A review of drug-induced lysosomal disorders of the liver in man and laboratory animals

Microscopy Research and Technique

Volumn 36, Issue 4, 1997, Pages 253-275

  Schneider, Peter ^a   Korolenko, Tatjana A ^b   Busch, Ulrich ^a  

^a Siberian Br Acad of Med Science ^*  (Germany)

^b INSTITUTE OF PHYSIOLOGY   (Russian Federation)

Author keywords

animals; antiparasitics; cytostatics; hepatocytes; hypolipidemi c drugs; man; metals; toxins

Indexed keywords

DRUG INTERACTIONS; ENZYME INHIBITION; INDIUM COMPOUNDS; MOLECULAR BIOLOGY;

ANTIPARASITIC; CYTOSTATIC; HEPATOCYTES; HYPOLIPIDEMI C DRUG; IN-VIVO; LABORATORY ANIMALS; LYSOSOMAL ENZYMES; LYSOSOMOTROPICS; MAN; TOXIN;

ANIMALS;

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMIODARONE; AUROTHIOMALATE; CHLOROQUINE; LEUPEPTIN; LYSOSOME ENZYME; METHOTREXATE; PERHEXILINE MALEATE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; SULMAZOLE; SURAMIN; THALLIUM; VINBLASTINE;

ARTICLE; DRUG METABOLISM; DRUG PROTEIN BINDING; ENZYME ACTIVITY; HUMAN; KUPFFER CELL; LIVER LYSOSOME; LIVER METABOLISM; LIVER TOXICITY; LYSOSOME STORAGE DISEASE; NONHUMAN; PRIORITY JOURNAL; TOXICITY TESTING;

ANIMALIA;

EID: 0030907276     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0029(19970215)36:4<253::AID-JEMT4>3.0.CO;2-N     Document Type: Article

References (154)

