Micellar nanocontainers distribute to defined cytoplasmic organelles

Science

Volumn 300, Issue 5619, 2003, Pages 615-618

  Savić, Radoslav ^a   Luo, Laibin ^a   Eisenberg, Adi ^a   Maysinger, Dusica ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCOMPATIBILITY; CELLS; DRUG DOSAGE; MICELLES;

MICELLAR NANOCONTAINERS;

NANOSTRUCTURED MATERIALS;

AZIDE; COPOLYMER; NANOPARTICLE; POLYCAPROLACTONE; POLYCAPROLACTONE BLOCK COPOLYMER; RHODAMINE; TETRAMETHYLRHODAMINE 5 CARBONYL AZIDE; UNCLASSIFIED DRUG;

DRUG DEVELOPMENT; MICROBIOLOGY;

ANIMAL CELL; ARTICLE; BIOCOMPATIBILITY; CELL ORGANELLE; CELL STRAIN 3T3; CELLULAR DISTRIBUTION; CHEMICAL STRUCTURE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; FLUORESCENCE; HYDROPHOBICITY; MICELLE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ANIMALS; AZIDES; BIOCOMPATIBLE MATERIALS; CELL NUCLEUS; CYTOPLASM; DIFFUSION; DRUG CARRIERS; ENDOPLASMIC RETICULUM; ETHYLENE OXIDE; FLUORESCEINS; FLUORESCENCE; GOLGI APPARATUS; HYDROPHOBICITY; LACTONES; LYSOSOMES; MICELLES; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; NANOTECHNOLOGY; ORGANELLES; PC12 CELLS; POLYETHYLENE GLYCOLS; POLYMERS; RATS; RHODAMINES; SOLUBILITY; SPECTROMETRY, FLUORESCENCE;

ANIMALIA;

EID: 0242584817     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1078192     Document Type: Article

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26. Supported by the Natural Sciences and Engineering Research Council of Canada and the Juvenile Diabetes Research Foundation. We thank J. Laliberté for technical assistance, P. Lim Soo for making the micelles, B. Hales for access to the microplate spectrofluorometer, and J. Diamond and B. Collier for comments on the manuscript.