Challenges in design of translational nanocarriers

Journal of Controlled Release

Volumn 164, Issue 2, 2012, Pages 156-169

  Sun, Qihang ^b   Radosz, MacIej ^b   Shen, Youqing ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b UNIVERSITY OF WYOMING   (United States)

Author keywords

Cancer drug delivery; Nanocarriers; Nanomedicine; Translational

Indexed keywords

DISEASES; DRUG DOSAGE; ENZYME INHIBITION; MEDICAL NANOTECHNOLOGY; TARGETED DRUG DELIVERY; TUMORS;

CANCER DRUG DELIVERIES; CLINICAL APPLICATION; DRUG RETENTION; MANUFACTURE PROCESS; NANO-CARRIERS; PHARMACEUTICAL EXCIPIENT; THERAPEUTIC EFFICACY; TRANSLATIONAL;

CONTROLLED DRUG DELIVERY;

NANOCARRIER;

CANCER CHEMOTHERAPY; DRUG ACTIVITY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG RELEASE; DRUG TRANSPORT; GOOD MANUFACTURING PRACTICE; HUMAN; LIVER; LYSOSOME; NANOMEDICINE; PERMEABILITY; PRIORITY JOURNAL; REVIEW; SAFETY; SPLEEN;

EID: 84869504124     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.05.042     Document Type: Article

References (215)

1. R. Tong, D.A. Christian, L. Tang, H. Cabral, J.R. Baker Jr., K. Kataoka, D.E. Discher, J. Cheng Nanopolymeric therapeutics MRS Bull. 34 2009 422 431
2. F. Danhier, O. Feron, V. Preat To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery J. Control. Release 148 2010 135 146
3. M.E.R. O'Brien, N. Wigler, M. Inbar, R. Rosso, E. Grischke, A. Santoro, R. Catane, D.G. Kieback, P. Tomczak, S.P. Ackland, F. Orlandi, L. Mellars, L. Alland, C. Tendler, C.B.C.S. Grp Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX (TM)/Doxil (R)) versus conventional doxorubicin for first-line treatment of metastatic breast cancer Ann. Oncol. 15 2004 440 449
4. E.P. Winer, D.A. Berry, S. Woolf, W. Duggan, A. Kornblith, L.N. Harris, R.A. Michaelson, J.A. Kirshner, G.F. Fleming, M.C. Perry, M.L. Graham, S.A. Sharp, R. Keresztes, C.I. Henderson, C. Hudis, H. Muss, L. Norton Failure of higher-dose paclitaxel to improve outcome in patients with metastatic breast cancer: cancer and leukemia Group B Trial 9342 J. Clin. Oncol. 22 2004 2061 2068
5. W.J. Gradishar, S. Tjulandin, N. Davidson, H. Shaw, N. Desai, P. Bhar, M. Hawkins, J. O'Shaughnessy Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer J. Clin. Oncol. 23 2005 7794 7803
6. V.P. Torchilin Drug targeting Eur. J. Pharm. Sci. 11 2000 S81 S91
7. H. Maeda, J. Wu, T. Sawa, Y. Matsumura, K. Hori Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review J. Control. Release 65 2000 271 284
8. C. Wong, T. Stylianopoulos, J. Cui, J. Martin, V.P. Chauhan, W. Jiang, Z. Popovic, R.K. Jain, M.G. Bawendi, D. Fukumura Multistage nanoparticle delivery system for deep penetration into tumor tissue Proc. Natl. Acad. Sci. U. S. A. 108 2011 2426 2431
9. M. Ye, S. Kim, K. Park Issues in long-term protein delivery using biodegradable microparticles J. Control. Release 146 2010 241 260
10. S.D. Allison Effect of structural relaxation on the preparation and drug release behavior of poly(lactic-co-glycolic)acid microparticle drug delivery systems J. Pharm. Sci. 97 2008 2022 2035
11. F. Mohamed, C.F. van der Walle Engineering biodegradable polyester particles with specific drug targeting and drug release properties J. Pharm. Sci. 97 2008 71 87
12. D. Peer, J.M. Karp, S. Hong, O.C. FaroKhzad, R. Margalit, R. Langer Nanocarriers as an emerging platform for cancer therapy Nat. Nanotechnol. 2 2007 751 760
13. G. Shazly, T. Nawroth, P. Langguth Comparison of dialysis and dispersion methods for in vitro release determination of drugs from multimellar liposomes Dissolut. Technol. 15 2008 7 10
14. B. Narasimhan, R. Langer Zero-order release of micro- and macromolecules from polymeric devices: the role of the burst effect J. Control. Release 47 1997 13 20
15. Z.L. Tyrrell, Y. Shen, M. Radosz Fabrication of micellar nanoparticles for drug delivery through the self-assembly of block copolymers Prog. Polym. Sci. 35 2010 1128 1143
16. C.O. Rangel-Yagui, A. Pessoa, L.C. Tavares Micellar solubilization of drugs J. Pharm. Pharm. Sci. 8 2005 147 163
17. Y. Shen, Y. Zhan, J. Tang, P. Xu, P.A. Johnson, M. Radosz, E.A. Van Kirk, W.J. Murdoch Multifunctioning pH-responsive nanoparticles from hierarchical self-assembly of polymer brush for cancer drug delivery AlChE J. 54 2008 2979 2989
18. Z.L. Tyrrell, Y. Shen, M. Radosz Near-critical fluid micellization for high and efficient drug loading: encapsulation of paclitaxel into PEG-b-PCL micelles J. Phys. Chem. C 115 2011 11951 11956
19. M. Yokoyama, G.S. Kwon, T. Okano, Y. Sakurai, T. Seto, K. Kataoka Preparation of micelle-forming polymer drug conjugates Bioconjug. Chem. 3 1992 295 301
20. M. Yokoyama, S. Inoue, K. Kataoka, N. Yui, Y. Sakurai Preparation of adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block Copolymer - a new type of polymeric anticancer agent Makromol. Chem., Rapid Commun. 8 1987 431 435
21. M. Harada, I. Bobe, H. Saito, N. Shibata, R. Tanaka, T. Hayashi, Y. Kato Improved anti-tumor activity of stabilized anthracycline polymeric micelle formulation, NC-6300 Cancer Sci. 102 2011 192 199