1. Abe, M., and Kishino, Y. (1982) Pathogenesis of fatty liver in rats fed a high protein diet without pyridoxine. J. Nutr., 112:205-210.
2. Abernathy, C.O., Zimmerman, H.J., Ishak, K.G., Utili, R., and Gillespie, J. (1992) Drug-induced cholestasis in the perfused rat liver and its reversal by tauroursodeoxycholate; an ultrastructural study. Proc. Soc. Exp. Biol. Med., 199:54-58.
3. Alt, E.R., Sternlieb, I., and Goldfischer, S. (1990) The cytopathology of metal overload. Int. Rev. Exp. Pathol., 31:165-188.
4. Altmann, H.W. (1980) Drug-induced liver reactions. A morphological approach. In: Drug induced pathology. E. Grundmann (ed.), Springer Verlag, Berlin, Heidelberg, New York, pp. 69-142.
5. Azumi, N. (1982) Copper and liver injury. Experimental studies on dogs with biliary obstruction and copper loading. Hokkaido. J. Med. Sci., 57:331-349.
6. Beaugrand, M., Callard, P., and Lageron, A. (1979) Liver and perhexiline therapy. Med. Chir. Dig., 8:411-413 (French).
7. Berkenstam, A., Ahlberg, J., and Glaumann, H. (1986) Lysosomal uptake of isolated cell organelles microinjected into HeLa cells. Exp. Cell. Res., 163:301-308.
8. Bjorkman, D.J., Hammond, E.H., Lee, R.G., Clegg, D.O., and Tolman, K.G. (1988) Hepatic ultrastructure after methotrexate therapy for rheumatoid arthritis. Arthritis Rheum., 31:1465-1472.
9. Bleiberg-Daniel, F., Lamri, Y., Feldmann, G., and Lardeux, B. (1994) Glucagon administration in vivo stimulates hepatic RNA and protein breakdown in fed and fasted rats. Biochemical Journal, 299:645-649.
10. Blohm, T.R. (1978) Drug-induced lysosomal lipidosis: Biochemical interpretations. Pharmacol. Rev., 30:593-603.
11. Bockhardt, H., Drenckhahn, D., and Lüllmann-Rauch, R. (1987) Amiodarone-induced lipidosis-like alterations in ocular tissues of rats. Albrecht v. Graefes Arch. klin. exp. Ophthal., 207:91-96.
12. Brekke, I.B., Danielsen, H., and Reith, A. (1983) Normalization of hepatic lysosomal autophagy in streptozotocin diabetic rats after pancreatic transplantation. Virchows Arch. B. Cell Pathol. Incl. Mol. Pathol., 43:189-198.
13. Buchheim, W., Drenckhahn, D., and Lüllmann-Rauch, R. (1979) Freeze-fracture studies of cytoplasmic inclusions occurring in experimental lipidosis as induced by amphiphilic cationic drugs. Biochim. Biophys. Acta, 575:71-80.
14. Buys, C. (1976) Uptake and degradation of circulating proteins by the liver. Groningen.
15. Buys, C.H.C.M., Bouma, J.M.W., Gruber, M., and Wisse, E. (1978) Induction of lysosomal storage by suramin. Naunyn-Schmiedeberg's Arch. Pharmacol., 304:183-190.
16. Byun, D.-S., Kasama, T., Shimizu, T., Yorifuji, H., and Seyama, Y. (1988) Effect of cholestanol feeding on sterol concentrations in the serum liver and cerebellum of mice. J. Biochem. (Tokyo), 103:375-379.
17. Capron-Chivrac, D., Reix, N., Quenum, C., and Capron, J.P. (1985) Amiodarone hepatopathy. Study of a case and review of the literature. Gastroenterol. Clin. Biol., 9:535-539 (French).
18. Cleton, M.I., Mostert, L.J., Sorer, L.W.J., De Jong, A.A.W., De Jeu-Jaspars, C.M.H., and De Bruijn, W.C. (1989) Effect of phlebotomy on the ferritin iron content in the rat liver as determined morphometrically with the use of electron energy loss spectroscopy. Cell Tissue Res., 256:601-606.
19. Colgan, T., Simon, G.T., and Kay, J.M. (1984) Amiodarone pulmonary toxicity. Ultrastruct. Pathol., 6:199-207.
20. Costa-Jussa, F.R., and Jacobs, J.M. (1985) The pathology of amiodarone neurotoxicity. I. Experimental studies with reference to changes in other tissues. Brain, 108:735-752.
21. Cox, J.W., Ulrich, R.G., Wynalda, M.A., Mckenna, R., Larsen, E.R., Ginsberg, L.C., and Epps, D.E. (1989) Reversible hepatic lysosomal phospholipidosis in rat induced by subchronic daily administration of trospectomycin sulfate. Biochem Pharmacol., 38:3535-3542.
22. D'Amico, D.J., Kenyon, K.R., and Ruskin, J.N. (1981) Amiodarone keratopathy. Drug-induced lipid storage disease. Arch. Ophthalmol., 99:257-261.
23. De Duve, C., De Barsy, T., Poole, B., Trouet, A., Tulkens, P., and Van Hoof, F. (1974) Lysosomotropic agents. Biochem. Pharmacol., 23: 2494-2531.
24. Decharneux, T., Dubois, F., Beauloye, C., Wattiaux de Coninck, S., and Wattiaux, R. (1992) Effect of various flavonoids on lysosomes subjected to an oxidative or an osmotic stress. Biochem. Pharmacol., 44:1243-1248.
