2011) Biochem. Pharmacol. , vol.81 , pp. 783-792
    • Li, X.1    Pan, Y.Z.2    Seigel, G.M.3    Hu, Z.H.4    Huang, M.5    Yu, A.M.6
  • 132
    • 69249096109 scopus 로고    scopus 로고
    • Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells
    • Li Y., VandenBoom T.G., Kong D., Wang Z., Ali S., Philip P.A., Sarkar F.H. Up-regulation of miR-200 and let-7 by natural agents leads to the reversal of epithelial-to-mesenchymal transition in gemcitabine-resistant pancreatic cancer cells. Cancer Res. 2009, 69:6704-6712.
    • (2009) Cancer Res. , vol.69 , pp. 6704-6712
    • Li, Y.1    VandenBoom, T.G.2    Kong, D.3    Wang, Z.4    Ali, S.5    Philip, P.A.6    Sarkar, F.H.7
  • 133
    • 78349257041 scopus 로고    scopus 로고
    • Hypoxia and hypoxia inducible factors in cancer stem cell maintenance
    • Li Z., Rich J.N. Hypoxia and hypoxia inducible factors in cancer stem cell maintenance. Curr. Top. Microbiol. Immunol. 2010, 345:21-30.
    • (2010) Curr. Top. Microbiol. Immunol. , vol.345 , pp. 21-30
    • Li, Z.1    Rich, J.N.2
  • 134
    • 36249025636 scopus 로고    scopus 로고
    • Wnt signaling, stem cells, and the cellular origin of breast cancer
    • Lindvall C., Bu W., Williams B.O., Li Y. Wnt signaling, stem cells, and the cellular origin of breast cancer. Stem Cell. Rev. 2007, 3:157-168.
    • (2007) Stem Cell. Rev. , vol.3 , pp. 157-168
    • Lindvall, C.1    Bu, W.2    Williams, B.O.3    Li, Y.4
  • 136
    • 84868108584 scopus 로고    scopus 로고
    • MiR-200c inhibits melanoma progression and drug resistance through down-regulation of Bmi-1
    • Liu S., Tetzlaff M.T., Cai R., Xu X. miR-200c inhibits melanoma progression and drug resistance through down-regulation of Bmi-1. Am. J. Pathol. 2012, 181(5):1823-1835.
    • (2012) Am. J. Pathol. , vol.181 , Issue.5 , pp. 1823-1835
    • Liu, S.1    Tetzlaff, M.T.2    Cai, R.3    Xu, X.4
  • 137
    • 84871146329 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN. Mol Cell Biochem., (PMID: 22956424).
    • Liu, Z.L., Wang, H., Liu, J., Wang, Z.X. MicroRNA-21 (miR-21) expression promotes growth, metastasis, and chemo- or radioresistance in non-small cell lung cancer cells by targeting PTEN. Mol Cell Biochem., (PMID: 22956424). http://dx.doi.org/10.1016/j.yexcr.2012.07.019.
    • Liu, Z.L.1    Wang, H.2    Liu, J.3    Wang, Z.X.4
  • 138
    • 79551708071 scopus 로고    scopus 로고
    • MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells
    • Lo W.L., Yu C.C., Chiou G.Y., Chen Y.W., Huang P.I., Chien C.S., Tseng L.M., Chu P.Y., Lu K.H., Chang K.W., et al. MicroRNA-200c attenuates tumour growth and metastasis of presumptive head and neck squamous cell carcinoma stem cells. J. Pathol. 2011, 223:482-495.
    • (2011) J. Pathol. , vol.223 , pp. 482-495
    • Lo, W.L.1    Yu, C.C.2    Chiou, G.Y.3    Chen, Y.W.4    Huang, P.I.5    Chien, C.S.6    Tseng, L.M.7    Chu, P.Y.8    Lu, K.H.9    Chang, K.W.10
  • 141
    • 40749150740 scopus 로고    scopus 로고
    • CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway
    • Ma S., Lee T.K., Zheng B.J., Chan K.W., Guan X.Y. CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway. Oncogene 2008, 27:1749-1758.