22. A. Ponta, Y. Bae PEG-poly(amino acid) block copolymer micelles for tunable drug release Pharm. Res. 27 2010 2330 2342
23. Y. Bae, A.W.G. Alani, N.C. Rockich, T.S.Z.C. Lai, G.S. Kwon Mixed pH-sensitive polymeric micelles for combination drug delivery Pharm. Res. 27 2010 2421 2432
24. C. Jin, N. Qian, W. Zhao, W. Yang, L. Bai, H. Wu, M. Wang, W. Song, K. Dou Improved therapeutic effect of DOX-PLGA-PEG micelles decorated with bivalent fragment HAb18 F(ab ')(2) for hepatocellular carcinoma Biomacromolecules 11 2010 2422 2431
25. L.S. del Rosario, B. Demirdirek, A. Harmon, D. Orban, K.E. Uhrich Micellar nanocarriers assembled from doxorubicin-conjugated amphiphilic macromolecules (DOX-AM) Macromol. Biosci. 10 2010 415 423
26. S. Aryal, C.-M.J. Hu, L. Zhang Polymer-cisplatin conjugate nanoparticles for acid-responsive drug delivery ACS Nano 4 2010 251 258
27. R. Tong, J. Cheng Controlled synthesis of camptothecin-polylactide conjugates and nanoconjugates Bioconjug. Chem. 21 2010 111 121
28. R. Tong, J. Cheng Ring-opening polymerization-mediated controlled formulation of polylactide-drug nanoparticles J. Am. Chem. Soc. 131 2009 4744 4754
29. A. Lavasanifar, J. Samuel, G.S. Kwon Poly(ethylene oxide)-block-poly(L- amino acid) micelles for drug delivery Adv. Drug Deliv. Rev. 54 2002 169 190
30. C. Wei, J. Guo, C. Wang Dual stimuli-responsive polymeric micelles exhibiting "AND" logic gate for controlled release of adriamycin Macromol. Rapid Commun. 32 2011 451 455
31. L. Wong, M. Kavallaris, V. Bulmus Doxorubicin conjugated, crosslinked, PEGylated particles prepared via one-pot thiol-ene modification of a homopolymer scaffold: synthesis and in vitro evaluation Polym. Chem. 2 2011 385 393
32. Y. Shen, E. Jin, B. Zhang, C.J. Murphy, M. Sui, J. Zhao, J. Wang, J. Tang, M. Fan, E. Van Kirk, W.J. Murdoch Prodrugs forming high drug loading multifunctional nanocapsules for intracellular cancer drug delivery J. Am. Chem. Soc. 132 2010 4259 4265
33. Y. Shen, H.D. Tang, C.J. Murphy, B. Zhang, M.H. Sui, E.A. Van Kirk, X.W. Feng, W.J. Murdoch Amphiphilic curcumin conjugate-forming nanoparticles as anticancer prodrug and drug carriers: in vitro and in vivo effects Nanomedicine (Lond.) 5 2010 855 865
34. H.S. Yoo, E.A. Lee, T.G. Park Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages J. Control. Release 82 2002 17 27
35. M.J. Joralemon, R.K. O'Reilly, C.J. Hawker, K.L. Wooley Shell click-crosslinked (SCC) nanoparticles: a new methodology for synthesis and orthogonal functionalization J. Am. Chem. Soc. 127 2005 16892 16899
36. Y.T. Li, B.S. Lokitz, S.P. Armes, C.L. McCormick Synthesis of reversible shell cross-linked micelles for controlled release of bioactive agents Macromolecules 39 2006 2726 2728
37. X.B. Xiong, A. Falamarzian, S.M. Garg, A. Lavasanifar Engineering of amphiphilic block copolymers for polymeric micellar drug and gene delivery J. Control. Release 155 2011 248 261
38. M. Iijima, Y. Nagasaki, T. Okada, M. Kato, K. Kataoka Core-polymerized reactive micelles from heterotelechelic amphiphilic block copolymers Macromolecules 32 1999 1140 1146
39. J.H. Kim, K. Emoto, M. Iijima, Y. Nagasaki, T. Aoyagi, T. Okano, Y. Sakurai, K. Kataoka Core-stabilized polymeric micelle as potential drug carrier: increased solubilization of taxol Polym. Adv. Technol. 10 1999 647 654
40. X. Jiang, J. Zhang, Y. Zhou, J. Xu, S. Liu Facile preparation of core-crosslinked micelles from azide-containing thermoresponsive double hydrophilic diblock copolymer via click chemistry J. Polym. Sci. A. Polym. Chem. 46 2008 860 871
41. J. Xiong, F. Meng, C. Wang, R. Cheng, Z. Liu, Z. Zhong Folate-conjugated crosslinked biodegradable micelles for receptor-mediated delivery of paclitaxel J. Mater. Chem. 21 2011 5786 5794
42. S.M. Garg, X.-B. Xiong, C. Lu, A. Lavasanifar Application of click chemistry in the preparation of poly(ethylene oxide)-block-poly(epsilon- caprolactone) with hydrolyzable cross-links in the micellar core Macromolecules 44 2011 2058 2066
43. F. Meng, W.E. Hennink, Z. Zhong Reduction-sensitive polymers and bioconjugates for biomedical applications Biomaterials 30 2009 2180 2198
44. N. Abdullah Al, H. Lee, Y.S. Lee, K.D. Lee, S.Y. Park Development of disulfide core-crosslinked pluronic nanoparticles as an effective anticancer-drug-delivery system Macromol. Biosci. 11 2011 1264 1271
45. D.E. Discher, F. Ahmed Polymersomes Annu. Rev. Biomed. Eng. 8 2006 323 341
46. S. Kim, Y. Shi, J.Y. Kim, K. Park, J.-X. Cheng Overcoming the barriers in micellar drug delivery: loading efficiency, in vivo stability, and micelle-cell interaction Expert Opin. Drug Deliv. 7 2010 49 62
47. T. Haliloglu, I. Bahar, B. Erman, W.L. Mattice Mechanisms of the exchange of diblock copolymers between micelles at dynamic equilibrium Macromolecules 29 1996 4764 4771
48. N. Rapoport Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery Prog. Polym. Sci. 32 2007 962 990