25. De Ferreyra, E.C., Villarruel, M.C., Fernandez, G., De Fenos, O.M., Bernacchi, A.S., De Castro, C.R., and Castro, J.A. (1989) Further studies on the mechanism of the late protective effects of phenylmethylsulfonyl fluoride on carbon tetrachloride-induced liver necrosis. Exp. Mol. Pathol., 50:253-269.
26. De La Iglesia, F.A., Feuer, G., Takada, A., and Matsuda, Y. (1974) Morphologic studies on secondary phospholipidosis in human liver. Lab. Invest., 30:539-549.
27. Elsafi, M.E., Hultberg, B., Isaksson, A., Hagerstrand, I., Prytz, H., and Stenram, U. (1994) Lysosomes and human liver disease: A biochemical and immunohistochemical study of beta-hexosaminidase. Europ. J. Clin. Chem. Clin. Biochem., 32:669-673.
28. Fleischner, G.M., Morecki, R., Hanaichi, T., Hayashi, H., Quintana, N., and Sternlieb, I. (1991) Light-and electron-microscopical study of a case of gold salt-induced hepatotoxicity. Hepatol., 14:422-425.
29. Fortner, J.H., Milisen, W.B., Lundeen, G.R., Jakowski, A.B., and Marsh, P.M. (1993) Tapetal effect of an azalide antibiotic following oral administration in Beagle dogs. Fundam. Appl. Toxicol., 21:164-173.
30. Fredman, P., Klinghardt, G., and Svennerholm, L. (1987) Effect of chloroquine on the activity of some lysosomal enzymes involved in ganglioside degradation. Biochim. Biophys. Acta, 917:1-8.
31. Fuentealba, I., Haywood, S., and Foster, J. (1989) Cellular mechanisms of toxicity and tolerance in the copper-loaded rat II. Pathogenesis of copper toxicity in the liver. Exp. Mol. Pathol., 50:26-37.
32. Fujimura, H., Kawasaki, N., Tanimoto, T., Sasaki, H., and Suzuki, T. (1995) Effects of acetaminophen on the ultrastructure of isolated rat hepatocytes. Exp. Toxic. Pathol., 47:345-351.
33. Gedigk, P., and Totovic, V. (1976) Lysosomes and pigments. Verh. Dtsch. Ges. Path. 60:64-94 (Ger.).
34. Ghadially, F.N., Trew, J.A., Lalonde, J.-M.A., and Chattopadhyay, P.K. (1980) Enzyme content of hepatocellular lysosomes in the liver of the tumor bearing mouse. Br. J. Exp. Pathol., 61:528-533.
35. Glaumann, H., Jansson, H., Arborgh, B., and Ericsson, J.L.E. (1975) Isolation of liver lysosomes by iron loading. Ultrastructural characterization. J. Cell Biol., 67:887-894.
36. Gorgas, K., and Krisans, S.K. (1989) Zonal heterogeneity of peroxisome proliferation and morphology in rat liver after gemfibrozil treatment. J. Lipid Res., 20:1859-1875.
37. Grinde, B. (1984) Inhibition of autophagy by benzyl alcohol. Biochim. Biophys. Acta., 800:140-144.
38. Groh, V., and Von Mayersbach, H. (1981) Histochemical tracing of lysosomal enzymes improved preparation technique for acid phosphatase, beta-glucuronidase, acid beta-galactosidase and aryl esterase in rat liver. Acta. Histochem., 69:1-11.
39. Guigui, B., Perrot, S., Berry, J.P., Fleury-Feith, J., Matrtin, N., Metreau, J.M., Dhumeaux, D., and Zafrani, E.S. (1988) Amiodarone-induced hepatic phospholipidosis: a morphological alteration independent of pseudoalcoholic liver disease. Hepatol., 8:1063-1068.
40. Guillen, F.J., and Vazquez, J.J. (1984) Cyanamide-induced liver cell injury. Experimental study in the rat. Lab. Invest., 50:385-393.
41. Hänichen, T., Brem, G., Spiess, C., and Hermanns, W. (1995) Canine lipid storage disease. Europ. J. Vet. Pathol., 1:37-44.
42. Harada, M., Sakisaka, S., Yoshitake, M., Shakadoh, S., Gondoh, D., Noguchi, K., Yoshida, H., Sata, M., and Tanikawa, K. (1994) Ultrastructure of the intracellular membranous system of rat hepatocytes in intrahepatic cholestasis induced by phalloidin. J. Hepatol., 21:560-566.
43. Hargis, A.M., and Prieur, D.J. (1985) Animal model. Light and electron microscopy of hepatocytes of cats with Chediak-Higashi syndrome. Am. J. Med. Genet., 22:659-668.
44. Hayashi, H., Winship, D.H., and Sternlieb, I. (1977) Lipolysosomes in human liver distribution in livers with fatty infiltration. Gastroenterol., 73:651-654.
45. Haynes, D., Hall, P., and Clark, D. (1983) A glycogen storage disease in rats. Morphological and biochemical investigations. Virchows Arch. B. Cell Pathol. Incl. Mol. Pathol., 42:289-302.
