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Volumn 34, Issue 9, 2011, Pages 611-628

Targeted drug delivery using immunoconjugates: Principles and applications

Author keywords

antibody fragments; antibody drug conjugates; cancer; immunoconjugates; monoclonal antibodies

Indexed keywords

AGS 16M8F; AMG 386; ANTIBODY CONJUGATE; BAY 794620; BLEOMYCIN; BRENTUXIMAB VEDOTIN; BT 062; CARBONATE DEHYDRATASE IX; DACARBAZINE; DOXORUBICIN; GEMTUZUMAB OZOGAMICIN; GLEMBATUMUMAB; HYBRID PROTEIN; IBRITUMOMAB TIUXETAN; IMGN 388; INOTUZUMAB OZOGAMICIN; LORVOTUZUMAB MERTANSINE; PACLITAXEL; RADIUM; RITUXIMAB; SAR 3419; SAR 566658; SGN 75; THORIUM; TOSITUMOMAB I 131; TRASTUZUMAB EMTANSINE; TUCOTUZUMAB CELMOLEUKIN; TUMOR ANTIGEN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINBLASTINE;

EID: 80055002179     PISSN: 15249557     EISSN: 15374513     Source Type: Journal    
DOI: 10.1097/CJI.0b013e318234ecf5     Document Type: Review
Times cited : (57)

References (179)
  • 1
    • 34249669497 scopus 로고
    • Experimental radiation therapy of tumors with I-131-carrying antibodies to fibrin
    • Bale WF, Spar IL, Goodland RL. Experimental radiation therapy of tumors with I-131-carrying antibodies to fibrin. Cancer Res. 1960;20:1488-1494.
    • (1960) Cancer Res , vol.20 , pp. 1488-1494
    • Bale, W.F.1    Spar, I.L.2    Goodland, R.L.3
  • 2
    • 0016203571 scopus 로고
    • An alkylating agentglobulin conjugate with both alkylating and antibody activity
    • Lindford JH, Froese G, Berczi I, et al. An alkylating agentglobulin conjugate with both alkylating and antibody activity. J Natl Cancer Inst. 1974;52:1665-1667.
    • (1974) J Natl Cancer Inst , vol.52 , pp. 1665-1667
    • Lindford, J.H.1    Froese, G.2    Berczi, I.3
  • 3
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 1975;256: 495-497.
    • (1975) Nature , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 4
    • 33646352962 scopus 로고    scopus 로고
    • Potent antibody therapeutics by design
    • Carter PJ. Potent antibody therapeutics by design. Nat Rev Immunol. 2006;6:343-357.
    • (2006) Nat Rev Immunol , vol.6 , pp. 343-357
    • Carter, P.J.1
  • 5
    • 78651387929 scopus 로고    scopus 로고
    • Antibody-based therapeutics to watch in 2011
    • Reichert JM. Antibody-based therapeutics to watch in 2011. MAbs. 2011;3:76-99.
    • (2011) MAbs , vol.3 , pp. 76-99
    • Reichert, J.M.1
  • 6
    • 84857232585 scopus 로고    scopus 로고
    • ImmunoGen Inc [ImmunoGen Inc.Web site] Accessed September 26,2011
    • ImmunoGen, Inc. Announces Submission of IND for Wholly Owned Product Candidate for Non-Hodgkin's Lymphoma [ImmunoGen, Inc.Web site] 2011. Available at: http://http://phx. corporate-ir.net/phoenix.zhtml?c=97573&p=irol- newsArticle& ID=1609366&highlight=. Accessed September 26, 2011.
    • (2011) Announces Submission of IND for Wholly Owned Product Candidate for Non-Hodgkin's Lymphoma
  • 7
    • 84857233327 scopus 로고    scopus 로고
    • ImmunoGen. ImmunoGen Inc (ImmunoGen Inc. Web site) Accessed July 20, 2011
    • ImmunoGen. ImmunoGen, Inc. Announces First Data for its Novel Therapeutic for Ovarian Cancer and Other Carcinomas (ImmunoGen, Inc. Web site) 2011. Available at: http://phx.corporate-ir.net/phoenix.zhtml?c=97573&p=irol-news Article&ID=1545497&highlight. Accessed July 20, 2011.
    • (2011) Announces First Data for Its Novel Therapeutic for Ovarian Cancer and Other Carcinomas
  • 8
    • 74849131675 scopus 로고    scopus 로고
    • Radioimmunotherapy of lymphoma: Bexxar and Zevalin
    • Goldsmith SJ. Radioimmunotherapy of lymphoma: Bexxar and Zevalin. Semin Nucl Med. 2010;40:122-135.
    • (2010) Semin Nucl Med , vol.40 , pp. 122-135
    • Goldsmith, S.J.1
  • 9
    • 77954681710 scopus 로고    scopus 로고
    • Inotuzumab ozogamicin as novel therapy in lymphomas
    • Wong BY, Dang NH. Inotuzumab ozogamicin as novel therapy in lymphomas. Expert Opin Biol Ther. 2010;10: 1251-1258.
    • (2010) Expert Opin Biol Ther , vol.10 , pp. 1251-1258
    • Wong, B.Y.1    Dang, N.H.2
  • 10
    • 79953830127 scopus 로고    scopus 로고
    • Brentuximab vedotin for the treatment of CD30+ lymphomas
    • Foyil KV, Bartlett NL. Brentuximab vedotin for the treatment of CD30+ lymphomas. Immunotherapy. 2011;3: 475-485.
    • (2011) Immunotherapy , vol.3 , pp. 475-485
    • Foyil, K.V.1    Bartlett, N.L.2
  • 11
    • 79960356302 scopus 로고    scopus 로고
    • Investigational antibody drug conjugates for solid tumors
    • Sapra P, Hooper AT, O'Donnell CJ, et al. Investigational antibody drug conjugates for solid tumors. Expert Opin Investig Drugs. 2011;20:1131-1149.
    • (2011) Expert Opin Investig Drugs , vol.20 , pp. 1131-1149
    • Sapra, P.1    Hooper, A.T.2    O'Donnell, C.J.3
  • 12
    • 79951898433 scopus 로고    scopus 로고
    • AMG 386: Profile of a novel angiopoietin antagonist in patients with ovarian cancer
    • Robson EJ, Ghatage P. AMG 386: profile of a novel angiopoietin antagonist in patients with ovarian cancer. Expert Opin Investig Drugs. 2011;20:297-304.
    • (2011) Expert Opin Investig Drugs , vol.20 , pp. 297-304
    • Robson, E.J.1    Ghatage, P.2
  • 13
    • 80054989315 scopus 로고    scopus 로고
    • Trastuzumab Emtansine (T-DM1): A novel agent for targeting HER2(+) breast cancer
    • Epub ahead of print
    • Burris HA 3rd, Tibbitts J, Holden SN, et al. Trastuzumab Emtansine (T-DM1): a novel agent for targeting HER2(+) breast cancer. Clin Breast Cancer. 2011. [Epub ahead of print].
    • (2011) Clin Breast Cancer
    • Burris Iii, H.A.1    Tibbitts, J.2    Holden, S.N.3
  • 15
    • 80052076003 scopus 로고    scopus 로고
    • CD30: An important new target in hematologic malignancies
    • Deutsch YE, Tadmor T, Podack ER, et al. CD30: an important new target in hematologic malignancies. Leuk Lymphoma. 2011;52:1641-1654.
    • (2011) Leuk Lymphoma , vol.52 , pp. 1641-1654
    • Deutsch, Y.E.1    Tadmor, T.2    Podack, E.R.3
  • 16
    • 78049515807 scopus 로고    scopus 로고
    • Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas
    • Younes A, Bartlett NL, Leonard JP, et al. Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas. N Engl J Med. 2010;363:1812-1821.
    • (2010) N Engl J Med , vol.363 , pp. 1812-1821
    • Younes, A.1    Bartlett, N.L.2    Leonard, J.P.3
  • 17
    • 79953146631 scopus 로고    scopus 로고
    • Brentuximab vedotin
    • Brentuximab vedotin. Drugs R D 2011;11:85-95.
