Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes

Journal of Controlled Release

Volumn 115, Issue 3, 2006, Pages 243-250

  Ishida, Tatsuhiro ^a   Ichihara, Masako ^a   Wang, XinYu ^a   Kiwada, Hiroshi ^a  

^a Institute of Health Biosciences   (Japan)

Author keywords

Accelerated blood clearance (ABC) phenomenon; Liposomes; Polyethylene glycol (PEG); Spleen; Splenectomy

Indexed keywords

BACTERIA; BACTERIOPHAGES; CELLS; PHOSPHOLIPIDS; REACTION KINETICS;

ACCELERATED BLOOD CLEARANCE (ABC) PHENOMENON; LIPOSOMES; SPLEEN; SPLENECTOMY;

POLYETHYLENE GLYCOLS;

1,2 DISTEAROYL SN GLYCERO 3 PHOSPHOETHANOLAMINE N [METHOXY(POLYETHYLENE GLYCOL)]; CHOLESTEROL; IMMUNOGLOBULIN M; LIPOSOME; MACROGOL 2000; MACROGOL DERIVATIVE; PHOSPHATIDYLCHOLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; DRUG CLEARANCE; DRUG FORMULATION; DRUG PROTEIN BINDING; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; INJECTION; MALE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT; SPLEEN; SPLEEN FUNCTION; SPLENECTOMY;

ANIMALS; ANTIGEN-ANTIBODY REACTIONS; CHOLESTEROL; COMPLEMENT ACTIVATION; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LIPOSOMES; LIVER; MALE; METABOLIC CLEARANCE RATE; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; SPLEEN; SPLENECTOMY; TISSUE DISTRIBUTION; TRITIUM;

EID: 33750324646     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2006.08.001     Document Type: Article

References (40)

