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Volumn 303, Issue 9, 2012, Pages

A network-oriented perspective on cardiac calcium signaling

Author keywords

Calcium; Chaos; Heart oscillation; Network; Plasticity; Synchronization

Indexed keywords

CAFFEINE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CALCIUM CHANNEL L TYPE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PROTEIN KINASE C; RYANODINE RECEPTOR 2; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE;

EID: 84868322954     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00388.2011     Document Type: Review
Times cited : (14)

References (180)
  • 2
    • 65349085291 scopus 로고    scopus 로고
    • Global networks of functional coupling in eukaryotes from comprehensive data integration
    • Alexeyenko A, Sonnhammer ELL. Global networks of functional coupling in eukaryotes from comprehensive data integration. Genome Res 19: 1107-1116, 2009.
    • (2009) Genome Res , vol.19 , pp. 1107-1116
    • Alexeyenko, A.1    Sonnhammer, E.L.L.2
  • 5
    • 33947526130 scopus 로고    scopus 로고
    • AMP-activated protein kinase in the heart: Role during health and disease
    • Arad M, Seidman CE, Seidman JG. AMP-activated protein kinase in the heart: role during health and disease. Circ Res 100: 474-488, 2007.
    • (2007) Circ Res , vol.100 , pp. 474-488
    • Arad, M.1    Seidman, C.E.2    Seidman, J.G.3
  • 6
    • 79959937543 scopus 로고    scopus 로고
    • Disease pathways and novel therapeutic targets in hypertrophic cardiomyopathy
    • Ashrafian H, McKenna WJ, Watkins H. Disease pathways and novel therapeutic targets in hypertrophic cardiomyopathy. Circ Res 109: 86-96, 2011.
    • (2011) Circ Res , vol.109 , pp. 86-96
    • Ashrafian, H.1    McKenna, W.J.2    Watkins, H.3
  • 7
    • 0028860021 scopus 로고
    • Excitationtranscription coupling mediated by zinc influx through voltage-dependent calcium channels
    • Atar D, Backx PH, Appel MM, Gao WD, Marban E. Excitationtranscription coupling mediated by zinc influx through voltage-dependent calcium channels. J Biol Chem 270: 2473-2477, 1995.
    • (1995) J Biol Chem , vol.270 , pp. 2473-2477
    • Atar, D.1    Backx, P.H.2    Appel, M.M.3    Gao, W.D.4    Marban, E.5
  • 8
    • 0038179669 scopus 로고    scopus 로고
    • How do beta-blockers improve ventricular function in patients with congestive heart failure?
    • Barry WH, Gilbert EM. How do beta-blockers improve ventricular function in patients with congestive heart failure? Circulation 107: 2395-2397, 2003.
    • (2003) Circulation , vol.107 , pp. 2395-2397
    • Barry, W.H.1    Gilbert, E.M.2
  • 11
    • 43549098268 scopus 로고    scopus 로고
    • Calcium cycling and signaling in cardiac myocytes
    • Bers DM. Calcium cycling and signaling in cardiac myocytes. Annu Rev Physiol 70: 23-49, 2008.
    • (2008) Annu Rev Physiol , vol.70 , pp. 23-49
    • Bers, D.M.1
  • 12
    • 84868319328 scopus 로고    scopus 로고
    • Calcium handling, contraction, and ryanodine receptors: Integration for cardiac "electricians"
    • Bers DM. Calcium handling, contraction, and ryanodine receptors: integration for cardiac "electricians". Dialogues Cardiovasc Med 15: 247-252, 2010.
    • (2010) Dialogues Cardiovasc Med , vol.15 , pp. 247-252
    • Bers, D.M.1
  • 13
    • 3242692393 scopus 로고    scopus 로고
    • Macromolecular complex regulating cardiac ryanodine receptor function
    • Bers DM. Macromolecular complex regulating cardiac ryanodine receptor function. J Mol Cell Cardiol 37: 417-429, 2004.
    • (2004) J Mol Cell Cardiol , vol.37 , pp. 417-429
    • Bers, D.M.1
  • 14
    • 84858652117 scopus 로고    scopus 로고
    • Ryanodine receptor S2808 phosphorylation in heart failure: Smoking gun or red herring
    • Bers DM. Ryanodine receptor S2808 phosphorylation in heart failure: smoking gun or red herring. Circ Res 110: 796-799, 2012.
    • (2012) Circ Res , vol.110 , pp. 796-799
    • Bers, D.M.1
  • 15
    • 0033555859 scopus 로고    scopus 로고
    • Emergent properties of networks of biological signaling pathways
    • Bhalla US, Iyengar R. Emergent properties of networks of biological signaling pathways. Science 283: 381-387, 1999.
    • (1999) Science , vol.283 , pp. 381-387
    • Bhalla, U.S.1    Iyengar, R.2
  • 16
    • 70849090419 scopus 로고    scopus 로고
    • Determinism and divergence of apoptosis susceptibility in mammalian cells
    • Bhola PD, Simon SM. Determinism and divergence of apoptosis susceptibility in mammalian cells. J Cell Sci 122: 4296-4302, 2009.
    • (2009) J Cell Sci , vol.122 , pp. 4296-4302
    • Bhola, P.D.1    Simon, S.M.2
  • 18
    • 33646165641 scopus 로고    scopus 로고
    • Calcium instabilities in mammalian cardiomyocyte networks
    • Bien H, Yin l, Entcheva E. Calcium instabilities in mammalian cardiomyocyte networks. Biophys J 90: 2628-2640, 2006.
    • (2006) Biophys J , vol.90 , pp. 2628-2640
    • Bien, H.1    Yin, L.2    Entcheva, E.3
  • 19
    • 84865957670 scopus 로고    scopus 로고
    • Afterthoughts as foundations for systems biology
    • In:, edited by Boogerd FC, Bruggeman FJ, Hofmeyr J-HS, and Westerfhoff HV. Amsterdam: Elsevier
    • Boogerd FC, Bruggeman FJ, Hofmeyr JHS, Westerhoff HV. Afterthoughts as foundations for systems biology. In: Systems Biology: Philosophical Foundations, edited by Boogerd FC, Bruggeman FJ, Hofmeyr J-HS, and Westerfhoff HV. Amsterdam: Elsevier, 2007, p. 321-336.
