Liberation of doxorubicin from HPMA copolymer conjugate is essential for the induction of cell cycle arrest and nuclear fragmentation in ovarian carcinoma cells

Journal of Controlled Release

Volumn 124, Issue 1-2, 2007, Pages 6-10

  Malugin, A ^a   Kopeckova P ^a,b   Kopecek J ^a,b  

^a UNIVERSITY OF UTAH   (United States)

^b Department of Electrical and Computer Engineering   (United States)

Author keywords

Cell cycle; Doxorubicin; HPMA copolymer; Ovarian cancer

Indexed keywords

AMIDES; BIOLOGICAL ORGANS; CELLS; CONJUGATED POLYMERS; CYTOTOXICITY; DNA; DRUG DELIVERY;

CELL CYCLE; DOXORUBICIN; HPMA COPOLYMER; NUCLEAR DNA; NUCLEAR FRAGMENTATION; OVARIAN CANCER;

ANTIBIOTICS;

DOXORUBICIN; N (2 HYDROXYPROPYL)METHACRYLAMIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE ARREST; CELL NUCLEUS; CONTROLLED STUDY; DRUG CONJUGATION; DRUG RELEASE; DRUG TRANSPORT; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; OVARY CARCINOMA; PRIORITY JOURNAL;

ACRYLAMIDES; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BIOLOGICAL AVAILABILITY; CELL CYCLE; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; DNA FRAGMENTATION; DOXORUBICIN; FEMALE; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MOLECULAR STRUCTURE; OVARIAN NEOPLASMS;

EID: 36048953413     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.08.016     Document Type: Article

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