    • (2008) Oncogene , vol.27 , pp. 1749-1758
    • Ma, S.1    Lee, T.K.2    Zheng, B.J.3    Chan, K.W.4    Guan, X.Y.5
  • 142
    • 78649681554 scopus 로고    scopus 로고
    • MiR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1
    • Ma S., Tang K.H., Chan Y.P., Lee T.K., Kwan P.S., Castilho A., Ng I., Man K., Wong N., To K.F., et al. miR-130b Promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1. Cell Stem Cell 2010, 7:694-707.
    • (2010) Cell Stem Cell , vol.7 , pp. 694-707
    • Ma, S.1    Tang, K.H.2    Chan, Y.P.3    Lee, T.K.4    Kwan, P.S.5    Castilho, A.6    Ng, I.7    Man, K.8    Wong, N.9    To, K.F.10
  • 145
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in Cancer
    • Massague J. TGFbeta in Cancer. Cell 2008, 134:215-230.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 146
    • 43049128928 scopus 로고    scopus 로고
    • Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice
    • May R., Riehl T.E., Hunt C., Sureban S.M., Anant S., Houchen C.W. Identification of a novel putative gastrointestinal stem cell and adenoma stem cell marker, doublecortin and CaM kinase-like-1, following radiation injury and in adenomatous polyposis coli/multiple intestinal neoplasia mice. Stem Cells 2008, 26:630-637.
    • (2008) Stem Cells , vol.26 , pp. 630-637
    • May, R.1    Riehl, T.E.2    Hunt, C.3    Sureban, S.M.4    Anant, S.5    Houchen, C.W.6
  • 148
    • 79961023271 scopus 로고    scopus 로고
    • Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition
    • McDonald O.G., Wu H., Timp W., Doi A., Feinberg A.P. Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat. Struct. Mol. Biol. 2012, 18:867-874.
    • (2012) Nat. Struct. Mol. Biol. , vol.18 , pp. 867-874
    • McDonald, O.G.1    Wu, H.2    Timp, W.3    Doi, A.4    Feinberg, A.P.5
  • 151
  • 152
    • 79951469197 scopus 로고    scopus 로고
    • AP-1-Dependent miR-21 expression contributes to chemoresistance in cancer stem cell-like SP cells
    • Misawa A., Katayama R., Koike S., Tomida A., Watanabe T., Fujita N. AP-1-Dependent miR-21 expression contributes to chemoresistance in cancer stem cell-like SP cells. Oncol. Res. 2010, 19:23-33.
    • (2010) Oncol. Res. , vol.19 , pp. 23-33
    • Misawa, A.1    Katayama, R.2    Koike, S.3    Tomida, A.4    Watanabe, T.5    Fujita, N.6
  • 153
    • 77956224494 scopus 로고    scopus 로고
    • Oxygen in stem cell biology: a critical component of the stem cell niche
    • Mohyeldin A., Garzon-Muvdi T., Quinones-Hinojosa A. Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell 2010, 7:150-161.
    • (2010) Cell Stem Cell , vol.7 , pp. 150-161
    • Mohyeldin, A.1    Garzon-Muvdi, T.2    Quinones-Hinojosa, A.3
  • 154
  • 156
    • 0032468051 scopus 로고    scopus 로고
    • Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines
    • Nakamura N., Takenaga K. Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines. Clin. Exp. Metastasis 1998, 16:471-479.
    • (1998) Clin. Exp. Metastasis , vol.16 , pp. 471-479
    • Nakamura, N.1    Takenaga, K.2
  • 157
    • 16844384464 scopus 로고    scopus 로고
    • Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays
    • Nishigaki M., Aoyagi K., Danjoh I., Fukaya M., Yanagihara K., Sakamoto H., Yoshida T., Sasaki H. Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays. Cancer Res. 2005, 65:2115-2124.
    • (2005) Cancer Res. , vol.65 , pp. 2115-2124
    • Nishigaki, M.1    Aoyagi, K.2    Danjoh, I.3    Fukaya, M.4    Yanagihara, K.5    Sakamoto, H.6    Yoshida, T.7    Sasaki, H.8
  • 158
    • 65249186793 scopus 로고    scopus 로고
    • The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors
    • Northcott P.A., Fernandez L.A., Hagan J.P., Ellison D.W., Grajkowska W., Gillespie Y., Grundy R., Van Meter T., Rutka J.T., Croce C.M., et al. The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors. Cancer Res. 2009, 69:3249-3255.