1. Klibanov A.L., Maruyama K., Torchilin V.P., and Huang L. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. 268 (1990) 235-237
2. Allen T.M., Hansen C., Martin F., Redemann C., and Yau-Young A. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo. Biochim. Biophys. Acta 1066 (1991) 29-36
3. Papahadjopoulos D., Allen T.M., Gabizon A., Mayhew E., Matthay K., Huang S.K., Lee K.D., Woodle M.C., Lasic D.D., Redemann C., and Martin F.J. Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc. Natl. Acad. Sci. U. S. A. 88 (1991) 11460-11464
4. Lasic D.D., Martin F.J., Gabizon A., Huang S.K., and Papahadjopoulos D. Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times. Biochim. Biophys. Acta 1070 (1991) 187-192
5. Torchilin V.P., Omelyanenko V.G., Papisov M.I., Bogdanov Jr. A.A., Trubetskoy V.S., Herron J.N., and Gentry C.A. Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity. Biochim. Biophys. Acta 1195 (1994) 11-20
6. Senior J., Delgado C., Fisher D., Tilcock C., and Gregoriadis G. Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: studies with poly(ethylene glycol)-coated vesicles. Biochim. Biophys. Acta 1062 (1991) 77-82
7. Szebeni J. Complement activation-related pseudoallergy caused by liposomes, micellar carriers of intravenous drugs, and radiocontrast agents. Crit. Rev. Ther. Drug Carr. Syst. 18 (2001) 567-606
8. Szebeni J., Baranyi L., Savay S., Milosevits J., Bodo M., Bunger R., and Alving C.R. The interaction of liposomes with the complement system: in vitro and in vivo assays. Methods Enzymol. 373 (2003) 136-154
9. Moghimi S.M., and Szebeni J. Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties. Prog. Lipid Res. 42 (2003) 463-478
10. Laverman P., Carstens M.G., Boerman O.C., Dams E.T., Oyen W.J., van Rooijen N., Corstens F.H., and Storm G. Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection. J. Pharmacol. Exp. Ther. 298 (2001) 607-612
11. Dams E.T., Laverman P., Oyen W.J., Storm G., Scherphof G.L., van Der Meer J.W., Corstens F.H., and Boerman O.C. Accelerated blood clearance and altered biodistribution of repeated injections of sterically stabilized liposomes. J. Pharmacol. Exp. Ther. 292 (2000) 1071-1079
12. Ishida T., Harada M., Wang X.Y., Ichihara M., Irimura K., and Kiwada H. Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes. J. Control. Release 105 (2005) 305-317
13. Wang X.Y., Ishida T., Ichihara M., and Kiwada H. Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats. J. Control. Release 104 (2005) 91-102
14. Ishida T., Ichikawa T., Ichihara M., Sadzuka Y., and Kiwada H. Effect of the physicochemical properties of initially injected liposomes on the clearance of subsequently injected PEGylated liposomes in mice. J. Control. Release 95 (2004) 403-412
15. Ishida T., Masuda K., Ichikawa T., Ichihara M., Irimura K., and Kiwada H. Accelerated clearance of a second injection of PEGylated liposomes in mice. Int. J. Pharm. 255 (2003) 167-174
16. Ishida T., Maeda R., Ichihara M., Irimura K., and Kiwada H. Accelerated clearance of PEGylated liposomes in rats after repeated injections. J. Control. Release 88 (2003) 35-42
17. Ishida T., Ichihara M., Wang X., Yamamoto K., Kimura J., Majima E., and Kiwada H. Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes. J. Control. Release 112 (2006) 15-25
18. Bohnsack J.F., and Brown E.J. The role of the spleen in resistance to infection. Annu. Rev. Med. 37 (1986) 49-59
19. Koch G., Lok B.D., van Oudenaren A., and Benner R. The capacity and mechanism of bone marrow antibody formation by thymus-independent antigens. J. Immunol. 128 (1982) 1497-1501
20. Hansen K., and Singer D.B. Asplenic-hyposplenic overwhelming sepsis: postsplenectomy sepsis revisited. Pediatr. Dev. Pathol. 4 (2001) 105-121
21. Styrt B. Infection associated with asplenia: risks, mechanisms, and prevention. Am. J. Med. 88 (1990) 33N-42N
22. Ge Y., Gao H., and Kong X.T. Immunoglobulins and complement in splenectomised and autotransplanted subjects. Ann. Med. 21 (1989) 265-267
23. Yasar Y., Zeki Y., Ahmet E., Metin S., and Huseyin K. Plasma gamma globulin levels after splenectomy and spleen salvage. HPB Surg. 1 (1989) 97-100
24. Harashima H., Yamane C., Kume Y., and Kiwada H. Kinetic analysis of AUC-dependent saturable clearance of liposomes: mathematical description of AUC dependency. J. Pharmacokinet. Biopharm. 21 (1993) 299-308
25. Bartlett G.R. Colorimetric assay methods for free and phosphorylated glyceric acids. J. Biol. Chem. 234 (1959) 469-471
26. Mayer M.M. Complement and complement fixation. In: Kabat E.A., and Mayer M.M. (Eds). Experimental Immunochemistry (1961), Charles C. Thomas, Springfield 133-240
27. Pabst R., Westermann J., and Rothkotter H.J. Immunoarchitecture of regenerated splenic and lymph node transplants. Int. Rev. Cyt. 128 (1991) 215-260
28. Holdsworth R.J., Irving A.D., and Cuschieri A. Postsplenectomy sepsis and its mortality rate: actual versus perceived risks. Br. J. Surg. 78 (1991) 1031-1038
29. Martin F., Oliver A.M., and Kearney J.F. Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens. Immunity 14 (2001) 617-629
30. Wang W.C., Herrod H.G., Valenski W.R., and Wyatt R.J. Lymphocyte and complement abnormalities in splenectomized patients with hematologic disorders. Am. J. Hematol. 28 (1988) 239-245
31. Semple S.C., Harasym T.O., Clow K.A., Ansell S.M., Klimuk S.K., and Hope M.J. Immunogenicity and rapid blood clearance of liposomes containing polyethylene glycol-lipid conjugates and nucleic Acid. J. Pharmacol. Exp. Ther. 312 (2005) 1020-1026
32. Judge A., McClintock K., Phelps J.R., and Maclachlan I. Hypersensitivity and loss of disease site targeting caused by antibody responses to PEGylated liposomes. Mol. Ther. 13 (2006) 328-337
33. Mossier D.E., and Sybbarao B. Thymus independent antigens: complexicity of lymphocyte B activation revealed. Immunol. Today 3 (1982) 217-222
34. Milner E.C., Anolik J., Cappione A., and Sanz I. Human innate B cells: a link between host defense and autoimmunity? Springer Semin. Immunopathology 26 (2005) 433-452
35. Mizoguchi A., and Bhan A.K. A case for regulatory B cells. J. Immunol. 176 (2006) 705-710
36. Li W.M., Bally M.B., and Schutze-Redelmeier M.P. Enhanced immune response to T-independent antigen by using CpG oligodeoxynucleotides encapsulated in liposomes. Vaccine 20 (2001) 148-157
37. Boeckler C., Dautel D., Schelte P., Frisch B., Wachsmann D., Klein J.P., and Schuber F. Design of highly immunogenic liposomal constructs combining structurally independent B cell and T helper cell peptide epitopes. Eur. J. Immunol. 29 (1999) 2297-2308
38. Dijkstra J., Swartz Jr. G.M., Raney J.J., Aniagolu J., Toro L., Nacy C.A., and Green S.J. Interaction of anti-cholesterol antibodies with human lipoproteins. J. Immunol. 157 (1996) 2006-2013
39. Laakel M., Bouchard M., and Lagace J. Measurement of mouse anti-phospholipid antibodies to solid-phase microspheres by both flow cytofluorometry and Alcian blue-pretreated microtitre plates in an ELISA. J. Immunol. Methods 190 (1996) 267-273
40. T. Ishida, K. Atobe, X.Y. Wang, H. Kiwada, Accelerated blood clearance of PEGylated liposomes upon repeated injections: effect of doxorubicin-encapsulation and high-dose first injection. J. Control. Release, in press.