Systematic research of peptide spacers controlling drug release from macromolecular prodrug system, carboxymethyldextran polyalcohol-peptide-drug conjugates

Bioconjugate Chemistry

Volumn 20, Issue 1, 2009, Pages 60-70

  Shiose, Yoshinobu ^a   Kuga, Hiroshi ^c   Ohki, Hitoshi ^b   Ikeda, Masahiro ^b   Yamashita, Fumiyoshi ^a   Hashida, Mitsuru ^a  

^a DAIICHI SANKYO CO   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c DAIICHI SANKYO INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ASPARAGINE; CARBOXYMETHYLDEXTRAN; CARBOXYMETHYLDEXTRAN POLYALCOHOL; CITRULLINE; DANSYL CHLORIDE; DOXORUBICIN; GLUTAMINE; GLYCINE; ISOLEUCINE; LEUCINE; METHIONINE; N (4 AMINOBUTYL) 5 (DIMETHYLAMINO) 1 NAPHTHALENESULFONAMIDE; PEPTIDE; PHENYLALANINE; PRODRUG; PROLINE; PROTEINASE; SERINE; SULFONAMIDE; TETRAPEPTIDE; THREONINE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SEQUENCE; AMINO ACID SYNTHESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG STRUCTURE; DRUG UPTAKE; FIBROSARCOMA; HOMOGENATE; HYDROPHOBICITY; MACROMOLECULE; MALE; MOUSE; NONHUMAN; SOLID TUMOR;

MURINAE; MUS;

EID: 61849185596     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc800238f     Document Type: Article

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