    • (2009) Cancer Res. , vol.69 , pp. 3249-3255
    • Northcott, P.A.1    Fernandez, L.A.2    Hagan, J.P.3    Ellison, D.W.4    Grajkowska, W.5    Gillespie, Y.6    Grundy, R.7    Van Meter, T.8    Rutka, J.T.9    Croce, C.M.10
  • 159
  • 160
  • 161
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano M., Bell D.W., Hber D.A., Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999, 99(3):247-257.
    • (1999) Cell , vol.99 , Issue.3 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Hber, D.A.3    Li, E.4
  • 162
    • 0141785202 scopus 로고    scopus 로고
    • Gene expression by Polycomb group of protein complexes: a distinct complex for every occasion?
    • Otte A.P., Kwaks T.H. Gene expression by Polycomb group of protein complexes: a distinct complex for every occasion?. Curr. Opin. Genet. Dev. 2003, 13(5):448-454.
    • (2003) Curr. Opin. Genet. Dev. , vol.13 , Issue.5 , pp. 448-454
    • Otte, A.P.1    Kwaks, T.H.2
  • 163
    • 77953920780 scopus 로고    scopus 로고
    • MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells
    • Pang R.T., Leung C.O., Ye T.M., Liu W., Chiu P.C., Lam K.K., Lee K.F., Yeung W.S. MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells. Carcinogenesis 2010, 31:1037-1044.
    • (2010) Carcinogenesis , vol.31 , pp. 1037-1044
    • Pang, R.T.1    Leung, C.O.2    Ye, T.M.3    Liu, W.4    Chiu, P.C.5    Lam, K.K.6    Lee, K.F.7    Yeung, W.S.8
  • 164
    • 70349904531 scopus 로고    scopus 로고
    • Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma
    • Park J.K., Lee E.J., Esau C., Schmittgen T.D. Antisense inhibition of microRNA-21 or -221 arrests cell cycle, induces apoptosis, and sensitizes the effects of gemcitabine in pancreatic adenocarcinoma. Pancreas 2009, 38:e190-199.
    • (2009) Pancreas , vol.38
    • Park, J.K.1    Lee, E.J.2    Esau, C.3    Schmittgen, T.D.4
  • 165
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • Park S.M., Gaur A.B., Lengyel E., Peter M.E. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 2008, 22:894-907.
    • (2008) Genes Dev. , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 166
    • 0345059765 scopus 로고    scopus 로고
    • Hedgehog signalling in cancer formation and maintenance
    • Pasca di Magliano M., Hebrok M. Hedgehog signalling in cancer formation and maintenance. Nat. Rev. Cancer 2003, 3:903-911.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 903-911
    • Pasca di Magliano, M.1    Hebrok, M.2
  • 168
    • 0346363757 scopus 로고    scopus 로고
    • Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex
    • Peinado H., Ballestar E., Esteller M., Cano A. Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol. Cell. Biol. 2004, 24:306-319.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 306-319
    • Peinado, H.1    Ballestar, E.2    Esteller, M.3    Cano, A.4
  • 169
    • 0036830524 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: a mesodermal cell strategy for evolutive innovation in Metazoans
    • Perez-Pomares J.M., Munoz-Chapuli R. Epithelial-mesenchymal transitions: a mesodermal cell strategy for evolutive innovation in Metazoans. Anat. Rec. 2002, 268:343-351.
    • (2002) Anat. Rec. , vol.268 , pp. 343-351
    • Perez-Pomares, J.M.1    Munoz-Chapuli, R.2
  • 170
    • 54249158400 scopus 로고    scopus 로고
    • Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling
    • Petrocca F., Vecchione A., Croce C.M. Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling. Cancer Res. 2008, 68:8191-8194.
    • (2008) Cancer Res. , vol.68 , pp. 8191-8194
    • Petrocca, F.1    Vecchione, A.2    Croce, C.M.3
  • 171
    • 0023946119 scopus 로고
    • Tumors as caricatures of the process of tissue renewal: prospects for therapy by directing differentiation
    • Pierce G.B., Speers W.C. Tumors as caricatures of the process of tissue renewal: prospects for therapy by directing differentiation. Cancer Res. 1988, 48:1996-2004.