46. Helman, R.G., Adams, L.G., Pierce, K.R., Bridges, C.H., and Bailey, E.M. (1985) The role of lysosomes in the pathogenesis of copper-induced hepatotoxicity. Morphological studies. J. Comp. Pathol., 95:25-36.
47. Hinton, R.H., Mitchell, F.E., Mann, A., Chescoe, D., Price, S.C., Nunn, A., Grasso, P., and Bridges, J.W. (1986) Effects of phthalic acid esters on the liver and thyroid. Environ. Health Perspect., 70:195-210.
48. Hirsimaki, P., and Pilstrom, L. (1982) Studies on vinblastine induced autophagocytosis in mouse liver 3. A quantitative study. Virchows Arch. B. Cell Pathol. Incl. Mol. Pathol., 41:51-66.
49. Hostetler, K.Y., and Matsuzawa, Y. (1981) Studies on the mechanism of drug-induced lipidosis. Cationic amphiphilic drug inhibition of lysosomal phospholipases A and C. Biochem. Pharmacol., 30:1121-1126.
50. Hultgren, B.D., Stevens, J.B., and Hardy, R.M. (1986) Inherited chronic progressive hepatic degeneration in Bedlington terriers with increased liver copper concentrations clinical and pathologic observations and comparison with other copper-associated liver diseases. Am. J. Vet. Res., 47:365-377.
51. Iancu, T.C., Lichterman, L., and Neustein, H.B. (1978) Hepatic sinusoidal cells in iron overload. Ultrastructural observations. Isr. J. Med. Sci., 14:1191-1201.
52. Ishikawa, T., Furuno, K., and Kato, K. (1983) Ultrastructural studies on autolysosomes in rat hepatocytes after leupeptin treatment. Exp. Cell Res., 144:15-24.
53. Job, K., Riede, U.N., and Zahradnik, H.P. (1990) The effect of prostaglandins on experimental storage disease in rats. J. Exp Pathol., 71:171-186.
54. Kanamaru, T. (1987) Enzyme-histochemical study of the liver ligated portal vein in view of acid phosphatase (ACP) activity. Kobe. J. Med. Sci., 33:35-51.
55. Kanz, M.F., and Reynolds, E.S. (1986) Early effects of 1,1-dichloroethylene on canalicular and plasma membranes: ultrastructure and stereology. Exp. Mol. Pathol., 44:93-110.
56. Kasza, L., Weinberger, M.A., Hinton, D.E., Trump, B.F., Patel, C., Friedman, L., and Garthoff, L.H. (1978) Comparative toxicity of polychlorinated biphenyl and polybrominated biphenyl in the rat liver: light and electron microscopic alterations after subacute dietary exposure. J. Environ. Pathol. Toxicol., 1:241-257.
57. Keller, J.C., and Kaminski, E.J. (1984) Toxic effects of Cu implants on liver. Fundam. Appl. Toxicol., 4:778-783.
58. Kitamura, T., Alroy, J., Gatmaitan, Z., Inoue, M., Mikami, T., Jansen, P., and Arias, I.M. (1992) Defective biliary excretion of epinephrine metabolites in mutant TR negative rats relation to the pathogenesis of black liver in the Dubin-Johnson syndrome and corriedale sheep with an analogous excretory defect. Hepatol., 15:1154-1159.
59. Konishi, Y., Okawa, Y., Hosokawa, S., Fujimori, K., and Fuwa, H. (1990) Lysosomal glycogen accumulation in rat liver and its in vivo kinetics after a single intraperitoneal injection of acarbose, an alpha-glucosidase inhibitor. J. Biochem., 107:197-201.
60. Korolenko, T.A. (1990) Catabolism of proteins in lysosomes. Novosibirsk: Nuka, (Rus.).
61. Korolenko, T.A., Pupyshev, A.B., and Malygin, A.E. (1981) Heterophagic function and rate of intralysosomal proteolysis during lysosomotropic agents administration. Acta biol. Med. Germ., 40: 1613-1617.
62. Korolenko, T.A., Rukavishnikova, E.V., Safine, A.F., Dushkin, M.I., and Mynkina, G.I. (1992) Endocytosis by liver cell during suppression of intralysosomal proteolysis. Biol. Chem., Hoppe-Seylet, 373: 573-580.
63. Kotoulas, O.B. (1986) The effects of cyclic 3′5-AMP on the lysosomes of newborn rat hepatocytes. J. Ultrastruct. Mol. Struct. Res., 97:210-215.
64. Kovacs, A.L., Laszlo, L., and Kovacs, J. (1985) Effect of amino acids and cycloheximide on changes caused by vinblastine, leupeptin and methylamine in the autophagic/lysosomal system of mouse hepatocytes in vivo. Exp. Cell. Res., 157:83-94.
65. Kremer, J.M., and Kaye, G.I. (1989) Electron microscopic analysis of sequential liver biopsy samples from patients with rheumatoid arthritis: correlation with light microscopic findings. Arthritis Rheum., 32:1202-1213.
66. Krstie, R.V. (1984) Illustrated encyclopedia of human histology. Springer-Verlag, Berlin, Heidelberg, New York, Tokyo.