    • (2011) Drugs R D , vol.11 , pp. 85-95
  • 18
    • 77950835018 scopus 로고    scopus 로고
    • Glembatumumab vedotin, a conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin e for the treatment of melanoma and breast cancer
    • Naumovski L, Junutula JR. Glembatumumab vedotin, a conjugate of an anti-glycoprotein non-metastatic melanoma protein B mAb and monomethyl auristatin E for the treatment of melanoma and breast cancer. Curr Opin Mol Ther. 2010;12:248-257.
    • (2010) Curr Opin Mol Ther , vol.12 , pp. 248-257
    • Naumovski, L.1    Junutula, J.R.2
  • 19
    • 79955832182 scopus 로고    scopus 로고
    • Trastuzumab emtansine: A novel antibody-drug conjugate for HER2-positive breast cancer
    • Burris HA. Trastuzumab emtansine: a novel antibody-drug conjugate for HER2-positive breast cancer. Expert Opin Biol Ther. 2011;11:807-819.
    • (2011) Expert Opin Biol Ther , vol.11 , pp. 807-819
    • Burris, H.A.1
  • 20
    • 77953200582 scopus 로고    scopus 로고
    • Trastuzumab emtansine, an antibodydrug conjugate for the treatment of HER2+ metastatic breast cancer
    • Niculescu-Duvaz I. Trastuzumab emtansine, an antibodydrug conjugate for the treatment of HER2+ metastatic breast cancer. Curr Opin Mol Ther. 2010;12:350-360.
    • (2010) Curr Opin Mol Ther , vol.12 , pp. 350-360
    • Niculescu-Duvaz, I.1
  • 21
    • 84857234890 scopus 로고    scopus 로고
    • ImmunoGen. ImmunoGen Inc [ImmunoGen Inc. Web site] Accessed July 20, 2011
    • ImmunoGen. ImmunoGen, Inc. Announces Encouraging IMGN388 Clinical Data Reported at ASCO [ImmunoGen, Inc. Web site]. 2010. Available at: http://phx.corporate-ir.net/phoenix.zhtml?c=97573&p=irol-newsArticle&ID= 1435268 &highlight=. Accessed July 20, 2011.
    • (2010) Announces Encouraging IMGN388 Clinical Data Reported at ASCO
  • 22
    • 4344569693 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and biological pharmacodynamics of the immunocytokine EMD 273066 (huKS-IL2): Results of a phase I trial in patients with prostate cancer
    • Ko YJ, Bubley GJ, Weber R, et al. Safety, pharmacokinetics, and biological pharmacodynamics of the immunocytokine EMD 273066 (huKS-IL2): results of a phase I trial in patients with prostate cancer. J Immunother. 2004;27:232-239. (Pubitemid 39118088)
    • (2004) Journal of Immunotherapy , vol.27 , Issue.3 , pp. 232-239
    • Ko, Y.-J.1    Bubley, G.J.2    Weber, R.3    Redfern, C.4    Gold, D.P.5    Finke, L.6    Kovar, A.7    Dahl, T.8    Gillies, S.D.9
  • 24
    • 77953097101 scopus 로고    scopus 로고
    • Phase 1 study of AMG 386, a selective angiopoietin 1/2-neutralizing peptibody, in combination with chemotherapy in adults with advanced solid tumors
    • Mita AC, Takimoto CH, Mita M, et al. Phase 1 study of AMG 386, a selective angiopoietin 1/2-neutralizing peptibody, in combination with chemotherapy in adults with advanced solid tumors. Clin Cancer Res. 2010;16:3044-3056.
    • (2010) Clin Cancer Res , vol.16 , pp. 3044-3056
    • Mita, A.C.1    Takimoto, C.H.2    Mita, M.3
  • 25
    • 70249114453 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors
    • Herbst RS, Hong D, Chap L, et al. Safety, pharmacokinetics, and antitumor activity of AMG 386, a selective angiopoietin inhibitor, in adult patients with advanced solid tumors. J Clin Oncol. 2009;27:3557-3565.
    • (2009) J Clin Oncol , vol.27 , pp. 3557-3565
    • Herbst, R.S.1    Hong, D.2    Chap, L.3
  • 28
    • 84857236377 scopus 로고    scopus 로고
    • ImmunoGen [ImmunoGen, Inc. Web site] Accessed July 20, 2011
    • ImmunoGen. Lorvotuzumab mertansine [ImmunoGen, Inc. Web site]. 2011. Available at: http://www.immunogen.com/wt/page/IMGN901b. Accessed July 20, 2011.
    • (2011) Lorvotuzumab Mertansine
  • 29
    • 77957083400 scopus 로고    scopus 로고
    • Clinical applications of VEGF-trap (aflibercept) in cancer treatment
    • Teng LS, Jin KT, He KF, et al. Clinical applications of VEGF-trap (aflibercept) in cancer treatment. J Chin Med Assoc. 2010;73:449-456.
    • (2010) J Chin Med Assoc , vol.73 , pp. 449-456
    • Teng, L.S.1    Jin, K.T.2    He, K.F.3
  • 30
    • 77951648118 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin's lymphoma: Results of a phase i study
    • Advani A, Coiffier B, Czuczman MS, et al. Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin's lymphoma: results of a phase I study. J Clin Oncol. 2010;28:2085-2093.
    • (2010) J Clin Oncol , vol.28 , pp. 2085-2093
    • Advani, A.1    Coiffier, B.2    Czuczman, M.S.3
  • 31
    • 77954839504 scopus 로고    scopus 로고
    • Phase i study of inotuzumab ozogamicin (CMC-544) in Japanese patients with follicular lymphoma pretreated with rituximab-based therapy
    • Ogura M, Tobinai K, Hatake K, et al. Phase I study of inotuzumab ozogamicin (CMC-544) in Japanese patients with follicular lymphoma pretreated with rituximab-based therapy. Cancer Sci. 2010;101:1840-1845.
    • (2010) Cancer Sci , vol.101 , pp. 1840-1845
    • Ogura, M.1    Tobinai, K.2    Hatake, K.3
  • 32
    • 80052387216 scopus 로고    scopus 로고
    • Clinical outcomes of postremission therapy using (90)yttrium ibritumomab tiuxetan [Zevalin(R)] for high-risk patients with diffuse large B-cell lymphoma
    • Han EJ, Lee SE, Kim SH, et al. Clinical outcomes of postremission therapy using (90)yttrium ibritumomab tiuxetan [Zevalin(R)] for high-risk patients with diffuse large B-cell lymphoma. Ann Hematol. 2011;90:1075-1082.
    • (2011) Ann Hematol , vol.90 , pp. 1075-1082
    • Han, E.J.1    Lee, S.E.2    Kim, S.H.3
  • 33
    • 75449105595 scopus 로고    scopus 로고
    • Consensus conference on the use of 90-yttrium-ibritumomab tiuxetan therapy in clinical practice: A project of the Italian society of hematology
    • Vitolo U, Barosi G, Fanti S, et al. Consensus conference on the use of 90-yttrium-ibritumomab tiuxetan therapy in clinical practice: a project of the Italian society of hematology. Am J Hematol. 2010;85:147-155.
    • (2010) Am J Hematol , vol.85 , pp. 147-155
    • Vitolo, U.1    Barosi, G.2    Fanti, S.3
  • 34
    • 79952687786 scopus 로고    scopus 로고
    • Yttrium ibritumomab tiuxetan in the treatment of non-Hodgkin's lymphoma: Current status and future prospects
    • Jacobs SA. Yttrium ibritumomab tiuxetan in the treatment of non-Hodgkin's lymphoma: current status and future prospects. Biologics. 2007;1:215-227.
    • (2007) Biologics , vol.1 , pp. 215-227
    • Jacobs, S.A.1
  • 36
    • 77957272703 scopus 로고    scopus 로고
    • High rates of durable responses with anti-CD22 fractionated radioimmunotherapy: Results of a multicenter, phase I/II study in non-Hodgkin's lymphoma
    • Morschhauser F, Kraeber-Bodere F, Wegener WA, et al. High rates of durable responses with anti-CD22 fractionated radioimmunotherapy: results of a multicenter, phase I/II study in non-Hodgkin's lymphoma. J Clin Oncol. 2010;28: 3709-3716.
    • (2010) J Clin Oncol , vol.28 , pp. 3709-3716
    • Morschhauser, F.1    Kraeber-Bodere, F.2    Wegener, W.A.3
  • 39
    • 0028840870 scopus 로고
    • Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac
    • Waldmann TA, White JD, Carrasquillo JA, et al. Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac. Blood. 1995;86:4063-4075.