    • (1988) Cancer Res. , vol.48 , pp. 1996-2004
    • Pierce, G.B.1    Speers, W.C.2
  • 173
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signaling and cancer
    • Polakis P. Wnt signaling and cancer. Genes Dev. 2000, 14:1837-1851.
    • (2000) Genes Dev. , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 174
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
    • Polyak K., Weinberg R.A. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat. Rev. Cancer 2009, 9:265-273.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 175
    • 69049120925 scopus 로고    scopus 로고
    • High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1
    • Qian B., Katsaros D., Lu L., Preti M., Durando A., Arisio R., Mu L., Yu H. High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1. Breast Cancer Res. Treat. 2009, 117:131-140.
    • (2009) Breast Cancer Res. Treat. , vol.117 , pp. 131-140
    • Qian, B.1    Katsaros, D.2    Lu, L.3    Preti, M.4    Durando, A.5    Arisio, R.6    Mu, L.7    Yu, H.8
  • 179
    • 64949113367 scopus 로고    scopus 로고
    • The SWI/SNF complex and cancer
    • Reisman D., Glaros S., Thompson E.A. The SWI/SNF complex and cancer. Oncogene 2009, 28:1653-1668.
    • (2009) Oncogene , vol.28 , pp. 1653-1668
    • Reisman, D.1    Glaros, S.2    Thompson, E.A.3
  • 180
    • 0037308717 scopus 로고    scopus 로고
    • Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis
    • Reisman D.N., Sciarrotta J., Wang W., Funkhouser W.K., Weissman B.E. Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis. Cancer Res. 2003, 63:560-566.
    • (2003) Cancer Res. , vol.63 , pp. 560-566
    • Reisman, D.N.1    Sciarrotta, J.2    Wang, W.3    Funkhouser, W.K.4    Weissman, B.E.5
  • 181
    • 39449112659 scopus 로고    scopus 로고
    • BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties
    • Rendl M., Polak L., Fuchs E. BMP signaling in dermal papilla cells is required for their hair follicle-inductive properties. Genes Dev. 2008, 22:543-557.
    • (2008) Genes Dev. , vol.22 , pp. 543-557
    • Rendl, M.1    Polak, L.2    Fuchs, E.3
  • 182
    • 8844265508 scopus 로고    scopus 로고
    • Epigenetic regulation of cellular memory by Polycomb and THritorax group proteins
    • Ringrose L., Paro R. Epigenetic regulation of cellular memory by Polycomb and THritorax group proteins. Annu. Rev. Genet. 2004, 38:413-443.
    • (2004) Annu. Rev. Genet. , vol.38 , pp. 413-443
    • Ringrose, L.1    Paro, R.2
  • 184
    • 1042290351 scopus 로고    scopus 로고
    • The SWI/SNF complex-chromatin and cancer
    • Roberts C.W., Orkin S.H. The SWI/SNF complex-chromatin and cancer. Nat. Rev. Cancer 2004, 4:133-142.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 133-142
    • Roberts, C.W.1    Orkin, S.H.2
  • 191
    • 21744457108 scopus 로고    scopus 로고
    • Global histone modification patterns predict risk of prostate cancer recurrence
    • Seligson D.B., Horvath S., Shi T., Yu H., Tze S., Grunstein M., Kurdistani S.K. Global histone modification patterns predict risk of prostate cancer recurrence. Nature 2005, 435:1262-1266.
    • (2005) Nature , vol.435 , pp. 1262-1266
    • Seligson, D.B.1    Horvath, S.2    Shi, T.3    Yu, H.4    Tze, S.5    Grunstein, M.6    Kurdistani, S.K.7
  • 193
    • 84255196931 scopus 로고    scopus 로고
    • Immune microenvironments in solid tumors: new targets for therapy
    • Shiao S.L., Ganesan A.P., Rugo H.S., Coussens L.M. Immune microenvironments in solid tumors: new targets for therapy. Genes Dev. 2011, 25:2559-2572.
    • (2011) Genes Dev. , vol.25 , pp. 2559-2572
    • Shiao, S.L.1    Ganesan, A.P.2    Rugo, H.S.3    Coussens, L.M.4
  • 195
    • 84880923339 scopus 로고    scopus 로고
    • Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers. Oncogene
    • Siu, M.K., Wong, E.S., Kong, D.S., Chan, H.Y., Jiang, L., Wong, O.G., Lam, E.W., Chan, K.K., Ngan, H.Y., Le, X.F., Cheung, A. N. Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers. Oncogene, http://dx.doi.org/10.1038/onc.2012.363.
