pH-Sensitive polymers that enhance intracellular drug delivery in vivo

Journal of Controlled Release

Volumn 78, Issue 1-3, 2002, Pages 295-303

  Kyriakides, Themis R ^a   Cheung, Charles Y ^b   Murthy, Niren ^b   Bornstein, Paul ^a   Stayton, Patrick S ^b   Hoffman, Allan S ^b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b University of Washington   (United States)

Author keywords

Antisense therapy; Endosomal release; Gene therapy; pH sensitive polymers

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; COMPLEMENTARY DNA; LIPID; LYSOSOME ENZYME; OLIGONUCLEOTIDE; PEPTIDE; PLASMID DNA; POLYACRYLIC ACID; RNA; THROMBOSPONDIN; THROMBOSPONDIN 2; TRIMETHYLAMMONIUM SALT DERIVATIVE; UNCLASSIFIED DRUG;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CELL COMPARTMENTALIZATION; CELL CULTURE; CELL STRAIN 3T3; COMPLEX FORMATION; CONFERENCE PAPER; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; DNA TRANSFECTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; ENDOSOME; EXPERIMENTAL MODEL; GENE EXPRESSION REGULATION; GENE TARGETING; GENE THERAPY; HEMOLYSIS; INJECTION; MEMBRANE DAMAGE; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; WOUND HEALING;

3T3 CELLS; ACRYLATES; ANIMALS; DNA; DRUG DELIVERY SYSTEMS; ENDOSOMES; FATTY ACIDS, MONOUNSATURATED; GENE THERAPY; HYDROGEN-ION CONCENTRATION; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; POLYMERS; QUATERNARY AMMONIUM COMPOUNDS; THROMBOSPONDINS; TRANSFECTION; WOUND HEALING; WOUNDS AND INJURIES;

EID: 0037122728     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00504-1     Document Type: Conference Paper

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