메뉴 건너뛰기




Volumn 39, Issue 1, 1999, Pages 13-30

Causes and consequences of acidic ph in tumors: A magnetic resonance study

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; LACTIC ACID; NUCLEOTIDE;

EID: 0032883946     PISSN: 00652571     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2571(98)00018-1     Document Type: Conference Paper
Times cited : (76)

References (43)
  • 3
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, the metabolic microenvironment of human tumors: A review
    • P. VAUPEL, F. KALLINOWSKI and P. OKUNIEFF, Blood flow, oxygen and nutrient supply, the metabolic microenvironment of human tumors: a review, Cancer Res. 49, 6449-6465 (1989).
    • (1989) Cancer Res. , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 4
    • 0025771650 scopus 로고
    • Are cancer cells acidic?
    • J. R. GRIFFITHS, Are cancer cells acidic?, Brit. J. Cancer 64, 425-427 (1991).
    • (1991) Brit. J. Cancer , vol.64 , pp. 425-427
    • Griffiths, J.R.1
  • 5
    • 0002344772 scopus 로고    scopus 로고
    • Tumor pH: Blood perfusion and microenvironment of human tumors
    • (M. MOLLS and P. VAUPEL, eds.). Springer Verlag, Berlin
    • M. STUBBS, Tumor pH: Blood perfusion and microenvironment of human tumors, pp 113-120 in Medical Radiology: Diagnostic Imaging and Radiation Oncology (M. MOLLS and P. VAUPEL, eds.). Springer Verlag, Berlin (1998).
    • (1998) Medical Radiology: Diagnostic Imaging and Radiation Oncology , pp. 113-120
    • Stubbs, M.1
  • 9
    • 0028214088 scopus 로고
    • Non-invasive in vivo measurements using a fluorinated pH probe and fluorine-19 magnetic resonance spectroscopy
    • T. FRENZEL, S. KOHLER, H. BAUER, U. NIEDBALLA and H. J. WEINMANN, Non-invasive in vivo measurements using a fluorinated pH probe and fluorine-19 magnetic resonance spectroscopy, Invest. Radiol. 29, S220-S222 (1994).
    • (1994) Invest. Radiol. , vol.29
    • Frenzel, T.1    Kohler, S.2    Bauer, H.3    Niedballa, U.4    Weinmann, H.J.5
  • 10
    • 0028465482 scopus 로고
    • 31PMRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate
    • 31PMRS measurements of extracellular pH of tumors using 3-aminopropylphosphonate, Am. J. Physiol. 267, C195-C203 (1994).
    • (1994) Am. J. Physiol. , vol.267
    • Gillies, R.J.1    Liu, Z.2    Bhujwalla, Z.3
  • 13
    • 0029971428 scopus 로고    scopus 로고
    • Cellular pH gradient in tumor versus normal tissue: Potential exploitation for the treatment of cancer
    • L. E. GERWECK and K. SEETHARAMAN, Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer, Cancer Res. 56, 1194-1198 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 1194-1198
    • Gerweck, L.E.1    Seetharaman, K.2
  • 14
    • 0028051737 scopus 로고
    • Relevance of microenvironmental pH for self-organised tumor growth and invasion
    • M. KRAUS, T. SEVERIN and B. WOLF, Relevance of microenvironmental pH for self-organised tumor growth and invasion, Anticancer Res. 14, 1573-1584 (1994).
    • (1994) Anticancer Res. , vol.14 , pp. 1573-1584
    • Kraus, M.1    Severin, T.2    Wolf, B.3
  • 15
    • 0029751950 scopus 로고    scopus 로고
    • A reaction-diffusion model of cancer invasion
    • R. A. GATENBY and E. T. GAWLINSKI, A reaction-diffusion model of cancer invasion, Cancer Res. 56, 5745-5753 (1996).
    • (1996) Cancer Res. , vol.56 , pp. 5745-5753
    • Gatenby, R.A.1    Gawlinski, E.T.2
  • 16
    • 0032521207 scopus 로고    scopus 로고
    • Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: A magnetic resonance study in vivo
    • P. J. M. MCSHEEHY, S. P. ROBINSON, A. C. E. OJUGO, M. B. CANNELL, M. O. LEACH, I. R. JUDSON and J. R. GRIFFITHS, Carbogen breathing increases 5-fluorouracil uptake and cytotoxicity in hypoxic murine RIF-1 tumors: a magnetic resonance study in vivo, Cancer. Res. 58, 1185-1194 (1998).
    • (1998) Cancer. Res. , vol.58 , pp. 1185-1194