    • Siu, M.K.1    Wong, E.S.2    Kong, D.S.3    Chan, H.Y.4    Jiang, L.5    Wong, O.G.6    Lam, E.W.7    Chan, K.K.8    Ngan, H.Y.9    Le, X.F.10    Cheung, A.N.11
  • 196
    • 33749440584 scopus 로고    scopus 로고
    • Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
    • Somervaille T.C., Cleary M.L. Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell 2006, 10:257-268.
    • (2006) Cancer Cell , vol.10 , pp. 257-268
    • Somervaille, T.C.1    Cleary, M.L.2
  • 198
    • 33750379420 scopus 로고    scopus 로고
    • Polycomb silencers control cell fate, development and cancer
    • Sparmann A., van Lohuizen M. Polycomb silencers control cell fate, development and cancer. Nat. Rev. Cancer 2006, 6:846-856.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 846-856
    • Sparmann, A.1    van Lohuizen, M.2
  • 199
    • 32944470488 scopus 로고    scopus 로고
    • Aberrant activation of notch signaling in human breast cancer
    • Stylianou S., Clarke R.B., Brennan K. Aberrant activation of notch signaling in human breast cancer. Cancer Res. 2006, 66:1517-1525.
    • (2006) Cancer Res. , vol.66 , pp. 1517-1525
    • Stylianou, S.1    Clarke, R.B.2    Brennan, K.3
  • 200
    • 0036733460 scopus 로고    scopus 로고
    • Decreased efficiency of gamma-ray-induced DNA double-strand break rejoining in malignant transformants of human bronchial epithelial cells generated by alpha-particle exposure
    • Sun J.F., Sui J.L., Zhou P.K., Geng Y., Hu Y.C., Cao Z.S., Ge S.L., Lou T.Z., Wu D.C. Decreased efficiency of gamma-ray-induced DNA double-strand break rejoining in malignant transformants of human bronchial epithelial cells generated by alpha-particle exposure. Int. J. Radiat. Biol. 2002, 78:773-780.
    • (2002) Int. J. Radiat. Biol. , vol.78 , pp. 773-780
    • Sun, J.F.1    Sui, J.L.2    Zhou, P.K.3    Geng, Y.4    Hu, Y.C.5    Cao, Z.S.6    Ge, S.L.7    Lou, T.Z.8    Wu, D.C.9
  • 206
    • 34250868124 scopus 로고    scopus 로고
    • Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest
    • Tarasov V., Jung P., Verdoodt B., Lodygin D., Epanchintsev A., Menssen A., Meister G., Hermeking H. Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle 2007, 6:1586-1593.
    • (2007) Cell Cycle , vol.6 , pp. 1586-1593
    • Tarasov, V.1    Jung, P.2    Verdoodt, B.3    Lodygin, D.4    Epanchintsev, A.5    Menssen, A.6    Meister, G.7    Hermeking, H.8
  • 207
    • 79954576652 scopus 로고    scopus 로고
    • EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells
    • Tellez C.S., Juri D.E., Do K., Bernauer A.M., Thomas C.L., Damiani L.A., Tessema M., Leng S., Belinsky S.A. EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells. Cancer Res. 2011, 71(8):3087-3097.
    • (2011) Cancer Res. , vol.71 , Issue.8 , pp. 3087-3097
    • Tellez, C.S.1    Juri, D.E.2    Do, K.3    Bernauer, A.M.4    Thomas, C.L.5    Damiani, L.A.6    Tessema, M.7    Leng, S.8    Belinsky, S.A.9
  • 208
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery J.P., Sleeman J.P. Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell. Biol. 2006, 7:131-142.