49. K.K. Jette, D. Law, E.A. Schmitt, G.S. Kwon Preparation and drug loading of poly(ethylene glycol)-block-poly(epsilon-caprolactone) micelles through the evaporation of a cosolvent azeotrope Pharm. Res. 21 2004 1184 1191
50. J. Liu, F. Zeng, C. Allen In vivo fate of unimers and micelles of a poly(ethylene glycol)-block-poly(caprolactone) copolymer in mice following intravenous administration Eur. J. Pharm. Biopharm. 65 2007 309 319
51. X.C. Zhang, J.K. Jackson, H.M. Burt Development of amphiphilic diblock copolymers as micellar carriers of taxol Int. J. Pharm. 132 1996 195 206
52. H.M. Burt, X.C. Zhang, P. Toleikis, L. Embree, W.L. Hunter Development of copolymers of poly(D, L-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel Colloids Surf. B 16 1999 161 171
53. R. Savic, T. Azzam, A. Eisenberg, D. Maysinger Assessment of the integrity of poly(caprolactone)-b-poly(ethylene oxide) micelles under biological conditions: a fluorogenic-based approach Langmuir 22 2006 3570 3578
54. H. Chen, S. Kim, W. He, H. Wang, P.S. Low, K. Park, J.-X. Cheng Fast release of lipophilic agents from circulating PEG-PDLLA micelles revealed by in vivo Forster resonance energy transfer imaging Langmuir 24 2008 5213 5217
55. J.L. Xia, P.L. Dubin, E. Kokufuta Dynamic and eletrophoretic light-scattering of a water-soluble comlex formed between pepsin and poly(ethylene glycol) Macromolecules 26 1993 6688 6690
56. S.M. Li, H. Garreau, B. Pauvert, J. McGrath, A. Toniolo, M. Vert Enzymatic degradation of block copolymers prepared from epsilon-caprolactone and poly(ethylene glycol) Biomacromolecules 3 2002 525 530
57. C. Chen, C.H. Yu, Y.C. Cheng, P.H.F. Yu, M.K. Cheung Biodegradable nanoparticles of amphiphilic triblock copolymers based on poly(3- hydroxybutyrate) and poly(ethylene glycol) as drug carriers Biomaterials 27 2006 4804 4814
58. M.G. Carstens, C.F. van Nostrum, R. Verrijk, L.G.J. De Leede, D.J.A. Crommelin, W.E. Hennink A mechanistic study on the chemical and enzymatic degradation of PEG-Oligo(epsilon-caprolactone) micelles J. Pharm. Sci. 97 2008 506 518
59. Y.H. Bae, H. Yin Stability issues of polymeric micelles J. Control. Release 131 2008 2 4
60. H. Chen, S. Kim, L. Li, S. Wang, K. Park, J.-X. Cheng Release of hydrophobic molecules from polymer micelles into cell membranes revealed by Forster resonance energy transfer imaging Proc. Natl. Acad. Sci. U. S. A. 105 2008 6596 6601
61. J.C. Ha, S.Y. Kim, Y.M. Lee Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (pluronic)/poly(epsilon-caprolactone) (PCL) amphiphilic block copolymeric nanospheres - I. Preparation and characterization J. Control. Release 62 1999 381 392
62. S.Y. Kim, J.C. Ha, Y.M. Lee Poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)/poly(epsilon-caprolactone) (PCL) amphiphilic block copolymeric nanospheres - II. Thermo-responsive drug release behaviors J. Control. Release 65 2000 345 358
63. T.A. Diezi, Y. Bae, G.S. Kwon Enhanced stability of PEG-block-poly(N- hexyl stearate L-aspartamide) micelles in the presence of serum proteins Mol. Pharm. 7 2010 1355 1360
64. X.T. Shuai, T. Merdan, A.K. Schaper, F. Xi, T. Kissel Core-cross-linked polymeric micelles as paclitaxel carriers Bioconjug. Chem. 15 2004 441 448
65. C.J. Rijcken, C.J. Snel, R.M. Schiffelers, C.F. van Nostrum, W.E. Hennink Hydrolysable core-crosslinked thermosensitive polymeric micelles: synthesis, characterisation and in vivo studies Biomaterials 28 2007 5581 5593
66. P.S. Xu, H.D. Tang, S.Y. Li, J. Ren, E. Van Kirk, W.J. Murdoch, M. Radosz, Y.Q. Shen Enhanced stability of core-surface cross-linked micelles fabricated from amphiphilic brush copolymers Biomacromolecules 5 2004 1736 1744
67. X. Xu, J.D. Flores, C.L. McCormick Reversible imine shell cross-linked micelles from aqueous RAFT-synthesized thermoresponsive triblock copolymers as potential nanocarriers for "pH-triggered" drug release Macromolecules 44 2011 1327 1334
68. J. Jiang, B. Qi, M. Lepage, Y. Zhao Polymer micelles stabilization on demand through reversible photo-cross-linking Macromolecules 40 2007 790 792
69. V. Torchilin Multifunctional and stimuli-sensitive pharmaceutical nanocarriers Eur. J. Pharm. Biopharm. 71 2009 431 444
70. M. Stubbs, P.M.J. McSheehy, J.R. Griffiths Causes and consequences of acidic pH in tumors: a magnetic resonance study Adv. Enzyme Regul. 39 1999 13 30
71. K. Miyata, Y. Kakizawa, N. Nishiyama, A. Harada, Y. Yamasaki, H. Koyama, K. Kataoka Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression J. Am. Chem. Soc. 126 2004 2355 2361
72. T. Xing, B. Lai, X. Ye, L. Yan Disulfide core cross-linked PEGylated polypeptide nanogel prepared by a one-step ring opening copolymerization of N-Carboxyanhydrides for drug delivery Macromol. Biosci. 11 2011 962 969
73. Y.C. Wang, Y. Li, T.M. Sun, M.H. Xiong, J. Wu, Y.Y. Yang, J. Wang Core-shell-corona micelle stabilized by reversible cross-linkage for intracellular drug delivery Macromol. Rapid Commun. 31 2010 1201 1206
74. G. Saito, J.A. Swanson, K.D. Lee Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities Adv. Drug Deliv. Rev. 55 2003 199 215