67. Krustev, L.P., Dronzin, R.T., Dontchev, N.C., Borov, B.I., Kamenova, B.B., and Beshevlieva, M.S. (1982) Ultrastructural changes in the liver of rats treated with aflatoxin B1 and undernutrition. Gegenbaurs Morphol. Jahrb., 128:176-187.
68. Kumaratilake, J.S., and Howell, J.M. (1989a) Intravenously administered tetra-thiomalate and the removal of copper from the liver of copper-loaded sheep. J. Comp. Pathol., 101:177-199.
69. Kumaratilake, J.S., and Howell, J.M. (1989b) Lysosomes in the pathogenesis of liver injury in chronic copper poisoned sheep. An ultrastructural and morphometric study. J. Comp. Pathol., 100:381-390.
70. Langer, K.H. (1976) Lysosomes and heterophagy. Verh. Dtsch. Ges. Path., 60:9-27 (Ger.).
71. Larusso, N.F., Kost, L.J., Carter, J.A., and Barham, S.S. (1982) Triton WR-1339 a lysosomotropic compound is excreted into bile and alters the biliary excretion of lysosomal enzymes and lipids. Hepatol., 2:209-215.
72. Lattke, H., Koch, H.K., Lesch, R., and Keppler, D.O.R. (1979) Consequences of recurrent phosphate trapping induced by repeated injections of 2 deoxy-D-galactose. Biochemical and morphological studies in rats. Virchows Arch. B. Cell Pathol. Incl. Mol. Pathol., 30:297-312.
73. Lauren, D.J., Teh, S.J., and Hinten, D.E. (1990) Cytotoxicity phase of diethylnitrosamine-induced hepatic neoplasia in medaka. Cancer Res., 50:5504-5514.
74. Lawrence, B.P., and Brown, W.J. (1992) Autophagic vacuoles rapidly fuse with preexisting lysosomes in cultured hepatocytes. J. Cell Sci., 102:515-526.
75. Lawson, K.J., Danpure, C.J., and Fyfe, D.A. (1977) The uptake and subcellular distribution of gold in rat liver cells after in vivo administration of sodium aurothiomalate. Biochem. Pharmacol., 26:2417-2426.
76. Leo, M.A., Sato, M., and Lieber, C.S. (1983) Effect of hepatic vitamin A depletion on the liver in humans and rats. Gastroenterol., 84:562-572.
77. Lesage, G.D., Kost, L.J., Barham, S.S., and Larusso, N.F. (1986) Biliary excretion of iron from hepatocyte lysosomes in the rat. A major excretory pathway in experimental iron overload. J. Clin. Invest., 77:90-97.
78. Lindblad, A., Hultcrantz, R., and Strandvik, B. (1994) High doses of aminoglycosides did not produce liver toxicity in patients with cystic fibrosis. J. Hepatol., 20:201-205.
79. Liu, F.L.-W., Cohen, R.D., and Downar, E. (1986) Amiodarone pulmonary toxicity: functional and ultrastructural evaluation. Thorax, 41:100-105.
80. Lucocq, J.M., Brada, D., and Roth, J. (1986) Immunolocalization of the oligosaccharide trimming enzyme glucosidase II. J. Cell Biol., 102:2137-2146.
81. Lüllmann-Rauch, R. (1981) Lysosomal glycogen storage mimicking in cytological picture of Pompe's disease as induced in rats by injection of an alpha-glucosidase inhibitor. Virchows Arch. B. Cell Path., 38:89-100.
82. Ludwig, J., Owen, C.A. Jr., Barham, S.S., McCall, J.T., and Hardy R.M. (1980) The liver in the inherited copper disease of bedlington terriers. Lab. Invest., 43:82-87.
83. Lyons, R.T., and Pitot, H.C. (1978) Protein degradation in normal and beige Chediak Higashi mice. J. Clin. Invest., 61:260-268.
84. Marchlinski, F.E., Gansler, T.S., Waxman, H.L., and Josephson, M.E. (1982) Amiodarone pulmonary toxicity. Ann. Intern. Med., 97:839-845.
85. Marjomaki, V., and Salminen, A. (1986) Morphological and enzymatic heterogeneity of suramin-induced lysosomal storage disease in some tissues in mice and rats. Exp. Mol. Pathol., 45:76-83.
86. Marzella, L., and Gluamann, H. (1980) Increased degradation in rat liver induced by vinblastine 2. Morphological characterization. Lab. Invest., 42:18-27.
87. Mego, J.L., and Chung, C.H. (1979) Effect of some antimal arials and related substances on intralysosomal proteolysis. Biochem. Pharmacol., 28:465-470.
88. Meijer, A.E.F.H., and Willighagen, R.G.J. (1963) The activity of glucose-6-phosphatase, adenosine triphosphatase, succinic dehydrogenase, and acid phosphatase after dextran or polyvinylpyrrolidone uptake by liver in vivo. Biochem. Pharmacol., 12:974-980.
89. Mellman, I., Fuchs, R., and Helenius, A. (1986) Acidification of the endocytic and exocytic pathways. Ann. Rev. Biochem., 55:663-700.
90. Muriana, F.J., Santamaria, C., and Ruiz, V. (1987) Ultrastructural alteration in the rat liver produced by benzyl viologen. Exp. Pathol., 32:65-72.