    • (2006) Nat. Rev. Mol. Cell. Biol. , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 209
    • 78649831855 scopus 로고    scopus 로고
    • GAM/ZFp/ZNF512B is central to a gene sensor circuitry involving cell-cycle regulators, TGF{beta} effectors, Drosha and microRNAs with opposite oncogenic potentials
    • Tili E., Michaille J.J., Liu C.G., Alder H., Taccioli C., Volinia S., Calin G.A., Croce C.M. GAM/ZFp/ZNF512B is central to a gene sensor circuitry involving cell-cycle regulators, TGF{beta} effectors, Drosha and microRNAs with opposite oncogenic potentials. Nucleic Acids Res. 2010, 38:7673-7688.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 7673-7688
    • Tili, E.1    Michaille, J.J.2    Liu, C.G.3    Alder, H.4    Taccioli, C.5    Volinia, S.6    Calin, G.A.7    Croce, C.M.8
  • 210
    • 40749118502 scopus 로고    scopus 로고
    • Histone modifications at the ABCG2 promoter following treatment with histone deacetylase inhibitor mirror those in multidrug-resistant cells
    • To K.K., Polgar O., Huff L.M., Morisaki K., Bates S.E. Histone modifications at the ABCG2 promoter following treatment with histone deacetylase inhibitor mirror those in multidrug-resistant cells. Mol. Cancer Res. 2008, 6:151-164.
    • (2008) Mol. Cancer Res. , vol.6 , pp. 151-164
    • To, K.K.1    Polgar, O.2    Huff, L.M.3    Morisaki, K.4    Bates, S.E.5
  • 212
    • 33846226977 scopus 로고    scopus 로고
    • Histone arginine methylation regulates pluripotency in the early mouse embryo
    • Torres-Padilla M.E., Parfitt D.E., Kouzarides T., Zernicka-Goetz M. Histone arginine methylation regulates pluripotency in the early mouse embryo. Nature 2007, 445:214-218.
    • (2007) Nature , vol.445 , pp. 214-218
    • Torres-Padilla, M.E.1    Parfitt, D.E.2    Kouzarides, T.3    Zernicka-Goetz, M.4
  • 213
    • 84863176405 scopus 로고    scopus 로고
    • Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains
    • Trowbridge J.J., Sinha A.U., Zhu N., Li M., Armstrong S.A., Orkin S.H. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes Dev. 2012, 26:344-349.
    • (2012) Genes Dev. , vol.26 , pp. 344-349
    • Trowbridge, J.J.1    Sinha, A.U.2    Zhu, N.3    Li, M.4    Armstrong, S.A.5    Orkin, S.H.6
  • 214
    • 79952532412 scopus 로고    scopus 로고
    • Cancer epigenetics: linking basic biology to clinical medicine
    • Tsai H.C., Baylin S.B. Cancer epigenetics: linking basic biology to clinical medicine. Cell. Res. 2011, 21:502-517.
    • (2011) Cell. Res. , vol.21 , pp. 502-517
    • Tsai, H.C.1    Baylin, S.B.2
  • 215
    • 78650412626 scopus 로고    scopus 로고
    • Epigenetic regulation of signaling pathways in cancer: role of the histone methyltransferase EZH2
    • Tsang D.P., Cheng A.S. Epigenetic regulation of signaling pathways in cancer: role of the histone methyltransferase EZH2. J. Gastroenterol. Hepatol. 2011, 26:19-27.
    • (2011) J. Gastroenterol. Hepatol. , vol.26 , pp. 19-27
    • Tsang, D.P.1    Cheng, A.S.2
  • 217
    • 79951810835 scopus 로고    scopus 로고
    • Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells
    • Vallejo D.M., Caparros E., Dominguez M. Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. Embo J. 2011, 30:756-769.
    • (2011) Embo J. , vol.30 , pp. 756-769
    • Vallejo, D.M.1    Caparros, E.2    Dominguez, M.3
  • 219
    • 47549098136 scopus 로고    scopus 로고
    • The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression
    • Vincan E., Barker N. The upstream components of the Wnt signalling pathway in the dynamic EMT and MET associated with colorectal cancer progression. Clin. Exp. Metastasis 2008, 25:657-663.
    • (2008) Clin. Exp. Metastasis , vol.25 , pp. 657-663
    • Vincan, E.1    Barker, N.2
  • 221
    • 78751676408 scopus 로고    scopus 로고
    • Cells of origin in cancer
    • Visvader J.E. Cells of origin in cancer. Nature 2011, 469:314-322.
    • (2011) Nature , vol.469 , pp. 314-322
    • Visvader, J.E.1
  • 223
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B., Kinzler K.W. Cancer genes and the pathways they control. Nat. Med. 2004, 10:789-799.