    • (1995) Blood , vol.86 , pp. 4063-4075
    • Waldmann, T.A.1    White, J.D.2    Carrasquillo, J.A.3
  • 40
    • 78649713153 scopus 로고    scopus 로고
    • Treatment strategies for nodal and gastrointestinal follicular lymphoma: Current status and future development
    • Watanabe T. Treatment strategies for nodal and gastrointestinal follicular lymphoma: current status and future development. World J Gastroenterol. 2010;16:5543-5554.
    • (2010) World J Gastroenterol , vol.16 , pp. 5543-5554
    • Watanabe, T.1
  • 41
    • 34848851982 scopus 로고    scopus 로고
    • Radioimmunotherapy for treatment of B-cell lymphomas and other hematologic malignancies
    • DOI 10.1097/MOH.0b013e3282efb17c, PII 0006275220071100000005
    • Park SI, Press OW. Radioimmunotherapy for treatment of B-cell lymphomas and other hematologic malignancies. Curr Opin Hematol. 2007;14:632-638. (Pubitemid 47494079)
    • (2007) Current Opinion in Hematology , vol.14 , Issue.6 , pp. 632-638
    • Park, S.I.1    Press, O.W.2
  • 42
    • 78650991430 scopus 로고    scopus 로고
    • Radioimmunotherapy of relapsed indolent non-Hodgkin lymphoma with 131I-rituximab in routine clinical practice: 10-year single-institution experience of 142 consecutive patients
    • Leahy MF, Turner JH. Radioimmunotherapy of relapsed indolent non-Hodgkin lymphoma with 131I-rituximab in routine clinical practice: 10-year single-institution experience of 142 consecutive patients. Blood. 2011;117:45-52.
    • (2011) Blood , vol.117 , pp. 45-52
    • Leahy, M.F.1    Turner, J.H.2
  • 48
    • 79957760097 scopus 로고    scopus 로고
    • The next generation of positron emission tomography radiopharmaceuticals in oncology
    • Rice SL, Roney CA, Daumar P, et al. The next generation of positron emission tomography radiopharmaceuticals in oncology. Semin Nucl Med. 2011;41:265-282.
    • (2011) Semin Nucl Med , vol.41 , pp. 265-282
    • Rice, S.L.1    Roney, C.A.2    Daumar, P.3
  • 50
    • 80051777429 scopus 로고    scopus 로고
    • Targeted, activatable, in vivo fluorescence imaging of Prostate-specific Membrane Antigen (PSMA)-positive tumors using the quenched humanized J591 antibody-ICG conjugate
    • Nakajima T, Mitsunaga M, Bander NH, et al. Targeted, activatable, in vivo fluorescence imaging of Prostate-specific Membrane Antigen (PSMA)-positive tumors using the quenched humanized J591 antibody-ICG conjugate. Bioconjug Chem. 2011;22:1700-1705.
    • (2011) Bioconjug Chem , vol.22 , pp. 1700-1705
    • Nakajima, T.1    Mitsunaga, M.2    Bander, N.H.3
  • 51
    • 70449347055 scopus 로고    scopus 로고
    • Approach to the patient after relapse of hairy cell leukemia
    • Kreitman RJ, Fitzgerald DJ, Pastan I. Approach to the patient after relapse of hairy cell leukemia. Leuk Lymphoma. 2009;50(Suppl 1):32-37.
    • (2009) Leuk Lymphoma , vol.50 , Issue.SUPPL. 1 , pp. 32-37
    • Kreitman, R.J.1    Fitzgerald, D.J.2    Pastan, I.3
  • 53
    • 79957455539 scopus 로고    scopus 로고
    • Recombinant immunotoxins and other therapies for relapsed/refractory hairy cell leukemia
    • Kreitman RJ, Arons E, Stetler-Stevenson M, et al. Recombinant immunotoxins and other therapies for relapsed/refractory hairy cell leukemia. Leuk Lymphoma. 2011;52(Suppl 2):82-86.
    • (2011) Leuk Lymphoma , vol.52 , Issue.SUPPL. 2 , pp. 82-86
    • Kreitman, R.J.1    Arons, E.2    Stetler-Stevenson, M.3
  • 55
    • 69349100450 scopus 로고    scopus 로고
    • Phase i trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P
    • Kreitman RJ, Hassan R, Fitzgerald DJ, et al. Phase I trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P. Clin Cancer Res. 2009;15:5274-5279.
    • (2009) Clin Cancer Res , vol.15 , pp. 5274-5279
    • Kreitman, R.J.1    Hassan, R.2    Fitzgerald, D.J.3
  • 56
    • 34548858453 scopus 로고    scopus 로고
    • Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers
    • DOI 10.1158/1078-0432.CCR-07-0869
    • Hassan R, Bullock S, Premkumar A, et al. Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers. Clin Cancer Res. 2007;13:5144-5149. (Pubitemid 47502082)
    • (2007) Clinical Cancer Research , vol.13 , Issue.17 , pp. 5144-5149
    • Hassan, R.1    Bullock, S.2    Premkumar, A.3    Kreitman, R.J.4    Kindler, H.5    Willingham, M.C.6    Pastan, I.7
  • 57
    • 3242698655 scopus 로고    scopus 로고
    • Phase i study of LMB-9 (B3(dsFv)PE38), a recombinant disulfide stabilized anti-Lewis y immunotoxin administered by continuous infusion
    • abstr 736
    • Hausner PF, Karp JE, Edelma NL, et al. Phase I study of LMB-9 (B3(dsFv)PE38), a recombinant disulfide stabilized anti-Lewis Y immunotoxin administered by continuous infusion. Proc Am Soc Clin Oncol. 2003:abstr 736.
    • (2003) Proc Am Soc Clin Oncol
    • Hausner, P.F.1    Karp, J.E.2    Edelma, N.L.3
  • 58
    • 1642494793 scopus 로고    scopus 로고
    • Pretreatment with Rituximab Does Not Inhibit the Human Immune Response against the Immunogenic Protein LMB-1
    • DOI 10.1158/1078-0432.CCR-1160-3
    • Hassan R, Williams-Gould J, Watson T, et al. Pretreatment with rituximab does not inhibit the human immune response against the immunogenic protein LMB-1. Clin Cancer Res. 2004;10:16-18. (Pubitemid 38114156)
    • (2004) Clinical Cancer Research , vol.10 , Issue.1 , pp. 16-18
    • Hassan, R.1    Williams-Gould, J.2    Watson, T.3    Pai-Scherf, L.4    Pastan, I.5
  • 59
    • 22144495793 scopus 로고    scopus 로고
    • A phase-1 trial of bexarotene and denileukin diftitox in patients with relapsed or refractory cutaneous T-cell lymphoma
    • DOI 10.1182/blood-2004-11-4570
    • Foss F, Demierre MF, DiVenuti G. A phase-1 trial of bexarotene and denileukin diftitox in patients with relapsed or refractory cutaneous T-cell lymphoma. Blood. 2005;106: 454-457. (Pubitemid 40981237)
    • (2005) Blood , vol.106 , Issue.2 , pp. 454-457
    • Foss, F.1    Demierre, M.F.2    DiVenuti, G.3
  • 61
    • 67749142288 scopus 로고    scopus 로고
    • A Phase II trial of Denileukin Diftitox in patients with previously treated advanced non-small cell lung cancer
    • Gerena-Lewis M, Crawford J, Bonomi P, et al. A Phase II trial of Denileukin Diftitox in patients with previously treated advanced non-small cell lung cancer. Am J Clin Oncol. 2009;32:269-273.
    • (2009) Am J Clin Oncol , vol.32 , pp. 269-273
    • Gerena-Lewis, M.1    Crawford, J.2    Bonomi, P.3
  • 62
    • 77951650540 scopus 로고    scopus 로고
    • Phase III placebocontrolled trial of denileukin diftitox for patients with cutaneous T-cell lymphoma
    • Prince HM, Duvic M, Martin A, et al. Phase III placebocontrolled trial of denileukin diftitox for patients with cutaneous T-cell lymphoma. J Clin Oncol. 2010;28:1870-1877.