    • (2007) Systems Biology: Philosophical Foundations , pp. 321-336
    • Boogerd, F.C.1    Bruggeman, F.J.2    Hofmeyr, J.H.S.3    Westerhoff, H.V.4
  • 20
    • 81155136133 scopus 로고    scopus 로고
    • What is systems biology?
    • Breitling R. What is systems biology? Front Physiol 1: 9, 2010.
    • (2010) Front Physiol , vol.1 , pp. 9
    • Breitling, R.1
  • 21
    • 77956597409 scopus 로고    scopus 로고
    • Cardiac mitochondria and arrhythmias
    • Brown DA, O'Rourke B. Cardiac mitochondria and arrhythmias. Cardiovasc Res 88: 241-249, 2010.
    • (2010) Cardiovasc Res , vol.88 , pp. 241-249
    • Brown, D.A.1    O'Rourke, B.2
  • 23
    • 0345047075 scopus 로고    scopus 로고
    • (Online). London: Demos. [available at
    • Chapman J. System Failure (Online). London: Demos. 2004. [available at http://wwwdemos.co.uk/files/systemfailure2].
    • (2004) System Failure
    • Chapman, J.1
  • 24
    • 0025178623 scopus 로고
    • Low dimensional chaos in cardiac tissue
    • Chialvo DR, Gilmour RF Jr, Jalife J. Low dimensional chaos in cardiac tissue. Nature 343: 653-657, 1990.
    • (1990) Nature , vol.343 , pp. 653-657
    • Chialvo, D.R.1    Gilmour Jr., R.F.2    Jalife, J.3
  • 26
    • 58149288067 scopus 로고    scopus 로고
    • Are transgenic mice the 'alkahest' to understanding myocardial hypertrophy and failure?
    • Cook SA, Clerk A, Sugden PH. Are transgenic mice the 'alkahest' to understanding myocardial hypertrophy and failure? J Mol Cell Cardiol 46: 118-129, 2008.
    • (2008) J Mol Cell Cardiol , vol.46 , pp. 118-129
    • Cook, S.A.1    Clerk, A.2    Sugden, P.H.3
  • 27
    • 0036500834 scopus 로고    scopus 로고
    • Reverse engineering of biological complexity
    • Csete ME, Doyle JC. Reverse engineering of biological complexity. Science 295: 1664-1669, 2002.
    • (2002) Science , vol.295 , pp. 1664-1669
    • Csete, M.E.1    Doyle, J.C.2
  • 28
    • 67649973701 scopus 로고    scopus 로고
    • Supramolecular assemblies and localized regulation of voltage-gated ion channels
    • Dai S, Hall DD, Hell JW. Supramolecular assemblies and localized regulation of voltage-gated ion channels. Physiol Rev 80: 411-452, 2009.
    • (2009) Physiol Rev , vol.80 , pp. 411-452
    • Dai, S.1    Hall, D.D.2    Hell, J.W.3
  • 29
    • 77952917698 scopus 로고    scopus 로고
    • Spatial organization of intracellular communication: Insights from imaging
    • Dehmelt L, Bastiaens PI. Spatial organization of intracellular communication: insights from imaging. Nat Rev Mol Cell Biol 11: 440-452, 2010.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 440-452
    • Dehmelt, L.1    Bastiaens, P.I.2
  • 31
    • 1942470638 scopus 로고    scopus 로고
    • Pharmacology of gap junctions in the cardiovascular system
    • Dhein S. Pharmacology of gap junctions in the cardiovascular system. Cardiovasc Res 62: 287-298, 2004.
    • (2004) Cardiovasc Res , vol.62 , pp. 287-298
    • Dhein, S.1
  • 32
    • 33744992976 scopus 로고    scopus 로고
    • The mAKAP signalling complex: Integration of cAMP, calcium and MAP kinase signalling pathways
    • Dodge-Kafka KL, Kapiloff MS. The mAKAP signalling complex: integration of cAMP, calcium and MAP kinase signalling pathways. Eur J Cell Biol 85: 593-602, 2006.
    • (2006) Eur J Cell Biol , vol.85 , pp. 593-602
    • Dodge-Kafka, K.L.1    Kapiloff, M.S.2
  • 33
    • 16744362714 scopus 로고    scopus 로고
    • Excitation-transcription coupling: Signaling by ion channels to the nucleus
    • Dolmetsch R. Excitation-transcription coupling: signaling by ion channels to the nucleus. Sci STKE 166: pe4, 2003.
    • (2003) Sci STKE , vol.166
    • Dolmetsch, R.1
  • 34
    • 77957284223 scopus 로고    scopus 로고
    • Two close, too close: Sarcoplasmic reticulummitochondrial crosstalk and cardiomyocyte fate
    • Dorn IIGW, Scorrano L. Two close, too close: sarcoplasmic reticulummitochondrial crosstalk and cardiomyocyte fate. Circ Res 107: 689-699, 2010.
    • (2010) Circ Res , vol.107 , pp. 689-699
    • Dorn, I.I.G.W.1    Scorrano, L.2
  • 36
    • 77956520011 scopus 로고    scopus 로고
    • Functional roles for noise in genetic circuits
    • Eldar A, Elowitz MB. Functional roles for noise in genetic circuits. Nature 467: 167-173, 2010.
    • (2010) Nature , vol.467 , pp. 167-173
    • Eldar, A.1    Elowitz, M.B.2
  • 37
    • 56749104130 scopus 로고    scopus 로고
    • Fluorescent probes for super-resolution imaging in living cells
    • Fernandez-Suarez M, Ting AY. Fluorescent probes for super-resolution imaging in living cells. Nat Rev Mol Cell Biol 9: 929-943, 2008.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 929-943
    • Fernandez-Suarez, M.1    Ting, A.Y.2
  • 39
    • 46749110040 scopus 로고    scopus 로고
    • Mapping the human protein interactome
    • Figeys D. Mapping the human protein interactome. Cell Res 18: 716-724, 2008.