91. Myers, B.M., Prendergast, F.G., Holman, R., Kuntz, S.M., and LaRusso, N.F. (1991) Alterations in the structure, physicochemical properties, and pH of hepatocyte lysosomes in experimental iron overload. J. Clin. Invest., 88:1207-1215.
92. Myers, B.M., Prendergast, F.G., Holman, R., Kuntz, S.M., and Larusso, N.F. (1993) Alterations in hepatocyte lysosomes in experimental hepatic copper overload in rats. Gastroenterol., 105:1814-1823.
93. Novikoff, P.M., and Yam, A. (1978) The cytochemical demonstration of golgi endoplasmic reticulum. Lysosomes in rat hepatocytes during lipoprotein mobilization. J. Histochem. Cytochem., 26:1-13.
94. Pessayre, D., Bichara, M., Degott, C., Potet, F., Benhamou, J.P., and Feldmann, G. (1979) Perhexiline maleate-induced cirrhosis. Gastroenterol., 76:170-177.
95. Pfeifer, U. (1976) Lysosomes and autophagy. Ver. Dtsch. Ges. Path., 60:28-64 (Ger.).
96. Popov, A.A., Apostolov, I.T., and Krutev, L.P. (1979) Lysosome activity in immunogenesis during experimental protein calorie malnutrition. Acta Histochem., 65:49-57.
97. Price, S.C., Hinton, R.H., Mitchell, F.E., Hall, D.E., Grasso, P., and Blane, G.F. (1986) Time and dose study on the response of rats to the hypolipidaemic drug fenofibrate. Toxicol., 41:169-191.
98. Pschyrembel, W. (1990a) Chediak-Steinbrink-Higashi-Syndrom. In: Clinical dictionary, Walter de Gruyter Verlag, Berlin, New York, 256. edition, p. 270 (Ger.).
99. Pschyrembel, W. (1990b) Dubin Johnson-Syndrom. In: Clinical dictionary, Walter de Gruyter Verlag, Berlin, New York, 256. edition, p. 379 (Ger.).
100. Pschyrembel, W. (1990c) Wolman-disease. In: Clinical dictionary, Walter de Gruyter Verlag, Berlin, New York, 256. edition, p. 182 (Ger.).
101. Pschyrembel, W. (1990d) Zellweger-Syndrom. In: Clinical dictionary, Walter de Gruyter Verlag, Berlin, New York, 256. edition, p. 1841 (Ger.).
102. Punnonen, E.-L., Pihakaski, K., Mattila, K., Lounatmaa, K., and Hirsimaki, P. (1989) Intramembrane particles and filipin labelling on the membranes of autophagic vacuoles and lysosomes in mouse liver. Cell Tissue Res., 258:269-276.
103. Raper, S.E., Burwen, S.J., Barker, M.E., and Jones, A.L. (1984) Chloroquine inhibits epidermal growth factor (EGF) degradation. Clin. Res., 32:28A.
104. Rappersberger, K., Konrad, K., and Wieser, E. (1986) Morphological changes in peripheral blood cell sand skin in amiodarone-treated patients Br. J. Dermatol., 114:189-196.
105. Rawson, A.J., Patton, G.W., Hofmann, S., Pietra, G.G., and Johns, L. (1993) Liver abnormalities associated with chronic mercury accumulation in stranded atlantic bottlenose dolphins. Ecotoxicol. Environ. Safety., 25:41-47.
106. Rees, S., Constantopoulos, G., and Brady, R. (1986) The suramin-treated rat as a model of mucopolysaccharidosis: reversibility of biochemical and morphological changes in the liver. Virchows Arch. B. Cell Pathol., 51:235-245.
107. Resnick, J.M., Krivit, W., Snover, D.C., Kersey, J.H., Ramsay, N.K.C., Blazar, B.R., and Whitley, C.B. (1992) Pathology of the liver in mucopolysaccharidosis. Light and electron microscopic assessment before and after bone marrow transplantation. Bone Marrow Transplant., 10:273-280.
108. Riede, U.-N., Rohrbach, R., Schaefer, H.-E., and Müller, H. (1989a) Disorders of cellular and extracellular organisation. In: General and special pathology. Riede, U.-N., Schaefer, H.-E., and Wehner, H., eds., Georg Thieme Verlag, Stuttgart, New York, pp. 7-49 (Ger).
109. Riede, U.-N., Schaefer, H.-E., Denk, H., and Stolte, M. (1989b) Metabolic lesions. In: General and special pathology. Riede, U.-N., Schaefer, H.-E., and Wehner, H., eds., Georg Thieme Verlag, Stuttgart, New York, pp. 675-676 (Ger.).
110. Rigas, B., Rosenfeld, L.E., and Barwick, K.W. (1986) Amiodarone hepatotoxicity. A clinicopathologic study of five patients. Ann. Intern. Med., 104:348-351.
111. Saftig, P., Hetman, M., Schmahl, W., Weber, K., Heine, L., Mossmann, H., Köster, A., Hess, B., Evers, M., von Figura, K., and Peters, Ch. (1995) Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucose and profound destruction of lymphoid cells. The EMBO J., 14:3599-3608.