    • (2010) J Clin Oncol , vol.28 , pp. 1870-1877
    • Prince, H.M.1    Duvic, M.2    Martin, A.3
  • 63
    • 79960501416 scopus 로고    scopus 로고
    • Novel immunotherapeutic agents and small molecule antagonists of signalling kinases for the treatment of metastatic melanoma
    • Natarajan N, Telang S, Miller D, et al. Novel immunotherapeutic agents and small molecule antagonists of signalling kinases for the treatment of metastatic melanoma. Drugs. 2011;71:1233-1250.
    • (2011) Drugs , vol.71 , pp. 1233-1250
    • Natarajan, N.1    Telang, S.2    Miller, D.3
  • 64
    • 78149246546 scopus 로고    scopus 로고
    • Pharmacology of anti-CD3 diphtheria immunotoxin in CD3 positive T-cell lymphoma trials
    • Woo JH, Lee YJ, Neville DM, et al. Pharmacology of anti-CD3 diphtheria immunotoxin in CD3 positive T-cell lymphoma trials. Methods Mol Biol. 2010;651:157-175.
    • (2010) Methods Mol Biol , vol.651 , pp. 157-175
    • Woo, J.H.1    Lee, Y.J.2    Neville, D.M.3
  • 65
    • 70249101823 scopus 로고    scopus 로고
    • Phase i dose escalation, pharmacokinetic and pharmacodynamic study of naptumomab estafenatox alone in patients with advanced cancer and with docetaxel in patients with advanced nonsmall-cell lung cancer
    • Borghaei H, Alpaugh K, Hedlund G, et al. Phase I dose escalation, pharmacokinetic and pharmacodynamic study of naptumomab estafenatox alone in patients with advanced cancer and with docetaxel in patients with advanced nonsmall-cell lung cancer. J Clin Oncol. 2009;27:4116-4123.
    • (2009) J Clin Oncol , vol.27 , pp. 4116-4123
    • Borghaei, H.1    Alpaugh, K.2    Hedlund, G.3
  • 67
    • 2142829523 scopus 로고    scopus 로고
    • A dominant linear B-cell epitope of ricin A-chain is the target of a neutralizing antibody response in Hodgkin's lymphoma patients treated with an anti-CD25 immunotoxin
    • DOI 10.1111/j.1365-2249.2004.02442.x
    • Castelletti D, Fracasso G, Righetti S, et al. A dominant linear B-cell epitope of ricin A-chain is the target of a neutralizing antibody response in Hodgkin's lymphoma patients treated with an anti-CD25 immunotoxin. Clin Exp Immunol. 2004; 136:365-372. (Pubitemid 38543458)
    • (2004) Clinical and Experimental Immunology , vol.136 , Issue.2 , pp. 365-372
    • Castelletti, D.1    Fracasso, G.2    Righetti, S.3    Tridente, G.4    Schnell, R.5    Engert, A.6    Colombatti, M.7
  • 70
    • 0029056665 scopus 로고
    • Continuous infusion of the anti-CD22 immunotoxin IgGRFB4-SMPT-dgA in patients with B-cell lymphoma: A phase i study
    • Sausville EA, Headlee D, Stetler-Stevenson M, et al. Continuous infusion of the anti-CD22 immunotoxin IgGRFB4-SMPT-dgA in patients with B-cell lymphoma: a phase I study. Blood. 1995;85:3457-3465.
    • (1995) Blood , vol.85 , pp. 3457-3465
    • Sausville, E.A.1    Headlee, D.2    Stetler-Stevenson, M.3
  • 73
    • 77955312203 scopus 로고    scopus 로고
    • Antibody-drug conjugates: Targeted drug delivery for cancer
    • Alley SC, Okeley NM, Senter PD. Antibody-drug conjugates: targeted drug delivery for cancer. Curr Opin Chem Biol. 2010;14:529-537.
    • (2010) Curr Opin Chem Biol , vol.14 , pp. 529-537
    • Alley, S.C.1    Okeley, N.M.2    Senter, P.D.3
  • 74
    • 84857235735 scopus 로고    scopus 로고
    • Food and Drug Administration Accessed September 26, 2011
    • Food and Drug Administration. Brentuximab Vedotin [FDA Web site]. 2011. Available at: http://www.fda.gov/AboutFDA/CentersOffices/CDER/ucm268969.htm, Accessed September 26, 2011.
    • (2011) Brentuximab Vedotin [FDA Web Site]
  • 75
    • 78651447411 scopus 로고    scopus 로고
    • A Phase II study of trastuzumab-DM1 (T-DM1), a Novel HER2 antibody-drug conjugate, in patients with HER2+ Metastatic breast cancer who were previously treated with an anthracycline, a taxane, capecitabine, lapatinib, and trastuzumab
    • Abstract 710
    • Krop I, Lo Russo P, Miller KD, et al, A Phase II Study of Trastuzumab-DM1 (T-DM1), a Novel HER2 Antibody-Drug Conjugate, in Patients with HER2+ Metastatic Breast Cancer who were Previously Treated with an Anthracycline, a Taxane, Capecitabine, Lapatinib, and Trastuzumab. 32nd Annual San Antonio Breast Cancer Symposium. 2009. Abstract 710.
    • (2009) 32nd Annual San Antonio Breast Cancer Symposium
    • Krop, I.1    Lo Russo, P.2    Miller, K.D.3
  • 76
    • 65249180124 scopus 로고    scopus 로고
    • Combining milatuzumab with bortezomib, doxorubicin, or dexamethasone improves responses in multiple myeloma cell lines
    • Stein R, Smith MR, Chen S, et al. Combining milatuzumab with bortezomib, doxorubicin, or dexamethasone improves responses in multiple myeloma cell lines. Clin Cancer Res. 2009;15:2808-2817.
    • (2009) Clin Cancer Res , vol.15 , pp. 2808-2817
    • Stein, R.1    Smith, M.R.2    Chen, S.3
  • 77
    • 79952992903 scopus 로고    scopus 로고
    • Immunoconjugates against solid tumors: Mind the gap
    • Ricart AD. Immunoconjugates against solid tumors: mind the gap. Clin Pharmacol Ther. 2011;89:513-523.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 513-523
    • Ricart, A.D.1
  • 79
    • 0026531995 scopus 로고
    • The macroscopic and microscopic pharmacology of monoclonal antibodies
    • Weinstein JN, van Osdol W. The macroscopic and microscopic pharmacology of monoclonal antibodies. Int J Immunopharmacol. 1992;14:457-463.
    • (1992) Int J Immunopharmacol , vol.14 , pp. 457-463
    • Weinstein, J.N.1    Van Osdol, W.2
  • 81
    • 70349083423 scopus 로고    scopus 로고
    • The pharmacologic basis for antibody-auristatin conjugate activity
    • Alley SC, Zhang X, Okeley NM, et al. The pharmacologic basis for antibody-auristatin conjugate activity. J Pharmacol Exp Ther. 2009;330:932-938.
    • (2009) J Pharmacol Exp Ther , vol.330 , pp. 932-938
    • Alley, S.C.1    Zhang, X.2    Okeley, N.M.3
  • 82
    • 4444290767 scopus 로고    scopus 로고
    • The radiation biology of radioimmunotherapy
    • DOI 10.1097/00006231-200309000-00002
    • Dixon KL. The radiation biology of radioimmunotherapy. Nucl Med Commun. 2003;24:951-957. (Pubitemid 39625408)
    • (2003) Nuclear Medicine Communications , vol.24 , Issue.9 , pp. 951-957
    • Dixon, K.L.1
  • 86
    • 78650868824 scopus 로고    scopus 로고
    • Radioimmunotherapy of solid tumors: Searching for the right target
    • Song H, Sgouros G. Radioimmunotherapy of solid tumors: searching for the right target. Curr Drug Deliv. 2011;8:26-44.
    • (2011) Curr Drug Deliv , vol.8 , pp. 26-44
    • Song, H.1    Sgouros, G.2
  • 88
    • 1642535523 scopus 로고    scopus 로고
    • Reducing the Immune Response to Immunotoxin
    • DOI 10.1158/1078-0432.CCR-1216-3
    • Frankel AE. Reducing the immune response to immunotoxin. Clin Cancer Res. 2004;10:13-15. (Pubitemid 38114155)
    • (2004) Clinical Cancer Research , vol.10 , Issue.1 , pp. 13-15
    • Frankel, A.E.1
  • 89
    • 0034895032 scopus 로고    scopus 로고
    • Antibody response to DT-GM, a novel fusion toxin consisting of a truncated diphtheria toxin (DT) linked to human granulocyte-macrophage colony stimulating factor (GM), during a phase i trial of patients with relapsed or refractory acute myeloid leukemia
    • Hall PD, Virella G, Willoughby T, et al. Antibody response to DT-GM, a novel fusion toxin consisting of a truncated diphtheria toxin (DT) linked to human granulocyte-macrophage colony stimulating factor (GM), during a phase I trial of patients with relapsed or refractory acute myeloid leukemia. Clin Immunol. 2001;100:191-197.