    • (2008) Cell Res , vol.18 , pp. 716-724
    • Figeys, D.1
  • 41
    • 77952007543 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR): Conducting the cellular signaling symphony
    • Foster KG, Fingar DC. Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony. J Biol Chem 285: 14071-14077, 2010.
    • (2010) J Biol Chem , vol.285 , pp. 14071-14077
    • Foster, K.G.1    Fingar, D.C.2
  • 44
    • 38849149701 scopus 로고    scopus 로고
    • 2+ leak in heart failure: Mere observation or functional relevance?
    • 2+ leak in heart failure: mere observation or functional relevance? Cardiovasc Res 77: 302-314, 2008.
    • (2008) Cardiovasc Res , vol.77 , pp. 302-314
    • George, C.H.1
  • 45
    • 39749193540 scopus 로고    scopus 로고
    • Refocussing therapeutic strategies for cardiac arrhythmias: Defining viable molecular targets to restore cardiac ion flux
    • George CH, Barberini-Jammaers SR, Muller CT. Refocussing therapeutic strategies for cardiac arrhythmias: defining viable molecular targets to restore cardiac ion flux. Expert Opin Ther Pat 18: 1-19, 2008.
    • (2008) Expert Opin Ther Pat , vol.18 , pp. 1-19
    • George, C.H.1    Barberini-Jammaers, S.R.2    Muller, C.T.3
  • 46
    • 0141571322 scopus 로고    scopus 로고
    • Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes
    • George CH, Higgs GV, Lai FA. Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes. Circ Res 93: 531-540, 2003.
    • (2003) Circ Res , vol.93 , pp. 531-540
    • George, C.H.1    Higgs, G.V.2    Lai, F.A.3
  • 47
    • 33845611191 scopus 로고    scopus 로고
    • Ryanodine receptors and ventricular arrhythmias: Emerging trends in mutations, mechanisms and therapies
    • George CH, Jundi H, Thomas NL, Fry DL, Lai FA. Ryanodine receptors and ventricular arrhythmias: emerging trends in mutations, mechanisms and therapies. J Mol Cell Cardiol 42: 34-50, 2007.
    • (2007) J Mol Cell Cardiol , vol.42 , pp. 34-50
    • George, C.H.1    Jundi, H.2    Thomas, N.L.3    Fry, D.L.4    Lai, F.A.5
  • 49
    • 36749102543 scopus 로고    scopus 로고
    • 2+ release channel dysfunction
    • 2+ release channel dysfunction. Curr Pharm Des 13: 3195-3211, 2007.
    • (2007) Curr Pharm Des , vol.13 , pp. 3195-3211
    • George, C.H.1    Lai, F.A.2
  • 51
    • 0035826148 scopus 로고    scopus 로고
    • Synchronization and rhythmic processes in physiology
    • Glass L. Synchronization and rhythmic processes in physiology. Nature 410: 277-284, 2001.
    • (2001) Nature , vol.410 , pp. 277-284
    • Glass, L.1
  • 52
    • 0018373214 scopus 로고
    • Pathological conditions resulting from instabilities in physiological control systems
    • Glass L, Mackey MC. Pathological conditions resulting from instabilities in physiological control systems. Ann NY Acad Sci 316: 214-235, 1979.
    • (1979) Ann NY Acad Sci , vol.316 , pp. 214-235
    • Glass, L.1    Mackey, M.C.2
  • 53
    • 0025161527 scopus 로고    scopus 로고
    • Complex bifurcations and chaos in simple theoretical models of cardiac oscillations
    • Glass L, Zeng WZ. Complex bifurcations and chaos in simple theoretical models of cardiac oscillations. Ann NY Acad Sci 591: 316-327, 2006.
    • (2006) Ann NY Acad Sci , vol.591 , pp. 316-327
    • Glass, L.1    Zeng, W.Z.2
  • 54
    • 0029870969 scopus 로고    scopus 로고
    • Non-linear dynamics for clinicians: Chaos theory, fractals, and complexity at the bedside
    • Goldberger AL. Non-linear dynamics for clinicians: chaos theory, fractals, and complexity at the bedside. Lancet 347: 1312-1314, 1996.
    • (1996) Lancet , vol.347 , pp. 1312-1314
    • Goldberger, A.L.1
  • 55
    • 79251626458 scopus 로고    scopus 로고
    • Integrative systems models of cardiac excitation-contraction coupling
    • Greenstein JL, Winslow RL. Integrative systems models of cardiac excitation-contraction coupling. Circ Res 108: 70-84, 2011.
    • (2011) Circ Res , vol.108 , pp. 70-84
    • Greenstein, J.L.1    Winslow, R.L.2
  • 56
    • 33645936966 scopus 로고    scopus 로고
    • Non-linear analysis and modelling of the cellular mechanisms that regulate arterial vasomotion
    • Griffith TM, Parthimos D, Edwards DH. Non-linear analysis and modelling of the cellular mechanisms that regulate arterial vasomotion. Proc Inst Mech Eng, part C: J Mech Eng Sci 220: 367-381, 2006.
    • (2006) Proc Inst Mech Eng, part C: J Mech Eng Sci , vol.220 , pp. 367-381
    • Griffith, T.M.1    Parthimos, D.2    Edwards, D.H.3
  • 59
    • 33750520546 scopus 로고    scopus 로고
    • 2+ lightning conveys cell-cell contact information inside the cells
    • 2+ lightning conveys cell-cell contact information inside the cells. EMBO Rep 7: 1117-1123, 2006.
    • (2006) EMBO Rep , vol.7 , pp. 1117-1123
    • Hashido, M.1    Hayashi, K.2    Hirose, K.3    Iino, M.4
  • 62
    • 79952744659 scopus 로고    scopus 로고
    • Topology of protein interaction network shapes protein abundances and strengths of their functional and non-specific interactions
    • Heo M, Maslov S, Shakhnovich E. Topology of protein interaction network shapes protein abundances and strengths of their functional and non-specific interactions. Proc Natl Acad Sci USA 108: 4258-4263, 2011.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 4258-4263
    • Heo, M.1    Maslov, S.2    Shakhnovich, E.3
  • 63
    • 7444253428 scopus 로고    scopus 로고
    • Systems biology and new technologies enable predictive and preventative medicine
    • Hood L, Heath JR, Phelps ME, Lin B. Systems biology and new technologies enable predictive and preventative medicine. Science 306: 640-643, 2004.