75. A. Mahmud, X.-B. Xiong, A. Lavasanifar Novel self-associating poly(ethylene oxide)-block-poly(epsilon-caprolactone) block copolymers with functional side groups on the polyester block for drug delivery Macromolecules 39 2006 9419 9428
76. C. Allen, D. Maysinger, A. Eisenberg Nano-engineering block copolymer aggregates for drug delivery Colloids Surf. B Biointerfaces 16 1999 3 27
77. K. Kataoka, A. Harada, Y. Nagasaki Block copolymer micelles for drug delivery: design, characterization and biological significance Adv. Drug Deliv. Rev. 47 2001 113 131
78. A.V. Kabanov, T.K. Bronich, V.A. Kabanov, K. Yu, A. Eisenberg Soluble stoichiometric complexes from poly(N-ethyl-4-vinylpyridinium) cations and poly(ethylene oxide)-block-polymethacrylate anions Macromolecules 29 1996 6797 6802
79. S.H. Kim, J.P.K. Tan, F. Nederberg, K. Fukushima, J. Colson, C. Yang, A. Nelson, Y.-Y. Yang, J.L. Hedrick Hydrogen bonding-enhanced micelle assemblies for drug delivery Biomaterials 31 2010 8063 8071
80. D. Wang, Y. Su, C. Jin, B. Zhu, Y. Pang, L. Zhu, J. Liu, C. Tu, D. Yan, X. Zhu Supramolecular copolymer micelles based on the complementary multiple hydrogen bonds of nucleobases for drug delivery Biomacromolecules 12 2011 1370 1379
81. D. Putnam, J. Kopecek Polymer conjugates with anticancer activity Biopolymers 122 1995 55 123
82. J. Kopecek, P. Kopeckova, T. Minko, Z.R. Lu, C.M. Peterson Water soluble polymers in tumor targeted delivery J. Control. Release 74 2001 147 158
83. A. Malugin, P. Kopeckova, J. Kopecek Liberation of doxorubicin from HPMA copolymer conjugate is essential for the induction of cell cycle arrest and nuclear fragmentation in ovarian carcinoma cells J. Control. Release 124 2007 6 10
84. H.S. Yoo, K.H. Lee, J.E. Oh, T.G. Park In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates J. Control. Release 68 2000 419 431
85. M. Yokoyama, S. Fukushima, R. Uehara, K. Okamoto, K. Kataoka, Y. Sakurai, T. Okano Characterization of physical entrapment and chemical conjugation of adriamycin in polymeric micelles and their design for in vivo delivery to a solid tumor J. Control. Release 50 1998 79 92
86. M. Shahin, A. Lavasanifar Novel self-associating poly(ethylene oxide)-b-poly(epsilon-caprolactone) based drug conjugates and nano-containers for paclitaxel delivery Int. J. Pharm. 389 2010 213 222
87. R. Agarwal, S.B. Kaye Ovarian cancer: strategies for overcoming resistance to chemotherapy Nat. Rev. Cancer 3 2003 502 516
88. M.M. Gottesman Mechanisms of cancer drug resistance Annu. Rev. Med. 53 2002 615 627
89. G.D. Wang, E. Reed, Q.Q. Li Molecular basis of cellular response to cisplatin chemotherapy in non-small cell lung cancer Oncol. Rep. 12 2004 955 965
90. E.V. Batrakova, A.V. Kabanov Pluronic block copolymers: evolution of drug delivery concept from inert nanocarriers to biological response modifiers J. Control. Release 130 2008 98 106
91. M. Michael, M.M. Doherty Tumoral drug metabolism: overview and its implications for cancer therapy J. Clin. Oncol. 23 2005 205 229
92. A.M. Kaufmann, J.P. Krise Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications J. Pharm. Sci. 96 2007 729 746
93. G. Sahay, D.Y. Alakhova, A.V. Kabanov Endocytosis of nanomedicines J. Control. Release 145 2010 182 195
94. R.M. Steinman, I.S. Mellman, W.A. Muller, Z.A. Cohn Endocytosis and the recycling of plasma-membrane J. Cell Biol. 96 1983 1 27
95. S. Ganta, H. Devalapally, A. Shahiwala, M. Amiji A review of stimuli-responsive nanocarriers for drug and gene delivery J. Control. Release 126 2008 187 204
96. K.D. Jensen, A. Nori, M. Tijerina, P. Kopeckova, J. Kopecek Cytoplasmic delivery and nuclear targeting of synthetic macromolecules J. Control. Release 87 2003 89 105
97. V.P. Torchilin Recent approaches to intracellular delivery of drugs and DNA and organelle targeting Annu. Rev. Biomed. Eng. 8 2006 343 375
98. B. Rihova, T. Etrych, M. Sirova, L. Kovar, O. Hovorka, M. Kovar, A. Benda, K. Ulbrich Synergistic action of doxorubicin bound to the polymeric carrier based on N-(2-Hydroxypropyl)methacrylamide copolymers through an amide or hydrazone bond Mol. Pharm. 7 2010 1027 1040
99. K. Ulbrich, T. Etrych, P. Chytil, M. Pechar, M. Jelinkova, B. Rihova Polymeric anticancer drugs with pH-controlled activation Int. J. Pharm. 277 2004 63 72
100. K. Ulbrich, T. Etrych, P. Chytil, M. Jelinkova, B. Rihova HPMA copolymers with pH-controlled release of doxorubicin - in vitro cytotoxicity and in vivo antitumor activity J. Control. Release 87 2003 33 47
101. T. Etrych, L. Kovar, J. Strohalm, P. Chytil, B. Rihova, K. Ulbrich Biodegradable star HPMA polymer-drug conjugates: biodegradability, distribution and anti-tumor efficacy J. Control. Release 154 2011 241 248
102. J.Z. Du, X.J. Du, C.Q. Mao, J. Wang Tailor-made dual pH-sensitive polymer-doxorubicin nanoparticles for efficient anticancer drug delivery J. Am. Chem. Soc. 133 2011 17560 17563