    • (2004) Nat. Med. , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 225
    • 77950095763 scopus 로고    scopus 로고
    • TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3
    • Wang B., Hsu S.H., Majumder S., Kutay H., Huang W., Jacob S.T., Ghoshal K. TGFbeta-mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene 2010, 29:1787-1797.
    • (2010) Oncogene , vol.29 , pp. 1787-1797
    • Wang, B.1    Hsu, S.H.2    Majumder, S.3    Kutay, H.4    Huang, W.5    Jacob, S.T.6    Ghoshal, K.7
  • 226
    • 82655179979 scopus 로고    scopus 로고
    • Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties
    • Wang J., Lu F., Ren Q., Sun H., Xu Z., Lan R., Liu Y., Ward D., Quan J., Ye T., Zhang H. Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties. Cancer Res. 2011, 71:7238-7249.
    • (2011) Cancer Res. , vol.71 , pp. 7238-7249
    • Wang, J.1    Lu, F.2    Ren, Q.3    Sun, H.4    Xu, Z.5    Lan, R.6    Liu, Y.7    Ward, D.8    Quan, J.9    Ye, T.10    Zhang, H.11
  • 227
    • 68049131195 scopus 로고    scopus 로고
    • MicroRNA-122a functions as a novel tumor suppressor downstream of adenomatous polyposis coli in gastrointestinal cancers
    • Wang X., Lam E.K., Zhang J., Jin H., Sung J.J. MicroRNA-122a functions as a novel tumor suppressor downstream of adenomatous polyposis coli in gastrointestinal cancers. Biochem. Biophys. Res. Commun. 2009, 387:376-380.
    • (2009) Biochem. Biophys. Res. Commun. , vol.387 , pp. 376-380
    • Wang, X.1    Lam, E.K.2    Zhang, J.3    Jin, H.4    Sung, J.J.5
  • 228
    • 84870745374 scopus 로고    scopus 로고
    • Epigenetic control of epithelial-to-mesenchymal transition and cancer metastasis. Exp Cell Res., (pii: S0014-4827(12)00361-8).
    • Wang, Y., Shang, Y. Epigenetic control of epithelial-to-mesenchymal transition and cancer metastasis. Exp Cell Res., (pii: S0014-4827(12)00361-8). http://dx.doi.org/10.1016/j.yexcr.2012.07.019.
    • Wang, Y.1    Shang, Y.2
  • 229
    • 65549141305 scopus 로고    scopus 로고
    • Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway
    • Wang Z., Li Y., Kong D., Banerjee S., Ahmad A., Azmi A.S., Ali S., Abbruzzese J.L., Gallick G.E., Sarkar F.H. Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res. 2009, 69:2400-2407.
    • (2009) Cancer Res. , vol.69 , pp. 2400-2407
    • Wang, Z.1    Li, Y.2    Kong, D.3    Banerjee, S.4    Ahmad, A.5    Azmi, A.S.6    Ali, S.7    Abbruzzese, J.L.8    Gallick, G.E.9    Sarkar, F.H.10
  • 234
    • 41449118521 scopus 로고    scopus 로고
    • Module map of stem cell genes guides creation of epithelial cancer stem cells
    • Wong D.J., Liu H., Ridky T.W., Cassarino D., Segal E., Chang H.Y. Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell 2008, 2:333-344.
    • (2008) Cell Stem Cell , vol.2 , pp. 333-344
    • Wong, D.J.1    Liu, H.2    Ridky, T.W.3    Cassarino, D.4    Segal, E.5    Chang, H.Y.6
  • 235
    • 84864922727 scopus 로고    scopus 로고
    • MiR-21 is a promising novel biomarker for lymph node metastasis in patients with gastric cancer
    • 2012, 640168.
    • Xu Y., Sun J., Xu J., Li Q., Guo Y., Zhang Q. miR-21 is a promising novel biomarker for lymph node metastasis in patients with gastric cancer. Gastroenterol. Res. Pract 2012, 2012, 640168.
    • (2012) Gastroenterol. Res. Pract
    • Xu, Y.1    Sun, J.2    Xu, J.3    Li, Q.4    Guo, Y.5    Zhang, Q.6
  • 238
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis
    • Yang J., Weinberg R.A. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev. Cell. 2008, 14:818-829.