    • (2004) Science , vol.306 , pp. 640-643
    • Hood, L.1    Heath, J.R.2    Phelps, M.E.3    Lin, B.4
  • 64
    • 77953812600 scopus 로고    scopus 로고
    • Does protein kinase A-mediated phosphorylation of the cardiac ryanodine receptor play any role in adrenergic regulation of calcium handling in health and disease
    • Houser SR. Does protein kinase A-mediated phosphorylation of the cardiac ryanodine receptor play any role in adrenergic regulation of calcium handling in health and disease. Circ Res 106: 1672-1674, 2010.
    • (2010) Circ Res , vol.106 , pp. 1672-1674
    • Houser, S.R.1
  • 65
    • 0033804245 scopus 로고    scopus 로고
    • Abnormalities of calcium cycling in the hypertrophied and failing heart
    • Houser SR, Piacentino V, Weisser J. Abnormalities of calcium cycling in the hypertrophied and failing heart. J Mol Cell Cardiol 32: 1595-1607, 2000.
    • (2000) J Mol Cell Cardiol , vol.32 , pp. 1595-1607
    • Houser, S.R.1    Piacentino, V.2    Weisser, J.3
  • 66
    • 59449085388 scopus 로고    scopus 로고
    • Energy metabolism in heart failure and remodelling
    • Ingwall JS. Energy metabolism in heart failure and remodelling. Cardiovasc Res 81: 412-419, 2009.
    • (2009) Cardiovasc Res , vol.81 , pp. 412-419
    • Ingwall, J.S.1
  • 67
    • 0034644509 scopus 로고    scopus 로고
    • Signaling networks: The origins of cellular multitasking
    • Jordan JD, Landau EM, Iyengar R. Signaling networks: the origins of cellular multitasking. Cell 103: 193-200, 2000.
    • (2000) Cell , vol.103 , pp. 193-200
    • Jordan, J.D.1    Landau, E.M.2    Iyengar, R.3
  • 69
    • 84855755332 scopus 로고    scopus 로고
    • Grand challenges in systems physiology
    • Kitano H. Grand challenges in systems physiology. Front Physiol 1: 3, 2010.
    • (2010) Front Physiol , vol.1 , pp. 3
    • Kitano, H.1
  • 71
    • 77956291358 scopus 로고    scopus 로고
    • Spatio-temporal oscillations of individual mitochondria in cardiac myocytes reveal modulation of synchronized mitochondrial clusters
    • Kurz FT, Aon MA, O'Rourke B, Armoundas AA. Spatio-temporal oscillations of individual mitochondria in cardiac myocytes reveal modulation of synchronized mitochondrial clusters. Proc Natl Acad Sci USA 107: 14315-14320, 2010.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14315-14320
    • Kurz, F.T.1    Aon, M.A.2    O'Rourke, B.3    Armoundas, A.A.4
  • 72
    • 84860527594 scopus 로고    scopus 로고
    • Noise in cellular signaling pathways: Causes and effects
    • Ladbury JE, Arold ST. Noise in cellular signaling pathways: causes and effects. Trends Biochem Sci 37: 173-178, 2012.
    • (2012) Trends Biochem Sci , vol.37 , pp. 173-178
    • Ladbury, J.E.1    Arold, S.T.2
  • 74
    • 0035205336 scopus 로고    scopus 로고
    • A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel
    • Lahat H, Pras E, Olender T, Avadan N, Ben-Asher E, Man O, Levy-Nissenbaum E, Khoury A, Lorber A, Goldman B, Lancet D, Eldar M. A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel. Am J Hum Genet 69: 1378-1384, 2001.
    • (2001) Am J Hum Genet , vol.69 , pp. 1378-1384
    • Lahat, H.1    Pras, E.2    Olender, T.3    Avadan, N.4    Ben-Asher, E.5    Man, O.6    Levy-Nissenbaum, E.7    Khoury, A.8    Lorber, A.9    Goldman, B.10    Lancet, D.11    Eldar, M.12
  • 75
    • 79953310548 scopus 로고    scopus 로고
    • 2+ cycling is a general regulator of how fast and how strong the heart beats
    • 2+ cycling is a general regulator of how fast and how strong the heart beats. Dialogues Cardiovasc Med 15: 253-278, 2010.
    • (2010) Dialogues Cardiovasc Med , vol.15 , pp. 253-278
    • Lakatta, E.G.1
  • 76
    • 67649104033 scopus 로고    scopus 로고
    • What keeps us ticking: A funny current, a calcium clock, or both?
    • Lakatta EG, DiFrancesco D. What keeps us ticking: a funny current, a calcium clock, or both? J Mol Cell Cardiol 47: 157-170, 2009.
    • (2009) J Mol Cell Cardiol , vol.47 , pp. 157-170
    • Lakatta, E.G.1    DiFrancesco, D.2
  • 77
    • 77949379471 scopus 로고    scopus 로고
    • 2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker
    • 2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circ Res 106: 659-673, 2010.
    • (2010) Circ Res , vol.106 , pp. 659-673
    • Lakatta, E.G.1    Maltsev, V.2    Vinogradova, T.M.3
  • 78
    • 0037458671 scopus 로고    scopus 로고
    • Cyclic variation of intracellular calcium: A critical factor for cardiac pacemaker cell dominance
    • Lakatta EG, Maltsev VA, Bogdanov KY, Stern MD, Vinogradova TM. Cyclic variation of intracellular calcium: a critical factor for cardiac pacemaker cell dominance. Circ Res 92: E45-E50, 2003.
    • (2003) Circ Res , vol.92
    • Lakatta, E.G.1    Maltsev, V.A.2    Bogdanov, K.Y.3    Stern, M.D.4    Vinogradova, T.M.5
  • 81
    • 77952944052 scopus 로고    scopus 로고
    • Designing customized cell signalling circuits
    • Lim WA. Designing customized cell signalling circuits. Nat Rev Mol Cell Biol 11: 393-403, 2010.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 393-403
    • Lim, W.A.1
  • 82
    • 70350302609 scopus 로고    scopus 로고
    • Photoactivatable fluorescent proteins for diffraction-limited and super-resolution imaging
    • Lippincott-Schwartz J, Patterson GH. Photoactivatable fluorescent proteins for diffraction-limited and super-resolution imaging. Trends Cell Biol 19: 555-565, 2009.
