Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy

Journal of Controlled Release

Volumn 154, Issue 3, 2011, Pages 241-248

  Etrych, Tomáš ^a   Kovář, Lubomír ^b   Strohalm, Jiří ^a   Chytil, Petr ^a   Říhová, Blanka ^b   Ulbrich, Karel ^a  

^a INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

^b INSTITUTE OF MICROBIOLOGY   (Czech Republic)

Author keywords

Drug release; HPMA copolymers; Polymer degradation; Star polymer; Tumor targeting

Indexed keywords

DRUG RELEASE; HPMA COPOLYMERS; POLYMER DEGRADATION; STAR POLYMER; TUMOR TARGETING;

AMIDES; BEARINGS (STRUCTURAL); BIODEGRADATION; BLOOD; COPOLYMERIZATION; COPOLYMERS; DEGRADATION; DENDRIMERS; ENZYME ACTIVITY; MAMMALS; ONCOLOGY; POLYDISPERSITY; STARS; SYNTHESIS (CHEMICAL); TUMORS;

BIODEGRADABLE POLYMERS;

CATHEPSIN B; COPOLYMER; DOXORUBICIN; GLUTATHIONE; HYDRAZONE DERIVATIVE; N (2 HYDROXYPROPYL)METHACRYLAMIDE; POLYAMIDOAMINE; POLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIODEGRADABILITY; CANCER CELL CULTURE; CANCER SURVIVAL; CONTROLLED STUDY; DRUG CLEARANCE; DRUG CONJUGATION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG RELEASE; DRUG STABILITY; DRUG SYNTHESIS; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEREOSPECIFICITY; SURVIVAL RATE; SURVIVAL TIME; T CELL LYMPHOMA;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BIOCOMPATIBLE MATERIALS; CELL LINE, TUMOR; DENDRIMERS; DOXORUBICIN; HUMANS; LYMPHOMA; METHACRYLATES; MICE;

EID: 80052517546     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.06.015     Document Type: Article

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