In vivo fate of unimers and micelles of a poly(ethylene glycol)-block-poly(caprolactone) copolymer in mice following intravenous administration

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 65, Issue 3, 2007, Pages 309-319

  Liu, Jubo ^a   Zeng, Faquan ^a   Allen, Christine ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Biodistribution; Block copolymer micelle; Drug delivery; In vivo fate; Kinetic stability; Pharmacokinetics; Poly(ethylene glycol) block poly(caprolactone)

Indexed keywords

COPOLYMER; NANOPARTICLE; POLY(ETHYLENE GLYCOL) BLOCK POLY(CAPROLACTONE) COPOLYMER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STABILITY; DRUG SYNTHESIS; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; KINETICS; MICELLE; MOUSE; NONHUMAN; PARTICLE SIZE; POLYMERIZATION; RING OPENING; THERMAL ANALYSIS; THERMODYNAMICS;

ANIMALS; BIOCOMPATIBLE MATERIALS; DRUG CARRIERS; HALF-LIFE; INJECTIONS, INTRAVENOUS; KIDNEY; LIVER; LUNG; MICE; MICE, INBRED BALB C; MICELLES; MYOCARDIUM; NANOPARTICLES; POLYESTERS; POLYETHYLENE GLYCOLS; PROTEIN BINDING; SPLEEN; THERMODYNAMICS; TISSUE DISTRIBUTION; TRITIUM;

EID: 33847246381     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2006.11.010     Document Type: Article

References (32)