    • (2009) Trends Cell Biol , vol.19 , pp. 555-565
    • Lippincott-Schwartz, J.1    Patterson, G.H.2
  • 83
    • 0026534404 scopus 로고
    • Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence
    • Lipsitz LA, Goldberger AL. Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence. JAMA 267: 1806-1809, 1992.
    • (1992) JAMA , vol.267 , pp. 1806-1809
    • Lipsitz, L.A.1    Goldberger, A.L.2
  • 85
    • 79958173577 scopus 로고    scopus 로고
    • The deletion of exon 3 in the cardiac ryanodine receptor is rescued by strand switching
    • Lobo PA, Kimlicka L, Tung CC, Van Petegem F. The deletion of exon 3 in the cardiac ryanodine receptor is rescued by strand switching. Structure 19: 790-798, 2011.
    • (2011) Structure , vol.19 , pp. 790-798
    • Lobo, P.A.1    Kimlicka, L.2    Tung, C.C.3    Van Petegem, F.4
  • 87
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • Ma XM, Blenis J. Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 10: 307-318, 2010.
    • (2010) Nat Rev Mol Cell Biol , vol.10 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 90
    • 0017714604 scopus 로고
    • Oscillation and chaos in physiological control systems
    • Mackey MC, Glass L. Oscillation and chaos in physiological control systems. Science 197: 287-289, 1977.
    • (1977) Science , vol.197 , pp. 287-289
    • Mackey, M.C.1    Glass, L.2
  • 95
    • 0034640113 scopus 로고    scopus 로고
    • PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts
    • Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 101: 365-376, 2000.
    • (2000) Cell , vol.101 , pp. 365-376
    • Marx, S.O.1    Reiken, S.2    Hisamatsu, Y.3    Jayaraman, T.4    Burkhoff, D.5    Rosemblit, N.6    Marks, A.R.7
  • 96
    • 35348813628 scopus 로고    scopus 로고
    • Propagation of large concentration changes in reversible protein-binding networks
    • Maslov S, Ispolatov I. Propagation of large concentration changes in reversible protein-binding networks. Proc Natl Acad Sci USA 104: 13655-13660, 2007.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 13655-13660
    • Maslov, S.1    Ispolatov, I.2
  • 97
    • 34548161097 scopus 로고    scopus 로고
    • Spreading out of perturbations in reversible reaction networks
    • Maslov S, Sneppen K, Ispolatov I. Spreading out of perturbations in reversible reaction networks. New J Phys 9: 273, 2007.
    • (2007) New J Phys , vol.9 , pp. 273
    • Maslov, S.1    Sneppen, K.2    Ispolatov, I.3
  • 98
    • 78149330589 scopus 로고    scopus 로고
    • Imaging with total internal reflection fluorescence microscopy for the cell biologist
    • Mattheyses AL, Simon SM, Rappoport JZ. Imaging with total internal reflection fluorescence microscopy for the cell biologist. J Cell Sci 123: 3621-3628, 2010.
    • (2010) J Cell Sci , vol.123 , pp. 3621-3628
    • Mattheyses, A.L.1    Simon, S.M.2    Rappoport, J.Z.3
  • 99
    • 79959451416 scopus 로고    scopus 로고
    • Reporting from the field: Genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems
    • Mehta S, Zhang J. Reporting from the field: genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems. Annu Rev Biochem 80: 375-401, 2011.
    • (2011) Annu Rev Biochem , vol.80 , pp. 375-401
    • Mehta, S.1    Zhang, J.2
  • 100
    • 59449097258 scopus 로고    scopus 로고
    • Remodelling of cardiac repolarization: How homeostatic responses can lead to arrhythmogenesis
    • Michael G, Xiao L, Qi XY, Dobrev D, Nattel S. Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis. Cardiovasc Res 81: 491-499, 2009.
    • (2009) Cardiovasc Res , vol.81 , pp. 491-499
    • Michael, G.1    Xiao, L.2    Qi, X.Y.3    Dobrev, D.4    Nattel, S.5
  • 105
    • 33751527644 scopus 로고    scopus 로고
    • Innovative approaches to anti-arrhythmic drug therapy
    • Nattel S, Carlsson L. Innovative approaches to anti-arrhythmic drug therapy. Nat Rev Drug Discov 5: 1034-1049, 2006.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 1034-1049
    • Nattel, S.1    Carlsson, L.2
  • 106
    • 33947239659 scopus 로고    scopus 로고
    • Mechanisms of disease: The failing heart-an engine out of fuel
    • Neubauer S. Mechanisms of disease: the failing heart-an engine out of fuel. N Engl J Med 356: 1140-1151, 2007.
    • (2007) N Engl J Med , vol.356 , pp. 1140-1151
    • Neubauer, S.1
  • 108
    • 56749160113 scopus 로고    scopus 로고
    • Design principles of biochemical oscillators
    • Novak B, Tyson JJ. Design principles of biochemical oscillators. Nat Rev Mol Cell Biol 9: 981-991, 2008.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 981-991
    • Novak, B.1    Tyson, J.J.2
  • 110
    • 77957061890 scopus 로고    scopus 로고
    • Prediction of metabolic fluxes by incorporating genomic context and flux-converging pattern analyses
    • Park JM, Kim TY, Lee SY. Prediction of metabolic fluxes by incorporating genomic context and flux-converging pattern analyses. Proc Natl Acad Sci USA 107: 14931-14936, 2010.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14931-14936
    • Park, J.M.1    Kim, T.Y.2    Lee, S.Y.3
  • 112
    • 79953168028 scopus 로고    scopus 로고
    • Compromised myocardial energetics in hypertrophied mouse hearts diminish the beneficial effect of overexpressing SERCA2a
    • Pinz I, Tian R, Swanson E, Dillmann W, Ingwall JS. Compromised myocardial energetics in hypertrophied mouse hearts diminish the beneficial effect of overexpressing SERCA2a. J Biol Chem 286: 10163-10168, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 10163-10168
    • Pinz, I.1    Tian, R.2    Swanson, E.3    Dillmann, W.4    Ingwall, J.S.5
  • 113
    • 0024960111 scopus 로고
    • Is it healthy to be chaotic?