    • (2001) Clin Immunol , vol.100 , pp. 191-197
    • Hall, P.D.1    Virella, G.2    Willoughby, T.3
  • 90
    • 0023465986 scopus 로고
    • Humoral immune response to a ricin a chain immunotoxin in patients with metastatic melanoma
    • Hertler AA, Spitler LE, Frankel AE. Humoral immune response to a ricin a chain immunotoxin in patients with metastatic melanoma. Cancer Drug Deliv. 1987;4:245-253.
    • (1987) Cancer Drug Deliv , vol.4 , pp. 245-253
    • Hertler, A.A.1    Spitler, L.E.2    Frankel, A.E.3
  • 91
    • 67650678448 scopus 로고    scopus 로고
    • Humanized immunotoxins: A new generation of immunotoxins for targeted cancer therapy
    • Mathew M, Verma RS. Humanized immunotoxins: a new generation of immunotoxins for targeted cancer therapy. Cancer Sci. 2009;100:1359-1365.
    • (2009) Cancer Sci , vol.100 , pp. 1359-1365
    • Mathew, M.1    Verma, R.S.2
  • 92
  • 94
    • 0033125226 scopus 로고    scopus 로고
    • Antitumor necrosis factor therapy for inflammatory bowel disease: A review of agents, pharmacology, clinical results, and safety
    • Sandborn WJ, Hanauer SB. Antitumor necrosis factor therapy for inflammatory bowel disease: a review of agents, pharmacology, clinical results, and safety. Inflamm Bowel Dis. 1999;5:119-133.
    • (1999) Inflamm Bowel Dis , vol.5 , pp. 119-133
    • Sandborn, W.J.1    Hanauer, S.B.2
  • 95
    • 38949192547 scopus 로고    scopus 로고
    • Targeted cancer therapy: Conferring specificity to cytotoxic drugs
    • Chari RV. Targeted cancer therapy: conferring specificity to cytotoxic drugs. Acc Chem Res. 2008;41:98-107.
    • (2008) Acc Chem Res , vol.41 , pp. 98-107
    • Chari, R.V.1
  • 97
    • 0031991416 scopus 로고    scopus 로고
    • Siglecs: A family of sialic-acid binding lectins
    • Crocker PR, Clark EA, Filbin M, et al. Siglecs: a family of sialic-acid binding lectins. Glycobiology. 1998;8:v.
    • (1998) Glycobiology , vol.8
    • Crocker, P.R.1    Clark, E.A.2    Filbin, M.3
  • 99
    • 0034773992 scopus 로고    scopus 로고
    • The EGFR family and its ligands in human cancer: Signalling mechanisms and therapeutic opportunities
    • PII S0959804901002301
    • Yarden Y. The EGFR family and its ligands in human cancer: signalling mechanisms and therapeutic opportunities. Eur J Cancer. 2001;37(Suppl 4):S3-S8. (Pubitemid 32938123)
    • (2001) European Journal of Cancer , vol.37 , Issue.SUPPL. 4
    • Yarden, Y.1
  • 101
    • 80055001527 scopus 로고    scopus 로고
    • Her-2/neu gene amplification and over-expression in stomach and esophageal adenocarcinoma: From pathology to treatment
    • [Epub ahead of print]
    • Maresch J, Schoppmann SF, Thallinger CM, et al. Her-2/neu gene amplification and over-expression in stomach and esophageal adenocarcinoma: from pathology to treatment. Crit Rev Oncol Hematol. 2011. [Epub ahead of print].
    • (2011) Crit Rev Oncol Hematol
    • Maresch, J.1    Schoppmann, S.F.2    Thallinger, C.M.3
  • 102
    • 67649335394 scopus 로고    scopus 로고
    • Advances in preclinical small molecules for the treatment of NSCLC
    • Zhang Q, Feng W, Zhou H, et al. Advances in preclinical small molecules for the treatment of NSCLC. Expert Opin Ther Pat. 2009;19:731-751.
    • (2009) Expert Opin Ther Pat , vol.19 , pp. 731-751
    • Zhang, Q.1    Feng, W.2    Zhou, H.3
  • 106
    • 0030500450 scopus 로고    scopus 로고
    • New perspectives in clinical oncology from angiogenesis research
    • Folkman J. New perspectives in clinical oncology from angiogenesis research. Eur J Cancer. 1996;32A:2534-2539.
    • (1996) Eur J Cancer , vol.32 A , pp. 2534-2539
    • Folkman, J.1
  • 107
    • 0031026481 scopus 로고    scopus 로고
    • Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature
    • DOI 10.1126/science.275.5299.547
    • Huang X, Molema G, King S, et al. Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature. Science. 1997;275:547-550. (Pubitemid 27051913)
    • (1997) Science , vol.275 , Issue.5299 , pp. 547-550
    • Huang, X.1    Molema, G.2    King, S.3    Watkins, L.4    Edgington, T.S.5    Thorpe, P.E.6
  • 108
    • 0032532656 scopus 로고    scopus 로고
    • Infarction of solid Hodgkin's tumors in mice by antibody-directed targeting of tissue factor to tumor vasculature
    • Ran S, Gao B, Duffy S, et al. Infarction of solid Hodgkin's tumors in mice by antibody-directed targeting of tissue factor to tumor vasculature. Cancer Res. 1998;58:4646-4653. (Pubitemid 28480630)
    • (1998) Cancer Research , vol.58 , Issue.20 , pp. 4646-4653
    • Ran, S.1    Gao, B.2    Duffy, S.3    Watkins, L.4    Rote, N.5    Thorpe, P.E.6
  • 109
    • 0032971818 scopus 로고    scopus 로고
    • Induction of lasting complete regression of preformed distinct solid tumors by targeting the tumor vasculature using two new anti-endoglin monoclonal antibodies
    • Matsuno F, Haruta Y, Kondo M, et al. Induction of lasting complete regression of preformed distinct solid tumors by targeting the tumor vasculature using two new anti-endoglin monoclonal antibodies. Clin Cancer Res. 1999;5:371-382. (Pubitemid 29085191)
    • (1999) Clinical Cancer Research , vol.5 , Issue.2 , pp. 371-382
    • Matsuno, F.1    Haruta, Y.2    Kondo, M.3    Tsai, H.4    Barcos, M.5    Seon, B.K.6
  • 110
    • 0031564123 scopus 로고    scopus 로고
    • Targeting the tumor vasculature: Inhibition of tumor growth by a vascular endothelial growth factor-toxin conjugate
    • Olson TA, Mohanraj D, Roy S, et al. Targeting the tumor vasculature: inhibition of tumor growth by a vascular endothelial growth factor-toxin conjugate. Int J Cancer. 1997;73:865-870. (Pubitemid 127483042)
    • (1997) International Journal of Cancer , vol.73 , Issue.6 , pp. 865-870
    • Olson, T.A.1    Mohanraj, D.2    Roy, S.3    Ramakrishnan, S.4
  • 111
    • 0032943892 scopus 로고    scopus 로고
    • Vascular endothelial growth factor chimeric toxin is highly active against endothelial cells
    • Arora N, Masood R, Zheng T, et al. Vascular endothelial growth factor chimeric toxin is highly active against endothelial cells. Cancer Res. 1999;59:183-188. (Pubitemid 29062976)
    • (1999) Cancer Research , vol.59 , Issue.1 , pp. 183-188
    • Arora, N.1    Masood, R.2    Zheng, T.3    Cai, J.4    Smith, D.L.5    Gill, P.S.6
  • 112
    • 0032535999 scopus 로고    scopus 로고
    • Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
    • DOI 10.1126/science.279.5349.377
    • Arap W, Pasqualini R, Ruoslahti E. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science. 1998;279:377-380. (Pubitemid 28063372)
    • (1998) Science , vol.279 , Issue.5349 , pp. 377-380
    • Arap, W.1    Pasqualini, R.2    Ruoslahti, E.3
  • 114
    • 0032580493 scopus 로고    scopus 로고
    • Delivery of molecular and cellular medicine to solid tumors
    • DOI 10.1016/S0168-3659(97)00237-X, PII S016836599700237X
    • Jain RK. Delivery of molecular and cellular medicine to solid tumors. J Control Release. 1998;53:49-67. (Pubitemid 28218689)
    • (1998) Journal of Controlled Release , vol.53 , Issue.1-3 , pp. 49-67
    • Jain, R.K.1
  • 115
    • 0037264969 scopus 로고    scopus 로고
    • Therapeutic antibodies for human diseases at the dawn of the twenty-first century
    • DOI 10.1038/nrd984
    • Brekke OH, Sandlie I. Therapeutic antibodies for human diseases at the dawn of the twenty-first century. Nat Rev Drug Discov. 2003;2:52-62. (Pubitemid 37361624)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.1 , pp. 52-62
    • Brekke, O.H.1    Sandlie, I.2
  • 116
    • 68349117269 scopus 로고    scopus 로고
    • Single domain antibodies: Promising experimental and therapeutic tools in infection and immunity
    • Wesolowski J, Alzogaray V, Reyelt J, et al. Single domain antibodies: promising experimental and therapeutic tools in infection and immunity. Med Microbiol Immunol. 2009;198: 157-174.