    • Mcsheehy, P.J.M.1    Robinson, S.P.2    Ojugo, A.C.E.3    Cannell, M.B.4    Leach, M.O.5    Judson, I.R.6    Griffiths, J.R.7
  • 17
    • 41949093884 scopus 로고
    • Image-selected in vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy
    • R. J. ORDIDGE, A. CONNELLY and J. A. B. LOHMAN, Image-selected in vivo spectroscopy (ISIS). A new technique for spatially selective NMR spectroscopy, J. Magn. Reson. 66, 283-294 (1986).
    • (1986) J. Magn. Reson. , vol.66 , pp. 283-294
    • Ordidge, R.J.1    Connelly, A.2    Lohman, J.A.B.3
  • 21
    • 0027418622 scopus 로고
    • Transport of lactate and other monocarboxylates across mammalian plasma membranes
    • Cell Physiol. 33
    • R. C. POOLE and A. P. HALESTRAP, Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am. J. Physiol. 264, (Cell Physiol. 33) C761-C782 (1993).
    • (1993) Am. J. Physiol. , vol.264
    • Poole, R.C.1    Halestrap, A.P.2
  • 22
    • 0014198230 scopus 로고
    • Coordination among rate limiting steps of glycolysis and respiration in intact ascites tumor cells
    • I.-Y. LEE, R. C. STRUNK and E. L. COE, Coordination among rate limiting steps of glycolysis and respiration in intact ascites tumor cells, J. Biol. Chem. 242, 2021-2028 (1967).
    • (1967) J. Biol. Chem. , vol.242 , pp. 2021-2028
    • Lee, I.-Y.1    Strunk, R.C.2    Coe, E.L.3
  • 24
    • 0024379967 scopus 로고
    • Acid pH in tumors and its potential for therapeutic exploitation
    • I. F. TANNOCK and D. ROTIN, Acid pH in tumors and its potential for therapeutic exploitation, Cancer Res. 49, 4373-4384 (1989).
    • (1989) Cancer Res. , vol.49 , pp. 4373-4384
    • Tannock, I.F.1    Rotin, D.2
  • 25
    • 0032080644 scopus 로고    scopus 로고
    • Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells
    • A. H. LEE and I. F. TANNOCK, Heterogeneity of intracellular pH and of mechanisms that regulate intracellular pH in populations of cultured cells, Cancer Res. 58, 1901-1908 (1998).
    • (1998) Cancer Res. , vol.58 , pp. 1901-1908
    • Lee, A.H.1    Tannock, I.F.2
  • 26
    • 0024286746 scopus 로고
    • Regulation of intracellular pH in eukaryotic cells
    • I. H. MADSHUS, Regulation of intracellular pH in eukaryotic cells, Biochem J. 250, 1-8 (1988).
    • (1988) Biochem J. , vol.250 , pp. 1-8
    • Madshus, I.H.1
  • 28
    • 0017306750 scopus 로고
    • L-Lactate transport in Ehrlich ascitestumour cells
    • T. L. SPENCER and A. L. LEHNINGER, L-Lactate transport in Ehrlich ascitestumour cells, Biochem. J. 154, 405-414 (1976).
    • (1976) Biochem. J. , vol.154 , pp. 405-414
    • Spencer, T.L.1    Lehninger, A.L.2
  • 29
    • 0027388949 scopus 로고
    • Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity
    • K. NEWELL, A. FRANCHI, J. POUYSSEGUR and I. TANNOCK, Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity, Proc. Natl. Acad. Sci. USA 90, 1127-1131 (1993).
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 1127-1131
    • Newell, K.1    Franchi, A.2    Pouyssegur, J.3    Tannock, I.4
  • 30
    • 0029763782 scopus 로고    scopus 로고
    • Dependence of proton generation on aerobic or anaerobic metbolism and implications for tumour pH
    • C. S. OWEN, Dependence of proton generation on aerobic or anaerobic metbolism and implications for tumour pH, Int. J Hyperthermia 12, 495-499 (1996).
    • (1996) Int. J Hyperthermia , vol.12 , pp. 495-499
    • Owen, C.S.1
  • 31
    • 0030207099 scopus 로고    scopus 로고
    • Relationships amongst lactate concentration, blood flow and histopathological profiles in rat C6 glioma
    • M. TERPSTRA, W. B. HIGH, Y. LUO, R. A. DE GRAAF, H. MERKLE and M. GARWOOD, Relationships amongst lactate concentration, blood flow and histopathological profiles in rat C6 glioma, NMR in Biomed. 9, 185-194 (1996).
    • (1996) NMR in Biomed. , vol.9 , pp. 185-194