103. Y. Shiose, H. Kuga, H. Ohki, M. Ikeda, F. Yamashita, M. Hashida Systematic research of peptide spacers controlling drug release from macromolecular prodrug system, carboxymethyldextran polyalcohol-peptide-drug conjugates Bioconjug. Chem. 20 2009 60 70
104. V. Subr, J. Strohalm, K. Ulbrich, R. Duncan, I.C. Hume Polymers containing enzymatically degradable bonds.12. Effect of spacer structure on the rate of release of daunomycin and adriamycin from poly N-(2-hydroxypropyl)- methacrylamide copolymer drug carriers in vitro and antitumor-activity measured in vivo J. Control. Release 18 1992 123 132
105. X. Huang, Y. Xiao, M. Lang Self-assembly of pH-sensitive mixed micelles based on linear and star copolymers for drug delivery J. Colloid Interface Sci. 364 2011 92 99
106. E.S. Lee, K. Na, Y.H. Bae Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor J. Control. Release 103 2005 405 418
107. J. Chen, X. Qiu, J. Ouyang, J. Kong, W. Zhong, M.M.Q. Xing pH and reduction dual-sensitive copolymeric micelles for intracellular doxorubicin delivery Biomacromolecules 12 2011 3601 3611
108. P.S. Xu, E.A. Van Kirk, W.J. Murdoch, Y.H. Zhan, D.D. Isaak, M. Radosz, Y.Q. Shen Anticancer efficacies of cisplatin-releasing pH-responsive nanoparticles Biomacromolecules 7 2006 829 835
109. P.S. Xu, E.A. Van Kirk, S.Y. Li, W.J. Murdoch, J. Ren, M.D. Hussain, M. Radosz, Y.Q. Shen Highly stable core-surface-crosslinked nanoparticles as cisplatin carriers for cancer chemotherapy Colloids Surf. B 48 2006 50 57
110. M. Belting, S. Sandgren, A. Wittrup Nuclear delivery of macromolecules: barriers and carriers Adv. Drug Deliv. Rev. 57 2005 505 527
111. T.R. Kyriakides, C.Y. Cheung, N. Murthy, P. Bornstein, P.S. Stayton, A.S. Hoffman pH-sensitive polymers that enhance intracellular drug delivery in vivo J. Control. Release 78 2002 295 303
112. R.A. Jones, C.Y. Cheung, F.E. Black, J.K. Zia, P.S. Stayton, A.S. Hoffman, M.R. Wilson Poly(2-alkylacrylic acid) polymers deliver molecules to the cytosol by pH-sensitive disruption of endosomal vesicles Biochem. J. 372 2003 65 75
113. A.K. Varkouhi, M. Scholte, G. Storm, H.J. Haisma Endosomal escape pathways for delivery of biologicals J. Control. Release 151 2011 220 228
114. S.L. Lo, S. Wang An endosomolytic Tat peptide produced by incorporation of histidine and cysteine residues as a nonviral vector for DNA transfection Biomaterials 29 2008 2408 2414
115. R.F. Minchin, S. Yang Endosomal disruptors in non-viral gene delivery Expert Opin. Drug Deliv. 7 2010 331 339
116. J.G. Huang, T. Leshuk, F.X. Gu Emerging nanomaterials for targeting subcellular organelles Nano Today 6 2011 478 492
117. A. Nori, J. Kopecek Intracellular targeting of polymer-bound drugs for cancer chemotherapy Adv. Drug Deliv. Rev. 57 2005 609 636
118. R. Savic, L.B. Luo, A. Eisenberg, D. Maysinger Micellar nanocontainers distribute to defined cytoplasmic organelles Science 300 2003 615 618
119. T. Wang, S. Yang, V.A. Petrenko, V.P. Torchilin Cytoplasmic delivery of liposomes into MCF-7 breast cancer cells mediated by cell-specific phage fusion coat protein Mol. Pharm. 7 2010 1149 1158
120. H. Hatakeyama, E. Ito, H. Akita, M. Oishi, Y. Nagasaki, S. Futaki, H. Harashima A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo J. Control. Release 139 2009 127 132
121. T. Kakudo, S. Chaki, S. Futaki, I. Nakase, K. Akaji, T. Kawakami, K. Maruyama, H. Kamiya, H. Harashima Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system Biochemistry 43 2004 5618 5628
122. E. Wagner Application of membrane-active peptides for nonviral gene delivery Adv. Drug Deliv. Rev. 38 1999 279 289
123. P. Xu, E.A. Van Kirk, Y. Zhan, W.J. Murdoch, M. Radosz, Y. Shen Targeted charge-reversal nanoparticles for nuclear drug delivery Angew. Chem. Int. Ed. 46 2007 4999 5002
124. C. Pichon, C. Goncalves, P. Midoux Histidine-rich peptides and polymers for nucleic acids delivery Adv. Drug Deliv. Rev. 53 2001 75 94
125. Y. Shen, Z. Zhuo, M. Sui, J. Tang, P. Xu, E.A. Van Kirk, W.J. Murdoch, M. Fan, M. Radosz Charge-reversal polyamidoamine dendrimer for cascade nuclear drug delivery Nanomedicine (Lond.) 5 2010 1205 1217
126. B. Romberg, W.E. Hennink, G. Storm Sheddable coatings for long-circulating nanoparticles Pharm. Res. 25 2008 55 71
127. J.A. Boomer, M.M. Qualls, H.D. Inerowicz, R.H. Haynes, V.S. Patri, J.-M. Kim, D.H. Thompson Cytoplasmic delivery of liposomal contents mediated by an acid-labile cholesterol-vinyl ether-PEG conjugate Bioconjug. Chem. 20 2009 47 59
128. S. Takae, K. Miyata, M. Oba, T. Ishii, N. Nishiyama, K. Itaka, Y. Yamasaki, H. Koyama, K. Kataoka PEG-detachable polyplex micelles based on disulfide-linked block catiomers as bioresponsive nonviral gene vectors J. Am. Chem. Soc. 130 2008 6001 6009
129. Z.P. Zhang, S.S. Feng In vitro investigation on poly(lactide)-tween 80 copolymer nanoparticles fabricated by dialysis method for chemotherapy Biomacromolecules 7 2006 1139 1146