    • (2009) Med Microbiol Immunol , vol.198 , pp. 157-174
    • Wesolowski, J.1    Alzogaray, V.2    Reyelt, J.3
  • 117
    • 77953653252 scopus 로고    scopus 로고
    • Antibody fragments: Hope and hype
    • Nelson AL. Antibody fragments: hope and hype. MAbs. 2010;2:77-83.
    • (2010) MAbs , vol.2 , pp. 77-83
    • Nelson, A.L.1
  • 118
    • 64349107630 scopus 로고    scopus 로고
    • Development trends for therapeutic antibody fragments
    • Nelson AL, Reichert JM. Development trends for therapeutic antibody fragments. Nat Biotechnol. 2009;27:331-337.
    • (2009) Nat Biotechnol , vol.27 , pp. 331-337
    • Nelson, A.L.1    Reichert, J.M.2
  • 119
    • 4043152053 scopus 로고    scopus 로고
    • Peptibodies: The new cool technology
    • DOI 10.1016/S1359-6446(04)03216-7, PII S1359644604032167
    • Sutherland S. Peptibodies: the new cool technology. Drug Discov Today. 2004;9:683. (Pubitemid 39070275)
    • (2004) Drug Discovery Today , vol.9 , Issue.16 , pp. 683
    • Sutherland, S.1
  • 120
    • 0037235949 scopus 로고    scopus 로고
    • Engineered antibodies
    • DOI 10.1038/nm0103-129
    • Hudson PJ, Souriau C. Engineered antibodies. Nat Med. 2003;9:129-134. (Pubitemid 36098274)
    • (2003) Nature Medicine , vol.9 , Issue.1 , pp. 129-134
    • Hudson, P.J.1    Souriau, C.2
  • 122
    • 33645500289 scopus 로고    scopus 로고
    • Antibodymaytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing
    • Erickson HK, Park PU, Widdison WC, et al. Antibodymaytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing. Cancer Res. 2006;66:4426-4433.
    • (2006) Cancer Res , vol.66 , pp. 4426-4433
    • Erickson, H.K.1    Park, P.U.2    Widdison, W.C.3
  • 123
    • 74949107560 scopus 로고    scopus 로고
    • Antibody-drug conjugates: Linking cytotoxic payloads to monoclonal antibodies
    • Ducry L, Stump B. Antibody-drug conjugates: linking cytotoxic payloads to monoclonal antibodies. Bioconjug Chem. 2010;21:5-13.
    • (2010) Bioconjug Chem , vol.21 , pp. 5-13
    • Ducry, L.1    Stump, B.2
  • 124
    • 0034651996 scopus 로고    scopus 로고
    • Unraveling the role of proteases in cancer
    • DOI 10.1016/S0009-8981(99)00224-7, PII S0009898199002247
    • Koblinski JE, Ahram M, Sloane BF. Unraveling the role of proteases in cancer. Clin Chim Acta. 2000;291:113-135. (Pubitemid 30089760)
    • (2000) Clinica Chimica Acta , vol.291 , Issue.2 , pp. 113-135
    • Koblinski, J.E.1    Ahram, M.2    Sloane, B.F.3
  • 125
    • 49449087300 scopus 로고    scopus 로고
    • Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
    • Junutula JR, Raab H, Clark S, et al. Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Nat Biotechnol. 2008;26:925-932.
    • (2008) Nat Biotechnol , vol.26 , pp. 925-932
    • Junutula, J.R.1    Raab, H.2    Clark, S.3
  • 126
    • 65549151884 scopus 로고    scopus 로고
    • Antibodydrug conjugates for the treatment of non-Hodgkin's lymphoma: Target and linker-drug selection
    • Polson AG, Calemine-Fenaux J, Chan P, et al. Antibodydrug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection. Cancer Res. 2009;69: 2358-2364.
    • (2009) Cancer Res , vol.69 , pp. 2358-2364
    • Polson, A.G.1    Calemine-Fenaux, J.2    Chan, P.3
  • 127
    • 34848861947 scopus 로고    scopus 로고
    • The dock and lock method: A novel platform technology for building multivalent, multifunctional structures of defined composition with retained bioactivity
    • DOI 10.1158/1078-0432.CCR-07-1217
    • Chang CH, Rossi EA, Goldenberg DM. The dock and lock method: a novel platform technology for building multivalent, multifunctional structures of defined composition with retained bioactivity. Clin Cancer Res. 2007;13: 5586s-5591s. (Pubitemid 47510391)
    • (2007) Clinical Cancer Research , vol.13 , Issue.18
    • Chang, C.-H.1    Rossi, E.A.2    Goldenberg, D.M.3
  • 128
    • 47049095740 scopus 로고    scopus 로고
    • Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides
    • Liu S. Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides. Adv Drug Deliv Rev. 2008;60:1347-1370.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 1347-1370
    • Liu, S.1
  • 129
    • 79960820705 scopus 로고    scopus 로고
    • Immunotoxins and anticancer drug conjugate assemblies: The role of the linkage between components
    • Dosio F, Brusa P, Cattel L. Immunotoxins and anticancer drug conjugate assemblies: the role of the linkage between components. Toxins. 2011;3:848-883.
    • (2011) Toxins , vol.3 , pp. 848-883
    • Dosio, F.1    Brusa, P.2    Cattel, L.3
  • 130
    • 77950224905 scopus 로고    scopus 로고
    • Antibodymaytansinoid conjugates designed to bypass multidrug resistance
    • Kovtun YV, Audette CA, Mayo MF, et al. Antibodymaytansinoid conjugates designed to bypass multidrug resistance. Cancer Res. 2010;70:2528-2537.
    • (2010) Cancer Res , vol.70 , pp. 2528-2537
    • Kovtun, Y.V.1    Audette, C.A.2    Mayo, M.F.3
  • 131
    • 0344082608 scopus 로고    scopus 로고
    • Progress in the development and acquisition of anticancer agents from marine sources
    • DOI 10.1093/annonc/mdg443
    • Amador ML, Jimeno J, Paz-Ares L, et al. Progress in the development and acquisition of anticancer agents from marine sources. Ann Oncol. 2003;14:1607-1615. (Pubitemid 37460970)
    • (2003) Annals of Oncology , vol.14 , Issue.11 , pp. 1607-1615
    • Amador, M.L.1    Jimeno, J.2    Paz-Ares, L.3    Cortes-Funes, H.4    Hidalgo, M.5
  • 136
    • 0024322591 scopus 로고
    • Calicheamicins, a novel family of antitumor antibiotics. 3: Isolation, purification and characterization of calicheamicins beta 1Br, gamma 1Br, alpha 2I, alpha 3I, beta 1I, gamma 1I and delta 1I
    • Lee MD, Manning JK, Williams DR, et al. Calicheamicins, a novel family of antitumor antibiotics. 3: isolation, purification and characterization of calicheamicins beta 1Br, gamma 1Br, alpha 2I, alpha 3I, beta 1I, gamma 1I and delta 1I. J Antibiot (Tokyo). 1989;42:1070-1087.