1. Allen C., Maysinger D., and Eisenberg A. Nano-engineering block copolymer aggregates for drug delivery. Colloids Surf. B Biointerfaces 16 (1999) 3-27
2. Kim T.Y., Kim D.W., Chung J.Y., Shin S.G., Kim S.C., Heo D.S., Kim N.K., and Bang Y.J. Phase I and pharmacokinetics study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced maglignacies. Clin. Cancer Res. 10 (2004) 3708-3716
3. Le Garrec D., Gori S., Luo L., Lessard D., Smith D.C., Yessine M.A., Ranger M., and Leroux J.C. Poly(N-vinylpyrrolidone)-block-poly(d,l-lactide) as a new polymeric solubilizer for hydrophobic anticancer drugs: in vitro and in vivo evaluation. J. Control. Release 99 (2004) 83-101
4. Adams M.L., Andes D.R., and Kwon G.S. Amphotericin B encapsulated in micelles based on poly(ethylene oxide)-block-poly(l-amino acid) derivatives exerts reduced in vitro hemolysis but maintains potent in vivo antifungal activity. Biomacromolecules 4 (2003) 750-757
5. Liggins R.T., and Burt H.M. Polyether-polyester diblock copolymers for the preparation of paclitaxel loaded polymeric micelle formulations. Adv. Drug Deliv. Rev. 54 (2002) 191-202
6. Burt H.M., Zhang X.C., Toleikis P., Embree L., and Hunter W.L. Development of copolymers of poly(d,l-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel. Colloids Surf. B Biointerfaces 16 (1999) 161-171
7. Hamaguchi T., Matsumura Y., Suzuki M., Shimizu K., Goda R., Nakamura I., Nakatomi I., Yokoyama M., Kataoka K., and Kakizoe T. NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel. Br. J. Cancer 92 (2005) 1240-1246
8. Nakanishi T., Fukushima S., Okamoto K., Suzuki M., Matsumura Y., Yokoyama M., Okano T., Sakurai Y., and Kataoka K. Development of the polymer micelle carrier system for doxorubicin. J. Control. Release 74 (2001) 295-302
9. Kim S.C., Kim D.W., Shim Y.H., Bang J.S., Oh H.S., Kim S.W., and Seo M.H. In vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and efficacy. J. Control. Release 72 (2001) 191-202
10. Kim S.Y., Lee Y.M., Shin H.J., and Kang J.S. Indomethacin-loaded methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) diblock copolymeric nanosphere: pharmacokinetic characteristics of indomethacin in the normal Sprague-Dawley rats. Biomaterials 22 (2001) 2049-2056
11. Mizumura Y., Matsumura Y., Hamaguchi T., Nishiyama N., Kataoka K., Kawaguchi T., Hrushesky W.J., Moriyasu F., and Kakizoe T. Cisplatin-incorporated polymeric micelles eliminate nephrotoxicity, while maintaining antitumor activity. Jpn. J. Cancer Res. 92 (2001) 328-336
12. Novakova K., Laznicek M., Rypacek F., and Machova L. I-125-labeled PLA/PEO block copolymer: biodistribution studies in rats. J. Bioactive Compatible Polymers 17 (2002) 285-296
13. Yamamoto Y., Nagasaki Y., Kato Y., Sugiyama Y., and Kataoka K. Long-circulating poly(ethylene glycol)-poly(d,l-lactide) block copolymer micelles with modulated surface charge. J. Control. Release 77 (2001) 27-38
14. Park Y.J., Lee J.Y., Chang Y.S., Jeong J.M., Chung J.K., Lee M.C., Park K.B., and Lee S.J. Radioisotope carrying polyethylene oxide-polycaprolactone copolymer micelles for targetable bone imaging. Biomaterials 23 (2002) 873-879
15. Batrakova E.V., Li S., Li Y., Alakhov V.Y., Elmquist W.F., and Kabanov A.V. Distribution kinetics of a micelle-forming block copolymer Pluronic P85. J. Control. Release 100 (2004) 389-397
16. Dunn S.E., Brindley A., Davis S.S., Davies M.C., and Illum L. Polystyrene-poly(ethylene glycol) (PS-PEG2000) particles as model systems for site specific drug delivery. 2. The effect of PEG surface density on the in vitro cell interaction and in vivo biodistribution. Pharm. Res. 11 (1994) 1016-1022
17. Lou X.D., Detrembleur C., and Jerome R. Living cationic polymerization of delta-valerolactone and synthesis of high molecular weight homopolymer and asymmetric telechelic and block copolymer. Macromolecules 35 (2002) 1190-1195
18. Zhang X., Jackson J.K., and Burt H.M. Determination of surfactant critical micelle concentration by a novel fluorescence depolarization technique. J. Biochem. Biophys. Methods 31 (1996) 145-150
19. Diederichs J.E. Plasma protein adsorption patterns on liposomes: establishment of analytical procedure. Electrophoresis 17 (1996) 607-611
20. Allen C., Dos Santos N., Gallagher R., Chiu G.N.C., Shu Y., Li W.M., Johnstone S.A., Janoff A.S., Mayer L.D., Webb M.S., and Bally M.B. Controlling the physical behavior and biological performance of liposome formulations through use of surface grafted poly(ethylene glycol). Biosci. Rep. 22 (2002) 225-250
21. Liu L., Mak E., Tirona R.G., Tan E., Novikoff P.M., Wang P., Wolkoff A.W., and Pang K.S. Vascular binding, blood flow, transporter, and enzyme interactions on the processing of digoxin in rat liver. J. Pharmacol. Exp. Ther. 315 (2005) 433-448
22. Lee H., Zeng F., Dunne M., and Allen C. Methoxy poly(ethylene glycol)-block-poly(delta-valerolactone) copolymer micelles for formulation of hydrophobic drugs. Biomacromolecules 6 (2005) 3119-3128
23. Skoglund P., and Fransson A. Continuous cooling and isothermal crystallization of polycaprolactone. J. Appl. Polymer Sci. 61 (1996) 2455-2465
24. Semple S.C., Chonn A., and Cullis P.R. Interactions of liposomes and lipid-based carrier systems with blood proteins: relation to clearance behaviour in vivo. Adv. Drug Deliv. Rev. 32 (1998) 3-17
25. Liu J., Zeng F., and Allen C. Influence of serum protein on polycarbonate-based copolymer micelles as a delivery system for a hydrophobic anti-cancer agent. J. Control. Release 103 (2005) 481-497
26. Liu J., Lee H., Huesca M., Young A., and Allen C. Liposome formulation of a novel hydrophobic aryl-imidazole compound for anti-cancer therapy. Cancer Chemother. Pharmacol. (2005) 1-13
27. King F.G., and Dedrick R.L. Physiological pharmacokinetic parameters for cis-dichlorodiammineplatinum(II) (DDP) in the mouse. J. Pharmacokinet. Biopharm. 20 (1992) 95-99
28. Jain R.K. Transport of molecules in the tumor interstitium: a review. Cancer Res. 47 (1987) 3039-3051
29. Jain R.K. Determinants of tumor blood flow: a review. Cancer Res. 48 (1988) 2641-2658
30. Baxter L.T., Zhu H., Mackensen D.G., and Jain R.K. Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice. Cancer Res. 54 (1994) 1517-1528
31. Papahadjopoulos D., Allen T.M., Gabizon A., Mayhew E., Matthay K., Huang S.K., Lee K.D., Woodle M.C., Lasic D.D., Redemann C., et al. Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy. Proc. Natl. Acad. Sci. USA 88 (1991) 11460-11464
32. Allen T.M., and Hansen C. Pharmacokinetics of stealth versus conventional liposomes: effect of dose. Biochim. Biophys. Acta 1068 (1991) 133-141