Retraction: Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease (Nature Communications (2012) 3 (623) DOI: 10.1038/ncomms1623);Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease

Nature Communications

Volumn 3, Issue , 2012, Pages

  Herrera Merchan, A ^a   Arranz, L ^a   Ligos, J M ^a   De Molina, A ^a   Dominguez, O ^b   Gonzalez, S ^a  

^a CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^b Centro Nacional de Investigaciones Oncológicas   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR EZH2; DNA BINDING PROTEIN; EZH2 PROTEIN, HUMAN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HISTONE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL PROLIFERATION; CONTROLLED STUDY; GAIN OF FUNCTION MUTATION; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; LEUKOCYTOSIS; METHYLATION; MOUSE; MYELOPROLIFERATIVE DISORDER; NONHUMAN; POPULATION DYNAMICS; SPLEEN; SPLENOMEGALY; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL SEPARATION; CELL TRANSPLANTATION; CYTOLOGY; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; IMMUNE SYSTEM; METABOLISM; METHODOLOGY; TIME; TRANSGENE; TRANSGENIC MOUSE;

MUS;

ANIMALS; CELL PROLIFERATION; CELL SEPARATION; CELL TRANSPLANTATION; DNA-BINDING PROTEINS; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM CELLS; HISTONES; IMMUNE SYSTEM; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MODELS, GENETIC; MYELOPROLIFERATIVE DISORDERS; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSGENES;

EID: 84856746717     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms14005     Document Type: Erratum

References (49)