    • (1989) J Antibiot (Tokyo) , vol.42 , pp. 1070-1087
    • Lee, M.D.1    Manning, J.K.2    Williams, D.R.3
  • 137
    • 0023820894 scopus 로고
    • Calicheamicin gamma 1I: An antitumor antibiotic that cleaves double-stranded DNA site specifically
    • Zein N, Sinha AM, McGahren WJ, et al. Calicheamicin gamma 1I: an antitumor antibiotic that cleaves double-stranded DNA site specifically. Science. 1988;240: 1198-1201.
    • (1988) Science , vol.240 , pp. 1198-1201
    • Zein, N.1    Sinha, A.M.2    McGahren, W.J.3
  • 138
    • 0025336716 scopus 로고
    • Structure/function analysis of interleukin-2-toxin (DAB486-IL-2): Fragment B sequences required for the delivery of fragment A to the cytosol of target cells
    • Williams DP, Snider CE, Strom TB, et al. Structure/function analysis of interleukin-2-toxin (DAB486-IL-2): fragment B sequences required for the delivery of fragment A to the cytosol of target cells. J Biol Chem. 1990;265:11885-11889.
    • (1990) J Biol Chem , vol.265 , pp. 11885-11889
    • Williams, D.P.1    Snider, C.E.2    Strom, T.B.3
  • 139
    • 0034468310 scopus 로고    scopus 로고
    • Principles of radioimmunotherapy for hematologists and oncologists
    • Press OW, Rasey J. Principles of radioimmunotherapy for hematologists and oncologists. Semin Oncol. 2000;27: 62-73. (Pubitemid 32164597)
    • (2000) Seminars in Oncology , vol.27 , Issue.6 SUPPL. 12 , pp. 62-73
    • Press, O.W.1    Rasey, J.2
  • 141
    • 0025827668 scopus 로고
    • Choosing the right radionuclide and antibody for intraperitoneal radioimmunotherapy
    • Larson SM. Choosing the right radionuclide and antibody for intraperitoneal radioimmunotherapy. J Natl Cancer Inst. 1991;83:1602-1604.
    • (1991) J Natl Cancer Inst , vol.83 , pp. 1602-1604
    • Larson, S.M.1
  • 142
    • 0032848896 scopus 로고    scopus 로고
    • Radioimmunotherapy for lymphoma
    • DOI 10.1097/00001622-199909000-00009
    • Zelenetz AD. Radioimmunotherapy for lymphoma. Curr Opin Oncol. 1999;11:375-380. (Pubitemid 29410880)
    • (1999) Current Opinion in Oncology , vol.11 , Issue.5 , pp. 375-380
    • Zelenetz, A.D.1
  • 143
    • 80052665722 scopus 로고    scopus 로고
    • Prostate-specific membrane antigen-based therapeutics
    • Akhtar NH, Pail O, Saran A, et al. Prostate-specific membrane antigen-based therapeutics. Advances in Urology. 2012;2012:973820.
    • (2012) Advances in Urology , vol.2012 , pp. 973820
    • Akhtar, N.H.1    Pail, O.2    Saran, A.3
  • 144
    • 68949213822 scopus 로고    scopus 로고
    • Antibody-directed enzyme prodrug therapy: A promising approach for a selective treatment of cancer based on prodrugs and monoclonal antibodies
    • Tietze LF, Krewer B. Antibody-directed enzyme prodrug therapy: a promising approach for a selective treatment of cancer based on prodrugs and monoclonal antibodies. Chem Biol Drug Des. 2009;74:205-211.
    • (2009) Chem Biol Drug des , vol.74 , pp. 205-211
    • Tietze, L.F.1    Krewer, B.2
  • 145
    • 80052972715 scopus 로고    scopus 로고
    • A humanized immunoenzyme with enhanced activity for glucuronide prodrug activation in the tumor microenvironment
    • Chen KC, Wu SY, Leu YL, et al. A humanized immunoenzyme with enhanced activity for glucuronide prodrug activation in the tumor microenvironment. Bioconjug Chem. 2011; 22:938-948.
    • (2011) Bioconjug Chem , vol.22 , pp. 938-948
    • Chen, K.C.1    Wu, S.Y.2    Leu, Y.L.3
  • 146
    • 74349104707 scopus 로고    scopus 로고
    • Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT
    • Afshar S, Olafsen T, Wu AM, et al. Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT. J Exp Clin Cancer Res. 2009;28:147.
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 147
    • Afshar, S.1    Olafsen, T.2    Wu, A.M.3
  • 147
    • 14644396096 scopus 로고    scopus 로고
    • Nanomedicine: Current status and future prospects
    • DOI 10.1096/fj.04-2747rev
    • Moghimi SM, Hunter AC, Murray JC. Nanomedicine: current status and future prospects. FASEB J. 2005;19: 311-330. (Pubitemid 40316520)
    • (2005) FASEB Journal , vol.19 , Issue.3 , pp. 311-330
    • Moghimi, S.M.1    Hunter, A.C.2    Murray, J.C.3
  • 148
    • 79953792313 scopus 로고    scopus 로고
    • Nanomedicine: A new frontier in cancer therapeutics
    • Lee PY, Wong KK. Nanomedicine: a new frontier in cancer therapeutics. Curr Drug Deliv. 2011;8:245-253.
    • (2011) Curr Drug Deliv , vol.8 , pp. 245-253
    • Lee, P.Y.1    Wong, K.K.2
  • 149
    • 77951888124 scopus 로고    scopus 로고
    • Nanotechnology applications in surgical oncology
    • Singhal S, Nie S, Wang MD. Nanotechnology applications in surgical oncology. Annu Rev Med. 2010;61:359-373.
    • (2010) Annu Rev Med , vol.61 , pp. 359-373
    • Singhal, S.1    Nie, S.2    Wang, M.D.3
  • 150
    • 3543022686 scopus 로고    scopus 로고
    • In vivo cancer targeting and imaging with semiconductor quantum dots
    • DOI 10.1038/nbt994
    • Gao X, Cui Y, Levenson RM, et al. In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol. 2004;22:969-976. (Pubitemid 39014473)
    • (2004) Nature Biotechnology , vol.22 , Issue.8 , pp. 969-976
    • Gao, X.1    Cui, Y.2    Levenson, R.M.3    Chung, L.W.K.4    Nie, S.5
  • 151
    • 43949092126 scopus 로고    scopus 로고
    • Imaging of primary and metastatic pancreatic cancer using a fluorophore-conjugated anti-CA19-9 antibody for surgical navigation
    • McElroy M, Kaushal S, Luiken GA, et al. Imaging of primary and metastatic pancreatic cancer using a fluorophore-conjugated anti-CA19-9 antibody for surgical navigation. World J Surg. 2008;32:1057-1066.
    • (2008) World J Surg , vol.32 , pp. 1057-1066
    • McElroy, M.1    Kaushal, S.2    Luiken, G.A.3
  • 152
    • 54349097441 scopus 로고    scopus 로고
    • Fluorophoreconjugated anti-CEA antibody for the intraoperative imaging of pancreatic and colorectal cancer
    • Kaushal S, McElroy MK, Luiken GA, et al. Fluorophoreconjugated anti-CEA antibody for the intraoperative imaging of pancreatic and colorectal cancer. J Gastrointest Surg. 2008;12:1938-1950.
    • (2008) J Gastrointest Surg , vol.12 , pp. 1938-1950
    • Kaushal, S.1    McElroy, M.K.2    Luiken, G.A.3
  • 153
    • 77950419552 scopus 로고    scopus 로고
    • From combinatorial peptide selection to drug prototype (II): Targeting the epidermal growth factor receptor pathway
    • Cardo-Vila M, Giordano RJ, Sidman RL, et al. From combinatorial peptide selection to drug prototype (II): targeting the epidermal growth factor receptor pathway. Proc Natl Acad Sci USA. 2010;107:5118-5123.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 5118-5123
    • Cardo-Vila, M.1    Giordano, R.J.2    Sidman, R.L.3
  • 155
    • 77956903170 scopus 로고    scopus 로고
    • Vascular endothelial growth factor as an anti-angiogenic target for cancer therapy
    • Niu G, Chen X. Vascular endothelial growth factor as an anti-angiogenic target for cancer therapy. Curr Drug Targets. 2010;11:1000-1017.