112. Schneider, P.D., and Gorschboth, C.M. (1983) Limiting ischemic liver injury by interfering with lysosomal autophagy. J. Surg. Res., 34:550-554.
113. Schneider, P. (1992) Drug-induced lysosomal disorders in laboratory animals: new substances acting on lysosomes. Arch. Toxicol., 66: 23-33.
114. Schneider, P. (1996, in preparation) Drug-induced lysosomal processes, disorders or morphologic phenomenons in kidneys of laboratory animals: a review. Exp. Toxic. Pathol.
115. Seglen, P.O. (1983) Inhibitors of lysosomal function. Methods in Enzymol., 96:737-764.
116. Seglen, P.O., Grinde, B., and Solheim, A.E. (1979) Inhibition of the lysosomal pathway of protein degradation in isolated rat hepatocytes by ammonia, methylamine, chloroquine and leupeptin. Eur. J. Biochem., 95:215-225.
117. Seglen, P.O., Gordon, P.B., Tolleshaug, H., and Hoyvik, H. (1985) Intracellular protein catabolism. Alan R. Liss, Inc., 437-446.
118. Sewell, R.B., Barham, S.S., and LaRusso, N.F. (1983) Effect of chloroquine on the form and function of hepatocyte lysosomes: morphologic modifications and physiologic alterations related to the biliary excretion of lipids and proteins. Gastroenterol., 85:1146-1153.
119. Sewell, R.B., Barham, S.S., Zinsmeister, A.R., and LaRusso, N.F. (1984) Microtubule modulation of biliary excretion of endogenous and exogenous hepatic lysosomal constituents. Am. J. Physiol., 246:8-15.
120. Sewell, R.B., Dillon, C., Grinpukel, S., Yeomans, N.D., and Smallwood, R.A. (1986) Pericanalicular location of hepatocyte lysosomes and effects of fasting. A morphometric analysis. Hepatol., 6:305-311.
121. Sewell, R.B., Grinpukel, S., Brook, C., and Horowitz, J. (1987) Perhexilene handling by liver: effects on lysosomal function. Gastroenterol., 92: p. 1773.
122. Sewell, R.B., Grinpukel, S.A., Zinsmeister, A.R., and LaRusso, N.F. (1988) Pharmacologic perturbation of rat liver lysosomes: effects on release of lysosomal enzymes and of lipids into bile. Gastroenterol., 95:1088-1098.
123. Sewell, R.B., Horowitz, J.D., Grinpukel, S.A., and Martin, G. (1989) Perhexilene: effects on hepatic lysosomal function in rats. Clin. Exp. Pharmacol. Physiol., 16:25-32.
124. Sewell, R.B., Kost, L.J., Barham, S.S., and LaRusso, N.R. (1983) Chloroquine alters the morphology and biochemistry of hepatic lysosomes and modulates biliary lipid secretion. Aust. N.Z.J. Med., 13:324.
125. Shepherd, N.A., Dawson, A.M., Crocker, P.R., and Levison, D.A. (1987) Granular cells as a marker of early amiodarone hepatotoxicity: A pathological and analytical study. J. Clin. Pathol., 40:418-423.
126. Shio, H., Fowler, S., Bhuvaneswaran, C., and Morris, M.D. (1982) Lysosome lipid storage disorder in NCTR-BALB-V mice 2. Morphologic and cytochemical studies. Am. J. Pathol., 108:150-159.
127. Sim, W.W., Earnest, D.L., Eskelson, C.D., and Chyvapil, M. (1984) Effects of hypervitaminosis A (hyper-A) on hepatic function. Gastroenterol., 86:1252.
128. Sorensen, E.M., Ramirez-Mitchell, R., Pradzynski, A., Bayer, T.L., and Wenz, L.L. (1985) Stereological analyses of hepatocyte changes parallel arsenic accumulation in the livers of green sunfish. J. Environ. Pathol. Toxicol. Oncol., 6:195-210.
129. Stachura, J., Tarnawski, A., Szczudrawa, J., Bogdal, J., Mach, T., Klimczyk, B., and Kirchmayer, S. (1980) Cytoprotective effect of 16-16′ dimethyl prostaglandin E2 and some drugs on an acute galactosamine induced liver damage in rats. Folia. Histochem. Cytochem., 18:311-317.
130. Stastna, J., and Burianova, A. (1982) Fine structure and quantitative occurrence of lysosomes in liver cells of some vertebrate species. Scr. Med. (Brno.), 55:3-14.
131. Tamaru, T., Fujibayashi, S., Brown, W.R., and Wenger, D.A. (1986) Immunocytochemical localization of sphigolipid activator protein-1. The sufatide-G-M-1 ganglioside activator to lysosomes in human liver and colon. Histochem., 86:195-200.
132. Tanaka, H., Furusato, M., Takasaki, S., Watanabe, M., and Hattori, Y. (1975) Morphological and biochemical alteration in the rat liver induced by maprotiline. Acta. Pathol. Jpn., 25:413-437.
133. Thirion, J., Thibaut-Vercruyssen, R., Ronveaux-Dupal, M.-F., and Wattiaux, R. (1983) Experimental sucrose overloading of rat liver lysosomes. Effect of pretreatment with invertase. Eur. J. Cell Biol., 31:107-113.
