Statistical pattern matching facilitates the design of polyvalent inhibitors of anthrax and cholera toxins

Nature Biotechnology

Volumn 24, Issue 5, 2006, Pages 582-586

  Rai, Prakash ^a   Padala, Chakradhar ^a   Poon, Vincent ^b   Saraph, Arundhati ^a   Basha, Saleem ^a   Kate, Sandesh ^a   Tao, Kevin ^b   Mogridge, Jeremy ^b   Kane, Ravi S ^a  

^a Rensselaer Polytechnic Institute   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMIMETIC MATERIALS; CONCENTRATION (PROCESS); DISEASES; MOLECULAR BIOLOGY; MOLECULAR STRUCTURE; SENSORS; SEPARATION; TOXICITY;

ANTHRAX TOXINS; BIOLOGICAL PROCESSES; BIOMIMETIC STRUCTURES; CHOLERA TOXINS;

ENZYME INHIBITION;

ANTHRAX TOXIN; CHOLERA TOXIN; INHIBITOR PROTEIN; LIPOSOME; POLYVALENT LIPOSOME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; DENSITY; DISSOCIATION; IN VITRO STUDY; IN VIVO STUDY; INTOXICATION; LIGAND BINDING; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSOR; STATISTICS; STOCHASTIC MODEL; THEORETICAL MODEL;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL TOXINS; CELL LINE; CHEMISTRY, PHARMACEUTICAL; CHOLERA TOXIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; LIPOSOMES; MICE; MODELS, STATISTICAL; MODELS, THEORETICAL; RATS; RATS, INBRED F344; SPECTROMETRY, FLUORESCENCE;

ANIMALIA;

EID: 33646593190     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt1204     Document Type: Article

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