    • (2010) Curr Drug Targets , vol.11 , pp. 1000-1017
    • Niu, G.1    Chen, X.2
  • 156
    • 79957701112 scopus 로고    scopus 로고
    • EGFR targeted PLGA nanoparticles using gemcitabine for treatment of pancreatic cancer
    • Aggarwal S, Yadav S, Gupta S. EGFR targeted PLGA nanoparticles using gemcitabine for treatment of pancreatic cancer. J Biomed Nanotechnol. 2011;7:137-138.
    • (2011) J Biomed Nanotechnol , vol.7 , pp. 137-138
    • Aggarwal, S.1    Yadav, S.2    Gupta, S.3
  • 157
    • 75549103960 scopus 로고
    • Physical structure and behavior of lipids and lipid enzymes
    • Bangham AD. Physical structure and behavior of lipids and lipid enzymes. Adv Lipid Res. 1963;1:65-104.
    • (1963) Adv Lipid Res , vol.1 , pp. 65-104
    • Bangham, A.D.1
  • 158
    • 0015379583 scopus 로고
    • Lysosomal localization of-fructofuranosidase-containing liposomes injected into rats
    • Gregoriadis G, Ryman BE. Lysosomal localization of-fructofuranosidase- containing liposomes injected into rats. Biochem J. 1972;129:123-133.
    • (1972) Biochem J , vol.129 , pp. 123-133
    • Gregoriadis, G.1    Ryman, B.E.2
  • 159
    • 0030681273 scopus 로고    scopus 로고
    • Liposomes: Opportunities in drug delivery
    • Allen TM. Liposomes: opportunities in drug delivery. Drugs. 1997;54(Suppl 4):8-14.
    • (1997) Drugs , vol.54 , Issue.SUPPL. 4 , pp. 8-14
    • Allen, T.M.1
  • 160
    • 0032851735 scopus 로고    scopus 로고
    • Immunoliposomes for the targeted delivery of antitumor drugs
    • DOI 10.1016/S0169-409X(99)00043-5, PII S0169409X99000435
    • Mastrobattista E, Koning GA, Storm G. Immunoliposomes for the targeted delivery of antitumor drugs. Adv Drug Deliv Rev. 1999;40:103-127. (Pubitemid 29486607)
    • (1999) Advanced Drug Delivery Reviews , vol.40 , Issue.1-2 , pp. 103-127
    • Mastrobattista, E.1    Koning, G.A.2    Storm, G.3
  • 163
    • 0032824375 scopus 로고    scopus 로고
    • Possibility of active targeting to tumor tissues with liposomes
    • DOI 10.1016/S0169-409X(99)00042-3, PII S0169409X99000423
    • Maruyama K, Ishida O, Takizawa T, et al. Possibility of active targeting to tumor tissues with liposomes. Adv Drug Deliv Rev. 1999;40:89-102. (Pubitemid 29486606)
    • (1999) Advanced Drug Delivery Reviews , vol.40 , Issue.1-2 , pp. 89-102
    • Maruyama, K.1    Ishida, O.2    Takizawa, T.3    Moribe, K.4
  • 164
    • 0023280158 scopus 로고
    • Fate and behavior of liposomes in vivo: A review of controlling factors
    • Senior JH. Fate and behavior of liposomes in vivo: a review of controlling factors. Crit Rev Ther Drug Carrier Syst. 1987;3:123-193. (Pubitemid 17219201)
    • (1987) Critical Reviews in Therapeutic Drug Carrier Systems , vol.3 , Issue.2 , pp. 123-193
    • Senior, J.H.1
  • 165
    • 0026541171 scopus 로고
    • Serum opsonins and liposomes: Their interaction and opsonophagocytosis
    • Patel HM. Serum opsonins and liposomes: their interaction and opsonophagocytosis. Crit Rev Ther Drug Carrier Syst. 1992;9:39-90.
    • (1992) Crit Rev Ther Drug Carrier Syst , vol.9 , pp. 39-90
    • Patel, H.M.1
  • 170
    • 0032946945 scopus 로고    scopus 로고
    • Targetability of novel immunoliposomes prepared by a new antibody conjugation technique
    • DOI 10.1016/S0378-5173(99)00002-2, PII S0378517399000022
    • Bendas G, Krause A, Bakowsky U, et al. Targetability of novel immunoliposomes prepared by a new antibody conjugation technique. Int J Pharm. 1999;181:79-93. (Pubitemid 29199890)
    • (1999) International Journal of Pharmaceutics , vol.181 , Issue.1 , pp. 79-93
    • Bendas, G.1    Krause, A.2    Bakowsky, U.3    Vogel, J.4    Rothe, U.5
  • 171
    • 0030876540 scopus 로고    scopus 로고
    • Immunoliposomes bearing polyethyleneglycol-coupled Fab' fragment show prolonged circulation time and high extravasation into targeted solid tumors in vivo
    • DOI 10.1016/S0014-5793(97)00905-8, PII S0014579397009058
    • Maruyama K, Takahashi N, Tagawa T, et al. Immunoliposomes bearing polyethyleneglycol-coupled Fab' fragment show prolonged circulation time and high extravasation into targeted solid tumors in vivo. FEBS Lett. 1997;413:177-180. (Pubitemid 27348659)
    • (1997) FEBS Letters , vol.413 , Issue.1 , pp. 177-180
    • Maruyama, K.1    Takahashi, N.2    Tagawa, T.3    Nagaike, K.4    Iwatsuru, M.5
  • 172
    • 0016666851 scopus 로고
    • The resistance of glycoproteins to proteolytic inactivation
    • Vegarud G, Christensen TB. The resistance of glycoproteins to proteolytic inactivation. Acta Chem Scand B. 1975;29:887-888.
    • (1975) Acta Chem Scand B , vol.29 , pp. 887-888
    • Vegarud, G.1    Christensen, T.B.2
  • 173
    • 75149183678 scopus 로고    scopus 로고
    • Glycosylation of therapeutic proteins: An effective strategy to optimize efficacy
    • Sola RJ, Griebenow K. Glycosylation of therapeutic proteins: an effective strategy to optimize efficacy. BioDrugs. 2010; 24:9-21.
    • (2010) BioDrugs , vol.24 , pp. 9-21
    • Sola, R.J.1    Griebenow, K.2
  • 174
    • 35248882544 scopus 로고    scopus 로고
    • Modulation of protein biophysical properties by chemical glycosylation: Biochemical insights and biomedical implications
    • DOI 10.1007/s00018-007-6551-y
    • Sola RJ, Rodriguez-Martinez JA, Griebenow K. Modulation of protein biophysical properties by chemical glycosylation: biochemical insights and biomedical implications. Cell Mol Life Sci. 2007;64:2133-2152. (Pubitemid 350092414)
    • (2007) Cellular and Molecular Life Sciences , vol.64 , Issue.16 , pp. 2133-2152
    • Sola, R.J.1    Rodriguez-Martinez, J.A.2    Griebenow, K.3
  • 175
    • 77956545725 scopus 로고    scopus 로고
    • Long-lasting antitumor protection by anti-CD20 antibody through cellular immune response
    • Abes R, Gelize E, Fridman WH, et al. Long-lasting antitumor protection by anti-CD20 antibody through cellular immune response. Blood. 2010;116:926-934.
    • (2010) Blood , vol.116 , pp. 926-934
    • Abes, R.1    Gelize, E.2    Fridman, W.H.3
  • 176
    • 0021891884 scopus 로고
    • Assembly of asparagine-linked oligosaccharides
    • Kornfeld R, Kornfeld S. Assembly of asparagine-linked oligosaccharides. Annu Rev Biochem. 1985;54:631-664. (Pubitemid 15073660)
    • (1985) Annual Review of Biochemistry , vol.54 , pp. 631-664
    • Kornfeld, R.1    Kornfeld, S.2
  • 179
    • 34548522063 scopus 로고    scopus 로고
    • Alternative non-antibody scaffolds for molecular recognition
    • DOI 10.1016/j.copbio.2007.04.010, PII S0958166907000808, Protein technologies / Systems Biology
    • Skerra A. Alternative non-antibody scaffolds for molecular recognition. Curr Opin Biotechnol. 2007;18:295-304. (Pubitemid 47385180)
    • (2007) Current Opinion in Biotechnology , vol.18 , Issue.4 , pp. 295-304
    • Skerra, A.1


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