130. D.P. Jones, J.L. Carlson, P.S. Samiec, P. Sternberg, V.C. Mody, R.L. Reed, L.A.S. Brown Glutathione measurement in human plasma evaluation of sample collection, storage and derivatization conditions for analysis of dansyl derivatives by HPLC Clin. Chim. Acta 275 1998 175 184
131. Y.E. Kurtoglu, R.S. Navath, B. Wang, S. Kannan, R. Romero, R.M. Kannan Poly(amidoamine) dendrimer-drug conjugates with disulfide linkages for intracellular drug delivery Biomaterials 30 2009 2112 2121
132. J.H. Ryu, R. Roy, J. Ventura, S. Thayumanavan Redox-sensitive disassembly of amphiphilic copolymer based micelles Langmuir 26 2010 7086 7092
133. R. Cheng, F. Feng, F. Meng, C. Deng, J. Feijen, Z. Zhong Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery J. Control. Release 152 2011 2 12
134. A.M. Sauer, A. Schlossbauer, N. Ruthardt, V. Cauda, T. Bein, C. Braeuchle Role of endosomal escape for disulfide-based drug delivery from colloidal mesoporous silica evaluated by live-cell imaging Nano Lett. 10 2010 3684 3691
135. H. Kim, S. Kim, C. Park, H. Lee, H.J. Park, C. Kim Glutathione-induced intracellular release of guests from mesoporous silica nanocontainers with cyclodextrin gatekeepers Adv. Mater. 22 2010 4280 4282
136. H.Y. Wen, H.Q. Dong, W.J. Xie, Y.Y. Li, K. Wang, G.M. Pauletti, D.L. Shi Rapidly disassembling nanomicelles with disulfide-linked PEG shells for glutathione-mediated intracellular drug delivery Chem. Commun. 47 2011 3550 3552
137. H. Sun, B. Guo, R. Cheng, F. Meng, H. Liu, Z. Zhong Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin Biomaterials 30 2009 6358 6366
138. N.T. Huynh, E. Roger, N. Lautram, J.-P. Benoit, C. Passirani The rise and rise of stealth nanocarriers for cancer therapy: passive versus active targeting Nanomedicine 5 2010 1415 1433
139. S.D. Li, L. Huang Pharmacokinetics and biodistribution of nanoparticles Mol. Pharm. 5 2008 496 504
140. F. Alexis, E. Pridgen, L.K. Molnar, O.C. Farokhzad Factors affecting the clearance and biodistribution of polymeric nanoparticles Mol. Pharm. 5 2008 505 515
141. J.W. Yoo, E. Chambers, S. Mitragotri Factors that control the circulation time of nanoparticles in blood: challenges, solutions and future prospects Curr. Pharm. Des. 16 2010 2298 2307
142. P. Decuzzi, B. Godin, T. Tanaka, S.Y. Lee, C. Chiappini, X. Liu, M. Ferrari Size and shape effects in the biodistribution of intravascularly injected particles J. Control. Release 141 2010 320 327
143. D.C. Litzinger, A.M.J. Buiting, N. Vanrooijen, L. Huang Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes Biochim. Biophys. Acta 1190 1994 99 107
144. K. Knop, R. Hoogenboom, D. Fischer, U.S. Schubert Poly(ethylene glycol) in drug delivery: pros and cons as well as potential alternatives Angew. Chem. Int. Ed. 49 2010 6288 6308
145. K. Ulbrich, V. Subr Structural and chemical aspects of HPMA copolymers as drug carriers Adv. Drug Deliv. Rev. 62 2010 150 166
146. M. Talelli, C.J.F. Rijcken, C.F. van Nostrum, G. Storm, W.E. Hennink Micelles based on HPMA copolymers Adv. Drug Deliv. Rev. 62 2010 231 239
147. M.P. Patel, R.R. Patel, J.K. Patel Chitosan mediated targeted drug delivery system: a review J. Pharm. Pharm. Sci. 13 2010 536 557
148. Y.I. Chung, J.C. Kim, Y.H. Kim, G. Tae, S.-Y. Lee, K. Kim, I.C. Kwon The effect of surface functionalization of PLGA nanoparticles by heparin- or chitosan-conjugated Pluronic on tumor targeting J. Control. Release 143 2010 374 382
149. M. Wang, M. Thanou Targeting nanoparticles to cancer Pharmacol. Res. 62 2010 90 99
150. K. Park To PEGylate or not to PEGylate, that is not the question J. Control. Release 142 2010 147 148
151. S. Dhar, N. Kolishetti, S.J. Lippard, O.C. Farokhzad Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo Proc. Natl. Acad. Sci. U. S. A. 108 2011 1850 1855
152. G. Prencipe, S.M. Tabakman, K. Welsher, Z. Liu, A.P. Goodwin, L. Zhang, J. Henry, H. Dai PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation J. Am. Chem. Soc. 131 2009 4783 4787
153. T.M. Allen, A. Chonn Large unilamellar liposomes with low uptake into the reticuloendothelial system FEBS Lett. 223 1987 42 46
154. G. Blume, G. Cevc Liposomes for the sustained drug release in vivo Biochim. Biophys. Acta 1029 1990 91 97
155. A.L. Klibanov, K. Maruyama, V.P. Torchilin, L. Huang Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes FEBS Lett. 268 1990 235 237
156. J.T. Thigpen, C.A. Aghajanian, D.S. Alberts, S.M. Campos, A.N. Gordon, M. Markman, D.S. McMeekin, B.J. Monk, P.G. Rose Role of pegylated liposomal doxorubicin in ovarian cancer Gynecol. Oncol. 96 2005 10 18
157. S.D. Li, L. Huang Stealth nanoparticles: high density but sheddable PEG is a key for tumor targeting J. Control. Release 145 2010 178 181
158. P.J. Photos, L. Bacakova, B. Discher, F.S. Bates, D.E. Discher Polymer vesicles in vivo: correlations with PEG molecular weight J. Control. Release 90 2003 323 334
159. Z. Liu, C. Davis, W. Cai, L. He, X. Chen, H. Dai Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy Proc. Natl. Acad. Sci. U. S. A. 105 2008 1410 1415
160. T. Ishida, H. Kiwada Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes Int. J. Pharm. 354 2008 56 62