134. Trautwein, G. (1991) Liver. In: Pathologie der Haustiere, Teil I, Organveränderungen (Pathology of domestic animals, part I.), L.-Cl. Schulz, ed., G. Fischer Verlag, Jena, p. 371 (Ger.).
135. Trimble, J.W., Mendelson, D.S., and Fetter, B.F. (1983) Cutaneous pigmentation secondary to amiodarone therapy. Arch. Dermatol., 119:914-918.
136. Trout, J.J., and Viles, J.M. (1978) Some cellular changes associated with Triton WR-1339 accumulation in rat hepatocytes. Virchows Arch. B. Cell Pathol., 28:279-286.
137. Trout, J.J., and Viles, J.M. (1979) Cellular changes associated with Triton WR-1339 accumulation in rat hepatocytes 2. Lysosomal Triton WR-1339 accumulation. Exp. Mol. Pathol., 31:81-90.
138. Trout, J.J., and Viles, J.M. (1981) Cellular changes associated with Triton WR-1339 accumulation in rat hepatocytes 3. Cellular clearance. Exp. Mol. Pathol., 34:183-190.
139. Tuchweber, B.R., Sieck, R., and Trost, W. (1979) Prevention by silybin of phalloidin induced acute hepatotoxicity. Toxicol. Appl Pharmacol., 51:265-276.
140. Tulkens, P. (1979) The role of lysosomes and plasma membranes in the intracellular accumulation of exogenous substances. Physiological, pharmacological and toxicological studies in cultured cells. Academic Thesis., Louvain: University of Louvain, p. 136.
141. Tulsiani, D.R.P., and Touster, O. (1992) Evidence that swainsonine pretreatment of rats leds to the formation of autophagic vacuoles and endosomes with decreased capacity to mature to or fuse with active lysosomes. Arch. Biochem. Biophys., 296:556-561.
142. Turner, J.N., and Collins, D.N. (1983) Liver morphology in guinea pigs administered either pyrolysis products of a polychlorinated biphenyl transformer fluid or 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl Pharmacol., 67:417-429.
143. Twedt, D.C., Hunsaker, H.A., and Allen, K.G.D. (1988) Use of 2,3,2-Tetramine as a hepatic copper chelating agent for treatment of copper hepatotoxicosis in bedlington terriers. J. Am. Vet. Med. Assoc., 192:52-56.
144. Vameco, J., Draye, J.-P., Van Hoof, F., Misson, J.-P., Evrard, P., Verellen, G., Eyssen, H.J., Van Eldere, J., and Schutgens, R.B.H. (1986) Multiple peroxisomal enzymatic deficiency disorders a comparative biochemical and morphologic study of zellweger cerebrohepatorenal syndrome and neonatal adrenoleukodystrophy. Am. J. Pathol., 125:524-535.
145. Warr, G.A., and Jacab, G.J. (1983) Lung macrophage defense responses during suramin-induced lysosomal dysfunction. Exp. Molec. Pathol., 38:193-207.
146. Wattiaux, R. (1966) Etude experimentale de la surcharge des lysosomes. J. Duculot, Gembloux.
147. Weintraub, H., Alroy, J., Degasperi, R., Goyal, V., Skutelsky, E. Pentchev, P.G., and Warren, C.D. (1992) Storage of glycoprotein in NCTR-BALB-C mouse lectin histochemistry and biochemical studies. Virchows Arch. B. Cell Pathol. Ind. Mol. Pathol., 62:347-352.
148. Wisner-Gebhart, A.M., Brabec, R.K., and Gray, R.H. (1980) Morphometric studies of chloroquine induced changes in hepatocytic organelles in the rat. Exp. Mol. Pathol., 33:144-152.
149. Woods, J.S., and Fowler, B.A. (1986) Alteration of hepatocellular structure and function by thallium chloride: ultrastructural, morphometric, and biochemical studies. Toxicol. Appl. Pharmacol., 83:218-229.
150. Yamamoto, K., and Ogawa, K. (1983) Fine structure and cytochemistry of lysosomes in the Ito cells of the rat liver. Cell Tissue Res., 233:45-57.
151. Yokota, S., Himeno, M., Roth, J., Brada, D., and Kato, K. (1993) Formation of autophagosomes during degradation of excess peroxisomes induced by di-(2-ethylexyl)phthalate treatment: II. Immunocytochemical analysis of early and late autophagosomes. Europ. J. Cell Biol., 62:372-383.
152. Yu, Q.-C., and Marzella, L. (1986) Modification of lysosomal proteolysis in mouse liver with taxol. Am. J. Pathol., 122:553-561.
153. Yu, Q.-C., and Marzella, L. (1988) Response of autophagic protein degradation to physiologic and pathologic stimuli in rat hepatocyte monolayer cultures. Lab. Invest., 58:643-652.
154. Yucel, T., Ahlberg, J., Blanck, A., and Glaumann, H. (1988) Protein degradation in lysosomes from chemically induced malignant rat hepatoma. Virchows Arch. B. Cell Pathol. Ind. Mol. Pathol., 55:1-10.