    • (2008) Dev. Cell. , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 239
    • 84883742665 scopus 로고    scopus 로고
    • MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1. Oncogene
    • Yang, S., Li, Y., Gao, J., Zhang, T., Li, S., Luo, A., Chen, H., Ding, F., Wang, X., Liu, Z. MicroRNA-34 suppresses breast cancer invasion and metastasis by directly targeting Fra-1. Oncogene, http://dx.doi.org/10.1038/onc.2012.432.
    • Yang, S.1    Li, Y.2    Gao, J.3    Zhang, T.4    Li, S.5    Luo, A.6    Chen, H.7    Ding, F.8    Wang, X.9    Liu, Z.10
  • 240
    • 78549261109 scopus 로고    scopus 로고
    • Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells
    • Yang X., Lin X., Zhong X., Kaur S., Li N., Liang S., Lassus H., Wang L., Katsaros D., Montone K., et al. Double-negative feedback loop between reprogramming factor LIN28 and microRNA let-7 regulates aldehyde dehydrogenase 1-positive cancer stem cells. Cancer Res. 2010, 70:9463-9472.
    • (2010) Cancer Res. , vol.70 , pp. 9463-9472
    • Yang, X.1    Lin, X.2    Zhong, X.3    Kaur, S.4    Li, N.5    Liang, S.6    Lassus, H.7    Wang, L.8    Katsaros, D.9    Montone, K.10
  • 241
    • 2342599619 scopus 로고    scopus 로고
    • The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases
    • Yang X.J. The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res. 2004, 32:959-976.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 959-976
    • Yang, X.J.1
  • 243
    • 84855279252 scopus 로고    scopus 로고
    • MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells
    • Yu F., Jiao Y., Zhu Y., Wang Y., Zhu J., Cui X., Liu Y., He Y., Park E.Y., Zhang H., et al. MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells. J. Biol. Chem. 2012, 287:465-473.
    • (2012) J. Biol. Chem. , vol.287 , pp. 465-473
    • Yu, F.1    Jiao, Y.2    Zhu, Y.3    Wang, Y.4    Zhu, J.5    Cui, X.6    Liu, Y.7    He, Y.8    Park, E.Y.9    Zhang, H.10
  • 245
    • 78650858779 scopus 로고    scopus 로고
    • MicroRNA expression profile of colon cancer stem-like cells in HT29 adenocarcinoma cell line
    • Zhang H., Li W., Nan F., Ren F., Wang H., Xu Y., Zhang F. MicroRNA expression profile of colon cancer stem-like cells in HT29 adenocarcinoma cell line. Biochem. Biophys. Res. Commun. 2011, 404:273-278.
    • (2011) Biochem. Biophys. Res. Commun. , vol.404 , pp. 273-278
    • Zhang, H.1    Li, W.2    Nan, F.3    Ren, F.4    Wang, H.5    Xu, Y.6    Zhang, F.7
  • 247
    • 33750203582 scopus 로고    scopus 로고
    • Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions
    • Zhao Z., Tavoosidana G., Sjolinder M., Gondor A., Mariano P., Wang S., Kanduri C., Lezcano M., Sandhu K.S., Singh U., et al. Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions. Nat. Genet. 2006, 38:1341-1347.
    • (2006) Nat. Genet. , vol.38 , pp. 1341-1347
    • Zhao, Z.1    Tavoosidana, G.2    Sjolinder, M.3    Gondor, A.4    Mariano, P.5    Wang, S.6    Kanduri, C.7    Lezcano, M.8    Sandhu, K.S.9    Singh, U.10
  • 248
    • 84862330054 scopus 로고    scopus 로고
    • Beta-Catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/beta-catenin-signaling pathway
    • Zhou A.D., Diao L.T., Xu H., Xiao Z.D., Li J.H., Zhou H., Qu L.H. beta-Catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/beta-catenin-signaling pathway. Oncogene 2012, 31:2968-2978.
    • (2012) Oncogene , vol.31 , pp. 2968-2978
    • Zhou, A.D.1    Diao, L.T.2    Xu, H.3    Xiao, Z.D.4    Li, J.H.5    Zhou, H.6    Qu, L.H.7


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