161. T. Ishida, M. Ichihara, X. Wang, K. Yamamoto, J. Kimura, E. Majima, H. Kiwada Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes J. Control. Release 112 2006 15 25
162. T. Ishida, M. Ichihara, X. Wang, H. Kiwada Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes J. Control. Release 115 2006 243 250
163. T. Tagami, K. Nakamura, T. Shimizu, N. Yamazaki, T. Ishida, H. Kiwada CpG motifs in pDNA-sequences increase anti-PEG IgM production induced by PEG-coated pDNA-lipoplexes J. Control. Release 142 2010 160 166
164. J.A. Champion, S. Mitragotri Role of target geometry in phagocytosis Proc. Natl. Acad. Sci. U. S. A. 103 2006 4930 4934
165. Y. Geng, P. Dalhaimer, S. Cai, R. Tsai, M. Tewari, T. Minko, D.E. Discher Shape effects of filaments versus spherical particles in flow and drug delivery Nat. Nanotechnol. 2 2007 249 255
166. D.A. Christian, S. Cai, O.B. Garbuzenko, T. Harada, A.L. Zajac, T. Minko, D.E. Discher Flexible filaments for in vivo imaging and delivery: persistent circulation of filomicelles opens the dosage window for sustained tumor shrinkage Mol. Pharm. 6 2009 1343 1352
167. J.A. Champion, S. Mitragotri Shape induced inhibition of phagocytosis of polymer particles Pharm. Res. 26 2009 244 249
168. G. Sharma, D.T. Valenta, Y. Altman, S. Harvey, H. Xie, S. Mitragotri, J.W. Smith Polymer particle shape independently influences binding and internalization by macrophages J. Control. Release 147 2010 408 412
169. T.J. Merkel, S.W. Jones, K.P. Herlihy, F.R. Kersey, A.R. Shields, M. Napier, J.C. Luft, H. Wu, W.C. Zamboni, A.Z. Wang, J.E. Bear, J.M. DeSimone Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles Proc. Natl. Acad. Sci. U. S. A. 108 2011 586 591
170. M.E. Fox, F.C. Szoka, J.M.J. Frechet Soluble polymer carriers for the treatment of cancer: the importance of molecular architecture Acc. Chem. Res. 42 2009 1141 1151
171. E. Gullotti, Y. Yeo Extracellularly activated nanocarriers: a new paradigm of tumor targeted drug delivery Mol. Pharm. 6 2009 1041 1051
172. V. Mishra, U. Gupta, N.K. Jain Surface-engineered dendrimers: a solution for toxicity Issues J. Biomater. Sci. Polym. Ed. 20 2009 141 166
173. N. Malik, R. Wiwattanapatapee, R. Klopsch, K. Lorenz, H. Frey, J.W. Weener, E.W. Meijer, W. Paulus, R. Duncan Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of I-125-labelled polyamidoamine dendrimers in vivo (vol 65, pg 133, 2000) J. Control. Release 68 2000 299 302
174. J. Shin, P. Shum, D.H. Thompson Acid-triggered release via dePEGylation of DOPE liposomes containing acid-labile vinyl ether PEG-lipids J. Control. Release 91 2003 187 200
175. H. Hatakeyama, H. Akita, K. Kogure, M. Oishi, Y. Nagasaki, Y. Kihira, M. Ueno, H. Kobayashi, H. Kikuchi, H. Harashima Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid Gene Ther. 14 2007 68 77
176. H. Hatakeyama, H. Akita, E. Ito, Y. Hayashi, M. Oishi, Y. Nagasaki, R. Danev, K. Nagayama, N. Kaji, H. Kikuchi, Y. Baba, H. Harashima Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid Biomaterials 32 2011 4306 4316
177. R. Roy, B. Zhang, M.A. Moses Making the cut: protease-mediated regulation of angiogenesis Exp. Cell Res. 312 2006 608 622
178. Z.X. Zhou, Y. Shen, J.B. Tang, M.H. Fan, E.A. Van Kirk, W.J. Murdoch, M. Radosz Charge-reversal drug conjugate for targeted cancer cell nuclear drug delivery Adv. Funct. Mater. 19 2009 3580 3589
179. V.A. Sethuraman, Y.H. Bae TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors J. Control. Release 118 2007 216 224
180. E.S. Lee, Z. Gao, D. Kim, K. Park, I.C. Kwon, Y.H. Bae Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance J. Control. Release 129 2008 228 236
181. N.M. Zaki, N. Tirelli Gateways for the intracellular access of nanocarriers: a review of receptor-mediated endocytosis mechanisms and of strategies in receptor targeting Expert Opin. Drug Deliv. 7 2010 895 913
182. P. Rai, C. Padala, V. Poon, A. Saraph, S. Basha, S. Kate, K. Tao, J. Mogridge, R.S. Kane Statistical pattern matching facilitates the design of polyvalent inhibitors of anthrax and cholera toxins Nat. Biotechnol. 24 2006 582 586
183. M. Ferrari Beyond drug delivery Nat. Nanotechnol. 3 2008 131 132
184. M.A. Phillips, M.L. Gran, N.A. Peppas Targeted nanodelivery of drugs and diagnostics Nano Today 5 2010 143 159
185. S. Zhu, L. Qian, M. Hong, L. Zhang, Y. Pei, Y. Jiang RGD-modified PEG-PAMAM-DOX conjugate: in vitro and in vivo targeting to both tumor neovascular endothelial cells and tumor cells Adv. Mater. 23 2011 H84 H89
186. X.B. Xiong, H. Uludag, A. Lavasanifar Virus-mimetic polymeric micelles for targeted siRNA delivery Biomaterials 31 2010 5886 5893
187. C. Zhan, B. Gu, C. Xie, J. Li, Y. Liu, W. Lu Cyclic RGD conjugated poly(ethylene glycol)-co-poly(lactic acid) micelle enhances paclitaxel anti-glioblastoma effect J. Control. Release 143 2010 136 142
188. M.V. Pasquetto, L. Vecchia, D. Covini, R. Digilio, C. Scotti Targeted drug delivery using immunoconjugates: principles and applications J. Immunother. 34 2011 611 628