    • Terpstra, M.1    High, W.B.2    Luo, Y.3    De Graaf, R.A.4    Merkle, H.5    Garwood, M.6
  • 33
    • 0020335069 scopus 로고
    • 31P Nuclear magnetic resonance evidence for the regulation of intracellular pH by Ehrlich ascites tumor cells
    • 31P Nuclear magnetic resonance evidence for the regulation of intracellular pH by Ehrlich ascites tumor cells, J. Cell. Biol. 95, 24-28 (1982).
    • (1982) J. Cell. Biol. , vol.95 , pp. 24-28
    • Gillies, R.J.1    Ogino, T.2    Shulman, R.G.3    Ward, D.C.4
  • 34
    • 0002642485 scopus 로고
    • Pathophysiological mechanisms of hyperthermia in cancer therapy
    • (M. GAUTHERIE, ed.) Springer Verlag, Heidelberg, Germany
    • P. VAUPEL, Pathophysiological mechanisms of hyperthermia in cancer therapy, pp. 73-134 in Biological Basis of Oncologic Thermotherapy (M. GAUTHERIE, ed.) Springer Verlag, Heidelberg, Germany (1990).
    • (1990) Biological Basis of Oncologic Thermotherapy , pp. 73-134
    • Vaupel, P.1
  • 35
    • 0030020131 scopus 로고    scopus 로고
    • Tumor angiogenesis and tissue factor
    • J. FOLKMAN, Tumor angiogenesis and tissue factor, Nature Med. 2, 167-168 (1996).
    • (1996) Nature Med. , vol.2 , pp. 167-168
    • Folkman, J.1
  • 36
    • 0023724350 scopus 로고
    • Effect of cyclophosphamide on the pathophysiology of RIF-1 solid tumors
    • P. BRAUNSCHWEIGER, Effect of cyclophosphamide on the pathophysiology of RIF-1 solid tumors, Cancer Res. 48, 4206-4210 (1988).
    • (1988) Cancer Res. , vol.48 , pp. 4206-4210
    • Braunschweiger, P.1
  • 37
    • 0026720341 scopus 로고
    • Effects of agents which inhibit the regulation of intracellular pH on murine solid tumors
    • K. W. NEWELL, P. WOOD, I. STRATFORD and I. TANNOCK, Effects of agents which inhibit the regulation of intracellular pH on murine solid tumors, Brit. J. Cancer 66, 311-317 (1992).
    • (1992) Brit. J. Cancer , vol.66 , pp. 311-317
    • Newell, K.W.1    Wood, P.2    Stratford, I.3    Tannock, I.4
  • 38
    • 0027477597 scopus 로고
    • Therapeutic potential of analogues of amiloride: Inhibition of the regulation of intracellular pH as a posssible mechanism of tumor selective therapy
    • R. P. MAIDORN, E. J. CRAGOE JR. and I. F. TANNOCK, Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a posssible mechanism of tumor selective therapy, Brit. J. Cancer 67, 297-303 (1993).
    • (1993) Brit. J. Cancer , vol.67 , pp. 297-303
    • Maidorn, R.P.1    Cragoe E.J., Jr.2    Tannock, I.F.3
  • 40
    • 0031981322 scopus 로고    scopus 로고
    • Cytotoxicity of weak electrolytes after the adaptation of cells to low pH: Role of the transmembrane pH gradient
    • S. V. KOZIN and L. E. GERWECK, Cytotoxicity of weak electrolytes after the adaptation of cells to low pH: role of the transmembrane pH gradient, Brit. J. Cancer 77, 1580-1585 (1998).
    • (1998) Brit. J. Cancer , vol.77 , pp. 1580-1585
    • Kozin, S.V.1    Gerweck, L.E.2
  • 41
    • 0029027185 scopus 로고
    • The cytotoxocity of melphalan and its relationship to pH, hypoxia and drug uptake
    • L. D. SKARSGARD, M. W. SKARCHUK, A. VINCZAN, J. KRISTL and D. J. CHAPLIN, The cytotoxocity of melphalan and its relationship to pH, hypoxia and drug uptake, Anticancer Res. 15, 219-224 (1995).
    • (1995) Anticancer Res. , vol.15 , pp. 219-224
    • Skarsgard, L.D.1    Skarchuk, M.W.2    Vinczan, A.3    Kristl, J.4    Chaplin, D.J.5
  • 43
    • 0031748828 scopus 로고    scopus 로고
    • The contribution of lactic acid to acidification of tumours: Studies of variant cells lacking lactate dehydrogenase
    • M. YAMAGATA, K. HASUDA, T. STAMATO and I. F. TANNOCK, The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase, Brit. J. Cancer 77, 1726-1731 (1998).
    • (1998) Brit. J. Cancer , vol.77 , pp. 1726-1731
    • Yamagata, M.1    Hasuda, K.2    Stamato, T.3    Tannock, I.F.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.