    • Pool R. Is it healthy to be chaotic? Science 243: 604-607, 1989.
    • (1989) Science , vol.243 , pp. 604-607
    • Pool, R.1
  • 115
    • 79954594124 scopus 로고    scopus 로고
    • 2+ handling and arrhythmogenesis
    • 2+ handling and arrhythmogenesis. Circ Res 108: 871-883, 2011.
    • (2011) Circ Res , vol.108 , pp. 871-883
    • Priori, S.G.1    Chen, S.R.2
  • 116
    • 77951638536 scopus 로고    scopus 로고
    • Not all noise is waste
    • Quaranta V, Garbett S. Not all noise is waste. Nat Methods 7: 269-272, 2010.
    • (2010) Nat Methods , vol.7 , pp. 269-272
    • Quaranta, V.1    Garbett, S.2
  • 118
    • 0037078982 scopus 로고    scopus 로고
    • Control, exploitation and tolerance of intracellular noise
    • Rao CV, Wolf DM, Arkin AP. Control, exploitation and tolerance of intracellular noise. Nature 420: 231-237, 2002.
    • (2002) Nature , vol.420 , pp. 231-237
    • Rao, C.V.1    Wolf, D.M.2    Arkin, A.P.3
  • 119
    • 25444468618 scopus 로고    scopus 로고
    • Noise in gene expression: Origins, consequences, and control
    • Raser JM, O'Shea EK. Noise in gene expression: origins, consequences, and control. Science 309: 2010-2013, 2005.
    • (2005) Science , vol.309 , pp. 2010-2013
    • Raser, J.M.1    O'Shea, E.K.2
  • 120
    • 56049121209 scopus 로고    scopus 로고
    • Monte Carlo simulation of cell death signaling predicts large cell-to-cell stochastic fluctuations through the type 2 pathway of apoptosis
    • Raychaudhuri S, Willgohs E, Nguyen TN, Kahn EM, Goldkorn T. Monte Carlo simulation of cell death signaling predicts large cell-to-cell stochastic fluctuations through the type 2 pathway of apoptosis. Biophys J 95: 3559-3562, 2008.
    • (2008) Biophys J , vol.95 , pp. 3559-3562
    • Raychaudhuri, S.1    Willgohs, E.2    Nguyen, T.N.3    Kahn, E.M.4    Goldkorn, T.5
  • 121
    • 0037414827 scopus 로고    scopus 로고
    • Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts: Role of phosphatases and response to isoproterenol
    • Reiken S, Gaburjakova M, Guatimosim S, Gomez AM, D'Armiento J, Burkhoff D, Wang J, Vassort G, Lederer WJ, Marks AR. Protein kinase A phosphorylation of the cardiac calcium release channel (ryanodine receptor) in normal and failing hearts: role of phosphatases and response to isoproterenol. J Biol Chem 278: 444-453, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 444-453
    • Reiken, S.1    Gaburjakova, M.2    Guatimosim, S.3    Gomez, A.M.4    D'Armiento, J.5    Burkhoff, D.6    Wang, J.7    Vassort, G.8    Lederer, W.J.9    Marks, A.R.10
  • 123
    • 0037050009 scopus 로고    scopus 로고
    • Seven-transmembrane-spanning receptors and heart function
    • Rockman HA, Koch WJ, Lefkowitz RJ. Seven-transmembrane-spanning receptors and heart function. Nature 415: 206-212, 2002.
    • (2002) Nature , vol.415 , pp. 206-212
    • Rockman, H.A.1    Koch, W.J.2    Lefkowitz, R.J.3
  • 124
    • 77956586695 scopus 로고    scopus 로고
    • Mitochondria in heart failure
    • Rosca MG, Hoppel CL. Mitochondria in heart failure. Cardiovasc Res 88: 40-50, 2010.
    • (2010) Cardiovasc Res , vol.88 , pp. 40-50
    • Rosca, M.G.1    Hoppel, C.L.2
  • 125
    • 4644271084 scopus 로고    scopus 로고
    • Magic shotguns versus magic bullets: Selectively non-selective drugs for moods disorders and schizophrenia
    • Roth BL, Sheffler DJ, Kroeze WK. Magic shotguns versus magic bullets: selectively non-selective drugs for moods disorders and schizophrenia. Nat Rev Drug Discov 3: 353-359, 2004.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 353-359
    • Roth, B.L.1    Sheffler, D.J.2    Kroeze, W.K.3
  • 126
    • 77956946055 scopus 로고    scopus 로고
    • The SR-mitochondria interaction: A new player in cardiac pathophysiology
    • Ruiz-Meana M, Fernandez-Sanz C, Garcia-Dorado D. The SR-mitochondria interaction: a new player in cardiac pathophysiology. Cardiovasc Res 88: 30-39, 2010.
    • (2010) Cardiovasc Res , vol.88 , pp. 30-39
    • Ruiz-Meana, M.1    Fernandez-Sanz, C.2    Garcia-Dorado, D.3
  • 127
    • 84861658382 scopus 로고    scopus 로고
    • Exploiting mathematical models to illuminate electrophysiological variability between individuals
    • Sarkar AX, Christini DJ, Sobie EA. Exploiting mathematical models to illuminate electrophysiological variability between individuals. J Physiol 590: 2555-2567, 2012.
    • (2012) J Physiol , vol.590 , pp. 2555-2567
    • Sarkar, A.X.1    Christini, D.J.2    Sobie, E.A.3
  • 128
    • 79954633668 scopus 로고    scopus 로고
    • Noise filtering strategies in adaptive biochemical signaling networks
    • Sartori P, Tu Y. Noise filtering strategies in adaptive biochemical signaling networks. J Stat Phys 142: 1206-1217, 2011.
    • (2011) J Stat Phys , vol.142 , pp. 1206-1217
    • Sartori, P.1    Tu, Y.2
  • 129
    • 77955688268 scopus 로고    scopus 로고
    • Irregularly appearing early after-depolarizations in cardiac myocytes: Random flucuatations or dynamical chaos?