189. J. Mathew, E.A. Perez Trastuzumab emtansine in human epidermal growth factor receptor 2-positive breast cancer: a review Curr. Opin. Oncol. 23 2011 594 600
190. M. Lopus Antibody-DM1 conjugates as cancer therapeutics Cancer Lett. 307 2011 113 118
191. W. Tan, H. Wang, Y. Chen, X. Zhang, H. Zhu, C. Yang, R. Yang, C. Liu Molecular aptamers for drug delivery Trends Biotechnol. 29 2011 634 640
192. T. Chen, M.I. Shukoor, Y. Chen, Q. Yuan, Z. Zhu, Z. Zhao, B. Gulbakan, W. Tan Aptamer-conjugated nanomaterials for bioanalysis and biotechnology applications Nanoscale 3 2011 546 556
193. D.J. Yoon, C.T. Liu, D.S. Quinlan, P.M. Nafisi, D.T. Kamei Intracellular trafficking considerations in the development of natural ligand-drug molecular conjugates for cancer Ann. Biomed. Eng. 39 2011 1235 1251
194. B. Rihova Receptor-mediated targeted drug or toxin delivery Adv. Drug Deliv. Rev. 29 1998 273 289
195. G. Trapani, N. Denora, A. Trapani, V. Laquintana Recent advances in ligand targeted therapy J. Drug Target. 20 2012 1 22
196. X.P. Ma, J.B. Tang, Y.Q. Shen, M.H. Fan, H.D. Tang, M. Radosz Facile synthesis of polyester dendrimers from sequential click coupling of asymmetrical monomers J. Am. Chem. Soc. 131 2009 14795 14803
197. Y. Shen, X. Ma, B. Zhang, Z. Zhou, Q. Sun, E. Jin, M. Sui, J. Tang, J. Wang, M. Fan Degradable dual pH- and temperature-responsive photoluminescent dendrimers Chem. Eur. J. 17 2011 5319 5326
198. E. Lavik, H. von Recum The role of nanomaterials in translational medicine ACS Nano 5 2011 3419 3424
199. S.T. Stern, J.B. Hall, L.L. Yu, L.J. Wood, G.F. Paciotti, L. Tamarkin, S.E. Long, S.E. McNeil Translational considerations for cancer nanomedicine J. Control. Release 146 2010 164 174
200. H.S. Choi, J.V. Frangioni Nanoparticles for biomedical imaging: fundamentals of clinical translation Mol. Imaging 9 2010 291 310
201. P. Dunn, T.T. Kuo, L.Y. Shih, P.N. Wang, C.F. Sun, M.W.J. Chang Bone marrow failure and myelofibrosis in a case of PVP storage disease Am. J. Hematol. 57 1998 68 71
202. T.T. Kuo, S. Hu, C.L. Huang, H.L. Chan, M.J.W. Chang, P. Dunn, Y.J. Chen Cutaneous involvement in polyvinylpyrrolidone storage disease: a clinicopathologic study of five patients, including two patients with severe anemia Am. J. Surg. Pathol. 21 1997 1361 1367
203. P. Schneider, T.A. Korolenko, U. Busch A review of drug-induced lysosomal disorders of the liver in man and laboratory animals Microsc. Res. Tech. 36 1997 253 275
204. L.W. Seymour, R. Duncan, J. Strohalm, J. Kopecek Effect of molecular-weight of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats J. Biomed. Mater. Res. 21 1987 1341 1358
205. M. Irfan, M. Seiler Encapsulation using hyperbranched polymers: from research and technologies to emerging applications Ind. Eng. Chem. Res. 49 2010 1169 1196
206. K.M. Huh, S.C. Lee, Y.W. Cho, J.W. Lee, J.H. Jeong, K. Park Hydrotropic polymer micelle system for delivery of paclitaxel J. Control. Release 101 2005 59 68
207. D.M. Vail, L.D. Kravis, A.J. Cooley, R. Chun, E.G. MacEwen Preclinical trial of doxorubicin entrapped in sterically stabilized liposomes in dogs with spontaneously arising malignant tumors Cancer Chemother. Pharmacol. 39 1997 410 416
208. S.Y. Kim, Y.M. Lee Taxol-loaded block copolymer nanospheres composed of methoxy poly(ethylene glycol) and poly(epsilon-caprolactone) as novel anticancer drug carriers Biomaterials 22 2001 1697 1704
209. J. Szebeni Complement activation-related pseudoallergy: a new class of drug-induced acute immune toxicity Toxicology 216 2005 106 121
210. J. Szebeni, L. Baranyi, S. Savay, J. Milosevits, R. Bunger, P. Laverman, J.M. Metselaar, G. Storm, A. Chanan-Khan, L. Liebes, F.M. Muggia, R. Cohen, Y. Barenholz, C.R. Alving Role of complement activation in hypersensitivity reactions to doxil and HYNICPEG liposomes: experimental and clinical studies J. Liposome Res. 12 2002 165 172
211. C. Zhang, G. Qu, Y. Sun, X. Wu, Z. Yao, Q. Guo, Q. Ding, S. Yuan, Z. Shen, Q. Ping, H. Zhou Pharmacokinetics, biodistribution, efficacy and safety of N-octyl-O-sulfate chitosan micelles loaded with paclitaxel Biomaterials 29 2008 1233 1241
212. W. Zhang, Y. Shi, Y. Chen, J. Hao, X. Sha, X. Fang The potential of Pluronic polymeric micelles encapsulated with paclitaxel for the treatment of melanoma using subcutaneous and pulmonary metastatic mice models Biomaterials 32 2011 5934 5944
213. T. Schluep, J.J. Cheng, K.T. Khin, M.E. Davis Pharmacokinetics and biodistribution of the camptothecin-polymer conjugate IT-101 in rats and tumor-bearing mice Cancer Chemother. Pharmacol. 57 2006 654 662
214. J. Hu, Y. Su, H. Zhang, T. Xu, Y. Cheng Design of interior-functionalized fully acetylated dendrimers for anticancer drug delivery Biomaterials 32 2011 9950 9959
215. D. Ding, Z. Zhu, Q. Liu, J. Wang, Y. Hu, X. Jiang, B. Liu Cisplatin-loaded gelatin-poly(acrylic acid) nanoparticles: synthesis, antitumor efficiency in vivo and penetration in tumors Eur. J. Pharm. Biopharm. 79 2011 142 149