Epigenetic gene silencing in the Wnt pathway in breast cancer

Epigenetics

Volumn 3, Issue 2, 2008, Pages 59-63

  Klarmann, George J ^a,b   Decker, Amy ^a,c,d   Farrar, William L ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY   (United States)

Author keywords

Breast cancer; Cancer stem cell; DNA methylation; Epigenetics; Wnt signaling; catenin

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; APC PROTEIN; BETA CATENIN; CASEIN KINASE I; CASEIN KINASE IGAMMA; CYCLIN D1; FRIZZLED PROTEIN; GENE PRODUCT; GLYCOGEN SYNTHASE KINASE 3BETA; HERMES ANTIGEN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; LYMPHOID ENHANCER FACTOR; MYC PROTEIN; NUCLEIC ACID BINDING PROTEIN; PROTEIN C JUN; PROTEIN DKK1; PROTEIN DKK3; PROTEIN HINT1; PROTEIN WIF1; T CELL FACTOR PROTEIN; WNT PROTEIN;

BREAST CANCER; BREAST CARCINOGENESIS; CANCER GROWTH; CANCER STEM CELL; CELL DIFFERENTIATION; CELL MOTION; CELL POLARITY; CELL PROLIFERATION; COLON POLYPOSIS; CYTOTOXICITY; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE MUTATION; GENE SILENCING; GENETIC TRANSDUCTION; HUMAN; REVIEW; SIGNAL TRANSDUCTION; BREAST TUMOR; FEMALE; GENETICS; METABOLISM;

BREAST NEOPLASMS; DNA METHYLATION; FEMALE; GENE SILENCING; HUMANS; NEOPLASTIC STEM CELLS; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 47149097853     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.3.2.5899     Document Type: Review

References (58)