    • Sato D, Xie LH, Nguyen TN, Weiss JN, Qu Z. Irregularly appearing early after-depolarizations in cardiac myocytes: random flucuatations or dynamical chaos? Biophys J 99: 765-773, 2010.
    • (2010) Biophys J , vol.99 , pp. 765-773
    • Sato, D.1    Xie, L.H.2    Nguyen, T.N.3    Weiss, J.N.4    Qu, Z.5
  • 130
    • 34347361680 scopus 로고    scopus 로고
    • Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen
    • Satoh M, Matter CM, Ogita H, Takeshita K, Wang CY, Dorn GW 2nd, Liao JK. Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen. Circulation 115: 3197-3204, 2007.
    • (2007) Circulation , vol.115 , pp. 3197-3204
    • Satoh, M.1    Matter, C.M.2    Ogita, H.3    Takeshita, K.4    Wang, C.Y.5    Dorn II, G.W.6    Liao, J.K.7
  • 131
    • 77954995399 scopus 로고    scopus 로고
    • A guide to superresolution fluorescence microscopy
    • Schermellah L, Heintzmann R, Leonhardt H. A guide to superresolution fluorescence microscopy. J Cell Biol 190: 165-175, 2010.
    • (2010) J Cell Biol , vol.190 , pp. 165-175
    • Schermellah, L.1    Heintzmann, R.2    Leonhardt, H.3
  • 133
    • 77953391669 scopus 로고    scopus 로고
    • Deterministic chaos and fractal complexity in the dynamics of cardiovascular behavior: Perspectives on a new frontier
    • Sharma V. Deterministic chaos and fractal complexity in the dynamics of cardiovascular behavior: perspectives on a new frontier. Open Cardiovasc Med J 3: 110-123, 2009.
    • (2009) Open Cardiovasc Med J , vol.3 , pp. 110-123
    • Sharma, V.1
  • 136
    • 80755130608 scopus 로고    scopus 로고
    • Searching for new cardiovascular drugs: Towards improved systems for drug screening?
    • Silvester NC, George CH. Searching for new cardiovascular drugs: towards improved systems for drug screening? Expert Opin Drug Discov 6: 1155-1170, 2011.
    • (2011) Expert Opin Drug Discov , vol.6 , pp. 1155-1170
    • Silvester, N.C.1    George, C.H.2
  • 137
    • 78951470515 scopus 로고    scopus 로고
    • Origins of regulated cell-to-cell variability
    • Snijder B, Pelkmans L. Origins of regulated cell-to-cell variability. Nat Rev Mol Cell Biol 12: 119-125, 2011.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 119-125
    • Snijder, B.1    Pelkmans, L.2
  • 138
    • 79954423832 scopus 로고    scopus 로고
    • Ryanodine receptor assembly: A novel systems biology approach to 3D mapping
    • Song DW, Lee JG, Youn HS, Eom SH, Kim DH. Ryanodine receptor assembly: a novel systems biology approach to 3D mapping. Prog Biophys Mol Biol 105: 145-161, 2011.
    • (2011) Prog Biophys Mol Biol , vol.105 , pp. 145-161
    • Song, D.W.1    Lee, J.G.2    Youn, H.S.3    Eom, S.H.4    Kim, D.H.5
  • 141
    • 79960015656 scopus 로고    scopus 로고
    • Systems biology approaches to heart development and congenital heart disease
    • Sperling SR. Systems biology approaches to heart development and congenital heart disease. Cardiovasc Res 91: 269-278, 2011.
    • (2011) Cardiovasc Res , vol.91 , pp. 269-278
    • Sperling, S.R.1
  • 144
    • 21244492310 scopus 로고    scopus 로고
    • Myocardial substrate metabolism in the normal and failing heart
    • Stanley WC, Recchia FA, Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 85: 1093-1129, 2005.
    • (2005) Physiol Rev , vol.85 , pp. 1093-1129
    • Stanley, W.C.1    Recchia, F.A.2    Lopaschuk, G.D.3
  • 145
    • 0035826155 scopus 로고    scopus 로고
    • Exploring complex networks
    • Strogatz SH. Exploring complex networks. Nature 410: 268-276, 2001.
    • (2001) Nature , vol.410 , pp. 268-276
    • Strogatz, S.H.1
  • 147
    • 0034686014 scopus 로고    scopus 로고
    • Calcium signal transmission between ryanodine receptors and mitochondria
    • Szalai G, Csordas G, Hantash BM, Thomas AP, Hajnoczky G. Calcium signal transmission between ryanodine receptors and mitochondria. J Biol Chem 275: 15305-15513, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 15305-15513
    • Szalai, G.1    Csordas, G.2    Hantash, B.M.3    Thomas, A.P.4    Hajnoczky, G.5
  • 148
    • 0000779360 scopus 로고
    • Detecting strange attractors in turbulence
    • In:, New York: Springer-Verlag
    • Takens F. Detecting strange attractors in turbulence. In: Dynamical Systems and Turbulence: Lecture Notes in Mathematics, vol. 898. New York: Springer-Verlag, 1981, pp. 366-381.
    • (1981) Dynamical Systems and Turbulence: Lecture Notes in Mathematics , vol.898 , pp. 366-381
    • Takens, F.1
  • 149
    • 36749067461 scopus 로고    scopus 로고
    • Ryanodine receptor mutations in arrhythmias: Advances in understanding the mechanisms of channel dysfunction
    • Thomas NL, George CH, Williams AJ, Lai FA. Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction. Biochem Soc Trans 35: 946-951, 2007.
    • (2007) Biochem Soc Trans , vol.35 , pp. 946-951
    • Thomas, N.L.1    George, C.H.2    Williams, A.J.3    Lai, F.A.4
  • 151
    • 79955451479 scopus 로고    scopus 로고
    • Metabolic remodelling in human heart failure
    • Tuunanen H, Knuuti J. Metabolic remodelling in human heart failure. Cardiovasc Res 90: 251-257, 2011.