1. Akala, O. O. & Clarke, M. F. Hematopoietic stem cell self-renewal. Curr. Opin. Genet. Dev. 16, 496-501 (2006). (Pubitemid 44345208)
2. Bracken, A. P. & Helin, K. Polycomb group proteins: Navigators of lineage pathways led astray in cancer. Nat. Rev. Cancer 9, 773-784 (2009).
3. Margueron, R. & Reinberg, D. The Polycomb complex PRC2 and its mark in life. Nature 469, 343-349 (2011).
4. Ben-Porath, I. et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet. 40, 499-507 (2008). (Pubitemid 351601215)
5. Schlesinger, Y. et al. Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat. Genet. 39, 232-236 (2007). (Pubitemid 46184355)
6. Martin-Perez, D., Piris, M. A. & Sanchez-Beato, M. Polycomb proteins in hematologic malignancies. Blood 116, 5465-5475 (2010).
7. Morin, R. D. et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat. Genet. 42, 181-185 (2010).
8. Sneeringer, C. J. et al. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc. Natl Acad. Sci. U S A 107, 20980-20985 (2011).
9. Yap, D. B. et al. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood 117, 2451-2459 (2010).
10. Xu, F. et al. Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: Relation to adverse epigenetic alteration and poor prognostic scoring. Ann. Hematol. 90, 643-653 (2010).
11. Paul, T. A. et al. Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML. Blood 115, 3098-3108 (2010).
12. Fiskus, W. et al. Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood 114, 2733-2743 (2009).
13. Nikoloski, G. et al. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes. Nat. Genet. 42, 665-667 (2010).
14. Ernst, T. et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders. Nat. Genet. 42, 722-726 (2010).
15. de Boer, J. et al. Transgenic mice with hematopoietic and lymphoid specific expression of Cre. Eur. J. Immunol. 33, 314-325 (2003).
16. Croker, B. A. et al. SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis. Immunity 20, 153-165 (2004). (Pubitemid 38258392)
17. Ogilvy, S. et al. Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment. Blood 94, 1855-1863 (1999). (Pubitemid 29430401)
18. Goodell, M. A. et al. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. J. Exp. Med. 183, 1797-1806 (1996). (Pubitemid 26134320)
19. Ventura, A. et al. Restoration of p53 function leads to tumour regression in vivo. Nature 445, 661-665 (2007). (Pubitemid 46232887)
20. Clausen, B. E. et al. Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res. 8, 265-277 (1999). (Pubitemid 29523965)
21. Passegue, E. et al. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J. Exp. Med. 202, 1599-1611 (2005). (Pubitemid 41746605)
22. Ashburner, M. et al. Gene ontology: Tool for the unification of biology. The gene ontology consortium. Nat. Genet. 25, 25-29 (2000). (Pubitemid 30257031)
23. Kiel, M. J., Radice, G. L. & Morrison, S. J. Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance. Cell Stem Cell 1, 204-217 (2007). (Pubitemid 47215590)
24. Arai, F. et al. Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118, 149-161 (2004). (Pubitemid 38962572)
25. Tam, W. F. et al. Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells. Blood 112, 1981-1992 (2008).
26. Forsberg, E. C. et al. Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells. PLoS One 5, e8785 (2010).
27. Buonamici, S. et al. EVI1 induces myelodysplastic syndrome in mice. J. Clin. Invest. 114, 713-719 (2004). (Pubitemid 39582822)
28. Goyama, S. et al. Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells. Cell Stem Cell 3, 207-220 (2008).
29. Goyama, S. et al. EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization. Leukemia 24, 81-88 (2010).
30. Bracken, A. P. et al. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 21, 525-530 (2007). (Pubitemid 46409467)
31. Sauvageau, M. & Sauvageau, G. Polycomb group proteins: Multi-faceted regulators of somatic stem cells and cancer. Cell Stem Cell 7, 299-313 (2010).
32. Tefferi, A. & Gilliland, D. G. Oncogenes in myeloproliferative disorders. Cell Cycle 6, 550-566 (2007). (Pubitemid 46440428)
33. Kogan, S. C. et al. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood 100, 238-245 (2002). (Pubitemid 35177453)
34. Vire, E. et al. The Polycomb group protein EZH2 directly controls DNA methylation. Nature 439, 871-874 (2006). (Pubitemid 43255707)
35. Ohm, J. E. et al. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat. Genet. 39, 237-242 (2007). (Pubitemid 46184356)
36. Widschwendter, M. et al. Epigenetic stem cell signature in cancer. Nat. Genet. 39, 157-158 (2007). (Pubitemid 46184343)
37. Coussens, L. M. & Werb, Z. Inflammation and cancer. Nature 420, 860-867 (2002). (Pubitemid 36019639)
38. Jones, P. A. & Baylin, S. B. The epigenomics of cancer. Cell 128, 683-692 (2007). (Pubitemid 46273572)
39. Bejar, R. et al. Clinical effect of point mutations in myelodysplastic syndromes. N. Engl. J. Med. 364, 2496-2506 (2011).
40. Lund, A. H. & van Lohuizen, M. Polycomb complexes and silencing mechanisms. Curr. Opin. Cell Biol. 16, 239-246 (2004). (Pubitemid 38610403)
41. Passegue, E. & Wagers, A. J. Regulating quiescence: New insights into hematopoietic stem cell biology. Dev. Cell 10, 415-417 (2006).
42. Li, Q. et al. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood 117, 2022-2032 (2011).
43. Cleary, M. L. Regulating the leukaemia stem cell. Best Pract. Res. Clin. Haematol. 22, 483-487 (2009).
44. Braun, B. S. et al. Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proc. Natl Acad. Sci. U S A 101, 597-602 (2004). (Pubitemid 38084682)
45. Mullally, A. et al. Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells. Cancer Cell 17, 584-596 (2010).
46. Warr, M. R., Pietras, E. M. & Passegue, E. Mechanisms controlling hematopoietic stem cell functions during normal hematopoiesis and hematological malignancies. Wiley Interdiscip. Rev. Syst. Biol. Med. 3, 681-701 (2011).
47. Herrera-Merchan, A. et al. miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal. Cell Cycle 9, 3277-3285 (2010).
48. Gonzalez, S., Pisano, D. G. & Serrano, M. Mechanistic principles of chromatin remodeling guided by siRNAs and miRNAs. Cell Cycle 7, 2601-2608 (2008).
49. Gonzalez, S. et al. Oncogenic activity of Cdc6 through repression of the INK4/ARF locus. Nature 440, 702-706 (2006).