1. Widschwendter M and Jones PA. DNA methylation and breast carcinogenesis. Oncogene 2002; 21:5462-82.
2. Lu Q, Qiu X, Hu N, Wen H, Su Y and Richardson B. Epigenetics, disease, and therapeutic interventions. Ageing Research Reviews 2006; 5:449-67.
3. Agoston AT, Argani P, Yegnasubramanian S, De Marzo AM, Ansari Lari MA, Hicks JL, Davidson NE and Nelson WG. Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer. J Biol Chem 2005; 280:18302-10.
4. Girault I, Tozlu S, Lidereau R and Bieche I. Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas. Clin Cancer Res 2003; 9:4415-22.
5. Jaiswal AS, Balusu R and Narayan S. Involvement of adenomatous polyposis coli in colorectal tumorigenesis. Front Biosci 2005; 10:1118-34.
6. Furuuchi K, Tada M, Yamada H, Kataoka A, Furuuchi N, Hamada J, Takahashi M, Todo S and Moriuchi T. Somatic mutations the APC gene in primary breast cancers. Am J Pathol 2000; 156:1997-2005.
7. Jin Z, Tamura G, Tsuchiya T, Sakata K, Kashiwaba M, Osakabe M and Motoyama T. Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers. Br J Cancer 2001; 85:69-73.
8. Kashiwaba M, Tamura G and Ishida M. Aberrations of the APC gene in primary breast carcinoma. J Cancer Res Clin Oncol 1994; 120:727-31.
9. Sarrio D, Moreno Bueno G, Hardisson D, Sanchez Estevez C, Guo M, Herman JG, Gamallo C, Esteller M and Palacios J. Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability. Int J Cancer 2003; 106:208-15.
10. Ayyanan A, Civenni G, Ciarloni L, Motel C, Mueller N, Lefort K, Mandinova A, Raffoul W, Fiche M, Dotto GP and Brisken C. Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci USA 2006; 103:3799-804.
11. Lin SY, Xia W, Wang JC, Kwong KY, Spohn B, Wen Y, Pestell RG and Hung MC. Betacatenin, a novel prognostic mariner for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci USA 2000; 97:4262-6.
12. Veeck J, Niederacher D, An H, Klopocki E, Wiesmann F, Betz B, Galm O, Camara O, Durst M, Kristiansen G, Huszka C, Knuchel R and Dabl E. Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis. Oncogene 2006; 25:3479-88.
13. Mohinta S, Wu H, Chaurasia P and Watabe K. Wnt pathway and breast cancer. Front Biosci 2007; 12:4020-33.
14. Aguilera O, Munoz A, Esteller M and Fraga MF. Epigenetic alterations of the Wnt/betacatenin pathway in human disease. Endocr Metab Immune Disord Drug Targets 2007; 7:13-21.
15. Howe LR and Brown AM. Wnt signaling and breast cancer. Cancer Biol Ther 2004; 3:36-41.
16. Cadigan KM and Nusse R. Wnt signaling: a common theme in animal development. Genes Dev 1997; 11:3286-305.
17. Katoh M. Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7 and MKN45. Int J Oncol 2002; 20:373-7.
18. Bafico A, Liu G, Goldin L, Harris V and Aaronson SA. An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell 2004; 6:497-506.
19. Klopocki E, Kristiansen G, Wild PJ, Klaman I, Castanos Velez E, Singer G, Stohr R, Simon R, Sauter G, Leibiger H, Essers L, Weber B, Hermann K, Rosenthal A, Hartmann A and Dahl E. Loss of SFRP1 is associated with breast cancer progression and poor prognosis in early stage tumors, Int J Oncol 2004; 25:641-9.
20. Ugolini F, Adelaide J, Charafe Jauffret E, Nguyen C, Jacquemier J, Jordan B, Birnbaum D and Pebusque MJ. Differential expression assay of chromosome arm 8p genes identifies Frizzled-related (FRP1/FRZB) and Fibroblast Growth Factor Receptor 1 (FGFR1) as candidate breast cancer genes. Oncogene 1999; 18:1903-10.
21. Bilic J, Huang YL, Davidson G, Zimmermann T, Cruciat CM, Bienz M and Niehrs C. Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science 2007; 316:1619-22.
22. Gordon MD and Nusse R. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 2006; 281:22429-33.
23. Lee YN, Gao Y and Wang HY. Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2 and -3. Cell Signal 2008; 20:443-52.
24. Kawano Y and Kypta R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci 2003; 116:2627-34.
25. Niehrs C. Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 2006; 25:7469-81.
26. Robertson KD. DNA methylation and human disease. Nat Rev Genet 2005; 6:597-610.
27. Ai L, Tao Q, Zhong S, Fields CR, Kim WJ, Lee MW, Cui Y, Brown KD and Robertson KD. Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer. Carcinogenesis 2006; 27:1341-8.
28. Suzuki H, Toyota M, Caraway H, Gabrielson E, Ohmura T, Fujikane T, Nishikawa N, Sogabe Y, Nojima M, Sonoda T, Mori M, Hirata K, Imai K, Shinomura Y, Baylin SB and Tokino T. Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer. Br J Cancer 2008; 98:11447-56.
29. Virmani AK, Rathi A, Sathyanarayana UG, Padar A, Huang CX, Cunnigham HT, Farinas AJ, Milchgrub S, Euhus DM, Gilcrease M, Herman J, Minna JD and Gazdar AF. Aberrant methylation of the adenomatous polypoasis coli (APC) gene promoter 1A in breast and lung carcinomas. Clin Cancer Res 2001; 7:1998-2004.