    • (2011) Cardiovasc Res , vol.90 , pp. 251-257
    • Tuunanen, H.1    Knuuti, J.2
  • 152
    • 0037376655 scopus 로고    scopus 로고
    • Sniffers, buzzers, toggles and blinkers: Dynamics of regulatory and signaling pathways in the cell
    • Tyson JJ, Chen KC, Novak B. Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell. Curr Opin Cell Biol 15: 221-231, 2003.
    • (2003) Curr Opin Cell Biol , vol.15 , pp. 221-231
    • Tyson, J.J.1    Chen, K.C.2    Novak, B.3
  • 154
    • 33846117456 scopus 로고    scopus 로고
    • Increasing ryanodine receptor open probability alone does not produce arrhythmogenic calcium waves-threshold sarcoplasmic reticulum calcium content is required
    • Venetucci LA, Trafford AW, Eisner DA. Increasing ryanodine receptor open probability alone does not produce arrhythmogenic calcium waves-threshold sarcoplasmic reticulum calcium content is required. Circ Res 100: 105-111, 2007.
    • (2007) Circ Res , vol.100 , pp. 105-111
    • Venetucci, L.A.1    Trafford, A.W.2    Eisner, D.A.3
  • 160
    • 84863010950 scopus 로고    scopus 로고
    • Threedimensional reconstruction of protein networks provides insight into human genetic disease
    • Wang X, Wei X, Thijssen B, Das J, Lipkin SM, Yu H. Threedimensional reconstruction of protein networks provides insight into human genetic disease. Nat Biotechnol 30: 159-164, 2012.
    • (2012) Nat Biotechnol , vol.30 , pp. 159-164
    • Wang, X.1    Wei, X.2    Thijssen, B.3    Das, J.4    Lipkin, S.M.5    Yu, H.6
  • 162
    • 0032482432 scopus 로고    scopus 로고
    • Collective dynamics of 'small-world' networks
    • Watts DJ, Strogatz SH. Collective dynamics of 'small-world' networks. Nature 393: 440-442, 1998.
    • (1998) Nature , vol.393 , pp. 440-442
    • Watts, D.J.1    Strogatz, S.H.2
  • 164
    • 31444432542 scopus 로고    scopus 로고
    • Ryanodine receptor/calcium release channel PKA phosphorylation: A critical mediator of heart failure progression
    • Wehrens XHT, Lehnart SE, Reiken S, Vest JA, Wronska A, Marks AR. Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci USA 103: 511-518, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 511-518
    • Wehrens, X.H.T.1    Lehnart, S.E.2    Reiken, S.3    Vest, J.A.4    Wronska, A.5    Marks, A.R.6
  • 166
    • 79953329175 scopus 로고    scopus 로고
    • How does falling out of phase of intracellular calcium and action potentials across the heart's wall spell the beginning of chaos for the heart?
    • Weiss JN. How does falling out of phase of intracellular calcium and action potentials across the heart's wall spell the beginning of chaos for the heart? Dialogues Cardiovasc Med 15: 302-310, 2010.
    • (2010) Dialogues Cardiovasc Med , vol.15 , pp. 302-310
    • Weiss, J.N.1
  • 167
    • 80054930783 scopus 로고    scopus 로고
    • Imaging the coordination of multiple signalling activities in living cells
    • Welch CM, Elliot H, Danuser G, Hahn KM. Imaging the coordination of multiple signalling activities in living cells. Nat Rev Mol Cell Biol 12: 749-756, 2011.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 749-756
    • Welch, C.M.1    Elliot, H.2    Danuser, G.3    Hahn, K.M.4
  • 168
    • 0028897281 scopus 로고
    • Stochastic resonance and the benefits of noise: From ice ages to crayfish and SQUIDs
    • Wiesenfeld K, Moss F. Stochastic resonance and the benefits of noise: from ice ages to crayfish and SQUIDs. Nature 373: 33-36, 1995.
    • (1995) Nature , vol.373 , pp. 33-36
    • Wiesenfeld, K.1    Moss, F.2
  • 171
    • 79960346334 scopus 로고    scopus 로고
    • Compartmentalization of beta-adrenergic signals in cardiomyocytes
    • Xiang YK. Compartmentalization of beta-adrenergic signals in cardiomyocytes. Circ Res 109: 231-244, 2011.
    • (2011) Circ Res , vol.109 , pp. 231-244
    • Xiang, Y.K.1
  • 173
    • 23844456403 scopus 로고    scopus 로고
    • Abnormal ryanodine receptor function in heart failure
    • Yano M, Yamamoto T, Ikemoto N, Matsuzaki M. Abnormal ryanodine receptor function in heart failure. Pharmacol Ther 107: 377-391, 2005.
    • (2005) Pharmacol Ther , vol.107 , pp. 377-391
    • Yano, M.1    Yamamoto, T.2    Ikemoto, N.3    Matsuzaki, M.4
  • 175
    • 49449110197 scopus 로고    scopus 로고
    • Constraints imposed by nonfunctional protein-protein interactions on gene expression and proteome size
    • Zhang J, Maslov S, Shakhnovich EI. Constraints imposed by nonfunctional protein-protein interactions on gene expression and proteome size. Mol Syst Biol 4: 210, 2008.
    • (2008) Mol Syst Biol , vol.4 , pp. 210
    • Zhang, J.1    Maslov, S.2    Shakhnovich, E.I.3
  • 178
    • 28044451344 scopus 로고    scopus 로고
    • Emerging concepts and therapeutic implications of β-adrenergic receptor subtype signaling
    • Zheng M, Zhu W, Han Q, Xiao RP. Emerging concepts and therapeutic implications of β-adrenergic receptor subtype signaling. Pharmacol Ther 108: 257-268, 2005.
    • (2005) Pharmacol Ther , vol.108 , pp. 257-268
    • Zheng, M.1    Zhu, W.2    Han, Q.3    Xiao, R.P.4
  • 179
    • 25444496192 scopus 로고    scopus 로고
    • i signaling in the heart: The good, the bad, and the ugly
    • i signaling in the heart: the good, the bad, and the ugly. Circ Res 97: 507-509, 2005.
    • (2005) Circ Res , vol.97 , pp. 507-509
    • Zhu, W.1    Zeng, X.2    Zheng, M.3    Xiao, R.P.4


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