30. Wissmann C, Wild PJ, Kaiser S, Roepcke S, Stoehr R, Woenckhaus M, Kristiansen G, Hsieh JC, Hofstaedter F, Hartmann A, Knuechel R, Rosenthal A and Pilarsky C. WIF1. a component of the Wnt pathway, is downregulated in prostate, breast, lung, and bladder cancer. J Pathol 2003; 201:204-12.
31. Ozaki S, Ikeda S, Ishizaki Y, Kurihara T, Tokumoto N, Iseki M, Arihiro K, Kataoka T, Okajima M and Asahara T. Alterations and correlations of the components in the Wnt signaling pathway and its target genes in breast cancer. Oncol Rep 2005; 14:1437-43.
32. Ryo A, Nakamura M, Wulf G, Liou YC and Lu KP. Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat Cell Biol 2001; 3:793-801.
33. Agrawal A, Murphy RF and Agrawal DK. DNA methylation in breast and colorectal cancers. Mod Pathol 2007; 20:711-21.
34. Shulewitz M, Soloviev I, Wu T, Koeppen H, Polakis P and Sakanaka C. Repressor roles for TCF-4 and Sfrp1 in Wnt signaling in breast cancer. Oncogene 2006; 25:4361-9.
35. Lo PK, Mehrotta J, D'Costa A, Fackler MJ, Garrett Mayer E, Argani P and Sukumar S. Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer. Cancer Biol Ther 2006; 5:281-6.
36. Dulaimi E, Hillinck J, Ibanez de Caceres I, Al-Saleem T and Cairns P. Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients. Clin Cancer Res 2004; 10:6189-93.
37. Medeiros AC, Nagai MA, Neto MM and Brennan RR. Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas. Cancer Epidemiol Biomarkers Prev 1994; 3:331-3.
38. Thompson AM, Morris RG, Wallace M, Wyllie AH, Steel CM and Carter DC. Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer. Br J Cancer 1993; 68:64-8.
39. Bastian PJ, Ellinger J, Wellmann A, Wernert N, Heukamp LC, Muller SC and von Ruecker A. Diagnostic and prognostic information in prostate cancer with the help of a small set of hypermethylated gene loci. Clin Cancer Res 2005; 11:4097-106.
40. Yang SZ, Kohno N, Yokoyama A, Kondo K, Hamada H and Hiwada K. Decreased E-cadherin augments beta-catenin nuclear localization: studies in breast cancer cell lines. Int J Oncol 2001; 18:541-8.
41. Lombaerts M, van Wezel T, Philippo K, Dierssen JW, Zimmerman RM, Oosting J, van Eijk R, Eilers PH, van de Water B, Cornelisse CJ and Cleton Jansen AM. E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines. Br J Cancer 2006; 94:661-71.
42. Aguilera O, Fraga MF, Ballestar E, Paz MF, Herranz M, Espada J, Garcia JM, Munoz A, Esteller M and Gonzalez Sancho JM. Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Oncogene 2006; 25:4116-21.
43. Cowling VH, D'Cruz CM, Chodosh LA and Cole MD. c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1. Mol Cell Biol 2007; 27:5135-46.
44. Chim CS, Pang R, Fung TK, Choi CL and Liang R. Epigenetic dysregulation of Wnt signaling pathway in multiple myeloma. Leukemia 2007; 21:2527-36.
45. Roman Gomez J, Cordeu L, Agirre X, Jimenez Velasco A, San Jose Eneriz E, Garate L, Calasanz MJ, Heiniger A, Torres A and Prosper F. Epigenetic regulation of Wnt-signaling pathway in acute lymphoblastic leukemia. Blood 2007; 109:3462-9.
46. Yue W, Sun Q, Dacic S, Landreneau RJ, Siegfried JM, Yu J and Zhang L. Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer. Carcinogenesis 2008; 29:84-92.
47. Weiske J and Huber O. The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription. J Cell Sci 2005; 118:3117-29.
48. Wang L, Zhang Y, Li H, Xu Z, Santella RM and Weinstein IB. Hint1 inhibits growth and activator protein-1 activity in human colon cancer cells. Cancer Res 2007; 67:4700-8.
49. Yuan BZ, Jefferson AM, Popescu NC and Reynolds SH. Aberrant gene expression in human non small cell lung carcinoma cells exposed to demethylating agent 5-aza-2′-deoxycytidine. Neoplasia 2004; 6:412-9.
50. Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, Adachi S, Ohwada S, Morishita Y, Shibuya H and Akiyama T. Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev 2000; 14:1741-9.
51. Hasegawa Y, Satoh K, Iizuka Kogo A, Shimomura A, Nomura R, Akiyama T and Senda T. Loss of ICAT gene function leads to arrest of ureteric bud branching and renal agenesis. Biochem Biophys Res Commun 2007; 362:988-94.
52. Lobo NA, Shimono Y, Qian D and Clarke MF. The biology of cancer stem cells. Annu Rev Cell Dev Biol 2007; 23:675-99.
53. Liu S, Dontu G and Wicha MS. Mammary stem cells. self-renewal pathways, and carcinogenesis. Breast Cancer Res 2005; 7:86-95.
54. Reya T and Clevers H. Wnt signalling in stem cells and cancer. Nature 2005; 434:843-50.
55. + prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells. Oncogene 2006; 25:1696-708.
56. Liu BY, McDermott SP, Khwaja SS and Alexander CM. The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. Proc Natl Acad Sci USA 2004; 101:4158-63.
57. Stresemann C, Brueckner B, Musch T, Stopper H and Lyko F. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res 2006; 66:2794-800.
58. Schlange T, Matsuda Y, Lienhard S, Huber A and Hynes NE. Autocrine WNT signaling contributes to breast cancer cell proliferation via the canonical WNT pathway and EGFR transactivation. Breast Cancer Res 2007; 9:63.